메뉴 건너뛰기




Volumn 16, Issue 9, 1997, Pages 2482-2492

Recognition of AUG and alternative initiator codons is augmented by G in position +4 but is not generally affected by the nucleotides in positions +5 and +6

Author keywords

Initiation codon context; mRNA structure; Protein synthesis; Scanning model; Translation

Indexed keywords

GUANOSINE; MESSENGER RNA; NUCLEOTIDE; PRIMER DNA;

EID: 0031010944     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.9.2482     Document Type: Article
Times cited : (423)

References (37)
  • 1
    • 0023003380 scopus 로고
    • In vivo half-life of a protein is a function of its amino-terminal residue
    • Bachmair, A., Finley, D. and Varshavsky, A. (1986) In vivo half-life of a protein is a function of its amino-terminal residue. Science, 234, 179-186.
    • (1986) Science , vol.234 , pp. 179-186
    • Bachmair, A.1    Finley, D.2    Varshavsky, A.3
  • 2
    • 0029016564 scopus 로고
    • Yeast N-terminal amidase. A new enzyme and component of the N-end rule pathway
    • Baker, R.T. and Varshavsky, A. (1995) Yeast N-terminal amidase. A new enzyme and component of the N-end rule pathway. J. Biol. Chem., 270, 12065-12074.
    • (1995) J. Biol. Chem. , vol.270 , pp. 12065-12074
    • Baker, R.T.1    Varshavsky, A.2
  • 3
    • 0028066841 scopus 로고
    • Positions +5 and +6 can be major determinants of the efficiency of non-AUG initiation codons for protein synthesis
    • Boeck, R. and Kolakofsky, D. (1994) Positions +5 and +6 can be major determinants of the efficiency of non-AUG initiation codons for protein synthesis. EMBO J., 13, 3608-3617.
    • (1994) EMBO J. , vol.13 , pp. 3608-3617
    • Boeck, R.1    Kolakofsky, D.2
  • 5
    • 0024297814 scopus 로고
    • Mutations at a Zn(II) finger motif in the yeast eIF-2β gene alter ribosomal start-site selection during the scanning process
    • Donahue, T.F. Cigan, A.M., Pabich, E.K. and Valavicius, B.C. (1988) Mutations at a Zn(II) finger motif in the yeast eIF-2β gene alter ribosomal start-site selection during the scanning process. Cell, 54, 621-632.
    • (1988) Cell , vol.54 , pp. 621-632
    • Donahue, T.F.1    Cigan, A.M.2    Pabich, E.K.3    Valavicius, B.C.4
  • 6
    • 0029022224 scopus 로고
    • Mutations in GCD11, the structural gene for eIF-2γ in yeast, alter translational regulation of GCN4 and the selection of the start site for protein synthesis
    • Dorris, D.R., Erickson, F.L. and Hannig, E.M. (1995) Mutations in GCD11, the structural gene for eIF-2γ in yeast, alter translational regulation of GCN4 and the selection of the start site for protein synthesis. EMBO J., 14, 2239-2249.
    • (1995) EMBO J. , vol.14 , pp. 2239-2249
    • Dorris, D.R.1    Erickson, F.L.2    Hannig, E.M.3
  • 7
    • 0025129247 scopus 로고
    • Translation of bicistronic viral mRNA in transfected cells: Regulation at the level of elongation
    • Fajardo, J.E. and Shatkin, A.J. (1990) Translation of bicistronic viral mRNA in transfected cells: regulation at the level of elongation. Proc. Natl Acad. Sci. USA, 87, 328-332.
    • (1990) Proc. Natl Acad. Sci. USA , vol.87 , pp. 328-332
    • Fajardo, J.E.1    Shatkin, A.J.2
  • 8
    • 0022508657 scopus 로고
    • Sequence determinants of cytosolic N-terminal protein processing
    • Flinta, C., Persson, B., Jörnvall, H. and von Heijne, G. (1986) Sequence determinants of cytosolic N-terminal protein processing. Eur. J. Biochem., 154, 193-196.
    • (1986) Eur. J. Biochem. , vol.154 , pp. 193-196
