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Volumn 118, Issue 19, 2011, Pages 5178-5188

CD40 stimulation sensitizes CLL cells to lysosomal cell death induction by type II anti-CD20 mAb GA101

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; OBINUTUZUMAB; PROTEIN P53;

EID: 81055149605     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-01-331702     Document Type: Article
Times cited : (42)

References (55)
  • 1
    • 70350734809 scopus 로고    scopus 로고
    • The microenvironment in mature B-cell malignancies: A target for new treatment strategies
    • Burger JA, Ghia P, Rosenwald A, Caligaris-Cappio F. The microenvironment in mature B-cell malignancies: a target for new treatment strategies. Blood. 2009;114(16):3367-3375.
    • (2009) Blood , vol.114 , Issue.16 , pp. 3367-3375
    • Burger, J.A.1    Ghia, P.2    Rosenwald, A.3    Caligaris-Cappio, F.4
  • 2
    • 0034651739 scopus 로고    scopus 로고
    • Modulation of NF-kappaB activity and apoptosis in chronic lymphocytic leukemia B cells
    • Furman RR, Asgary Z, Mascarenhas JO, Liou HC, Schattner EJ. Modulation of NF-kappa B activity and apoptosis in chronic lymphocytic leukemia B cells. J Immunol. 2000;164(4):2200-2206. (Pubitemid 30108780)
    • (2000) Journal of Immunology , vol.164 , Issue.4 , pp. 2200-2206
    • Furman, R.R.1    Asgary, Z.2    Mascarenhas, J.O.3    Liou, H.-C.4    Schattner, E.J.5
  • 3
    • 58149378361 scopus 로고    scopus 로고
    • C-Abl kinase inhibitors overcome CD40-mediated drug resistance in CLL: Implications for therapeutic targeting of chemoresistant niches
    • Hallaert DY, Jaspers A, van Noesel CJ, et al. c-Abl kinase inhibitors overcome CD40-mediated drug resistance in CLL: implications for therapeutic targeting of chemoresistant niches. Blood. 2008;112(13):5141-5149.
    • (2008) Blood , vol.112 , Issue.13 , pp. 5141-5149
    • Hallaert, D.Y.1    Jaspers, A.2    Van Noesel, C.J.3
  • 4
    • 8844226681 scopus 로고    scopus 로고
    • CD40 stimulation of B-cell chronic lymphocytic leukaemia cells enhances the anti-apoptotic profile, but also Bid expression and cells remain susceptible to autologous cytotoxic T-lymphocyte attack
    • DOI 10.1111/j.1365-2141.2004.05225.x
    • Kater AP, Evers LM, Remmerswaal EB, et al. CD40 stimulation of B-cell chronic lymphocytic leukaemia cells enhances the anti-apoptotic profile, but also Bid expression and cells remain susceptible to autologous cytotoxic T-lymphocyte attack. Br J Haematol. 2004;127(4):404-415. (Pubitemid 39536592)
    • (2004) British Journal of Haematology , vol.127 , Issue.4 , pp. 404-415
    • Kater, A.P.1    Evers, L.M.2    Remmerswaal, E.B.M.3    Jaspers, A.4    Oosterwijk, M.F.5    Van Lier, R.A.W.6    Van Oers, M.H.J.7    Eldering, E.8
  • 6
    • 66149147044 scopus 로고    scopus 로고
    • Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia
    • Vogler M, Butterworth M, Majid A, et al. Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia. Blood. 2009;113(18):4403-4413.
