The predicted truncation from a cancer-associated variant of the MSH2 initiation codon alters activity of the MSH2-MSH6 mismatch repair complex

Molecular Carcinogenesis

Volumn 51, Issue 8, 2012, Pages 647-658

  Cyr, Jennifer L ^a   Brown, Graham D ^a   Stroop, Jennifer ^a   Heinen, Christopher D ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

DNA mismatch repair; Lynch syndrome; Missense variants; MSH2 MSH6

Indexed keywords

ADENOSINE; AMINO ACID; PROTEIN MSH2; PROTEIN MSH6;

ADULT; ALLELE; ARTICLE; CANCER RISK; CASE REPORT; DNA DAMAGE; FAMILY HISTORY; FEMALE; GENE MUTATION; GENETIC RISK; GENETIC VARIABILITY; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HUMAN; HUMAN CELL; MALE; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; OVARY CANCER; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN PURIFICATION; PROTEIN STRUCTURE; PROTEIN TRUNCATION; START CODON; TRANSLATION INITIATION; TUMOR GENE;

AMINO ACID SEQUENCE; BASE PAIR MISMATCH; BASE SEQUENCE; CODON, INITIATOR; DNA-BINDING PROTEINS; FAMILY HEALTH; FEMALE; HUMANS; MALE; MIDDLE AGED; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; MUTATION; MUTS HOMOLOG 2 PROTEIN; OVARIAN NEOPLASMS; PEDIGREE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 81255123835     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20838     Document Type: Article

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