    • Flinta, C.1    Persson, B.2    Jörnvall, H.3    Von Heijne, G.4
  • 10
    • 0028136218 scopus 로고
    • The immediate downstream codon strongly influences the efficiency of utilization of eukaryotic translation initiation codons
    • Grünert, S. and Jackson, R.J. (1994) The immediate downstream codon strongly influences the efficiency of utilization of eukaryotic translation initiation codons. EMBO J., 13, 3618-3630.
    • (1994) EMBO J. , vol.13 , pp. 3618-3630
    • Grünert, S.1    Jackson, R.J.2
  • 11
    • 0024252185 scopus 로고
    • Extension inhibition analysis of translation initiation complexes
    • Hartz, D., McPheeters, D.S., Traut, R. and Gold, L. (1988) Extension inhibition analysis of translation initiation complexes. Methods Enzymol., 164, 419-425.
    • (1988) Methods Enzymol. , vol.164 , pp. 419-425
    • Hartz, D.1    McPheeters, D.S.2    Traut, R.3    Gold, L.4
  • 12
    • 0018801461 scopus 로고
    • Aminoacyl-tRNA populations in mammalian cells. Chromatographic profiles and patterns of codon recognition
    • Hatfield, D., Matthews, C.R. and Rice, M. (1979) Aminoacyl-tRNA populations in mammalian cells. Chromatographic profiles and patterns of codon recognition. Biochim. Biophys. Acta, 564, 414-423.
    • (1979) Biochim. Biophys. Acta , vol.564 , pp. 414-423
    • Hatfield, D.1    Matthews, C.R.2    Rice, M.3
  • 13
    • 0020490479 scopus 로고
    • The aminoacyl-tRNA population of human reticulocytes
    • Hatfield, D., Varricchio, E. Rice, M. and Forget, B.G. (1982) The aminoacyl-tRNA population of human reticulocytes. J. Biol. Chem., 257, 3183-3188.
    • (1982) J. Biol. Chem. , vol.257 , pp. 3183-3188
    • Hatfield, D.1    Varricchio, E.2    Rice, M.3    Forget, B.G.4
  • 14
    • 0029162727 scopus 로고
    • Codon pair utilization biases influence translational elongation step times
    • Irwin, B., Heck, J.D. and Hatfield, G.W. (1995) Codon pair utilization biases influence translational elongation step times. J. Biol. Chem., 270, 22801-22806.
    • (1995) J. Biol. Chem. , vol.270 , pp. 22801-22806
    • Irwin, B.1    Heck, J.D.2    Hatfield, G.W.3
  • 15
    • 0026703067 scopus 로고
    • Isolation and characterization of the methionine aminopeptidase from porcine liver responsible for the co-translational processing of proteins
    • Kendall, R.L. and Bradshaw, R.A. (1992) Isolation and characterization of the methionine aminopeptidase from porcine liver responsible for the co-translational processing of proteins. J. Biol. Chem., 267, 20667-20673.
    • (1992) J. Biol. Chem. , vol.267 , pp. 20667-20673
    • Kendall, R.L.1    Bradshaw, R.A.2
  • 16
    • 0022552131 scopus 로고
    • Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes
    • Kozak, M. (1986a) Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell, 44, 283-292.
    • (1986) Cell , vol.44 , pp. 283-292
    • Kozak, M.1
  • 17
    • 0023054773 scopus 로고
    • Bifunctional messenger RNAs in eukaryotes
    • Kozak, M. (1986b) Bifunctional messenger RNAs in eukaryotes. Cell, 47, 481-483.
    • (1986) Cell , vol.47 , pp. 481-483
    • Kozak, M.1
  • 18
    • 0023665902 scopus 로고
    • An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs
    • Kozak, M. (1987) An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res., 15, 8125-8148.
    • (1987) Nucleic Acids Res. , vol.15 , pp. 8125-8148
    • Kozak, M.1
  • 19
    • 0024546509 scopus 로고
    • The scanning model for translation: An update
