Optimisation of spray drying process conditions for sugar nanoporous microparticles (NPMPs) intended for inhalation

International Journal of Pharmaceutics

Volumn 421, Issue 1, 2011, Pages 99-109

  Amaro, Maria Inês ^a   Tajber, Lidia ^a   Corrigan, Owen I ^a   Healy, Anne Marie ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Factorial design; Inhalation; Raffinose; Specific surface area; Spray drying; Trehalose

Indexed keywords

RAFFINOSE; TREHALOSE;

ADSORPTION; ARTICLE; CONTROLLED STUDY; ENERGY YIELD; FACTORIAL DESIGN; FLOW RATE; GAS FLOW; INHALATION; PARTICLE SIZE; POWDER; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SCANNING ELECTRON MICROSCOPY; SPRAY DRYING; SURFACE PROPERTY; TEMPERATURE;

ADMINISTRATION, INHALATION; DESICCATION; DRUG CARRIERS; DRUG COMPOUNDING; PARTICLE SIZE; POROSITY; RAFFINOSE; SURFACE PROPERTIES; TREHALOSE;

EID: 81155148185     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.09.021     Document Type: Article

References (38)

1. S. Al-Asheh, R. Jumah, F. Banat, and S. Hammad The use of experimental factorial design for analysing the effect of spray dryer operating variables on the production of tomato powder Food Bioprod. Process. 1 2003 81 88 (Pubitemid 351636050)
2. A. Baldinger, L. Clerdent, J. Rantanen, M. Yang, and H. Grohganz Quality by design approach in the optimization of the spray-drying process Pharm. Dev. Technol. 2011 1 9
3. A. Billon, B. Bataille, G. Cassanas, and M. Jacob Development of spray-dried acetaminophen microparticles using experimental designs Int. J. Pharm. 203 2000 159 168 (Pubitemid 30627636)
4. C. Bosquillon, C. Lombry, V. Préat, and Vanbever Influence of formulation excipients and physical characteristics of inhalation dry powders on their aerosolisation performance J. Control. Release 70 2001 329 339 (Pubitemid 32155456)
5. H. Brandenberger Development of a novel high-performance cyclone to increase the yield in a mini spray dryer. Best@buchi evaporation Inf. Bull. 27 2003
6. J.F. Carpenter, and J.H. Crowe The mechanism of cryoprotection of proteins by solutes Cryobiology 25 1988 244 255
7. J.F. Carpenter, and J.H. Crowe Infrared spectroscopic studies on the interaction of carbohydrates with dried proteins Biochemistry 28 1989 3916 3922 (Pubitemid 19125443)
8. D.F. Bagster Chew, and H.K. Chan Effect of particle size, air flow and inhaler device on the aerosolisation of disodium cromoglycate powders Int. J. Pharm. 206 2000 75 83
9. A. Chow, H. Tong, P. Chattopadhyay, and B. Shekunov Particle engineering for pulmonary drug delivery Pharm. Res. 24 2007 411 437 (Pubitemid 46295160)
10. C. Colaco, S. Sen, M. Thangavelu, S. Pinder, and B. Roser Extraordinary stability of enzymes dried in trehalose: simplified molecular biology Biotechnology 10 1992 1007 1011
11. D.I. Daniher, and J. Zhu Dry powder platform for pulmonary drug delivery Particuology 6 2008 225 238
12. J. Elversson, and A. Millqvist-Fureby Particle size and density in spray drying-effects of carbohydrates properties J. Pharm. Sci. 94 2005 2049 2060 (Pubitemid 41551488)
13. European Pharmacopoeia Preparations for Inhalation: Aerodynamic Assessment of Fine Particles 7th edition 2011 Council of Europe Strasbourg pp. 274-284
14. European Pharmacopoeia Residual Solvents 7th edition 2011 Council of Europe Strasbourg pp. 583-590
15. E. Fournier Colorimetric Quantification of Carbohydrates. Current Protocols in Food Analytical Chemistry 2001 John Wiley & Sons, Inc.
16. F. Franks, R.H.M. Hatley, and S.F. Mathias Material science and the production of shelf stable biologicals BioPharm 4 1991 38 55
17. S.J. Gregg, and K.S.W. Sing Adsorption, Surface Area and Porosity 2nd edition 1982 Academic Press London
