-
1
-
-
0037177552
-
Schizophrenia: Diverse approaches to a complex disease
-
Sawa A, Snyder SH. Schizophrenia: diverse approaches to a complex disease. Science 2002; 296: 692-5.
-
(2002)
Science
, vol.296
, pp. 692-695
-
-
Sawa, A.1
Snyder, S.H.2
-
3
-
-
35848947251
-
Molecular mechanisms of schizophrenia
-
Lang UE, Puls I, Muller DJ, Strutz-Seebohm N, Gallinat J. Molecular mechanisms of schizophrenia. Cell Physiol Biochem 2007; 20: 687-702.
-
(2007)
Cell Physiol Biochem
, vol.20
, pp. 687-702
-
-
Lang, U.E.1
Puls, I.2
Muller, D.J.3
Strutz-Seebohm, N.4
Gallinat, J.5
-
4
-
-
0023254675
-
Dopamine receptors and the dopamine hypothesis of schizophrenia
-
Seeman P. Dopamine receptors and the dopamine hypothesis of schizophrenia. Synapse 1987; 1: 133-52.
-
(1987)
Synapse
, vol.1
, pp. 133-152
-
-
Seeman, P.1
-
5
-
-
0032987558
-
The regulation of forebrain dopamine transmission: Relevance to the pathophysiology and psychopathology of schizophrenia
-
Moore H, West AR, Grace AA. The regulation of forebrain dopamine transmission: relevance to the pathophysiology and psychopathology of schizophrenia. Biol Psychiatry 1999; 46: 40-55.
-
(1999)
Biol Psychiatry
, vol.46
, pp. 40-55
-
-
Moore, H.1
West, A.R.2
Grace, A.A.3
-
6
-
-
17844368319
-
Midbrain dopamine and prefrontal function in humans: Interaction and modulation by COMT genotype
-
Meyer-Lindenberg A, Kohn PD, Kolachana B, et al. Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype. Nat Neurosci 2005; 8: 594-6.
-
(2005)
Nat Neurosci
, vol.8
, pp. 594-596
-
-
Meyer-Lindenberg, A.1
Kohn, P.D.2
Kolachana, B.3
-
7
-
-
0036955771
-
Selective prefrontal cortex inputs to dopamine cells: Implications for schizophrenia
-
Sesack SR, Carr DB. Selective prefrontal cortex inputs to dopamine cells: implications for schizophrenia. Physiol Behav 2002; 77: 513-7.
-
(2002)
Physiol Behav
, vol.77
, pp. 513-517
-
-
Sesack, S.R.1
Carr, D.B.2
-
8
-
-
0036794815
-
Dopamine and antipsychotic drug action revisited
-
Jones HM, Pilowsky LS. Dopamine and antipsychotic drug action revisited. Br J Psychiatry 2002; 181: 271-5.
-
(2002)
Br J Psychiatry
, vol.181
, pp. 271-275
-
-
Jones, H.M.1
Pilowsky, L.S.2
-
9
-
-
1942458526
-
Describing an atypical antipsychotic: Receptor binding and its role in pathophysiology
-
Stahl SM. Describing an atypical antipsychotic: Receptor binding and its role in pathophysiology. Primary Care Companion. J Clin Psychiatry 2003; 5: 9-13.
-
(2003)
Primary Care Companion. J Clin Psychiatry
, vol.5
, pp. 9-13
-
-
Stahl, S.M.1
-
10
-
-
0024468417
-
Clinical studies on the mechanism of action of clozapine: The dopamine-serotonin hypothesis of schizophrenia
-
Meltzer HY. Clinical studies on the mechanism of action of clozapine: the dopamine-serotonin hypothesis of schizophrenia. Psychopharmacology [Berl] 1989; 99 Suppl: S18-S27.
-
(1989)
Psychopharmacology [Berl]
, vol.99
, Issue.SUPPL.
-
-
Meltzer, H.Y.1
-
11
-
-
0036365725
-
Commentary on clinical studies on the mechanism of action of clozapine; the dopamine-serotonin hypothesis of schizophrenia
-
Meltzer HY. Commentary on clinical studies on the mechanism of action of clozapine; the dopamine-serotonin hypothesis of schizophrenia. Psychopharmacology [Berl] 2002; 163: 1-3.
-
(2002)
Psychopharmacology [Berl]
, vol.163
, pp. 1-3
-
-
Meltzer, H.Y.1
-
12
-
-
52949139104
-
Does stimulation of 5-HT [1A] receptors improve cognition in schizophrenia?
-
Meltzer HY, Sumiyoshi T. Does stimulation of 5-HT [1A] receptors improve cognition in schizophrenia? Behav Brain Res 2008; 195: 98-102.
-
(2008)
Behav Brain Res
, vol.195
, pp. 98-102
-
-
Meltzer, H.Y.1
Sumiyoshi, T.2
-
13
-
-
0035094264
-
Does fast dissociation from the dopamine d [2] receptor explain the action of atypical antipsychotics?: A new hypothesis
-
Kapur S, Seeman P. Does fast dissociation from the dopamine d [2] receptor explain the action of atypical antipsychotics?: A new hypothesis. Am J Psychiatry 2001; 158: 360-9.
-
(2001)
Am J Psychiatry
, vol.158
, pp. 360-369
-
-
Kapur, S.1
Seeman, P.2
-
14
-
-
0027964721
-
Genomic organization of the human catechol O-methyltransferase gene and its expression from two distinct promoters
-
Tenhunen J, Salminen M, Lundstrom K, Kiviluoto T, Savolainen R, Ulmanen I. Genomic organization of the human catechol O-methyltransferase gene and its expression from two distinct promoters. Eur J Biochem 1994; 223: 1049-59.
-
(1994)
Eur J Biochem
, vol.223
, pp. 1049-1059
-
-
Tenhunen, J.1
Salminen, M.2
Lundstrom, K.3
Kiviluoto, T.4
Savolainen, R.5
Ulmanen, I.6
-
15
-
-
0025801604
-
Cloning and characterization of human placental catechol-O-methyltransferase cDNA
-
Lundström K, Salminen M, Jalanko A, Savolainen R, Ulmanen I. Cloning and characterization of human placental catechol-O-methyltransferase cDNA. DNA Cell Biol 1991; 10: 181-9.