    • Kozak, M. (1989a) The scanning model for translation: an update. J. Cell Biol., 108, 229-241.
    • (1989) J. Cell Biol. , vol.108 , pp. 229-241
    • Kozak, M.1
  • 20
    • 0024394362 scopus 로고
    • Context effects and (inefficient) initiation at non-AUG codons in eucaryotic cell-free translation systems
    • Kozak, M. (1989b) Context effects and (inefficient) initiation at non-AUG codons in eucaryotic cell-free translation systems. Mol. Cell. Biol., 9, 5073-5080.
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 5073-5080
    • Kozak, M.1
  • 21
    • 0025107694 scopus 로고
    • Downstream secondary structure facilitates recognition of initiator codons by eukaryotic ribosomes
    • Kozak, M. (1990a) Downstream secondary structure facilitates recognition of initiator codons by eukaryotic ribosomes. Proc. Natl Acad. Sci. USA, 87, 8301-8305.
    • (1990) Proc. Natl Acad. Sci. USA , vol.87 , pp. 8301-8305
    • Kozak, M.1
  • 22
    • 0025270438 scopus 로고
    • Evaluation of the fidelity of initiation of translation in reticulocyte lysates from commercial sources
    • Kozak, M. (1990b) Evaluation of the fidelity of initiation of translation in reticulocyte lysates from commercial sources. Nucleic Acids Res., 18, 2828.
    • (1990) Nucleic Acids Res. , vol.18 , pp. 2828
    • Kozak, M.1
  • 23
    • 0026342613 scopus 로고
    • An analysis of vertebrate mRNA sequences: Intimations of translational control
    • Kozak, M. (1991) An analysis of vertebrate mRNA sequences: intimations of translational control. J. Cell. Biol., 115, 887-903.
    • (1991) J. Cell. Biol. , vol.115 , pp. 887-903
    • Kozak, M.1
  • 24
    • 0026648379 scopus 로고
    • A consideration of alternative models for the initiation of translation in eukaryotes
    • Kozak, M. (1992) A consideration of alternative models for the initiation of translation in eukaryotes. Crit. Rev. Biochem. Mol. Biol., 27, 385-402.
    • (1992) Crit. Rev. Biochem. Mol. Biol. , vol.27 , pp. 385-402
    • Kozak, M.1
  • 25
    • 0028140591 scopus 로고
    • Features in the 5′ noncoding sequences of rabbit a and β-globin mRNAs that affect translational efficiency
    • Kozak, M. (1994) Features in the 5′ noncoding sequences of rabbit a and β-globin mRNAs that affect translational efficiency. J. Mol. Biol., 235, 95-110.
    • (1994) J. Mol. Biol. , vol.235 , pp. 95-110
    • Kozak, M.1
  • 26
    • 0028914004 scopus 로고
    • Adherence to the first-AUG rule when a second AUG codon follows closely upon the first
    • Kozak, M. (1995) Adherence to the first-AUG rule when a second AUG codon follows closely upon the first. Proc. Natl Acad. Sci. USA, 92, 2662-2666 (and p. 7134).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 2662-2666
    • Kozak, M.1
  • 27
    • 0030213227 scopus 로고    scopus 로고
    • Interpreting cDNA sequences: Some insights from studies on translation
    • Kozak, M. (1996) Interpreting cDNA sequences: some insights from studies on translation. Mammalian Genome, 7, 563-574.
    • (1996) Mammalian Genome , vol.7 , pp. 563-574
    • Kozak, M.1
  • 28
    • 0017706877 scopus 로고
    • Sequences and properties of two ribosome binding sites from the small size class of reovirus messenger RNA
    • Kozak, M. and Shatkin, A.J. (1977) Sequences and properties of two ribosome binding sites from the small size class of reovirus messenger RNA. J. Biol. Chem., 252, 6895-6908.
    • (1977) J. Biol. Chem. , vol.252 , pp. 6895-6908
    • Kozak, M.1    Shatkin, A.J.2
  • 29