    • (2009) Blood , vol.113 , Issue.18 , pp. 4403-4413
    • Vogler, M.1    Butterworth, M.2    Majid, A.3
  • 7
    • 0242298176 scopus 로고    scopus 로고
    • Role of the microenvironment in chronic lymphocytic leukaemia
    • DOI 10.1046/j.1365-2141.2003.04679.x
    • Caligaris-Cappio F. Role of the microenvironment in chronic lymphocytic leukaemia. Br J Haematol. 2003;123(3):380-388. (Pubitemid 37363477)
    • (2003) British Journal of Haematology , vol.123 , Issue.3 , pp. 380-388
    • Caligaris-Cappio, F.1
  • 8
    • 0034051534 scopus 로고    scopus 로고
    • The indispensable role of microenvironment in the natural history of low-grade B-cell neoplasms
    • Ghia P, Caligaris-Cappio F. The indispensable role of microenvironment in the natural history of low-grade B-cell neoplasms. Adv Cancer Res. 2000;79:157-173. (Pubitemid 30228123)
    • (2000) Advances in Cancer Research , vol.79 , pp. 157-173
    • Ghia, P.1    Caligaris-Cappio, F.2
  • 10
    • 0037850927 scopus 로고    scopus 로고
    • Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy
    • DOI 10.1038/sj.cdd.4401194
    • Sturm I, Bosanquet AG, Hermann S, et al. Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy. Cell Death Differ. 2003;10(4):477-484. (Pubitemid 36626360)
    • (2003) Cell Death and Differentiation , vol.10 , Issue.4 , pp. 477-484
    • Sturm, I.1    Bosanquet, A.G.2    Hermann, S.3    Guner, D.4    Dorken, B.5    Daniel, P.T.6
  • 11
    • 77957664665 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial
    • Hallek M, Fischer K, Fingerle-Rowson G, et al. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet. 2010;376(9747):1164-1174.
    • (2010) Lancet , vol.376 , Issue.9747 , pp. 1164-1174
    • Hallek, M.1    Fischer, K.2    Fingerle-Rowson, G.3
  • 12
    • 77950478885 scopus 로고    scopus 로고
    • Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia
    • Robak T, Dmoszynska A, Solal-Celigny P, et al. Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia. J Clin Oncol. 2010;28(10):1756-1765.
    • (2010) J Clin Oncol , vol.28 , Issue.10 , pp. 1756-1765
    • Robak, T.1    Dmoszynska, A.2    Solal-Celigny, P.3
  • 13
    • 0036408912 scopus 로고    scopus 로고
    • CD20-mediated apoptosis: Signalling through lipid rafts
    • DOI 10.1046/j.1365-2567.2002.01495.x
    • Deans JP, Li H, Polyak MJ. CD20-mediated apoptosis: signalling through lipid rafts. Immunology. 2002;107(2):176-182. (Pubitemid 35279043)
    • (2002) Immunology , vol.107 , Issue.2 , pp. 176-182
    • Deans, J.P.1    Li, H.2    Polyak, M.J.3
  • 14
    • 34548221347 scopus 로고    scopus 로고
    • Mechanisms of killing by anti-CD20 monoclonal antibodies
    • DOI 10.1016/j.molimm.2007.06.151, PII S0161589007002623, XIth European meeting on Complement in Human Disease
    • Glennie MJ, French RR, Cragg MS, Taylor RP. Mechanisms of killing by anti-CD20 monoclonal antibodies. Mol Immunol. 2007;44(16):3823-3837. (Pubitemid 47332625)
    • (2007) Molecular Immunology , vol.44 , Issue.16 , pp. 3823-3837
    • Glennie, M.J.1    French, R.R.2    Cragg, M.S.3    Taylor, R.P.4
  • 15
    • 77951561987 scopus 로고    scopus 로고
    • Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct-and immune effector cell-mediated B-cell cytotoxicity
    • Mössner E, Brunker P, Moser S, et al. Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct-and immune effector cell-mediated B-cell cytotoxicity. Blood. 2010;115(22):4393-4402.
    • (2010) Blood , vol.115 , Issue.22 , pp. 4393-4402
    • Mössner, E.1    Brunker, P.2    Moser, S.3
  • 16
    • 47749135829 scopus 로고    scopus 로고
    • Induction of cytosolic calcium flux by CD20 is dependent upon B Cell antigen receptor signaling
    • Walshe CA, Beers SA, French RR, et al. Induction of cytosolic calcium flux by CD20 is dependent upon B Cell antigen receptor signaling. J Biol Chem. 2008;283(25):16971-16984.
    • (2008) J Biol Chem , vol.283 , Issue.25 , pp. 16971-16984
    • Walshe, C.A.1    Beers, S.A.2    French, R.R.3
  • 18
    • 79960497321 scopus 로고    scopus 로고
    • Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies
    • Niederfellner G, Lammens A, Mundigl O, et al. Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies. Blood. 2011;118(2):358-367.
