In vivo and in vitro effects of the Canova medicine on experimental infection with Paracoccidioides brasiliensis in mice

Indian Journal of Pharmacology

Volumn 38, Issue 5, 2006, Pages 350-354

  Takahachi, G ^a   Maluf, M L F ^a   Svidzinski, T I E ^a   Dalalio, M M O ^a   Bersani Amado, C A ^a   Cuman, Roberto K Nakamura ^a  

^a STATE UNIVERSITY OF MARINGÁ   (Brazil)

Author keywords

Immunomodulator; Macrophage activation; Systemic mycosis

Indexed keywords

ARSENIC TRIOXIDE; CANOVA; HOMEOPATHIC AGENT; IMMUNOMODULATING AGENT; LACHESIS MUTA EXTRACT; NITRIC OXIDE; THUYA OCCIDENTALIS EXTRACT; UNCLASSIFIED DRUG;

ACONITUM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRYONIA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG DETERMINATION; DRUG EFFECT; EXPERIMENTAL INFECTION; FOLLOW UP; IN VITRO STUDY; IN VIVO STUDY; INFECTION PREVENTION; LEUKOCYTE DIFFERENTIAL COUNT; MACROPHAGE; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; OXIDATIVE STRESS; PARACOCCIDIOIDES BRASILIENSIS; SOUTH AMERICAN BLASTOMYCOSIS;

EID: 33749607079     PISSN: 02537613     EISSN: None     Source Type: Journal    
DOI: 10.4103/0253-7613.27704     Document Type: Article

References (23)

1. Sasaki MGM, Mariano FC, Gurgel LP, Probst S. Estudo clínico randomizado placebo controlado para avaliar a eficácia e segurança do Método Canova® na terapêutica de pacientes portadores de HIV/Aids em uso de anti-retrovirais. Braz J Infect Dis 2001;5:58.
2. Sato DYO, Wal R, Oliveira CC, Cattaneo RII, Malvezzi M, Garbado J, et al. Histopathological and immunophenotyping studies on normal and sarcoma 180-bearing mice treated with a complex homeopathic medication. Homeopathy 2004;94:26-32.
3. 1 integrins and actin filaments distribution in peritoneal mouse macrophages treated with homeopathic medicament. J Submicrosc Cytol Pathol 2002;34:255-63.
4. Pereira WKV, Lonardoni MVC, Grespan R, Caparroz-Assef SM, Cuman RKN, Bersani-Amado CA. Immunomodulatory effect of Canova medication on experimental Leishmania amazonensis infection. J Infect 2005;51: 157-64.
5. Mendes RP. The Gamut of Clinical Manifestations. In: M Franco MS, Lacaz A, Restrepo-Moreno G, Del Negro, editors. Paracoccidioidomycosis. Boca Raton: CRC Press; 1994. p. 233-58.
6. Coutinho ZF, Silva D, Lazera M, Petri V, Oliveira RM, Sabroza PC, Wanke B. Paracoccidioidomycosis mortality in Brazil (1980-1995). Cad Saúde Pública 2002;18:1441-454.
7. Maluf MLF, Pereira SRC, Takahachi G, Svidzinski TIE. Prevalência de paracoccidioidomicose-infecção determinada através de teste sorológico em doadores de sangue na região Noroeste do Paraná, Brasil. Rev Soc Bras Med Trop 2003;36:11-6.
8. Popi AF, Lopes JD, Mariano M. GP 43 from Paracoccidioides brasiliensis inhibits macrophage functions. An evasion mechanism of the fungus. Cell Immunol 2002;218:87-94.
9. Calich VLG, Vaz CAC, Burger E. Immunity to Paracoccidioides brasiliensis infection. Res Immunol 1998;149:407-17.
10. Benard G, Hong MA, Del Negro GM, Batista L, Shinakanai-Yassuda MA, Duarte AJ. Antigen-specific immunosuppression in paracoccidioidomycosis. Am J Trop Med Hyg 1996;54:7-12.
11. Calich VLG, Kashino SS. Cytokines produced by susceptible and resistant mice in the course of Paracoccidioides brasiliensis infection. Braz J Med Biol Res 1998;31:615-23.
12. Cano LE, Kashino SS, Arruda C, Andre D, Xidieh CF, Singer-Vermes LM, et al. Protective role of Gamma Interferon in Experimental pulmonary paracoccidioidomycosis. Infect Immun 1998;66:800-6.
13. Brummer E, Hanson LH, Stevens DA. Gamma-Interferon activation of macrophages for killing of Paracoccidioides brasiliensis and evidence for nonoxidative mechanisms. Int J Immunopharmacol 1988;10:945-52.
14. Singer-Vermes LM, Caldeira CB, Burger E, Calich VLG. Experimental murine paracoccidioidomycosis: relationship among the dissemination of the infection, humoral and cellular immune responses. Clin Exp Immunol 1993;94:75-9.
15. Ding AH, Nathan CF, Stuehr DJ. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages: comparison of activating cytokines and evidence for independent production. J Immunol 1988;141:2407-12.
16. Camargo ZP, Franco, MF. Current knowledge on pathogenesis and immunodiagnosis of paracoccidioidomycosis. Rev Iberoam Micol 2000; 17: 41-8.
17. Gonzalez A, Gregori W, Velez D, Restrepo A, Cano LE. Nitric oxide in the fungicidal mechanism of gamma interferon-activated murine macrophages against Paracoccidioides brasiliensis conidia. Infect Immun 2000;68: 2546-52.
18. MacMicking J, Xie Q, Nathan C. Nitric Oxide and macrophage function. Annu Rev Immunol 1997;15:323-50.
19. Barbuto JA. Imunidade natural e inflamação. In: Calich V, Vaz C, editors. Imunologia. Rio de Janeiro: Revinter; 2001. p. 179-93.
20. Jancar S. Imunidade natural e inflamação. In: Calich V, Vaz C, editor. Imunologia. Rio de Janeiro: Revinter; 2001. p. 11-30.
21. Lane TE, Otero GC, Wa-Hsieh B, Howard DH. Expression of inducible nitric oxide synthase by stimulated macrophages correlates with their antihistoplasma activity. Infect Immun 1994;62:1940-5.
22. Norris KA, Schirimpf JE, Flynn JL, Morris Jr SM. Enhancement of macrophages microbicidal activity: supplemental arginine and citrulline augment nitric oxide production in murine peritoneal macrophages and promote intracellular killing of Trypanossoma cruzi. Infect Immun 1995;63: 2793-6.
23. James SL, Glaven J. Macrophage citotoxicity against schistosomula of Schistosoma mansoni involved arginine-dependent production of reactive nitrogen intermediates. J Immunol 1989;143:4208-12.