Canova medication modifies parasitological parameters in mice infected with Trypanosoma cruzi

Experimental Parasitology

Volumn 126, Issue 4, 2010, Pages 435-440

  Pupulin, Aurea Regina Telles ^a   Marques Araujo, Silvana ^a   Toledo, Max Jean Ornelas ^a   Gomes, Mônica Lúcia ^a   Takejima, Edilson ^a   Cuman, Roberto Kenji Nakamura ^a   Bersani Amado, Ciomar Aparecida ^a  

^a STATE UNIVERSITY OF MARINGÁ   (Brazil)

Author keywords

Benznidazole; Canova medicament; Tissue parasitism; Trypanosoma cruzi

Indexed keywords

ACONITUM NAPELLUS EXTRACT; ANTIPARASITIC AGENT; ARSENIC TRIOXIDE; BENZNIDAZOLE; BRYONIA ALBA EXTRACT; CANOVA; CEDAR LEAF OIL; HOMEOPATHIC AGENT; PLANT EXTRACT; UNCLASSIFIED DRUG; ANTITRYPANOSOMAL AGENT; CANOVA MEDICATION; NITROIMIDAZOLE DERIVATIVE; SNAKE VENOM;

ACONITUM; ACONITUM NAPELLUS; AMASTIGOTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BARK; BRYONIA; BRYONIA ALBA; CHAGAS DISEASE; CONTROLLED STUDY; DRUG EFFICACY; DRUG RESPONSE; HEART; HERBAL MEDICINE; HOST PARASITE INTERACTION; IMMUNOMODULATION; INTESTINE; LIVER; MALE; MORTALITY; MOUSE; NONHUMAN; PARASITEMIA; PARASITISM; PLANT ROOT; PRIORITY JOURNAL; SPLEEN; TISSUE DISTRIBUTION; TRYPANOSOMA CRUZI; ANIMAL; DRUG COMBINATION; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; HOST PATHOGEN INTERACTION; PARASITOLOGY; PHYSIOLOGY; PUBLICATION;

ANIMALS; CHAGAS DISEASE; CROTALID VENOMS; DRUG THERAPY, COMBINATION; FORMULARIES, HOMEOPATHIC; HEART; HOST-PATHOGEN INTERACTIONS; INTESTINES; LIVER; MALE; MICE; NITROIMIDAZOLES; PARASITEMIA; PLANT EXTRACTS; SPLEEN; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

ANIMALIA; MUS; TRYPANOSOMA CRUZI;

EID: 81155152731     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2010.04.002     Document Type: Article

References (54)

