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Volumn 38, Issue 10, 2011, Pages 1679-1690

Introducing process analytical technology (PAT) in filamentous cultivation process development: Comparison of advanced online sensors for biomass measurement

Author keywords

Biomass Filamentous fermentation; Dielectric spectroscopy; Multi wavelength fluorescence spectroscopySoftware sensors; Real time monitoring

Indexed keywords

CARBON DIOXIDE; DISSOLVED OXYGEN;

EID: 81055140624     PISSN: 13675435     EISSN: 14765535     Source Type: Journal    
DOI: 10.1007/s10295-011-0957-0     Document Type: Article
Times cited : (28)

References (36)
  • 1
    • 36749020097 scopus 로고    scopus 로고
    • On-line monitoring of infected Sf-9 insect cell cultures by scanning permittivity measurements and comparison with off-line biovolume measurements
    • DOI 10.1007/s10616-007-9093-0, JAACT 2005- Special Issue
    • Ansorge S, Esteban G, Schmid G (2007) On-line monitoring of infected Sf-9 insect cell cultures by scanning permittivity measurements and comparison with off-line biovolume measurements. Cytotechnology 55:115-124 (Pubitemid 350212030)
    • (2007) Cytotechnology , vol.55 , Issue.2-3 , pp. 115-124
    • Ansorge, S.1    Esteban, G.2    Schmid, G.3
  • 2
    • 76849104099 scopus 로고    scopus 로고
    • Multifrequency permittivity measurements enable on-line monitoring of changes in intracellular conductivity due to nutrient limitations during batch cultivations of CHO cells
    • Ansorge S, Esteban G, Schmid G (2010) Multifrequency permittivity measurements enable on-line monitoring of changes in intracellular conductivity due to nutrient limitations during batch cultivations of CHO cells. Biotechnol Prog 26:272-283
    • (2010) Biotechnol Prog , vol.26 , pp. 272-283
    • Ansorge, S.1    Esteban, G.2    Schmid, G.3
  • 3
    • 27144529910 scopus 로고    scopus 로고
    • Lactic acid bacteria biomass monitoring in highly conductive media by permittivity measurements
    • DOI 10.1007/s10529-005-1781-2
    • Arnoux AS, Preziosi-Belloy L, Esteban G, Teissier P, Ghommidh C (2005) Lactic acid bacteria biomass monitoring in highly conductive media by permittivity measurements. Biotechnol Lett 27:1551-1557 (Pubitemid 41504245)
    • (2005) Biotechnology Letters , vol.27 , Issue.20 , pp. 1551-1557
    • Arnoux, A.S.1    Preziosi-Belloy, L.2    Esteban, G.3    Teissier, P.4    Ghommidh, C.5
  • 4
    • 15944374204 scopus 로고    scopus 로고
    • Effect of cycle time on fungal morphology, broth rheology, and recombinant enzyme productivity during pulsed addition of limiting carbon source
    • DOI 10.1002/bit.20355
    • Bhargava S, Wenger KS, Rane K, Rising V, Marten MR (2005) Effect of cycle time on fungal morphology, broth rheology, and recombinant enzyme productivity during pulsed addition of limiting carbon source. Biotechnol Bioeng 89:524-529 (Pubitemid 40444806)
    • (2005) Biotechnology and Bioengineering , vol.89 , Issue.5 , pp. 524-529
    • Bhargava, S.1    Wenger, K.S.2    Rane, K.3    Rising, V.4    Marten, M.R.5
  • 5
    • 26444526644 scopus 로고    scopus 로고
    • Sensor combination and chemometric modelling for improved process monitoring in recombinant E. coli fed-batch cultivations
    • Clementschitsch F, Kern J, Pötschacher F, Bayer K (2005) Sensor combination and chemometric modelling for improved process monitoring in recombinant E. coli fed-batch cultivations. J Biotechnol 120:183-197