-
(1991)
DNA Cell Biol
, vol.10
, pp. 181-189
-
-
Lundström, K.1
Salminen, M.2
Jalanko, A.3
Savolainen, R.4
Ulmanen, I.5
-
16
-
-
67650064594
-
The consensus coding sequence [CCDS] project: Identifying a common proteincoding gene set for the human and mouse genomes
-
Pruitt KD, Harrow J, Harte RA, et al. The consensus coding sequence [CCDS] project: Identifying a common proteincoding gene set for the human and mouse genomes. Genome Res 2009; 19: 1316-23.
-
(2009)
Genome Res
, vol.19
, pp. 1316-1323
-
-
Pruitt, K.D.1
Harrow, J.2
Harte, R.A.3
-
17
-
-
34548681418
-
Expression of multiple catechol-o-methyltransferase [COMT] mRNA variants in human brain
-
Tunbridge EM, Lane TA, Harrison PJ. Expression of multiple catechol-o-methyltransferase [COMT] mRNA variants in human brain. Am J Med Genet B Neuropsychiatr Genet 2007; 144B: 834-9.
-
(2007)
Am J Med Genet B Neuropsychiatr Genet
, vol.144 B
, pp. 834-839
-
-
Tunbridge, E.M.1
Lane, T.A.2
Harrison, P.J.3
-
18
-
-
0028918413
-
Kinetics of human soluble and membrane-bound catechol O-methyltransferase: A revised mechanism and description of the thermolabile variant of the enzyme
-
Lotta T, Vidgren J, Tilgmann C, et al. Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry 1995; 34: 4202-10.
-
(1995)
Biochemistry
, vol.34
, pp. 4202-4210
-
-
Lotta, T.1
Vidgren, J.2
Tilgmann, C.3
-
19
-
-
6344265879
-
Functional analysis of genetic variation in catechol-O-methyltransferase [COMT]: Effects on mRNA, protein, and enzyme activity in postmortem human brain
-
Chen J, Lipska BK, Halim N, et al. Functional analysis of genetic variation in catechol-O-methyltransferase [COMT]: effects on mRNA, protein, and enzyme activity in postmortem human brain. Am J Hum Genet 2004; 75: 807-21.
-
(2004)
Am J Hum Genet
, vol.75
, pp. 807-821
-
-
Chen, J.1
Lipska, B.K.2
Halim, N.3
-
20
-
-
48649084143
-
Breast cancer risk reduction and membrane-bound catechol-O-methyltransferase genetic polymorphisms
-
Ji Y, Olson J, Zhang J, et al. Breast cancer risk reduction and membrane-bound catechol-O-methyltransferase genetic polymorphisms. Cancer Res 2008; 68: 5997-6005.
-
(2008)
Cancer Res
, vol.68
, pp. 5997-6005
-
-
Ji, Y.1
Olson, J.2
Zhang, J.3
-
21
-
-
14044255978
-
Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans
-
Lee SG, Joo Y, Kim B, et al. Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans. Hum Genet 2005; 116: 319-28.
-
(2005)
Hum Genet
, vol.116
, pp. 319-328
-
-
Lee, S.G.1
Joo, Y.2
Kim, B.3
-
22
-
-
0038389841
-
A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain
-
Bray NJ, Buckland PR, Williams NM, et al. A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain. Am J Hum Genet 2003; 73: 152-61.
-
(2003)
Am J Hum Genet
, vol.73
, pp. 152-161
-
-
Bray, N.J.1
Buckland, P.R.2
Williams, N.M.3
-
23
-
-
33845899137
-
Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure
-
Nackley AG, Shabalina SA, Tchivileva IE, et al. Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure. Science 2006; 314: 1930-3.
-
(2006)
Science
, vol.314
, pp. 1930-1933
-
-
Nackley, A.G.1
Shabalina, S.A.2
Tchivileva, I.E.3
-
24
-
-
58149218090
-
Identification of a novel haplotype of the human catechol-O-methyltransferase gene
-
Bai HW, Zhu BT. Identification of a novel haplotype of the human catechol-O-methyltransferase gene. Pharmacogenet Genomics 2009; 19: 87-9.
-
(2009)
Pharmacogenet Genomics
, vol.19
, pp. 87-89
-
-
Bai, H.W.1
Zhu, B.T.2
-
25
-
-
65249101239
-
Low enzymatic activity haplotypes of the human catechol-Omethyltransferase gene: Enrichment for marker SNPs
-
Nackley AG, Shabalina SA, Lambert JE, et al. Low enzymatic activity haplotypes of the human catechol-Omethyltransferase gene: enrichment for marker SNPs. PLoS One 2009; 4: e5237.
-
(2009)
PLoS One
, vol.e5237
, pp. 4
-
-
Nackley, A.G.1
Shabalina, S.A.2
Lambert, J.E.3
-
26
-
-
0018853550
-
Catecholoestrogens (2-and 4- hydroxyoestrogens): Chemistry, biogenesis, metabolism, occurrence and physiological significance
-
Ball P, Knuppen R. Catecholoestrogens (2-and 4- hydroxyoestrogens): chemistry, biogenesis, metabolism, occurrence and physiological significance. Acta Endocrinol Suppl (Copenh) 1980; 232: 1-127.
-
(1980)
Acta Endocrinol Suppl (Copenh)
, vol.232
, pp. 1-127
-
-
Ball, P.1
Knuppen, R.2
-
27
-
-
0035884689
-
Catechol-O-methyltransferase [COMT]-mediated metabolism of catechol estrogens: Comparison of wild-type and variant COMT isoforms
-
Dawling S, Roodi N, Mernaugh RL, Wang X, Parl FF. Catechol-O-methyltransferase [COMT]-mediated metabolism of catechol estrogens: comparison of wild-type and variant COMT isoforms. Cancer Res 2001; 61: 6716-22.
-
(2001)
Cancer Res
, vol.61
, pp. 6716-6722
-
-
Dawling, S.1
Roodi, N.2
Mernaugh, R.L.3
Wang, X.4
Parl, F.F.5
-
28
-
-
1642309315
-
Association between the low activity genotype of catechol-O-methyltransferase and myocardial infarction in a hypertensive population
-
Eriksson AL, Skrtic S, Niklason A, et al. Association between the low activity genotype of catechol-O-methyltransferase and myocardial infarction in a hypertensive population. Eur Heart J 2004; 25: 386-91.
-
(2004)
Eur Heart J
, vol.25
, pp. 386-391
-
-
Eriksson, A.L.1
Skrtic, S.2
Niklason, A.3
-
29
-
-
20644466036
-
Estrogen-metabolizing gene COMT polymorphism synergistic APOE epsilon4 allele increases the risk of Alzheimer disease
-
Wang PN, Liu HC, Liu TY, et al. Estrogen-metabolizing gene COMT polymorphism synergistic APOE epsilon4 allele increases the risk of Alzheimer disease. Dement Geriatr Cogn Disord 2005; 19: 120-5.