    • (2011) Blood , vol.118 , Issue.2 , pp. 358-367
    • Niederfellner, G.1    Lammens, A.2    Mundigl, O.3
  • 19
    • 78651354250 scopus 로고    scopus 로고
    • Comparison of the in vitro effects of the anti-CD20 antibodies rituximab and GA101 on chronic lymphocytic leukaemia cells
    • Patz M, Isaeva P, Forcob N, et al. Comparison of the in vitro effects of the anti-CD20 antibodies rituximab and GA101 on chronic lymphocytic leukaemia cells. Br J Haematol. 2011;152(3):295-306.
    • (2011) Br J Haematol , vol.152 , Issue.3 , pp. 295-306
    • Patz, M.1    Isaeva, P.2    Forcob, N.3
  • 20
    • 76949107685 scopus 로고    scopus 로고
    • Phase 1 study of RO5072759 (GA101) in relapsed/ refractory chronic lymphocytic leukemia
    • Abstract
    • Morschhauser F, Cartron G, Lamy T, et al. Phase 1 study of RO5072759 (GA101) in relapsed/ refractory chronic lymphocytic leukemia [Abstract]. Blood. 2009;114(suppl 1):884.
    • (2009) Blood , vol.114 , Issue.SUPPL. 1 , pp. 884
    • Morschhauser, F.1    Cartron, G.2    Lamy, T.3
  • 21
    • 79955979273 scopus 로고    scopus 로고
    • Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies
    • Alduaij W, Ivanov A, Honeychurch J, et al. Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies. Blood. 2011;117(17):4519- 4529.
    • (2011) Blood , vol.117 , Issue.17 , pp. 4519-4529
    • Alduaij, W.1    Ivanov, A.2    Honeychurch, J.3
  • 22
    • 68849108368 scopus 로고    scopus 로고
    • Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells
    • Ivanov A, Beers SA,Walshe CA, et al. Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells. J Clin Invest. 2009;119(8):2143- 2159.
    • (2009) J Clin Invest , vol.119 , Issue.8 , pp. 2143-2159
    • Ivanov, A.1    Beers, S.A.2    Walshe, C.A.3
  • 23
  • 24
    • 33744477614 scopus 로고    scopus 로고
    • Redirection of CMV-specific CTL towards B-CLL via CD20-targeted HLA/CMV complexes
    • DOI 10.1038/sj.leu.2404185, PII 2404185
    • Mous R, Savage P, Remmerswaal EB, et al. Redirection of CMV-specific CTL towards B-CLL via CD20-targeted HLA/CMV complexes. Leukemia. 2006;20(6):1096-1102. (Pubitemid 43797303)
    • (2006) Leukemia , vol.20 , Issue.6 , pp. 1096-1102
    • Mous, R.1    Savage, P.2    Remmerswaal, E.B.M.3    Van Lier, R.A.W.4    Eldering, E.5    Van Oers, M.H.J.6
  • 26
    • 78649302683 scopus 로고    scopus 로고
    • Ultrasensitive in situ visualization of active glucocerebrosidase molecules
    • Witte MD, KallemeijnWW, Aten J, et al. Ultrasensitive in situ visualization of active glucocerebrosidase molecules. Nat Chem Biol. 2010;6(12):907-913.
    • (2010) Nat Chem Biol , vol.6 , Issue.12 , pp. 907-913
    • Witte, M.D.1    Kallemeijn, W.W.2    Aten, J.3
  • 28
    • 0016738010 scopus 로고
    • Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining
    • Krishan A. Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. J Cell Biol. 1975;66(1):188-193.
    • (1975) J Cell Biol , vol.66 , Issue.1 , pp. 188-193
    • Krishan, A.1
  • 29
    • 0028904061 scopus 로고
    • Drug combination testing in acute lymphoblastic leukemia using the MTT assay
    • Kaspers GJ, Veerman AJ, Pieters R, et al. Drug combination testing in acute lymphoblastic leukemia using the MTT assay. Leuk Res. 1995;19(3):175-181.
    • (1995) Leuk Res , vol.19 , Issue.3 , pp. 175-181
    • Kaspers, G.J.1    Veerman, A.J.2    Pieters, R.3
  • 30
    • 77949424740 scopus 로고    scopus 로고
    • R-DHAP is effective in fludarabine-refractory chronic lymphocytic leukemia
    • Tonino SH, van GM, Eldering E, van Oers MH, Kater AP. R-DHAP is effective in fludarabine-refractory chronic lymphocytic leukemia. Leukemia. 2010;24(3):652-654.