    • (2005) J Biotechnol , vol.120 , pp. 183-197
    • Clementschitsch, F.1    Kern, J.2    Pötschacher, F.3    Bayer, K.4
  • 6
    • 66149183267 scopus 로고    scopus 로고
    • Data reconciliation of concentration estimates from midinfrared and dielectric spectral measurements for improved online monitoring of bioprocesses
    • Dabros M, Amrhein M, Bonvin D, Marison IW, von Stockar U (2009) Data reconciliation of concentration estimates from midinfrared and dielectric spectral measurements for improved online monitoring of bioprocesses. Biotechnol Prog 25:578-588
    • (2009) Biotechnol Prog , vol.25 , pp. 578-588
    • Dabros, M.1    Amrhein, M.2    Bonvin, D.3    Marison, I.W.4    Von Stockar, U.5
  • 8
    • 32044436302 scopus 로고    scopus 로고
    • Determination of cell mass and polymyxin using multi-wavelength fluorescence
    • DOI 10.1016/j.jbiotec.2005.08.007, PII S016816560500489X
    • Eliasson Lantz A, Jørgensen P, Poulsen E, Lindemann C, Olsson L (2006) Determination of cell mass and polymyxin using multiwavelength fluorescence. J Biotechnol 121:544-554 (Pubitemid 43201931)
    • (2006) Journal of Biotechnology , vol.121 , Issue.4 , pp. 544-554
    • Eliasson Lantz, A.1    Jorgensen, P.2    Poulsen, E.3    Lindemann, C.4    Olsson, L.5
  • 9
    • 0032486513 scopus 로고    scopus 로고
    • Specific heat flow rate: An on-line monitor and potential control variable of specific metabolic rate in animal cell culture that combines microcalorimetry with dielectric spectroscopy
    • DOI 10.1002/(SICI)1097-0290(19980605)58:5<464::AID-BIT2>3.0.CO;2-B
    • Guan Y, Evans PM, Kemp RB (1998) Specific heat flow rate: an online monitor and potential control variable of specific metabolic rate in animal cell culture that combines microcalorimetry with dielectric spectroscopy. Biotechnol Bioeng 58:464-477 (Pubitemid 28178248)
    • (1998) Biotechnology and Bioengineering , vol.58 , Issue.5 , pp. 464-477
    • Guan, Y.1    Evans, P.M.2    Kemp, R.B.3
  • 10
    • 4644271786 scopus 로고    scopus 로고
    • On-line cell mass monitoring of Saccharomyces cerevisiae cultivations by multi-wavelength fluorescence
    • DOI 10.1016/j.jbiotec.2004.05.009, PII S0168165604002731
    • Haack MB, Eliasson A, Olsson L (2004) On-line cell mass monitoring of Saccharomyces cerevisiae cultivations by multiwavelength fluorescence. J Biotechnol 114:199-208 (Pubitemid 39298297)
    • (2004) Journal of Biotechnology , vol.114 , Issue.1-2 , pp. 199-208
    • Haack, M.B.1    Eliasson, A.2    Olsson, L.3
  • 11
    • 33947597321 scopus 로고    scopus 로고
    • Chemometric analysis of in-line multi-wavelength fluorescence measurements obtained during cultivations with a lipase producing Aspergillus oryzae strain
    • DOI 10.1002/bit.21170
    • Haack MB, Eliasson Lantz A, Mortensen PP, Olsson L (2007) Chemometric analysis of in-line multi-wavelength fluorescence measurements obtained during cultivations with a lipase producing Aspergillus oryzae strain. Biotechnol Bioeng 96:904-913 (Pubitemid 46479553)
    • (2007) Biotechnology and Bioengineering , vol.96 , Issue.5 , pp. 904-913
    • Haack, M.B.1    Lantz, A.E.2    Mortensen, P.P.3    Olsson, L.4
  • 12
    • 30944445000 scopus 로고    scopus 로고