-
(2005)
Dement Geriatr Cogn Disord
, vol.19
, pp. 120-125
-
-
Wang, P.N.1
Liu, H.C.2
Liu, T.Y.3
-
30
-
-
34447636936
-
Role of the COMT gene Val158Met polymorphism in mental disorders: A review
-
Hosak L. Role of the COMT gene Val158Met polymorphism in mental disorders: a review. Eur Psychiatry 2007; 22: 276-81.
-
(2007)
Eur Psychiatry
, vol.22
, pp. 276-281
-
-
Hosak, L.1
-
31
-
-
53049101630
-
The association of functional catechol-Omethyltransferase haplotypes with risk of Parkinson's disease, levodopa treatment response, and complications
-
Bialecka M, Kurzawski M, Klodowska-Duda G, Opala G, Tan EK, Drozdzik M. The association of functional catechol-Omethyltransferase haplotypes with risk of Parkinson's disease, levodopa treatment response, and complications. Pharmacogenet Genomics 2008; 18: 815-21.
-
(2008)
Pharmacogenet Genomics
, vol.18
, pp. 815-821
-
-
Bialecka, M.1
Kurzawski, M.2
Klodowska-Duda, G.3
Opala, G.4
Tan, E.K.5
Drozdzik, M.6
-
32
-
-
0029117652
-
Cloning, expression and structure of catechol- O-methyltransferase
-
Lundstrom K, Tenhunen J, Tilgmann C, Karhunen T, Panula P, Ulmanen I. Cloning, expression and structure of catechol- O-methyltransferase. Biochim Biophys Acta Prot Struct Mol Enzymol 1995; 1251: 1-10.
-
(1995)
Biochim Biophys Acta Prot Struct Mol Enzymol
, vol.1251
, pp. 1-10
-
-
Lundstrom, K.1
Tenhunen, J.2
Tilgmann, C.3
Karhunen, T.4
Panula, P.5
Ulmanen, I.6
-
33
-
-
0028094857
-
3-Methoxytyramine is the major metabolite of released dopamine in the rat frontal cortex: Reassessment of the effects of antipsychotics on the dynamics of dopamine release and metabolism in the frontal cortex, nucleus accumbens, and striatum by a simple two pool model
-
Karoum F, Chrapusta SJ, Egan MF. 3-Methoxytyramine is the major metabolite of released dopamine in the rat frontal cortex: reassessment of the effects of antipsychotics on the dynamics of dopamine release and metabolism in the frontal cortex, nucleus accumbens, and striatum by a simple two pool model. J Neurochem 1994; 63: 972-9.
-
(1994)
J Neurochem
, vol.63
, pp. 972-979
-
-
Karoum, F.1
Chrapusta, S.J.2
Egan, M.F.3
-
34
-
-
34250849812
-
Treatment of cognitive deficits associated with schizophrenia: Potential role of catechol-Omethyltransferase inhibitors
-
Apud JA, Weinberger DR. Treatment of cognitive deficits associated with schizophrenia: potential role of catechol-Omethyltransferase inhibitors. CNS Drugs 2007; 21: 535-57.
-
(2007)
CNS Drugs
, vol.21
, pp. 535-557
-
-
Apud, J.A.1
Weinberger, D.R.2
-
35
-
-
0034785524
-
Catecholamine release and uptake in the mouse prefrontal cortex
-
Mundorf ML, Joseph JD, Austin CM, Caron MG, Wightman RM. Catecholamine release and uptake in the mouse prefrontal cortex. J Neurochem 2001; 79: 130-42.
-
(2001)
J Neurochem
, vol.79
, pp. 130-142
-
-
Mundorf, M.L.1
Joseph, J.D.2
Austin, C.M.3
Caron, M.G.4
Wightman, R.M.5
-
36
-
-
0037123757
-
Effects of catecholamine uptake blockers in the caudate-putamen and subregions of the medial prefrontal cortex of the rat
-
Mazei MS, Pluto CP, Kirkbride B, Pehek EA. Effects of catecholamine uptake blockers in the caudate-putamen and subregions of the medial prefrontal cortex of the rat. Brain Res 2002; 936: 58-67.
-
(2002)
Brain Res
, vol.936
, pp. 58-67
-
-
Mazei, M.S.1
Pluto, C.P.2
Kirkbride, B.3
Pehek, E.A.4
-
37
-
-
34548813860
-
Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum
-
Yavich L, Forsberg MM, Karayiorgou M, Gogos JA, Mannisto PT. Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum. J Neurosci 2007; 27: 10196-209.
-
(2007)
J Neurosci
, vol.27
, pp. 10196-10209
-
-
Yavich, L.1
Forsberg, M.M.2
Karayiorgou, M.3
Gogos, J.A.4
Mannisto, P.T.5
-
38
-
-
0036896470
-
Effect of dopamine uptake inhibition on brain catecholamine levels and locomotion in catechol-Omethyltransferase- disrupted mice
-
Huotari M, Santha M, Lucas LR, Karayiorgou M, Gogos JA, Männistö PT. Effect of dopamine uptake inhibition on brain catecholamine levels and locomotion in catechol-Omethyltransferase- disrupted mice. J Pharmacol Exp Ther 2002; 303: 1309-16.
-
(2002)
J Pharmacol Exp Ther
, vol.303
, pp. 1309-1316
-
-
Huotari, M.1
Santha, M.2
Lucas, L.R.3
Karayiorgou, M.4
Gogos, J.A.5
Männistö, P.T.6
-
39
-
-
0026688379
-
Effects of COMT inhibitors on striatal dopamine metabolism: A microdialysis study
-
Kaakkola S, Wurtman RJ. Effects of COMT inhibitors on striatal dopamine metabolism: a microdialysis study. Brain Res 1992; 587: 241-9.
-
(1992)
Brain Res
, vol.587
, pp. 241-249
-
-
Kaakkola, S.1
Wurtman, R.J.2
-
40
-
-
35048842703
-
Relationship of catechol-Omethyltransferase to schizophrenia and its correlates: Evidence for associations and complex interactions
-
Lewandowski KE. Relationship of catechol-Omethyltransferase to schizophrenia and its correlates: evidence for associations and complex interactions. Harv Rev Psychiatry 2007; 15: 233-44.