    • (2010) Leukemia , vol.24 , Issue.3 , pp. 652-654
    • Tonino, S.H.1    Van, G.M.2    Eldering, E.3    Van Oers, M.H.4    Kater, A.P.5
  • 32
    • 0028102478 scopus 로고
    • Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
    • DOI 10.1038/371346a0
    • Lazebnik YA, Kaufmann SH, Desnoyers S, Poirier GG, Earnshaw WC. Cleavage of poly-(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature. 1994;371(6495):346-347. (Pubitemid 24300618)
    • (1994) Nature , vol.371 , Issue.6495 , pp. 346-347
    • Lazebnik, Y.A.1    Kaufmann, S.H.2    Desnoyers, S.3    Poirier, G.G.4    Earnshaw, W.C.5
  • 33
    • 77956628724 scopus 로고    scopus 로고
    • Dichotomy in NF-kappaB signaling and chemoresistance in immunoglobulin variable heavy-chain-mutated versus unmutated CLL cells upon CD40/TLR9 triggering
    • Tromp JM, Tonino SH, Elias JA, et al. Dichotomy in NF-kappaB signaling and chemoresistance in immunoglobulin variable heavy-chain-mutated versus unmutated CLL cells upon CD40/TLR9 triggering. Oncogene. 2010;29(36):5071-5082.
    • (2010) Oncogene , vol.29 , Issue.36 , pp. 5071-5082
    • Tromp, J.M.1    Tonino, S.H.2    Elias, J.A.3
  • 34
    • 0026343687 scopus 로고
    • Transmembrane signals generated through MHC class II, CD19, CD20, CD39, and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinase-dependent pathway
    • Kansas GS, Tedder TF. Transmembrane signals generated through MHC class II, CD19, CD20, CD39, and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinase-dependent pathway. J Immunol. 1991;147(12):4094-4102.
    • (1991) J Immunol , vol.147 , Issue.12 , pp. 4094-4102
    • Kansas, G.S.1    Tedder, T.F.2
  • 35
    • 0031973188 scopus 로고    scopus 로고
    • Differential adhesion pattern of B cell chronic lymphocytic leukemia cells
    • Behr SI, Korinth D, Schriever F. Differential adhesion pattern of B cell chronic lymphocytic leukemia cells. Leukemia. 1998;12(1):71-77. (Pubitemid 28043766)
    • (1998) Leukemia , vol.12 , Issue.1 , pp. 71-77
    • Behr, S.I.1    Korinth, D.2    Schriever, F.3
  • 36
    • 0027515846 scopus 로고
    • Folimycin (concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitis virus before arrival to the Golgi apparatus
    • Muroi M, Shiragami N, Nagao K, Yamasaki M, Takatsuki A. Folimycin (concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitis virus before arrival to the Golgi apparatus. Cell Struct Funct. 1993;18(3):139-149. (Pubitemid 23307469)
    • (1993) Cell Structure and Function , vol.18 , Issue.3 , pp. 139-149
    • Muroi, M.1    Shiragami, N.2    Nagao, K.3    Yamasaki, M.4    Takatsuki, A.5
  • 37
    • 28544435485 scopus 로고    scopus 로고
    • Lysosomes and autophagy in cell death control
    • DOI 10.1038/nrc1738
    • Kroemer G, Jaattela M. Lysosomes and autophagy in cell death control. Nat Rev Cancer. 2005;5(11):886-897. (Pubitemid 41746033)
    • (2005) Nature Reviews Cancer , vol.5 , Issue.11 , pp. 886-897
    • Kroemer, G.1    Jaattela, M.2
  • 38
    • 55749105875 scopus 로고    scopus 로고
    • P53-mediated apoptosis of CLL cells: Evidence for a transcription- independent mechanism
    • Steele AJ, Prentice AG, Hoffbrand AV, et al. p53-mediated apoptosis of CLL cells: evidence for a transcription-independent mechanism. Blood. 2008;112(9):3827-3834.
