Human p53 induces cell death and downregulates thioredoxin expression in Saccharomyces cerevisiae

FEMS Yeast Research

Volumn 8, Issue 8, 2008, Pages 1254-1262

  Hadj Amor, Ines Yacoubi ^a   Smaoui, Kamel ^a   Chaabène, Ines ^a   Mabrouk, Imed ^a   Djemal, Lamia ^a   Elleuch, Henda ^b   Allouche, Michèle ^c   Mokdad Gargouri, Raja ^a   Gargouri, Ali ^a  

^a CENTRE DE BIOTECHNOLOGIE DE SFAX   (Tunisia)

^b Centre Regional de Transfusion Sanguine de Sfax   (Tunisia)

^c INSERM   (France)

Author keywords

Apoptosis; Hot spot mutant; p53; Reactive oxygen species (ROS); Saccharomyces cerevisiae; Thioredoxin

Indexed keywords

DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; DIHYDRORHODAMINE 123; DNA NUCLEOTIDYLEXOTRANSFERASE; LIPOCORTIN 5; PHOSPHATIDYLSERINE; PROTEIN P53; REACTIVE OXYGEN METABOLITE; THIOREDOXIN;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DOWN REGULATION; FUNGUS GROWTH; GENE EXPRESSION; GENETIC TRANSCRIPTION; NONHUMAN; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE;

APOPTOSIS; CULTURE MEDIA; DOWN-REGULATION; GENE EXPRESSION REGULATION, FUNGAL; HUMANS; REACTIVE OXYGEN SPECIES; SACCHAROMYCES CEREVISIAE; THIOREDOXINS; TUMOR SUPPRESSOR PROTEIN P53;

SACCHAROMYCES CEREVISIAE;

EID: 55349108917     PISSN: 15671356     EISSN: 15671364     Source Type: Journal    
DOI: 10.1111/j.1567-1364.2008.00445.x     Document Type: Article

References (31)

1. Balzan R, Sapienza K, Galea DR, Vassallo N, Frey H Bannister WH (2004) Aspirin commits yeast cells to apoptosis depending on carbon source. Microbiology 150 : 109 115.
2. Beroud C Soussi T (2003) The UMD-p53 database: new mutations and analysis tools. Hum Mutat 21 : 176 181.
3. Bullock AN Fersht AR (2001) Rescuing the function of mutant p53. Nat Rev Cancer 1 : 68 76.
4. Cullin C Pompon D (1988) Synthesis of functional mouse cytochromes P-450 P1 and chimeric P-450 P3-1 in the yeast Saccharomyces cerevisiae. Gene 65 : 203 217.
5. Del Carratore R, Petrucci A, Simili M, Fronza G Galli A (2004) Involvement of human p53 in induced intrachromosomal recombination in Saccharomyces cerevisiae. Mutagenesis 19 : 333 339.
6. Flaman J-M, Frebourg T, Moreau V et al 1995) A simple p53 functional assay for screening cell lines, blood, and tumors. Proc Natl Acad Sci USA 92 : 3963 3967.
7. Gan ZR (1991) Yeast thioredoxin genes. J Biol Chem 266 : 1692 1696.
8. Gourlay C, Du W Ayscough KR (2006) Apoptosis in yeast - mechanisms and benefits to a unicellular organism. Mol Microbiol 62 : 1515 1521.
9. Hainaut P, Hernandez T, Robinson A et al 1998) ARC database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools. Nucleic Acids Res 26 : 205 213.
10. Harris S Levine A (2005) The p53 pathway: positive and negative feedback loops. Oncogene 24 : 2899 2908.
11. Ito H, Fukuda Y, Murata K Kimura A (1983) Transformation of intact yeast cells treated with alkali cations. J Bacteriol 153 : 163 168.
12. Jacks T Weinberg RA (1996) Cell-cycle control and its watchman. Nature 381 : 643 644.
13. Kato S, Han SY, Liu W, Otsuka K, Shibata H, Kanamaru R Ishioka C (2003) Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis. Proc Natl Acad Sci USA 100 : 8424 8429.
14. Levine AJ, Wu MC, Chang A, Silver A, Attiyeh EF Lin J (1995) The spectrum of mutations at the p53 locus. Evidence for tissue-specific mutagenesis, selection of mutant alleles, and a "gain of function" phenotype. Ann NY Acad Sci 768 : 111 128.
15. Ligr M, Madeo F, Frohlich E, Hilt W, Frohlich KU Wolf DH (1998) Mammalian Bax triggers apoptotic changes in yeast. FEBS Lett 438 : 61 65.
16. Ludovico P, Sousa MJ, Silva MT, Leão C Côrte-Real M (2001) Saccharomyces cerevisiae commits to a programmed cell death process in response to acetic acid. Microbiology 147 : 2409 2415.
17. Madeo F, Frohlich E Frohlich KU (1997) A yeast mutant showing diagnostic markers of early and late apoptosis. J Cell Biol 139 : 729 734.
18. Madeo F, Frohlich E, Ligr M, Grey M, Sigrist SJ, Wolf DH Frohlich KU (1999) Oxygen stress: a regulator of apoptosis in yeast. J Cell Biol 145 : 757 767.
19. Madeo F, Engelhardt S, Herker E et al 2002) Apoptosis in yeast: a new model system with applications in cell biology and medicine. Curr Genet 41 : 208 216.
20. Masaya U, Yasuo M, Hajime N et al 2000) Possible association of thioredoxin and p53 in breast cancer. Immunol Lett 75 : 15 20.
21. Merrill GF, Dowell P Pearson GD (1999) The human p53 negative regulatory domain mediates inhibition of reporter gene transactivation in yeast lacking thioredoxin reductase. Cancer Res 59 : 3175 3179.
22. Mokdad-Gargouri R, Belhadj K Gargouri A (2001) Translational control of human p53 expression in yeast mediated by 5′-UTR-ORF structural interaction. Nucleic Acids Res 29 : 1222 1227.
23. Nigro J, Sikorski R, Reed S Vogelstein B (1992) Human p53 and CDC2Hs genes combine to inhibit the proliferation of Saccharomyces cerevisiae. Mol Cell Biol 12 : 1357 1365.
24. Ocón-Garrido E Grant CM (2002) Role of thioredoxins in the response of Saccharomyces cerevisiae to oxidative stress induced by hydroperoxides. Mol Microbiol 43 : 993 1003.
25. Pearson GD Merrill GF (1998) Deletion of Saccharomyces cerevisiae TRR1 gene encoding thioredoxin reductase inhibits p53-dependant reporter gene expression. J Biol Chem 273 : 5431 5434.
26. Prives C Hall PA (1999) The p53 pathway. J Pathol 187 : 112 126.
27. Ribeiro G, Corte-Real M Johansson B (2006) Characterization of DNA damage in yeast apoptosis induced by hydrogen peroxide, acetic acid and hyperosmotic shock. Mol Biol Cell 17 : 4584 4591.
28. Scharer E Iggo R (1992) Mammalian p53 can function as transcription factor in yeast. Nucleic Acids Res 20 : 1539 1545.
29. SeungJin K, Yasuo M, Tetsuya T et al 2005) High thioredoxin expression is associated with resistance to docetaxel in primary breast cancer. Clin Cancer Res 11 : 8425 8429.
30. Sigal A Rotter V (2000) Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome. Cancer Res 60 : 6788 6793.
31. Zambetti G Levine A (1993) A comparison of the biological activities of wild-type and mutant p53. FASEB J 7 : 855 865.