    • Two-dimensional fluorescence spectroscopy: A novel approach for controlling fed-batch cultivations
    • DOI 10.1016/j.jbiotec.2005.07.016, PII S0168165605004384
    • Hantelmann K, Kollecker M, Hüll D, Hitzmann B, Scheper T (2006) Two-dimensional fluorescence spectroscopy: a novel approach for controlling fed-batch cultivations. J Biotechnol 121:410-417 (Pubitemid 43113114)
    • (2006) Journal of Biotechnology , vol.121 , Issue.3 , pp. 410-417
    • Hantelmann, K.1    Kollecker, M.2    Hull, D.3    Hitzmann, B.4    Scheper, T.5
  • 13
    • 0023306390 scopus 로고
    • Dielectric permittivity of microbial suspensions at radio frequencies: A novel method for the real-time estimation of microbial biomass
    • DOI 10.1016/0141-0229(87)90075-5
    • Harris CM, Todd RW, Bungard SJ, Lovitt RW, Morris JG, Kell DB (1987) Dielectric permittivity of microbial suspensions at radio frequencies: a novel method for the real-time estimation of microbial biomass. Enzyme Microb Technol 9:181-186 (Pubitemid 17028857)
    • (1987) Enzyme and Microbial Technology , vol.9 , Issue.3 , pp. 181-186
    • Harris, C.M.1    Tood, R.W.2    Bungard, S.J.3
  • 15
    • 33645736967 scopus 로고    scopus 로고
    • Estimation of biomass concentrations in fermentation processes for recombinant protein production
    • DOI 10.1007/s00449-006-0051-6
    • Jenzsch M, Simutis R, Eisbrenner G, Stückrath I, Lübbert A (2006) Estimation of biomass concentrations in fermentation processes for recombinant protein production. Bioprocess Biosyst Eng 29:19-27 (Pubitemid 43829501)
    • (2006) Bioprocess and Biosystems Engineering , vol.29 , Issue.1 , pp. 19-27
    • Jenzsch, M.1    Simutis, R.2    Eisbrenner, G.3    Stuckrath, I.4    Lubbert, A.5
  • 17
    • 46949087562 scopus 로고    scopus 로고
    • Biomass measurement online: The performance of in situ measurements and software sensors
    • Kiviharju K, Salonen K, Moilanen U, Eerikäinen T (2008) Biomass measurement online: the performance of in situ measurements and software sensors. J Ind Microbiol Biotechnol 35:657-665
    • (2008) J Ind Microbiol Biotechnol , vol.35 , pp. 657-665
    • Kiviharju, K.1    Salonen, K.2    Moilanen, U.3    Eerikäinen, T.4
  • 18
    • 0025920326 scopus 로고
    • Monitoring cell concentration and activity by multiple excitation fluorometry
    • Li JK, Asali EC, Humphrey AE, Horvath JJ (1991) Monitoring cell concentration and activity by multiple excitation fluorometry. Biotechnol Prog 7:21-27
    • (1991) Biotechnol Prog , vol.7 , pp. 21-27
    • Li, J.K.1    Asali, E.C.2    Humphrey, A.E.3    Horvath, J.J.4
  • 19
    • 0347040053 scopus 로고    scopus 로고
    • 2-Dimensional fluorescence spectroscopy for on-line bioprocess monitoring
    • PII S0925400598001956
    • Lindemann C, Marose S, Nielsen HO, Scheper T (1998) 2-Dimensional fluorescence spectroscopy for on-line bioprocess monitoring. Sens Actuators B Chem 51:273-277 (Pubitemid 128433393)
    • (1998) Sensors and Actuators, B: Chemical , vol.51 , Issue.1-3 , pp. 273-277
    • Lindemann, C.1    Marose, S.2    Nielsen, H.O.3    Scheper, T.4
  • 21
    • 0025756355 scopus 로고
    • The permittistat a novel type of turbidostat
    • Markx GH, Davey CL, Kell DB (1991) The permittistat a novel type of turbidostat. J Gen Microbiol 137:737-744
    • (1991) J Gen Microbiol , vol.137 , pp. 737-744
    • Markx, G.H.1    Davey, C.L.2    Kell, D.B.3