    • (2008) Blood , vol.112 , Issue.9 , pp. 3827-3834
    • Steele, A.J.1    Prentice, A.G.2    Hoffbrand, A.V.3
  • 40
    • 77749283145 scopus 로고    scopus 로고
    • Pharmacological activation of the p53 pathway in haematological malignancies
    • Saha MN, Micallef J, Qiu L, Chang H. Pharmacological activation of the p53 pathway in haematological malignancies. J Clin Pathol. 2010;63(3):204-209.
    • (2010) J Clin Pathol , vol.63 , Issue.3 , pp. 204-209
    • Saha, M.N.1    Micallef, J.2    Qiu, L.3    Chang, H.4
  • 42
    • 34047257880 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib acts independently of p53 and induces cell death via apoptosis and mitotic catastrophe in B-cell lymphoma cell lines
    • DOI 10.1158/0008-5472.CAN-06-3254
    • Strauss SJ, Higginbottom K, Juliger S, et al. The proteasome inhibitor bortezomib acts independently of p53 and induces cell death via apoptosis and mitotic catastrophe in B-cell lymphoma cell lines. Cancer Res. 2007;67(6):2783-2790. (Pubitemid 46548967)
    • (2007) Cancer Research , vol.67 , Issue.6 , pp. 2783-2790
    • Strauss, S.J.1    Higginbottom, K.2    Juliger, S.3    Maharaj, L.4    Allen, P.5    Schenkein, D.6    Lister, T.A.7    Joel, S.P.8
  • 43
    • 79951512093 scopus 로고    scopus 로고
    • ROS-mediated upregulation of Noxa overcomes chemoresistance in chronic lymphocytic leukemia
    • Tonino SH, van LJ, van Oers MH, et al. ROS-mediated upregulation of Noxa overcomes chemoresistance in chronic lymphocytic leukemia. Oncogene. 2011;30(6):701-713.
    • (2011) Oncogene , vol.30 , Issue.6 , pp. 701-713
    • Tonino, S.H.1    Van, L.J.2    Van Oers, M.H.3
  • 44
    • 35548991084 scopus 로고    scopus 로고
    • Cellular immune therapy for chronic lymphocytic leukemia
    • DOI 10.1182/blood-2007-01-068932
    • Kater AP, van Oers MH, Kipps TJ. Cellular immune therapy of chronic lymphocytic leukemia. Blood. 2007;110(8):2811-2818. (Pubitemid 350006933)
    • (2007) Blood , vol.110 , Issue.8 , pp. 2811-2818
    • Kater, A.P.1    Van Oers, M.H.J.2    Kipps, T.J.3
  • 45
    • 54949137644 scopus 로고    scopus 로고
    • Lysosomal membrane permeabilization in cell death
    • Boya P, Kroemer G. Lysosomal membrane permeabilization in cell death. Oncogene. 2008;27(50):6434-6451.
    • (2008) Oncogene , vol.27 , Issue.50 , pp. 6434-6451
    • Boya, P.1    Kroemer, G.2
  • 46
    • 78049394216 scopus 로고    scopus 로고
    • Possible misinterpretation of the mode of action of therapeutic antibodies in vitro: Homotypic adhesion and flow cytometry result in artefactual direct cell death
    • Golay J, Bologna L, Andre PA, et al. Possible misinterpretation of the mode of action of therapeutic antibodies in vitro: homotypic adhesion and flow cytometry result in artefactual direct cell death. Blood. 2010;116(17):3372- 3373.