1. Abud A.P., Cesar B., Cavazzani L.F., de Oliveira C.C., Gabardo J., Buchi D.F. Activation of bone marrow cells treated with Canova in vitro. Cell Biology International 2006, 30:808-816.
2. Aleixo D.L., Ferraz F.N., Melo C.S., Gomes M.L., Toledo M.J., Kaneshima E.N., Bersani-Amado C.A., Araújo S.M. Changes of RAPD profile of Trypanosoma cruzi II with Canova and Benznidazole. Homeopathy 2008, 97:59-64.
3. Anez N., Carrasco H., Parada H. Myocardial parasite persistence in chronic chagasic patients. American Society for Tropical Medicine and Hygiene 1999, 60:726-732.
4. Andrade Z.A., Rocha da Silva H.R. Parasitismo of adipocytes by Trypanosoma cruzi. Memórias do Instituto Oswaldo Cruz 1995, 90:521-522.
5. Andrade S.G., Figueira R.M. Experimental study on the therapeutic action of RO 7-1091 on infection caused by different strains of Trypanosoma cruzi. Revista do Instituto de Medicina Tropical São Paulo 1977, 19:335-341.
6. Ávila H.A., Sigman D., Cohen L., Milikan K., Simpson L. Polymerase Caín reaction of Trypanosoma cruzi kinetoplast minicircle DNA isolated from whole blood lysate: diagnosis of chronic Chagas' disease. Molecular and Biochemical Parasitology 1991, 48:211-222.
7. Ballow M., Nelson R. Immunopharmacology: immunomodulation and immunotherapy. Journal of the American Medical Association Chicago 1997, 278:2008-2017.
8. Berger B.J., Fairlamb A.H. Interactions between immunity and chemotherapy in the treatment of trypanosomiases and leishmaniases. Parasitology 1992, 105:S71-S78.
9. Bin-Hafeez Rizwanul H., Suhel P., Suwarna P., Iqbal S., Raisuddin S. Immunomodulatory effects of fenugreek (Trigonella foenum gaecum L.) extract in mice. International Journal of Immunopharmacology 2003, 3:257-265.
10. Brener Z. Therapeutic activity and criterion of cure on mice experimentally infected with Trypanosoma cruzi. Revista do Instituto de Medicina Tropical São Paulo 1962, 4:389-396.
11. Buchi D.F., Vecchio M.D. Qualidade de vida para pacientes com câncer e Aids. Myta'y 2002, 1:33-38.
12. Burbano R.R., Leal M.F., Costa J.B., Bahia M.O., Lima P.D., Khayat A.S., Seligman I.C., Assumpção P.P., Buchi D.F., Smith M.A.C. Lymphocyte proliferation stimulated by activated human macrophages treated with Canova. Homeopathy 2009, 98:45-48.
13. Camargo E.P. Growth and differentiation in Trypanosoma cruzi I. Orogin of metaciclic tripanosomes in liquid media. Revista do Instituto de Medicina Tropical São Paulo 1964, 6:93-100.
14. Consenso Brasileiro em Doença de Chagas, 2006. Revista da Sociedade Brasileira de Medicina Tropical 38 suplemento III.
15. Coura J.R., De Castro S.L. A critical review on Chagas disease chemotheraphy. Memória do Instituto Oswaldo Cruz 2002, 97:3-24.
16. Croft S.L., Gamage S.A., Figgitt D.P., Wojcik S.J., Ralph R.K., Ransijn A., Manuel J., Yardley V., Snowdon D., Denny W.A. Structure-activity relationships for the antileishmanial and antitrypanosomal activities of 1'substuted 9 anilinoacridines. Journal of Medicinal Chemistry 1997, 40:2634-2642.
17. CRFB, 1997. Comissão Permanente de Revisão da Farmacopéia Brasileira. Farmacopéia Homeopática Brasileira, second ed. São Paulo, SP, Brazil, Ateneu.
18. De Souza A.P., Olivieri B.P., de Castro S.L., Araujo-Jorge T.C. Enzymatic markers heart lesion in mice infected with Trypanosoma cruzi and submitted to benznidazole chemotherapy. Parasitology Research 2000, 86:800-808.
19. Docampo R., Moreno S.N. Biphosphonates as chemotherapeutic agents against trypanosomatid and apicomplexan parasites. Current Drug Targets Infectious Disorders 2001, 1:51-61.
20. Di Bernardi, 2005. Recuperação de pacientes HIV/AIDS em Botswana, África, com o uso do medicamento homeopático Canova Dissertação Curso de pós-graduação Universidade Federal do Paraná.
21. Filardi L.S., Brener Z. Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically Chagas' disease. Transactions of the Royal Society of Tropical Medicine and Hygiene 1987, 81:755-759.
22. Fuentes G, Borges GS, Maia F S, Stumbo AC, Azevedo NL, 2001. Study of interaction between macrophages treated by Método Canova and Toxoplasma gondii Canova do Brasil, Curitiba-Pr.
23. Gazzinelli R.T., Oswald I.P., Hieny S., James S.L., Sher A. The microbicial activity of interferon-γ-treated macrophages against Trypanosoma cruzi involves an l-arginine-dependent, nitrogen oxide mediated mechanism inhibitable by interleukin-10 and transforming growth factor-β. European Journal of Immunology 1992, 22:2501-2506.
24. Gomes M.L., Macedo A.M., Vago R., Pena S.D.J., Galvão L.M.C., Chiari E. Trypanosoma cruzi: optimization of polymerase chain reaction for detection in human blood. Experimental Parasitology 1998, 88:28-33.
25. Lacerda, P. Vade-mecum de Medina homeopática: biomolecualr e homotoxicologia, first ed. Rio de Janeiro: Medsi, 1998.
26. Laucella S.A., Segura E.L., Riarte A., Sosa E.S. Soluble platelet selectin (sP-selectin) and soluble vascular cell adhesion molecule-1 decrease during therapy with benznidazole in children with indeterminate form of Chagas' disease. Clinical and Experimental Immunology 1999, 118:423-427.
27. Lopes L., Godoy L.M., de Oliveira C.C., Gabardo J., Schadeck R.J., de Freitas Buchi D. Phagocytosis, endosomal/lisossomal system and other cellular aspects of macrophage activation by Canova medication. Micron 2006, 37:277-287.
