Overexpression of ΔNp63 in a human nasopharyngeal carcinoma cell line downregulates CKIs and enhances cell proliferation

Journal of Cellular Physiology

Volumn 219, Issue 1, 2009, Pages 117-122

  Chiang, Chi Tai ^a   Chu, Wing Keung ^a   Chow, Shu Er ^b   Chen, Jan Kan ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN DEPENDENT KINASE INHIBITOR 1C; MESSENGER RNA; PROTEIN P63; SMALL INTERFERING RNA; CDKN1B PROTEIN, HUMAN; SIGNAL PEPTIDE; TP63 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CARCINOGENESIS; CARCINOMA CELL; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; GENE SILENCING; GROWTH INHIBITION; HUMAN; HUMAN CELL; NASOPHARYNX CARCINOMA; PRIORITY JOURNAL; UPREGULATION; APOPTOSIS; CELL CYCLE; GENETICS; METABOLISM; NASOPHARYNX TUMOR; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P57; DOWN-REGULATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NASOPHARYNGEAL NEOPLASMS; RNA, SMALL INTERFERING; TRANS-ACTIVATORS; TUMOR SUPPRESSOR PROTEINS;

EID: 60849130706     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21656     Document Type: Article

References (41)

1. Augustin M, Bamberger C, Paul D, Schmale H. 1998. Cloning and chromosomal mapping of the human p53-related KET gene to chromosome 3q27 and its murine homolog Ket to mouse chromosome 16. Mamm Genome 9:899-902.
2. Barbieri CE, Pietenpol JA. 2006. p63 and epithelial biology. Exp Cell Res 312:695-706.
3. Benard J, Douc-Rasy S, Ahomadegbe JC. 2003. TP53 family members and human cancers. Hum Mutat 21:182-191.
4. Beretta C, Chiarelli A, Testoni B, Mantovani R, Guerrini L. 2005. Regulation of the cyclin- dependent kinase inhibitor p57Kip2 expression by p63. Cell Cycle 4:1625-1631.
5. Buettner M, Heussinger N, Niedobitek G. 2006. Expression of Epstein-Barr virus (EBV)- encoded latent membrane proteins and STAT3 activation in nasopharyngeal carcinoma. Virchows Arch 449:513-519.
6. Carracedo A, Gironella M, Lorente M, Garcia S, Guzman M, Velasco G, Iovanna JL. 2006. Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes. Cancer Res 66:6748-6755.
7. Chang YS, Lin SY, Lee PF, Durff T, Chung HC, Tsai MS. 1989. Establishment and characterization of a tumor cell line from human nasopharyngeal carcinoma tissue. Cancer Res 49:6752-6757.
8. Chu WK, Dai PM, Li HL, Chen J-K. 2008. Transcriptional activity of the {Delta}Np63 promoter is regulated by STAT3. J Biol Chem 283:7328-7337.
9. Cordon-Cardo C. 1995. Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia. Am J Pathol 147:545-560.
10. Crook T, Nicholls JM, Brooks L, O'Nions J, Allday MJ. 2000. High level expression of deltaN- p63: A mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC)? Oncogene 19:3439-3444.
11. Dohn M, Zhang S, Chen X. 2001. p63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes. Oncogene 20:3193-3205.
12. Fang WY, Liu TF, Xie WB, Yang XY, Wang S, Ren CP, Deng X, Liu QZ, Huang ZX, Li X, Ding YQ, Yao KT. 2005. Reexploring the possible roles of some genes associated with nasopharyngeal carcinoma using microarray-based detection. Acta Biochim Biophys Sin (Shanghai) 37:541-546.
13. Flores ER, Tsai KY, Crowley D, Sengupta S, Yang A, McKeon F, Jacks T. 2002. p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature 416:560-564.
14. Hunter T, Pines J. 1994. Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. Cell 79:573-582.
15. Jalal C, Uhlmann-Schiffler H, Stahl H. 2007. Redundant role of DEAD box proteins p68 (Ddx5) and p72/p82 (Ddx17) in ribosome biogenesis and cell proliferation. Nucleic Acids Res 35:3590-3601.
16. Ku WC, Cheng AJ, Wang TC. 1997. Inhibition of telomerase activity by PKC inhibitors in human nasopharyngeal cancer cells in culture. Biochem Biophys Res Commun 241:730-736.
17. Kypriotou M, Beauchef G, ChadjichristosC, Widom R, Renard E, Jimenez SA, Korn J, Maquart F-X, Oddos T, Von Stetten O, Pujol J-P, Galera P. 2007. Human collagen Krox up-regulates type i collagen expression in normal and scleroderma fibroblasts through interaction with Sp1 and Sp3 transcription factors. J Biol Chem 282:32000-32014.
18. Liao SK, Perng YP, Shen YC, Chung PJ, Chang YS, Wang CH. 1998. Chromosomal abnormalities ofa new nasopharyngeal carcinomacell line (NPC-BM1) derivedfrom a bone marrow metastatic lesion. Cancer Genet Cytogenet 103:52-58.
19. Lin CT, Wong CI, Chan WY, Tzung KW, Ho JK, Hsu MM, Chuang SM. 1990. Establishment and characterization of two nasopharyngeal carcinoma cell lines. Lab Invest 62:713-724.