  • 22
    • 0025743931 scopus 로고
    • The dielectric permittivity at radio frequencies and the Bruggeman probe: Novel techniques for the on-line determination of biomass concentrations in plant cell cultures
    • Markx GH, Davey CL, Kell DB, Morris P (1991) The dielectric permittivity at radio frequencies and the Bruggeman probe: novel techniques for the on-line determination of biomass concentrations in plant cell cultures. J Biotechnol 20:279-290
    • (1991) J Biotechnol , vol.20 , pp. 279-290
    • Markx, G.H.1    Davey, C.L.2    Kell, D.B.3    Morris, P.4
  • 23
    • 0031907915 scopus 로고    scopus 로고
    • Two-dimensional fluorescence spectroscopy: A new tool for on-line bioprocess monitoring
    • DOI 10.1021/bp970124o
    • Marose S, Lindemann C, Scheper T (1998) Two-dimensional fluorescence spectroscopy: a new tool for on-line bioprocess monitoring. Biotechnol Prog 14:63-74 (Pubitemid 28118265)
    • (1998) Biotechnology Progress , vol.14 , Issue.1 , pp. 63-74
    • Marose, S.1    Lindemann, C.2    Scheper, T.3
  • 24
    • 0034681009 scopus 로고    scopus 로고
    • Real time monitoring biomass concentration in Streptomyces clavuligerus cultivations with industrial media using a capacitance probe
    • Neves AA, Pereira DA, Vieira LM, Menezes JC (2000) Real time monitoring biomass concentration in Streptomyces clavuligerus cultivations with industrial media using a capacitance probe. J Biotechnol 84:45-52
    • (2000) J Biotechnol , vol.84 , pp. 45-52
    • Neves, A.A.1    Pereira, D.A.2    Vieira, L.M.3    Menezes, J.C.4
  • 25
    • 0345369598 scopus 로고    scopus 로고
    • Dielectric spectroscopy in the cultivation of suspended and immobilized hybridoma cells
    • DOI 10.1016/S0168-1656(98)00080-7, PII S0168165698000807
    • Noll T, Biselli M (1998) Dielectric spectroscopy in the cultivation of suspended and immobilized hybridoma cells. J Biotechnol 63:187-198 (Pubitemid 29023101)
    • (1998) Journal of Biotechnology , vol.63 , Issue.3 , pp. 187-198
    • Noll, T.1    Biselli, M.2
  • 26
    • 0033675439 scopus 로고    scopus 로고
    • Evaluation of on-line viable biomass measurements during fermentations of Candida utilis
    • November EJ, Van Impe JF (2000) Evaluation of on-line viable biomass measurements during fermentations of Candida utilis. Bioprocess Eng 23:473-477
    • (2000) Bioprocess Eng , vol.23 , pp. 473-477
    • November, E.J.1    Van Impe, J.F.2
  • 27
    • 0031543428 scopus 로고    scopus 로고
    • On-line and in situ monitoring of biomass in submerged cultivations
    • DOI 10.1016/S0167-7799(97)01136-0, PII S0167779997011360
    • Olsson L, Nielsen J (1997) Online and in situ monitoring of biomass in submerged cultivations. Trends Biotechnol 15:517-522 (Pubitemid 27504851)
    • (1997) Trends in Biotechnology , vol.15 , Issue.12 , pp. 517-522
    • Olsson, L.1    Nielsen, J.2
  • 28
    • 77956970513 scopus 로고    scopus 로고
    • Quantitative modeling of viable cell density, cell size, intracellular conductivity, and membrane capacitance in batch and fed-batch CHO processes using dielectric spectroscopy
    • Opel CF, Li J, Amanullah A (2010) Quantitative modeling of viable cell density, cell size, intracellular conductivity, and membrane capacitance in batch and fed-batch CHO processes using dielectric spectroscopy. Biotechnol Prog 26:1187-1199