28. Michailowsky V., Murta S.M.F., Carvalho-Oliveira L., Pereira M.E.S., Ferreira L.R.P., Brener Z., Romanha A.J., Gazzinelli R.T. Interleukin-12 enhances in vivo parasiticial effect of benznidazole during acute experimental infection with a naturally drug-resistant strain of Trypanosoma cruzi. Antimicrobial Agents Chemotherapy 1998, 42:2549-2556.
29. Minoprio P., Coutinho A., Spinella S., Hontebeyrie-Joskowicz M. The Xid immunodeficiency impairs increased parasite clearance and resistance to pathology in experimental Chagas' disease. International Immunology 1991, 3:427-433.
30. Mungantiwar A.A., Nair A.M., Shinde U.A., Dikshit V.J., Saraf M.N., Thakur V.S., Sainis K.B. Studies on the immunomodulatory effects of Boerhaavia diffusa alkaloidal fraction. Journal of Ethnopharmacology 1999, 65:125-131.
31. Murta S.M., Gazzinelli R.T., Brener Z., Romanha A.J. Molecular characterization of susceptible and naturally resistant strains of Trypanosoma cruzi to benznidazole and nifurtimox. Molecular and Biochemical Parasitology 1998, 93:203-214.
32. 8+ T-cell expansion and promotes resistance to reinfection. Antimicrobial Agents and Chemotherapy 2002, 46:3790-3796.
33. 8+ double positive thymocytes. Antimicrobial Agents and Chemotherapy 2005, 49:1981-1987.
34. Paulino M., Iribarne F., Dubin M., Aquilera-Morales S., Tapia O., Stoppani A.O. The chemotherapy of Chagas' disease; an overview. Mini Reviews in Medicinal Chemistry 2005, 5:499-519.
35. Pereira da Silva L.H., Nussenzweig V. Sobre uma cepa de Trypanosoma cruzi altamente virulenta para o camundongo branco. Folia Clinical Biology 1953, 20:191-208.
36. Pereira W.K.V., Lonardoni M.V.C., Grespan R., Caparroz-Assef S.M., Cuman R.K.N., Bersani-Amado C.A. Immunomodulatory effect of Canova medication on experimental Leishmania amazonensis infection. Journal of Infection 2005, 51:157-164.
37. Plata F., Garcia-Pons F., Wietzerbin J. Immune resistance to Trypanosoma cruzi: synergy of specific antibodies and recombinant interferon gamma in vivo. Annales de l'Institut Pasteur Immunologie 1987, 138:397-408.
38. Piaggio E., Roggero E., Pitashny M., Wietzerbin J., Bottasso A.O., Revelli S.S. Treatment with benznidazole and its immunomodulating effects on Trypanosoma cruzi infected rats. Parasitology Research 2001, 87:539-547.
39. Piemonte R.M., Buchi D.F. Análisis of IL-2, IFN-γ and TNF-α production, α5β1 integrins and filaments distribution in peritoneal mouse macrophages treated with homeopathic medicament. Journal of Submicroscopic Cytology and Pathology 2002, 34:255-263.
40. Romanha A.J., Alves Ro., Murta S.M.F., Silva J.S., Ropert C., Gazinelli R.T. Experimental chemotherapy against Trypanosoma cruzi infection: role of endogenous interferon-γ in mediating parasitologic cure. Journal of Infectious Diseases 2002, 186:823-828.
41. Sato D.Y., Wal R., de Oliveira C.C., Cattaneo R.I., Malvezzi M., Gabardo J., Buchi D.F. Histopathological and immunophenotyping studies on normal and sarcoma 180-bearing mice treated with a complex homeopathic medication. Homeopathy 2005, 94:26-32.
42. Seligman I.C., Lima P.D.L., Cardoso P.C.S., Khayat A.S., Bahia M.O., Buchi D.F., Cabral I.R., Burbano R.R. The anticancer homeophatic composite 'Canova method' is not genotoxic for human lymphocytes in vitro. Genetics and Molecular Research 2003, 2:223-228.
43. Senior K. Chagas disease: moving towards global elimination. Lancet Infectious Diseases 2007, 7:572-581.
44. Smit E., Pretorius E., Anderson R., Oommen J.U., Potjo M. Differentiation of human monocytes in vitro following exposure to Canova in the absence of cytokines. Ultrastructural Pathology 2008, 32:147-152.
45. Smit E., Oberholzer H.M., Pretorius E. A review of immunomodulators with reference to Canova. Homeopathy 2009, 98:169-176.
46. Stroparo, E. 2005. Pacientes HIV/AIDS tratados com o medicamento homeopatico Canova, melhoram indices laboratoriais, clínicos e de qualidade de vida Dissertação Programa de Pós- graduação Universidade Federal do Paraná.
47. Takahachi G., Maluf M.L.F., Svidzinski T.I.E., Akimoto Gunther L.S., Hubler M.R.N., Bersani-Amado C.A., Cuman R.K.N. Biochemical responses in mice experimentally infected with Paracoccidioides brasiliensis and treated with Canova. Brazilian Archives of Biology and Technology 2006, 49:897-903.
48. Takahachi G., Maluf M.L.F., Svidzinski T.I.E., Dalalio M.M.O., Bersani-Amado C.A., Cuman R.K.N. In vivo and in vitro effects of Canova medicine on experimental infection with Paracoccidioides brasiliensis. Indian Journal of Pharmacology 2006, 38:350-354.
49. Targett G.A. Chemotherapy and the immune response in parasitic infections. Parasitology 1985, 90:661-673.
50. 8+ T cells increases susceptibility and reverses vaccine-induced immunity in mice infected with Trypanosoma cruzi. Journal of Immunology 1990, 144:117-124.
51. Tarleton R.L. The role of T-cells subpopulations in experimental Chagas' disease. Research in Immunology 1991, 142:130-133.
52. Vespa G.N., Cunha F.Q., Silva J.S. Nitric oxide is involved in control of T. cruzi induced parasitemia and directly kills the parasite. Infection and Immunity 1994, 62:5177-5182.
53. Wirth J.J., Kierzenbaum F., Sonnenfeld G., Zlotnik A. Enhancing effects of gamma interferon on phagocytic cells association with and killing of T. cruzi. Infection and Immunity 1985, 49:61-66.
54. World Health Organization Control of Chagas disease. Technical Reports Series 2002, 905:1-109.