    • (2010) Blood , vol.116 , Issue.17 , pp. 3372-3373
    • Golay, J.1    Bologna, L.2    Andre, P.A.3
  • 47
    • 0037223288 scopus 로고    scopus 로고
    • Susceptibility of lysosomes to rupture is a determinant for plasma membrane disruption in tumor necrosis factor alpha-induced cell death
    • DOI 10.1128/MCB.23.2.665-676.2003
    • Ono K, Kim SO, Han J. Susceptibility of lysosomes to rupture is a determinant for plasma membrane disruption in tumor necrosis factor alpha-induced cell death. Mol Cell Biol. 2003;23(2):665-676. (Pubitemid 36050559)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.2 , pp. 665-676
    • Ono, K.1    Kim, S.O.2    Han, J.3
  • 48
    • 1642306050 scopus 로고    scopus 로고
    • Antibody specificity controls in vivo effector mechanisms of anti-CD20 reagents
    • DOI 10.1182/blood-2003-06-2031
    • Cragg MS, Glennie MJ. Antibody specificity controls in vivo effector mechanisms of anti-CD20 reagents. Blood. 2004;103(7):2738-2743. (Pubitemid 38393032)
    • (2004) Blood , vol.103 , Issue.7 , pp. 2738-2743
    • Cragg, M.S.1    Glennie, M.J.2
  • 49
    • 33745017226 scopus 로고    scopus 로고
    • Caspase-independent killing of Burkitt lymphoma cell lines by rituximab
    • DOI 10.1007/s10495-006-6314-5
    • Daniels I, Abulayha AM, Thomson BJ, Haynes AP. Caspase-independent killing of Burkitt lymphoma cell lines by rituximab. Apoptosis. 2006;11(6):1013-1023. (Pubitemid 43876831)
    • (2006) Apoptosis , vol.11 , Issue.6 , pp. 1013-1023
    • Daniels, I.1    Abulayha, A.M.2    Thomson, B.J.3    Haynes, A.P.4
  • 50
    • 0036733456 scopus 로고    scopus 로고
    • CD20-induced B cell death can bypass mitochondria and caspase activation
    • van der Kolk LE, Evers LM, Omene C, et al. CD20-induced B cell death can bypass mitochondria and caspase activation. Leukemia. 2002;16(9):1735-1744.
    • (2002) Leukemia , vol.16 , Issue.9 , pp. 1735-1744
    • Van Der Kolk, L.E.1    Evers, L.M.2    Omene, C.3
  • 51
    • 0035282930 scopus 로고    scopus 로고
    • Homodimers but not monomers of Rituxan (chimeric anti-CD20) induce apoptosis in human B-lymphoma cells and synergize with a chemotherapeutic agent and an immunotoxin
    • DOI 10.1182/blood.V97.5.1392
    • Ghetie MA, Bright H, Vitetta ES. Homodimers but not monomers of Rituxan (chimeric anti-CD20) induce apoptosis in human B-lymphoma cells and synergize with a chemotherapeutic agent and an immunotoxin. Blood. 2001;97(5):1392-1398. (Pubitemid 32183764)
    • (2001) Blood , vol.97 , Issue.5 , pp. 1392-1398
    • Ghetie, M.-A.1    Bright, H.2    Vitetta, E.S.3
  • 52
    • 0942265544 scopus 로고    scopus 로고
    • Selective Disruption of Lysosomes in HeLa Cells Triggers Apoptosis Mediated by Cleavage of Bid by Multiple Papain-like Lysosomal Cathepsins
    • DOI 10.1074/jbc.M308347200
    • Cirman T, Oresic K, Mazovec GD, et al. Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins. J Biol Chem. 2004;279(5):3578-3587. (Pubitemid 38140598)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.5 , pp. 3578-3587
    • Cirman, T.1    Oresic, K.2    Mazovec, G.D.3    Turk, V.4    Reed, J.C.5    Myers, R.M.6    Salvesen, G.S.7    Turk, B.8
  • 53
    • 74549113851 scopus 로고    scopus 로고
    • Bendamustine for the treatment of chronic lymphocytic leukemia and rituximab-refractory, indolent B-cell non-Hodgkin lymphoma
    • Dennie TW, Kolesar JM. Bendamustine for the treatment of chronic lymphocytic leukemia and rituximab-refractory, indolent B-cell non-Hodgkin lymphoma. Clin Ther. 2009;31 (pt 2):2290-2311.
    • (2009) Clin Ther , vol.31 , Issue.PART 2 , pp. 2290-2311
    • Dennie, T.W.1    Kolesar, J.M.2
  • 54
    • 58149214372 scopus 로고    scopus 로고
    • Bendamustine is effective in p53-deficient B-cell neoplasms and requires oxidative stress and caspase-independent signaling
    • Roué G, Lopez-Guerra M, Milpied P, et al. Bendamustine is effective in p53-deficient B-cell neoplasms and requires oxidative stress and caspase-independent signaling. Clin Cancer Res. 2008;14(21):6907-6915.
    • (2008) Clin Cancer Res , vol.14 , Issue.21 , pp. 6907-6915
    • Roué, G.1    Lopez-Guerra, M.2    Milpied, P.3


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