Gating of a pH-sensitive K2P potassium channel by an electrostatic effect of basic sensor residues on the selectivity filter

PLoS ONE

Volumn 6, Issue 1, 2011, Pages

  Zúñiga, Leandro ^a,f   Márquez, Valeria ^c   González Nilo, Fernando D ^c   Chipot, Christophe ^d,e   Cid, L Pablo ^a   Sepúlveda, Francisco V ^a,b   Niemeyer, María Isabel ^a  

^a CENTRO DE ESTUDIOS CIENTÍFICOS CECS   (Chile)

^b Centro de Ingeniería de la Innovación del CECS CIN   (Switzerland)

^c UNIVERSIDAD DE TALCA   (Chile)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^e UNIVERSITÉ DE LORRAINE   (France)

^f UNIVERSITY OF CONCEPCIÓN   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; POTASSIUM CHANNEL; POTASSIUM CHANNEL TASK 2; POTASSIUM ION; PROTON; UNCLASSIFIED DRUG; AMINO ACID; KCNK5 PROTEIN, MOUSE; TANDEM PORE DOMAIN POTASSIUM CHANNEL;

ARTICLE; BIOSENSOR; CHANNEL GATING; CONTROLLED STUDY; HUMAN; HUMAN CELL; ION TRANSPORT; MOLECULAR DYNAMICS; MOLECULAR MODEL; NUCLEOTIDE SEQUENCE; PH; POTASSIUM CONDUCTANCE; POTASSIUM CURRENT; PROTON TRANSPORT; STATIC ELECTRICITY; ANIMAL; CHEMISTRY; ENZYME SPECIFICITY; METABOLISM; MOUSE; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; SIGNAL TRANSDUCTION;

AMINO ACIDS; ANIMALS; HYDROGEN-ION CONCENTRATION; ION CHANNEL GATING; MICE; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; RECEPTOR CROSS-TALK; STATIC ELECTRICITY; SUBSTRATE SPECIFICITY;

EID: 79551547731     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0016141     Document Type: Article

References (52)