-
(2007)
Harv Rev Psychiatry
, vol.15
, pp. 233-244
-
-
Lewandowski, K.E.1
-
41
-
-
33750244045
-
Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder
-
Abdolmaleky HM, Cheng KH, Faraone SV, et al. Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder. Hum Mol Genet 2006; 15: 3132-45.
-
(2006)
Hum Mol Genet
, vol.15
, pp. 3132-3145
-
-
Abdolmaleky, H.M.1
Cheng, K.H.2
Faraone, S.V.3
-
42
-
-
74049110540
-
Genes, cognition and brain through a COMT lens
-
Dickinson D, Elvevag B. Genes, cognition and brain through a COMT lens. Neuroscience 2009; 164: 72-87.
-
(2009)
Neuroscience
, vol.164
, pp. 72-87
-
-
Dickinson, D.1
Elvevag, B.2
-
44
-
-
0029851636
-
Preferential transmission of the high activity allele of COMT in schizophrenia
-
Li T, Sham PC, Vallada H, et al. Preferential transmission of the high activity allele of COMT in schizophrenia. Psychiatr Genet 1996; 6: 131-3.
-
(1996)
Psychiatr Genet
, vol.6
, pp. 131-133
-
-
Li, T.1
Sham, P.C.2
Vallada, H.3
-
45
-
-
0031910582
-
Association study of a functional catechol-O-methyltransferase gene polymorphism in Japanese schizophrenics
-
Ohmori O, Shinkai T, Kojima H, et al. Association study of a functional catechol-O-methyltransferase gene polymorphism in Japanese schizophrenics. Neurosci Lett 1998; 243: 109-12.
-
(1998)
Neurosci Lett
, vol.243
, pp. 109-112
-
-
Ohmori, O.1
Shinkai, T.2
Kojima, H.3
-
46
-
-
0842329756
-
The molecular genetics of schizophrenia: New findings promise new insights
-
Owen MJ, Williams NM, O'Donovan MC. The molecular genetics of schizophrenia: new findings promise new insights. Mol Psychiatry 2004; 9: 14-27.
-
(2004)
Mol Psychiatry
, vol.9
, pp. 14-27
-
-
Owen, M.J.1
Williams, N.M.2
O'Donovan, M.C.3
-
47
-
-
3142767559
-
Genetic abnormalities of chromosome 22 and the development of psychosis
-
Williams NM, Owen MJ. Genetic abnormalities of chromosome 22 and the development of psychosis. Curr Psychiatry Rep 2004; 6: 176-82.
-
(2004)
Curr Psychiatry Rep
, vol.6
, pp. 176-182
-
-
Williams, N.M.1
Owen, M.J.2
-
49
-
-
44149125060
-
Genes, brain development and psychiatric phenotypes in velo-cardio-facial syndrome
-
Gothelf D, Schaer M, Eliez S. Genes, brain development and psychiatric phenotypes in velo-cardio-facial syndrome. Dev Disabil Res Rev 2008; 14: 59-68.
-
(2008)
Dev Disabil Res Rev
, vol.14
, pp. 59-68
-
-
Gothelf, D.1
Schaer, M.2
Eliez, S.3
-
50
-
-
0035810850
-
Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia
-
Egan MF, Goldberg TE, Kolachana BS, et al. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA 2001; 98: 6917-22.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 6917-6922
-
-
Egan, M.F.1
Goldberg, T.E.2
Kolachana, B.S.3
-
51
-
-
33745703902
-
Catechol-omethyltransferase, cognition, and psychosis: Val158Met and beyond
-
Tunbridge EM, Harrison PJ, Weinberger DR. Catechol-omethyltransferase, cognition, and psychosis: Val158Met and beyond. Biol Psychiatry 2006; 60: 141-51.
-
(2006)
Biol Psychiatry
, vol.60
, pp. 141-151
-
-
Tunbridge, E.M.1
Harrison, P.J.2
Weinberger, D.R.3
-
53
-
-
0037947438
-
Catechol Omethyltransferase val158-met genotype and individual variation in the brain response to amphetamine
-
Mattay VS, Goldberg TE, Fera F, et al. Catechol Omethyltransferase val158-met genotype and individual variation in the brain response to amphetamine. Proc Natl Acad Sci USA 2003; 100: 6186-91.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 6186-6191
-
-
Mattay, V.S.1
Goldberg, T.E.2
Fera, F.3
-
54
-
-
0030889078
-
Analysis of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia: Evidence for association with aggressive and antisocial behavior
-
Strous RD, Bark N, Parsia SS, Volavka J, Lachman HM. Analysis of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia: evidence for association with aggressive and antisocial behavior. Psychiatry Res 1997; 69: 71-7.
-
(1997)
Psychiatry Res
, vol.69
, pp. 71-77
-
-
Strous, R.D.1
Bark, N.2
Parsia, S.S.3
Volavka, J.4
Lachman, H.M.5
-
55
-
-
8444233260
-
The catechol-O-methyltransferase polymorphism: Relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes
-
Bilder RM, Volavka J, Lachman HM, Grace AA. The catechol-O-methyltransferase polymorphism: relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes. Neuropsychopharmacology 2004; 29: 1943-61.
-
(2004)
Neuropsychopharmacology
, vol.29
, pp. 1943-1961
-
-
Bilder, R.M.1
Volavka, J.2
Lachman, H.M.3
Grace, A.A.4
-
56
-
-
0033842481
-
The tonic/phasic model of dopamine system regulation and its implications for understanding alcohol and psychostimulant craving
-
Grace AA. The tonic/phasic model of dopamine system regulation and its implications for understanding alcohol and psychostimulant craving. Addiction 2000; 95 Suppl 2: S119-S28.
-
(2000)
Addiction
, vol.95
, Issue.SUPPL. 2
-
-
Grace, A.A.1
-
57
-
-
9344251126
-
Mechanisms underlying differential D1 versus D2 dopamine receptor regulation of inhibition in prefrontal cortex
-
Trantham-Davidson H, Neely LC, Lavin A, Seamans JK. Mechanisms underlying differential D1 versus D2 dopamine receptor regulation of inhibition in prefrontal cortex. J Neurosci 2004; 24: 10652-9.
-
(2004)
J Neurosci
, vol.24
, pp. 10652-10659
-
-
Trantham-Davidson, H.1
Neely, L.C.2
Lavin, A.3
Seamans, J.K.4
-
58
-
-
0041859307
-
Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission
-
Floresco SB, West AR, Ash B, Moore H, Grace AA. Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission. Nat Neurosci 2003; 6: 968-73.
