External Ba 2+ block of the two-pore domain potassium channel TREK-1 defines conformational transition in its selectivity filter

Journal of Biological Chemistry

Volumn 286, Issue 46, 2011, Pages 39813-39822

  Ma, Xiao Yun ^a   Yu, Jin Mei ^a   Zhang, Shu Zhuo ^a   Liu, Xiao Yan ^a   Wu, Bao Hong ^a   Wei, Xiao Li ^a   Yan, Jia Qing ^a   Sun, Hong Liang ^a   Yan, Hai Tao ^a   Zheng, Jian Quan ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONAL TRANSITIONS; EXTRACELLULAR; GATING MECHANISMS; INHIBITORY EFFECT; INTRACELLULAR SIGNALS; ISOFORMS; N-TERMINALS; PATHOLOGICAL PROCESS; POTASSIUM CHANNELS; POTASSIUM EFFLUX; SELECTIVITY FILTER; TIME-DEPENDENT;

ENZYME ACTIVITY;

BARIUM;

BARIUM ION; ISOPROTEIN; POTASSIUM CHANNEL; POTASSIUM CHANNEL TREK 1; POTASSIUM ION; PROTON; UNCLASSIFIED DRUG; BARIUM; DIVALENT CATION; MONOVALENT CATION; POTASSIUM; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL PROTEIN TREK 1; POTASSIUM CHANNEL PROTEIN TREK-1; TANDEM PORE DOMAIN POTASSIUM CHANNEL;

ACIDIFICATION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CHANNEL GATING; CONCENTRATION (PARAMETERS); CONFORMATIONAL TRANSITION; CONTROLLED STUDY; EXTRACELLULAR SPACE; HUMAN; HUMAN CELL; ION PERMEABILITY; MUTAGENESIS; NONHUMAN; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTEIN DOMAIN; REGULATORY MECHANISM; TRANSLATION INITIATION; ANIMAL; CELL STRAIN HEK293; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; ION TRANSPORT; METABOLISM; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; XENOPUS LAEVIS;

ANIMALS; BARIUM; BINDING SITES; CATIONS, DIVALENT; CATIONS, MONOVALENT; DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HUMANS; ION CHANNEL GATING; ION TRANSPORT; MUTAGENESIS; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; XENOPUS LAEVIS;

EID: 81155123688     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.264788     Document Type: Article

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