    • (2010) Biotechnol Prog , vol.26 , pp. 1187-1199
    • Opel, C.F.1    Li, J.2    Amanullah, A.3
  • 29
    • 70350247465 scopus 로고    scopus 로고
    • On-line estimation of biomass, glucose and ethanol in Saccharomyces cerevisiae cultivations using in situ multi-wavelength fluorescence and software sensors
    • Ödman P, Johansen CL, Olsson L, Gernaey KV, Eliasson Lantz A (2009) On-line estimation of biomass, glucose and ethanol in Saccharomyces cerevisiae cultivations using in situ multi-wavelength fluorescence and software sensors. J Biotechnol 144:102-112
    • (2009) J Biotechnol , vol.144 , pp. 102-112
    • Ödman, P.1    Johansen, C.L.2    Olsson, L.3    Gernaey, K.V.4    Eliasson Lantz, A.5
  • 30
    • 77952883702 scopus 로고    scopus 로고
    • Sensor combination and chemometric variable selection for online monitoring of Streptomyces coelicolor fed-batch cultivations
    • Ödman P, Johansen C, Olsson L, Gernaey KV, Eliasson Lantz A (2010) Sensor combination and chemometric variable selection for online monitoring of Streptomyces coelicolor fed-batch cultivations. Appl Microbiol Biotechnol 86:1745-1759
    • (2010) Appl Microbiol Biotechnol , vol.86 , pp. 1745-1759
    • Ödman, P.1    Johansen, C.2    Olsson, L.3    Gernaey, K.V.4    Eliasson Lantz, A.5
  • 31
    • 0030298021 scopus 로고    scopus 로고
    • The relationships between biomass concentration, determined by a capacitance-based probe, rheology and morphology of Saccharopolyspora erythraea cultures
    • DOI 10.1016/0168-1656(96)01612-4, PII S0168165696016124
    • Sarra M, Ison AP, Lilly MD (1996) The relationships between biomass concentration, determined by a capacitance-based probe, rheology and morphology of Saccharopolyspora erythraea cultures. J Biotechnol 51:157-165 (Pubitemid 26375854)
    • (1996) Journal of Biotechnology , vol.51 , Issue.2 , pp. 157-165
    • Sarra, M.1    Ison, A.P.2    Lilly, M.D.3
  • 32
    • 0343417087 scopus 로고    scopus 로고
    • Biomass measurement by inductive permittivity
    • DOI 10.1002/(SICI)1097-0290(19970720)55:2<289::AID-BIT7>3.0.CO;2-E
    • Siano SA (1997) Biomass measurement by inductive permittivity. Biotechnol Bioeng 55:289-304 (Pubitemid 27291198)
    • (1997) Biotechnology and Bioengineering , vol.55 , Issue.2 , pp. 289-304
    • Siano, S.A.1
  • 33
    • 38349147666 scopus 로고    scopus 로고
    • Software sensors for fermentation processes
    • Sundström H, Enfors S (2008) Software sensors for fermentation processes. Bioprocess Biosyst Eng 31:145-152
    • (2008) Bioprocess Biosyst Eng , vol.31 , pp. 145-152
    • Sundström, H.1    Enfors, S.2
  • 36
    • 43549087887 scopus 로고    scopus 로고
    • Real-time viable-cell mass monitoring in high-cell-density fed-batch glutathione fermentation by Saccharomyces cerevisiae T65 in industrial complex medium
    • DOI 10.1263/jbb.105.409, PII S1389172308700859
    • Xiong Z, Guo M, Guo Y, Chu J, Zhuang Y, Zhang S (2008) Realtime viable-cell mass monitoring in high-cell-density fed-batch glutathione fermentation by Saccharomyces cerevisiae T65 in industrial complex medium. J Biosci Bioeng 105:409-413 (Pubitemid 351680741)
    • (2008) Journal of Bioscience and Bioengineering , vol.105 , Issue.4 , pp. 409-413
    • Xiong, Z.-Q.1    Guo, M.-J.2    Guo, Y.-X.3    Chu, J.4    Zhuang, Y.-P.5    Zhang, S.-L.6


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