18. A.M. Healy, B.F. McDonald, L. Tajber, and O.I. Corrigan Characterisation of excipient-free nanoporous microparticles (NPMPs) of bendroflumethiazide Eur. J. Pharm. Biopharm. 69 2008 1182 1186
19. K.A. Johnson Preparation of peptide and protein powders for inhalation Adv. Drug Deliv. Rev. 26 1997 3 15 (Pubitemid 27288480)
20. K. Koushik, and U.B. Kompella Particle and device engineering for inhalation drug delivery Drug Dev. Technol. 4 2004 40 50
21. E.C. López-Díez, and S. Bone The interaction of trypsin with trehalose: an investigation of protein preservation mechanisms Biochim. Biophys. Acta 673 2004 139 148 (Pubitemid 38981767)
22. Y.F. Maa, H.R. Constantino, P.A. Nguyen, and C.C. Hsu The effect of operating and formulation variables on the morphology of spray dried particles Pharm. Dev. Technol. 2 1997 213 223 (Pubitemid 28252517)
23. M.J. Maltesen, S. Bjerregaard, L. Hovgaard, S. Havelund, and M. van de Weert Quality by design - spray drying of insulin intended for inhalation Eur. J. Pharm. Biopharm. 70 2008 828 838
24. K. Masters Spray Drying Handbook 5th edition 1991 Longman New York
25. T. Masuko, A. Minami, N. Iwasaki, T. Majima, S.I. Nishimura, and Y.C. Lee Carbohydrate analysis by a phenol-sulfuric acid method in microplate format Anal. Chem. 339 2005 69 72 (Pubitemid 40342680)
26. M. Maury, K. Murphy, K. Sandeep, L. Shi, and G. Lee Effects of process variables on the powder yield of spray-dried trehalose on a laboratory spray-dryer Eur. J. Pharm. Biopharm. 59 2005 565 573 (Pubitemid 40342530)
27. C.D. Montgomery Design and Analysis of Experiments 5th edition 1997 John Wiley & Sons New York
28. O. Ní Ógáin, J. Li, L. Tajber, O.I. Corrigan, and A.M. Healy Particle engineering of materials for oral inhalation by dry powder inhalers. I. Particles of sugar excipients (trehalose and raffinose) incorporating a model protein Int. J. Pharm. 405 2011 23 25
29. J.S. Patton Mechanics of macromolecule absorption by the lungs Adv. Drug Deliv. Rev. 19 1996 3 36
30. J.S. Patton, J.G. Bukar, and M.A. Eldon Clinical pharmacokinetics and pharmacodynamics of inhaled insulin Clin. Pharmacokinet. 43 2004 781 801 (Pubitemid 39382220)
31. C. Papelis, W. Um, C.E. Russel, and J.B. Chapman Measuring the specific surface area of natural and manmade glasses: effects of formation process, morphology, and particle size Colloids Surf. A: Physicochem. Eng. Aspects 215 2003 221 239 (Pubitemid 36344056)
32. K.B. Prinn, H.R. Constantino, and M. Tracy Statistical modelling of protein spray drying at the lab scale AAPS PharmSciTech 3 2002 E4
33. K. Stähl, M. Claesson, P. Lilliehorn, H. Lindén, and K. Bäckström The effect of process variables on the degradation and physical properties of spray dried insulin intended for inhalation Int. J. Pharm. 233 2002 227 237 (Pubitemid 34230435)
34. D. Tabor Surface forces and surface interactions J. Colloid Interface Sci. 58 1977 2 13
35. L. Tajber, O.I. Corrigan, and A.M. Healy Spray drying of budesonide, formoterol fumarate and their composites - II. Statistical factorial design and in vitro deposition properties Int. J. Pharm. 367 2009 86 96
36. Technical data Büchi B-290. Drying, Mini Spray Dryer B-290, available at: www.buchi.com (data accessed 15.01.2009).
37. F. Tewes, L. Tajber, O.I. Corrigan, C. Ehrhardt, and A.M. Healy Development and characterisation of soluble polymeric particles for pulmonary peptide delivery Eur. J. Pharm. Sci. 41 2010 337 352
38. H. Yoshii, F. Buche, N. Takeuchi, C. Terrol, M. Ohgawana, and T. Furuta Effects of protein on retention of ADH enzyme activity encapsulated in trehalose matrices by spray drying J. Food Eng. 87 2008 37 39