The M1/M4 preferring agonist xanomeline is analgesic in rodent models of chronic inflammatory and neuropathic pain via central site of action

Pain

Volumn 152, Issue 12, 2011, Pages 2852-2860

  Martino, Giovanni ^a   Puma, Carole ^a   Yu, Xiao Hong ^a   Gilbert, Annie Kim ^a   Coupal, Martin ^a   Markoglou, Nektaria ^a   McIntosh, Fraser S ^a   Perkins, Martin N ^a   Laird, Jennifer M A ^a,b,c  

^a ASTRAZENECA   (United Kingdom)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Inflammatory; MT 3; MT 7; Neuropathic; Supraspinal; Xanomeline

Indexed keywords

MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC M7 RECEPTOR; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; PIRENZEPINE; SCOPOLAMINE; UNCLASSIFIED DRUG; XANOMELINE;

ALLODYNIA; ANALGESIC ACTIVITY; ARTICLE; CENTRAL NERVOUS SYSTEM; CHRONIC INFLAMMATION; DRUG ANTAGONISM; DRUG EFFICACY; DRUG MECHANISM; DRUG PENETRATION; HUMAN; HUMAN CELL; HYPERALGESIA; MALE; MOUSE; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; RAT;

ANALGESICS; ANIMALS; CENTRAL NERVOUS SYSTEM; CHO CELLS; CHRONIC PAIN; CRICETINAE; DISEASE MODELS, ANIMAL; MALE; MICE; MICE, INBRED C57BL; MUSCARINIC AGONISTS; NEURALGIA; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, MUSCARINIC M1; RECEPTOR, MUSCARINIC M4; THIADIAZOLES;

EID: 81055155895     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2011.09.017     Document Type: Article

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