1. + conduction and selectivity. Science 280: 69-77.
2. Lesage F, Lazdunski M (2000) Molecular and functional properties of two-poredomain potassium channels. Am J Physiol 279: F793-F801.
3. Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001) Potassium leak channels and the KCNK family of two-P-domain subunits. Nat Rev Neurosci 2: 175-184.
4. + channels. Cell Biochem Biophys 47: 209-256.
5. Lopes CMB, Zilberberg N, Goldstein SA (2001) Block of Kcnk3 by protons. evidence that 2-P-domain potassium channel subunits function as homodimers. J Biol Chem 276: 24449-24452.
6. + channel without having an essential effect upon activity. Mol Membr Biol 20: 185-191.
7. 2P potassium channels based on 23 pairs of interacting sites and continuum electrostatics. J Gen Physiol 134: 53-68.
8. + channel from human kidney. J Biol Chem 273: 30863-30869.
9. + channel family. J Biol Chem 275: 9340-9347.
10. + channel: an extracellular histidine as pH sensor. J Biol Chem 275: 16650-16657.
11. Sandoz G, Douguet D, Chatelain F, Lazdunski M, Lesage F (2009) Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue. Proc Natl Acad Sci U S A 106: 14628-14633.
12. 2P2.1 channel gating. Facilitation of C-type gating by protonation of extracellular histidine residues. J Biol Chem 283: 19448-19455.
13. + channel TASK-2 (KCNK5) by changes in cell volume. J Biol Chem 276: 43166-43174.
14. Barrière H, Belfodil R, Rubera I, Tauc M, Lesage F, et al. (2003) Role of TASK2 potassium channels regarding volume regulation in primary cultures of mouse proximal tubules. J Gen Physiol 122: 177-190.
15. + channel-deficient mice reveals a mechanism for stabilizing bicarbonate transport. Proc Natl Acad Sci U S A 101: 8215-8220.
16. + channels. Biochem Biophys Res Commun 282: 249-256.
17. 2 sensitivity. Proc Natl Acad Sci U S A 107: 2325-2330.
18. 2P potassium channel TASK-2 by intra- and extracellular pH. J Biol Chem 285: 16467-16475.
19. + channel, TASK2. Proc Natl Acad Sci U S A 102: 16102-16106.
20. + channel. Proc Natl Acad Sci U S A 104: 666-671.
21. + channels of the TALK family. Biochem Biophys Res Commun 315: 836-844.
22. + channels by extracellular pH. Biochem Soc Trans 34: 903-906.
23. Cohen A, Ben-Abu Y, Zilberberg N (2009) Gating the pore of potassium leak channels. Eur Biophys J 39: 61-73.
24. Darve E, Pohorille A (2001) Calculating free energies using average force. J Chem Phys 115: 9169-9183.
25. + channel-Fab complex at 2.0 A resolution. Nature 414: 43-48.
26. + channel Kir2.2 at 3.1 A resolution. Science 326: 1668-1674.
27. + channel. Proc Natl Acad Sci U S A 100: 8644-8648.
28. Yellen G (2002) The voltage-gated potassium channels and their relatives. Nature 419: 35-42.
29. Jiang Y, Lee A, Chen J, Cadene M, Chait BT, et al. (2002) Crystal structure and mechanism of a calcium-gated potassium channel. Nature 417: 515-522.
30. Armstrong CM (2003) Voltage-gated K channels. Sci STKE 2003: re10.
31. + channels. Biochemistry 43: 13242-13247.
32. + channel gates underlies distinct roles in electrical signaling. Nat Struct Mol Biol 16: 71-79.
33. + channels: effects of alterations in the carboxy-terminal region. Neuron 7: 547-556.
34. Zilberberg N, Ilan N, Goldstein SA (2001) KCNKO: opening and closing the 2-P-domain potassium leak channel entails "C-type" gating of the outer pore. Neuron 32: 635-648.
35. Stansfeld PJ, Grottesi A, Sands ZA, Sansom MS, Gedeck P, et al. (2008) Insight into the mechanism of inactivation and pH sensitivity in potassium channels from molecular dynamics simulations. Biochemistry 47: 7414-7422.
36. Yuill KH, Stansfeld PJ, Ashmole I, Sutcliffe MJ, Stanfield PR (2007) The selectivity, voltage-dependence and acid sensitivity of the tandem pore potassium channel TASK-1: contributions of the pore domains. Pflugers Arch 455: 333-348.
37. Bernèche S, Roux B (2005) A gate in the selectivity filter of potassium channels. Structure (Camb) 13: 591-600.
38. + channel. Nature 466: 203-208.
39. Graham FL, Smiley J, Russell WC, Nairn R (1977) Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gen Virol 36: 59-74.
40. Cid LP, Niemeyer MI, Ramírez A, Sepúlveda FV (2000) Splice variants of a ClC-2 chloride channel with differing functional characteristics. Am J Physiol 279: C1198-C1210.
41. + currents in HeLa cells. Pflügers Arch 430: 168-180.
42. Barry PH (1994) JPCalc, a software package for calculating liquid junction potential corrections in patch-clamp, intracellular, epithelial and bilayer measurements and for correcting junction potential measurements. J Neurosci Meth 51: 107-116.
43. Sali A, Blundell TL (1993) Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol 234: 779-815.
44. Humphrey W, Dalke A, Schulten K (1996) VMD: visual molecular dynamics. J Mol Graph 14: 33-38.
45. Phillips JC, Braun R, Wang W, Gumbart J, Tajkhorshid E, et al. (2005) Scalable molecular dynamics with NAMD. J Comput Chem 26: 1781-1802.
46. Jorgensen WL, Chandrasekhar J, Madura JD, Impey RW, Klein ML (1983) Comparison of simple potential functions for simulating liquid water. J Chem Phys 79: 926-935.
47. Tuckerman ME, Martyna GJ, Berne BJ (1992) Reversible multiple time scale molecular dynamics. J Chem Phys 97: 1990-2001.
48. Essmann U, Perera L, Berkowitz LM, Darden T, Lee H, et al. (1995) A smooth particle mesh Ewald method. J Chem Phys 103: 8577-8593.
49. Andersen HC (2010) Rattle: A "velocity" version of the shake algorithmfor molecular dynamics calculations. J Comp Phys 52: 24-34.
50. Hénin J, Chipot C (2004) Overcoming free energy barriers using unconstrained molecular dynamics simulations. J Chem Phys 121: 2904-2914.
51. Rodríguez-Gómez D, Darve E, Pohorille A (2004) Assessing the efficiency of free energy calculation methods. J Chem Phys 120: 3563-3578.
52. Smart OS, Neduvelil JG, Wang X, Wallace BA, Sansom MS (1996) HOLE: a program for the analysis of the pore dimensions of ion channel structural models. J Mol Graph 14: 354-60, 376.