-
(2003)
Nat Neurosci
, vol.6
, pp. 968-973
-
-
Floresco, S.B.1
West, A.R.2
Ash, B.3
Moore, H.4
Grace, A.A.5
-
59
-
-
0036706019
-
Candidate gene polymorphisms among North Indians and their association with schizophrenia in a case-control study
-
Semwal P, Prasad S, Varma PG, Bhagwat AM, Deshpande SN, Thelma BK. Candidate gene polymorphisms among North Indians and their association with schizophrenia in a case-control study. J Genet 2002; 81: 65-71.
-
(2002)
J Genet
, vol.81
, pp. 65-71
-
-
Semwal, P.1
Prasad, S.2
Varma, P.G.3
Bhagwat, A.M.4
Deshpande, S.N.5
Thelma, B.K.6
-
60
-
-
34447270459
-
No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population
-
Nunokawa A, Watanabe Y, Muratake T, Kaneko N, Koizumi M, Someya T. No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population. Neurosci Res 2007; 58: 291-6.
-
(2007)
Neurosci Res
, vol.58
, pp. 291-296
-
-
Nunokawa, A.1
Watanabe, Y.2
Muratake, T.3
Kaneko, N.4
Koizumi, M.5
Someya, T.6
-
61
-
-
0036913209
-
A highly significant association between a COMT haplotype and schizophrenia
-
Shifman S, Bronstein M, Sternfeld M, et al. A highly significant association between a COMT haplotype and schizophrenia. Am J Hum Genet 2002; 71: 1296-302.
-
(2002)
Am J Hum Genet
, vol.71
, pp. 1296-1302
-
-
Shifman, S.1
Bronstein, M.2
Sternfeld, M.3
-
62
-
-
67650045643
-
A hotspot of inactivation: The A22S and V108M polymorphisms individually destabilize the active site structure of catechol O-methyltransferase
-
Rutherford K, Daggett V. A hotspot of inactivation: The A22S and V108M polymorphisms individually destabilize the active site structure of catechol O-methyltransferase. Biochemistry 2009; 48: 6450-60.
-
(2009)
Biochemistry
, vol.48
, pp. 6450-6460
-
-
Rutherford, K.1
Daggett, V.2
-
63
-
-
46249104490
-
Systematic metaanalyses and field synopsis of genetic association studies in schizophrenia: The SzGene database
-
Allen NC, Bagade S, McQueen MB, et al. Systematic metaanalyses and field synopsis of genetic association studies in schizophrenia: The SzGene database. Nat Genet 2008; 40: 827-34.
-
(2008)
Nat Genet
, vol.40
, pp. 827-834
-
-
Allen, N.C.1
Bagade, S.2
McQueen, M.B.3
-
64
-
-
79959503826
-
The International HapMap Project
-
International HapMap Consortium
-
International HapMap Consortium. The International HapMap Project. Nature 2003; 426: 789-96.
-
(2003)
Nature
, vol.426
, pp. 789-796
-
-
-
65
-
-
28044436937
-
The Indian Genome Variation database (IGVdb): A project overview
-
Indian Genome Variation Consortium
-
Indian Genome Variation Consortium. The Indian Genome Variation database (IGVdb): a project overview. Hum Genet 2005; 118: 1-11.
-
(2005)
Hum Genet
, vol.118
, pp. 1-11
-
-
-
66
-
-
44149107150
-
Genetic landscape of the people of India: A canvas for disease gene exploration
-
Indian Genome Variation Consortium
-
Indian Genome Variation Consortium. Genetic landscape of the people of India: a canvas for disease gene exploration. J Genet 2008; 87: 3-20.
-
(2008)
J Genet
, vol.87
, pp. 3-20
-
-
-
69
-
-
77956425352
-
Neural substrates of pleiotropic action of genetic variation in COMT: A metaanalysis
-
Mier D, Kirsch P, Meyer-Lindenberg A. Neural substrates of pleiotropic action of genetic variation in COMT: a metaanalysis. Mol Psychiatry 2010, 15, 918-27.
-
(2010)
Mol Psychiatry
, vol.15
, pp. 918-927
-
-
Mier, D.1
Kirsch, P.2
Meyer-Lindenberg, A.3
-
70
-
-
12144252916
-
Catechol-Omethyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: A large-scale association study plus meta-analysis
-
Fan JB, Zhang CS, Gu NF, et al. Catechol-Omethyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: a large-scale association study plus meta-analysis. Biol Psychiatry 2005; 57: 139-44.
-
(2005)
Biol Psychiatry
, vol.57
, pp. 139-144
-
-
Fan, J.B.1
Zhang, C.S.2
Gu, N.F.3
-
71
-
-
23744517092
-
Lack of association of the COMT (Val158/108 Met) gene and schizophrenia: A meta-analysis of case-control studies
-
Munafo MR, Bowes L, Clark TG, Flint J. Lack of association of the COMT (Val158/108 Met) gene and schizophrenia: a meta-analysis of case-control studies. Mol Psychiatry 2005; 10: 765-70.
-
(2005)
Mol Psychiatry
, vol.10
, pp. 765-770
-
-
Munafo, M.R.1
Bowes, L.2
Clark, T.G.3
Flint, J.4
-
73
-
-
70649105569
-
Association of tagging single nucleotide polymorphisms on 8 candidate genes in dopaminergic pathway with schizophrenia in Croatian population
-
Pal P, Mihanović M, Molnar S, et al. Association of tagging single nucleotide polymorphisms on 8 candidate genes in dopaminergic pathway with schizophrenia in Croatian population. Croat Med J 2009; 50: 361-9.
-
(2009)
Croat Med J
, vol.50
, pp. 361-369
-
-
Pal, P.1
Mihanović, M.2
Molnar, S.3
-
74
-
-
65549114069
-
Association of the 3' region of COMT with schizophrenia in Taiwan
-
Chien YL, Liu CM, Fann CS, Liu YL, Hwu HG. Association of the 3' region of COMT with schizophrenia in Taiwan. J Formos Med Assoc 2009; 108: 301-9.
-
(2009)
J Formos Med Assoc
, vol.108
, pp. 301-309
-
-
Chien, Y.L.1
Liu, C.M.2
Fann, C.S.3
Liu, Y.L.4
Hwu, H.G.5
-
75
-
-
77949488208
-
Critical reappraisal of a catechol-O-methyltransferase transversion variant in schizophrenia
-
Sand PG, Domani M, Smesny S. Critical reappraisal of a catechol-O-methyltransferase transversion variant in schizophrenia. Biol Psychiatry 2010; 67: e41-e2.