20. Lou PJ, Chen WP, Lin CT, DePhilip RM, Wu JC. 1999. E-, P-, and N-cadherin are co-expressed in the nasopharyngeal carcinoma cell line TW-039. J Cell Biochem 76:161-172.
21. MacLachlan TK, Sang N, Giordano A. 1995. Cyclins, cyclin-dependent kinases and cdk inhibitors: Implications in cell cycle control and cancer. Crit Rev Eukaryot Gene Expr 5:127-156.
22. Maddika S, Ande SR, Panigrahi S, Paranjothy T, Weglarczyk K, Zuse A, Eshraghi M, Manda KD, Wiechec E, Los M. 2007. Cell survival, cell death and cell cycle pathways are interconnected: Implications for cancer therapy. Drug Resist Updat 10:13-29.
23. Massion PP, Taflan PM, Jamshedur Rahman SM, Yildiz P, Shyr Y, Edgerton ME, Westfall MD, Roberts JR, Pietenpol JA, Carbone DP, Gonzalez AL. 2003. Significance of p63 amplification and overexpression in lung cancer development and prognosis. Cancer Res 63:7113-7121.
24. Oya M, Schulz WA. 2000. Decreased expression of p57(KIP2)mRNA in human bladder cancer. Br J Cancer 83:626-631.
25. Park BJ, Lee SJ, Kim JI, Lee CH, Chang SG, Park JH, Chi SG. 2000. Frequent alteration of p63 expression in human primary bladder carcinomas. Cancer Res 60:3370-3374.
26. Pateras IS, Apostolopoulou K, Koutsami M, Evangelou K, Tsantoulis P, Liloglou T, Nikolaidis G, Sigala F, Kittas C, Field JK, Kotsinas A, Gorgoulis VG. 2006. Downregulation of the KIP family members p27(KIP1) and p57(KIP2) by SKP2 and the role of methylation in p57(KIP2) inactivation in nonsmall cell lung cancer. Int J Cancer 119:2546-2556.
27. Polyak K, Lee MH, Erdjument-Bromage H, Koff A, Roberts JM, Tempst P, Massague J. 1994. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78:59-66.
28. Rosenberg E, Demopoulos RI, Zeleniuch-Jacquotte A, Yee H, Sorich J, Speyer JL, Newcomb EW. 2001. Expression of cell cycle regulators p57(KIP2), cyclin D1, and cyclin E in epithelial ovarian tumors and survival. Hum Pathol 32:808-813.
29. Roussel MF. 1999. The INK4 family of cell cycle inhibitors in cancer. Oncogene 18:5311-5317.
30. Shin JY, Kim HS, Lee KS, Kim J, Park JB, Won MH, Chae SW, Choi YH, Choi KC, Park YE, Lee JY. 2000. Mutation and expression of the p27KIP1 and p57KIP2 genes in human gastric cancer. Exp Mol Med 32:79-83.
31. Taniere P, Martel-Planche G, Saurin JC, Lombard-Bohas C, Berger F, Scoazec JY, Hainaut P. 2001. TP53 mutations, amplification of P63 and expression of cell cycle proteins in squamous cell carcinoma of the oesophagus from a low incidence area in Western Europe. Br J Cancer 85:721-726.
32. Thurfjell N, Coates PJ, Uusitalo T, Mahani D, Dabelsteen E, Dahlqvist A, Sjostrom B, Roos G, Nylander K. 2004. Complex p63 mRNA isoform expression patterns in squamous cell carcinoma of the head and neck. Int J Oncol 25:27-35.
33. Thurfjell N, Coates PJ, Vojtesek B, Benham-Motlagh P, Eisold M, Nylander K. 2005. Endogenous p63 acts as a survival factor for tumour cells of SCCHN origin. Int J Mol Med 16:1065-1070.
34. Trink B, Okami K, Wu L, Sriuranpong V, Jen J, Sidransky D. 1998. A new human p53 homologue. Nat Med 4:747-748.
35. Tsao SW, Wang X, Liu Y, Cheung YC, Feng H, Zheng Z, Wong N, Yuen PW, Lo AK, Wong YC, Huang DP. 2002. Establishment of two immortalized nasopharyngeal epithelial cell lines using SV40 large T and HPV16E6/E7 viral oncogenes. Biochim Biophys Acta 1590:150-158.
36. Vlachos P, Nyman U, Hajji N, Joseph B. 2007. The cell cycle inhibitor p57(Kip2) promotes cell death via the mitochondrial apoptotic pathway. Cell Death Differ 14:1497-1507.
37. Westfall MD, Mays DJ, Sniezek JC, Pietenpol JA. 2003. The delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations. Mol Cell Biol 23: 2264-2276.
38. Wu G, Nomoto S, Hoque MO, Dracheva T, Osada M, Lee CC, Dong SM, Guo Z, Benoit N, Cohen Y, Rechthand P, Califano J, Moon CS, Ratovitski E, Jen J, Sidransky D, Trink B. 2003. DeltaNp63alpha and TAp63alpha regulate transcription of genes with distinct biological functions in cancer and development. Cancer Res 63:2351-2357.
39. Yang A, Kaghad M, WangY, Gillett E, Fleming MD, DotschV, Andrews NC, Caput D, McKeon F. 1998. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell 2:305-316.
40. Yang A, Walker N, Bronson R, Kaghad M, Oosterwegel M, Bonnin J, Vagner C, Bonnet H, Dikkes P, Sharpe A, McKeon F, Caput D. 2000. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature 404:99-103.
41. Zhang H, Tsao SW, Jin C, Strombeck B, Yuen PW, Kwong YL, Jin Y. 2004. Sequential cytogenetic and molecular cytogenetic characterization of an SV40T-immortalized nasopharyngeal cell line transformed by Epstein-Barr virus latent membrane protein-1 gene. Cancer Genet Cytogenet 150:144-152.