    • 0027420920 scopus 로고
    • A 30-kDa alternative translation product of the CCAAT/enhancer binding protein α message: Transcriptional activator lacking antimitotic activity
    • Lin, F.-T., MacDougald, O.A., Diehl, A.M. and Lane, M.D. (1993) A 30-kDa alternative translation product of the CCAAT/enhancer binding protein α message: transcriptional activator lacking antimitotic activity. Proc. Natl Acad. Sci. USA, 90, 9606-9610.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 9606-9610
    • Lin, F.-T.1    MacDougald, O.A.2    Diehl, A.M.3    Lane, M.D.4
  • 30
    • 0025200973 scopus 로고
    • The specificities of yeast methionine aminopeptidase and acetylation of amino-terminal methionine in vivo
    • Moerschell, R.P., Hosokawa, Y., Tsunasawa, S. and Sherman, F. (1990) The specificities of yeast methionine aminopeptidase and acetylation of amino-terminal methionine in vivo. J. Biol. Chem., 265, 19638-19643.
    • (1990) J. Biol. Chem. , vol.265 , pp. 19638-19643
    • Moerschell, R.P.1    Hosokawa, Y.2    Tsunasawa, S.3    Sherman, F.4
  • 31
    • 0027214319 scopus 로고
    • CCAAT/enhancer binding protein mRNA is translated into multiple proteins with different transcription activation potentials
    • Ossipow, V., Descombes, P. and Schibler, U. (1993) CCAAT/enhancer binding protein mRNA is translated into multiple proteins with different transcription activation potentials. Proc. Natl Acad. Sci. USA 90, 8219-8223.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 8219-8223
    • Ossipow, V.1    Descombes, P.2    Schibler, U.3
  • 32
    • 0023664886 scopus 로고
    • Translation initiation at an ACG triplet in mammalian cells
    • Peabody, D.S. (1987) Translation initiation at an ACG triplet in mammalian cells. J. Biol. Chem., 262, 11847-11851.
    • (1987) J. Biol. Chem. , vol.262 , pp. 11847-11851
    • Peabody, D.S.1
  • 33
    • 0028364392 scopus 로고
    • Identification of a sequence in the unique 5′ ORF of the gene encoding glycosylated gag which influences the incubation period of neurodegenerative disease induced by a murine retrovirus
    • Portis, J.L., Spangrude, G.J. and McAtee, F.J. (1994) Identification of a sequence in the unique 5′ ORF of the gene encoding glycosylated gag which influences the incubation period of neurodegenerative disease induced by a murine retrovirus. J. Virol., 68, 3879-3887.
    • (1994) J. Virol. , vol.68 , pp. 3879-3887
    • Portis, J.L.1    Spangrude, G.J.2    McAtee, F.J.3
  • 36
    • 0024293471 scopus 로고
    • On the role of the Shine-Dalgarno sequence in determining the efficiency of translation initiation at a weak start codon in the car operon of Escherichia coli K12
    • Weyens, G., Charlier, D., Roovers, M., Piérard, A. and Glansdorff, N. (1988) On the role of the Shine-Dalgarno sequence in determining the efficiency of translation initiation at a weak start codon in the car operon of Escherichia coli K12. J. Mol. Biol., 204, 1045-1048.
    • (1988) J. Mol. Biol. , vol.204 , pp. 1045-1048
    • Weyens, G.1    Charlier, D.2    Roovers, M.3    Piérard, A.4    Glansdorff, N.5
  • 37
    • 0026010217 scopus 로고
    • Low-usage codons in Escherichia coli, yeast, fruit fly and primates
    • Zhang, S., Zubay, G. and Goldman, E. (1991) Low-usage codons in Escherichia coli, yeast, fruit fly and primates. Gene, 105, 61-72.
    • (1991) Gene , vol.105 , pp. 61-72
    • Zhang, S.1    Zubay, G.2    Goldman, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.