Lynch syndrome-associated mutations in MSH2 alter DNA repair and checkpoint response functions in vivo

Human Mutation

Volumn 31, Issue 10, 2010, Pages

  Mastrocola, Adam S ^a   Heinen, Christopher D ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

DNA checkpoint response; DNA mismatch repair; Lynch Syndrome; Missense mutations; MSH2; MSH6

Indexed keywords

PROTEIN MSH2; MSH2 PROTEIN, HUMAN; PROTEIN SUBUNIT;

AMINO ACID ANALYSIS; ARTICLE; CANCER GENETICS; CELL CYCLE ARREST; CELL CYCLE S PHASE; CHROMATIN IMMUNOPRECIPITATION; COLON CARCINOGENESIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA REPAIR; EXPRESSION VECTOR; FLUORESCENCE ACTIVATED CELL SORTING; GENE FUNCTION; GENETIC ASSOCIATION; GENETIC COUNSELING; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HUMAN; HUMAN CELL; IN VIVO STUDY; LENTIVIRINAE; MISMATCH REPAIR; MISSENSE MUTATION; MUTATIONAL ANALYSIS; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; TRANSLATION INITIATION; WESTERN BLOTTING; CHEMICAL STRUCTURE; CHEMISTRY; GENE; GENETIC PREDISPOSITION; GENETICS; METABOLISM; MUTATION; PHYSIOLOGY; TUMOR CELL LINE;

CELL LINE, TUMOR; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA MISMATCH REPAIR; DNA REPAIR; GENES, CDC; GENETIC PREDISPOSITION TO DISEASE; GERM-LINE MUTATION; HUMANS; MODELS, MOLECULAR; MUTATION, MISSENSE; MUTS HOMOLOG 2 PROTEIN; PROTEIN SUBUNITS;

EID: 79952115905     PISSN: 10597794     EISSN: 10981004     Source Type: Journal    
DOI: 10.1002/humu.21333     Document Type: Article

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