-
(2010)
Biol Psychiatry
, vol.67
-
-
Sand, P.G.1
Domani, M.2
Smesny, S.3
-
76
-
-
0032544012
-
Catechol-Omethyltransferase- deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior
-
Gogos JA, Morgan M, Luine V, et al. Catechol-Omethyltransferase- deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Proc Natl Acad Sci USA 1998; 95: 9991-6.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 9991-9996
-
-
Gogos, J.A.1
Morgan, M.2
Luine, V.3
-
77
-
-
33748055408
-
Impact of complex genetic variation in COMT on human brain function
-
Meyer-Lindenberg A, Nichols T, Callicott JH, et al. Impact of complex genetic variation in COMT on human brain function. Mol Psychiatry 2006; 11: 867-77, 797.
-
(2006)
Mol Psychiatry
, vol.867
-
-
Meyer-Lindenberg, A.1
Nichols, T.2
Callicott, J.H.3
-
78
-
-
64549107574
-
Association studies of catechol-O-methyltransferase [COMT] gene with schizophrenia and response to antipsychotic treatment
-
Gupta M, Bhatnagar P, Grover S, et al. Association studies of catechol-O-methyltransferase [COMT] gene with schizophrenia and response to antipsychotic treatment. Pharmacogenomics 2009; 10: 385-97.
-
(2009)
Pharmacogenomics
, vol.10
, pp. 385-397
-
-
Gupta, M.1
Bhatnagar, P.2
Grover, S.3
-
79
-
-
75549087950
-
The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase
-
Mukherjee N, Kidd KK, Pakstis AJ, et al. The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase. Mol Psychiatry 2010; 15: 216-25.
-
(2010)
Mol Psychiatry
, vol.15
, pp. 216-225
-
-
Mukherjee, N.1
Kidd, K.K.2
Pakstis, A.J.3
-
80
-
-
65549159155
-
Genetic susceptibility to schizophrenia: Role of dopaminergic pathway gene polymorphisms
-
Gupta M, Chauhan C, Bhatnagar P, et al. Genetic susceptibility to schizophrenia: role of dopaminergic pathway gene polymorphisms. Pharmacogenomics 2009; 10: 277-91.
-
(2009)
Pharmacogenomics
, vol.10
, pp. 277-291
-
-
Gupta, M.1
Chauhan, C.2
Bhatnagar, P.3
-
81
-
-
69449095609
-
Epistasis between the DAT 3' UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophrenia
-
Prata DP, Mechelli A, Fu CH, et al. Epistasis between the DAT 3' UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophrenia. Proc Natl Acad Sci USA 2009; 106: 13600-5.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 13600-13605
-
-
Prata, D.P.1
Mechelli, A.2
Fu, C.H.3
-
82
-
-
49949105630
-
Effects of brain-derived neurotrophic factor-catecholamine-O-methyltransferase gene interaction on schizophrenic symptoms
-
Han DH, Park DB, Choi TY, et al. Effects of brain-derived neurotrophic factor-catecholamine-O-methyltransferase gene interaction on schizophrenic symptoms. Neuroreport 2008; 19: 1155-8.
-
(2008)
Neuroreport
, vol.19
, pp. 1155-1158
-
-
Han, D.H.1
Park, D.B.2
Choi, T.Y.3
-
83
-
-
79955424773
-
Interactive effects of DAOA (G72) and catechol-O-methyltransferase on neurophysiology in prefrontal cortex
-
Nixon DC, Prust MJ, Sambataro F, et al. Interactive effects of DAOA (G72) and catechol-O-methyltransferase on neurophysiology in prefrontal cortex. Biol Psychiatry 2011, 69, 1006-8.
-
(2011)
Biol Psychiatry
, vol.69
, pp. 1006-1008
-
-
Nixon, D.C.1
Prust, M.J.2
Sambataro, F.3
-
84
-
-
67149146923
-
Evidence of epistasis between the catechol-O-methyltransferase and aldehyde dehydrogenase 3B1 genes in paranoid schizophrenia
-
Wang Y, Hu Y, Fang Y, et al. Evidence of epistasis between the catechol-O-methyltransferase and aldehyde dehydrogenase 3B1 genes in paranoid schizophrenia. Biol Psychiatry 2009; 65: 1048-54.
-
(2009)
Biol Psychiatry
, vol.65
, pp. 1048-1054
-
-
Wang, Y.1
Hu, Y.2
Fang, Y.3
-
85
-
-
45749149476
-
Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans
-
Tan HY, Nicodemus KK, Chen Q, et al. Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans. J Clin Invest 2008; 118: 2200-8.
-
(2008)
J Clin Invest
, vol.118
, pp. 2200-2208
-
-
Tan, H.Y.1
Nicodemus, K.K.2
Chen, Q.3
-
86
-
-
34547637452
-
Epistasis between catechol- O-methyltransferase and type II metabotropic glutamate receptor 3 genes on working memory brain function
-
Tan HY, Chen Q, Sust S, et al. Epistasis between catechol- O-methyltransferase and type II metabotropic glutamate receptor 3 genes on working memory brain function. Proc Natl Acad Sci USA 2007; 104: 12536-41.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 12536-12541
-
-
Tan, H.Y.1
Chen, Q.2
Sust, S.3
-
87
-
-
70349560659
-
Over-expression of a human chromosome 22q11.2 segment including TXNRD2, COMT and ARVCF developmentally affects incentive learning and working memory in mice
-
Suzuki G, Harper KM, Hiramoto T, et al. Over-expression of a human chromosome 22q11.2 segment including TXNRD2, COMT and ARVCF developmentally affects incentive learning and working memory in mice. Hum Mol Genet 2009; 18: 3914-25.
-
(2009)
Hum Mol Genet
, vol.18
, pp. 3914-3925
-
-
Suzuki, G.1
Harper, K.M.2
Hiramoto, T.3
-
88
-
-
4544266907
-
Environmental influences in schizophrenia: The known and the unknown
-
Leask SJ. Environmental influences in schizophrenia: the known and the unknown. Adv Psychiatr Treat 2004; 10: 323-30.
-
(2004)
Adv Psychiatr Treat
, vol.10
, pp. 323-330
-
-
Leask, S.J.1
-
89
-
-
34250635128
-
Catechol-Omethyltransferase val108/158met genotype and response to antipsychotic medication in schizophrenia
-
Illi A, Kampman O, Hanninen K, et al. Catechol-Omethyltransferase val108/158met genotype and response to antipsychotic medication in schizophrenia. Hum Psychopharmacol 2007; 22: 211-5.
-
(2007)
Hum Psychopharmacol
, vol.22
, pp. 211-215
-
-
Illi, A.1
Kampman, O.2
Hanninen, K.3
-
90
-
-
7444232703
-
Catechol-Omethyltransferase val108/158met genotype predicts working memory response to antipsychotic medications
-
Weickert TW, Goldberg TE, Mishara A, et al. Catechol-Omethyltransferase val108/158met genotype predicts working memory response to antipsychotic medications. Biol Psychiatry 2004; 56: 677-82.
-
(2004)
Biol Psychiatry
, vol.56
, pp. 677-682
-
-
Weickert, T.W.1
Goldberg, T.E.2
Mishara, A.3
-
91
-
-
34548160606
-
COMT Val158Met polymorphism predicts negative symptoms response to treatment with olanzapine in schizophrenia
-
Bertolino A, Caforio G, Blasi G, et al. COMT Val158Met polymorphism predicts negative symptoms response to treatment with olanzapine in schizophrenia. Schizophr Res 2007; 95: 253-5.
-
(2007)
Schizophr Res
, vol.95
, pp. 253-255
-
-
Bertolino, A.1
Caforio, G.2
Blasi, G.3
-
92
-
-
33846624143
-
COMT val108/158met genotype, cognitive function, and cognitive improvement with clozapine in schizophrenia
-
Woodward ND, Jayathilake K, Meltzer HY. COMT val108/158met genotype, cognitive function, and cognitive improvement with clozapine in schizophrenia. Schizophr Res 2007; 90: 86-96.
-
(2007)
Schizophr Res
, vol.90
, pp. 86-96
-
-
Woodward, N.D.1
Jayathilake, K.2
Meltzer, H.Y.3
-
93
-
-
34548185207
-
Clinical involvement of catechol-O-methyltransferase polymorphisms in schizophrenia spectrum disorders: Influence on the severity of psychotic symptoms and on the response to neuroleptic treatment
-
Molero P, Ortuno F, Zalacain M, Patino-Garcia A. Clinical involvement of catechol-O-methyltransferase polymorphisms in schizophrenia spectrum disorders: influence on the severity of psychotic symptoms and on the response to neuroleptic treatment. Pharmacogenomics J 2007; 7: 418-26.
-
(2007)
Pharmacogenomics J
, vol.7
, pp. 418-426
-
-
Molero, P.1
Ortuno, F.2
Zalacain, M.3
Patino-Garcia, A.4
-
94
-
-
76549096827
-
Interaction of catechol-O-methyltransferase (COMT) Val108/158 Met genotype and risperidone treatment in Chinese Han patients with schizophrenia
-
Kang CY, Xu XF, Shi ZY, Yang JZ, Liu H, Xu HH. Interaction of catechol-O-methyltransferase (COMT) Val108/158 Met genotype and risperidone treatment in Chinese Han patients with schizophrenia. Psychiatry Res 2010; 176: 94-5.
-
(2010)
Psychiatry Res
, vol.176
, pp. 94-95
-
-
Kang, C.Y.1
Xu, X.F.2
Shi, Z.Y.3
Yang, J.Z.4
Liu, H.5
Xu, H.H.6
-
95
-
-
0042322722
-
Relationship between catechol-O-methyltransferase polymorphism and treatmentresistant schizophrenia
-
Inada T, Nakamura A, Iijima Y. Relationship between catechol-O-methyltransferase polymorphism and treatmentresistant schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2003; 120B: 35-9.
-
(2003)
Am J Med Genet B Neuropsychiatr Genet
, vol.120 B
, pp. 35-39
-
-
Inada, T.1
Nakamura, A.2
Iijima, Y.3
-
96
-
-
42149089334
-
COMT genotypes and use of antipsychotic medication: Linking population-based prescription database to the HUNT study
-
Hagen K, Stovner LJ, Skorpen F, Pettersen E, Zwart JA. COMT genotypes and use of antipsychotic medication: linking population-based prescription database to the HUNT study. Pharmacoepidemiol Drug Saf 2008; 17: 372-7.
-
(2008)
Pharmacoepidemiol Drug Saf
, vol.17
, pp. 372-377
-
-
Hagen, K.1
Stovner, L.J.2
Skorpen, F.3
Pettersen, E.4
Zwart, J.A.5
-
97
-
-
0346025677
-
Effect of DRD2, 5-HT2A, and COMT genes on antipsychotic response to risperidone
-
Yamanouchi Y, Iwata N, Suzuki T, Kitajima T, Ikeda M, Ozaki N. Effect of DRD2, 5-HT2A, and COMT genes on antipsychotic response to risperidone. Pharmacogenomics J 2003; 3: 356-61.
-
(2003)
Pharmacogenomics J
, vol.3
, pp. 356-361
-
-
Yamanouchi, Y.1
Iwata, N.2
Suzuki, T.3
Kitajima, T.4
Ikeda, M.5
Ozaki, N.6
-
98
-
-
33744499186
-
Catechol-Omethyltransferase and monoamine oxidase-A polymorphisms and treatment response to typical and atypical neuroleptics
-
Nolan KA, Czobor P, Citrome LL, et al. Catechol-Omethyltransferase and monoamine oxidase-A polymorphisms and treatment response to typical and atypical neuroleptics. J Clin Psychopharmacol 2006; 26: 338-40.
-
(2006)
J Clin Psychopharmacol
, vol.26
, pp. 338-340
-
-
Nolan, K.A.1
Czobor, P.2
Citrome, L.L.3
-
99
-
-
70349706135
-
Candidate-gene association analysis of response to risperidone in African- American and white patients with schizophrenia
-
Fijal BA, Kinon BJ, Kapur S, et al. Candidate-gene association analysis of response to risperidone in African- American and white patients with schizophrenia. Pharmacogenomics J 2009; 9: 311-8.
-
(2009)
Pharmacogenomics J
, vol.9
, pp. 311-318
-
-
Fijal, B.A.1
Kinon, B.J.2
Kapur, S.3
-
101
-
-
0038287034
-
Catechol-Omethyltransferase [COMT]: Biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors
-
Mannisto PT, Kaakkola S. Catechol-Omethyltransferase [COMT]: biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors. Pharmacol Rev 1999; 51: 593-628.
-
(1999)
Pharmacol Rev
, vol.51
, pp. 593-628
-
-
Mannisto, P.T.1
Kaakkola, S.2
-
102
-
-
0029044201
-
Integrated pharmacokinetics and pharmacodynamics of the novel catechol-O-methyltransferase inhibitor tolcapone during first administration to humans
-
Dingemanse J, Jorga KM, Schmitt M, et al. Integrated pharmacokinetics and pharmacodynamics of the novel catechol-O-methyltransferase inhibitor tolcapone during first administration to humans. Clin Pharmacol Ther 1995; 57: 508-17.
-
(1995)
Clin Pharmacol Ther
, vol.57
, pp. 508-517
-
-
Dingemanse, J.1
Jorga, K.M.2
Schmitt, M.3
-
104
-
-
0031016506
-
Peripheral and central inhibitors of catechol-O-methyl transferase: Effects on liver and brain COMT activity and L-DOPA metabolism
-
Brannan T, Prikhojan A, Yahr MD. Peripheral and central inhibitors of catechol-O-methyl transferase: effects on liver and brain COMT activity and L-DOPA metabolism. J Neural Transm 1997; 104: 77-87.
-
(1997)
J Neural Transm
, vol.104
, pp. 77-87
-
-
Brannan, T.1
Prikhojan, A.2
Yahr, M.D.3
-
105
-
-
7344259588
-
A pilot evaluation of the tolerability, safety, and efficacy of tolcapone alone and in combination with oral selegiline in untreated Parkinson's disease patients
-
Tolcapone De Novo Study Group
-
Hauser RA, Molho E, Shale H, Pedder S, Dorflinger EE. A pilot evaluation of the tolerability, safety, and efficacy of tolcapone alone and in combination with oral selegiline in untreated Parkinson's disease patients. Tolcapone De Novo Study Group. Mov Disord 1998; 13: 643-67.
-
(1998)
Mov Disord
, vol.13
, pp. 643-667
-
-
Hauser, R.A.1
Molho, E.2
Shale, H.3
Pedder, S.4
Dorflinger, E.E.5
-
106
-
-
55749092627
-
Pharmacokinetic-pharmacodynamic interaction between nebicapone, a novel catechol-o-methyltransferase inhibitor, and controlled-release levodopa/carbidopa 200 mg/50 mg: Randomized, double-blind, placebo-controlled, crossover study in healthy subjects
-
Vaz-da-Silva M, Loureiro AI, Nunes T, et al. Pharmacokinetic-pharmacodynamic interaction between nebicapone, a novel catechol-o-methyltransferase inhibitor, and controlled-release levodopa/carbidopa 200 mg/50 mg: randomized, double-blind, placebo-controlled, crossover study in healthy subjects. Drugs R D 2008; 9: 435-46.
-
(2008)
Drugs R D
, vol.9
, pp. 435-446
-
-
Vaz-da-Silva, M.1
Loureiro, A.I.2
Nunes, T.3
-
107
-
-
0037309490
-
Pharmacokinetics and pharmacodynamics of entacapone and tolcapone after acute and repeated administration: A comparative study in the rat
-
Forsberg M, Lehtonen M, Heikkinen M, Savolainen J, Jarvinen T, Mannisto PT. Pharmacokinetics and pharmacodynamics of entacapone and tolcapone after acute and repeated administration: a comparative study in the rat. J Pharmacol Exp Ther 2003; 304: 498-506.
-
(2003)
J Pharmacol Exp Ther
, vol.304
, pp. 498-506
-
-
Forsberg, M.1
Lehtonen, M.2
Heikkinen, M.3
Savolainen, J.4
Jarvinen, T.5
Mannisto, P.T.6
-
108
-
-
0034959834
-
Switch over from tolcapone to entacapone in severe Parkinson's disease patients
-
Onofrj M, Thomas A, Iacono D, Di Iorio A, Bonanni L. Switch over from tolcapone to entacapone in severe Parkinson's disease patients. Eur Neurol 2001; 46: 11-6.
-
(2001)
Eur Neurol
, vol.46
, pp. 11-16
-
-
Onofrj, M.1
Thomas, A.2
Iacono, D.3
Di Iorio, A.4
Bonanni, L.5
-
109
-
-
0025657620
-
Ro 40-7592: Inhibition of COMT in rat brain and extracerebral tissues
-
Zürcher G, Colzi A, Da Prada M. Ro 40-7592: inhibition of COMT in rat brain and extracerebral tissues. J Neural Transm Suppl 1990; 32: 375-80.
-
(1990)
J Neural Transm Suppl
, vol.32
, pp. 375-380
-
-
Zürcher, G.1
Colzi, A.2
da Prada, M.3
-
110
-
-
0033230217
-
Tolcapone: A novel approach to Parkinson's disease
-
Micek ST, Ernst ME. Tolcapone: a novel approach to Parkinson's disease. Am J Health Syst Pharm 1999; 56: 2195-205.
-
(1999)
Am J Health Syst Pharm
, vol.56
, pp. 2195-2205
-
-
Micek, S.T.1
Ernst, M.E.2
-
111
-
-
38449102820
-
Utility of tolcapone in fluctuating Parkinson's disease
-
Stocchi F, De Pandis MF. Utility of tolcapone in fluctuating Parkinson's disease. Clin Interv Aging 2006; 1: 317-25.
-
(2006)
Clin Interv Aging
, vol.1
, pp. 225-317
-
-
Stocchi, F.1
de Pandis, M.F.2
-
112
-
-
40049104890
-
Effects of nebicapone on levodopa pharmacokinetics, catechol-O-methyltransferase activity, and motor fluctuations in patients with Parkinson disease
-
Ferreira JJ, Almeida L, Cunha L, et al. Effects of nebicapone on levodopa pharmacokinetics, catechol-O-methyltransferase activity, and motor fluctuations in patients with Parkinson disease. Clin Neuropharmacol 2008; 31: 2-18.
-
(2008)
Clin Neuropharmacol
, vol.31
, pp. 2-18
-
-
Ferreira, J.J.1
Almeida, L.2
Cunha, L.3
-
113
-
-
77951107243
-
Discovery of a longacting, peripherally selective inhibitor of catechol-Omethyltransferase
-
Kiss LE, Ferreira HS, Torrão L, et al. Discovery of a longacting, peripherally selective inhibitor of catechol-Omethyltransferase. J Med Chem 2010; 53: 3396-411.
-
(2010)
J Med Chem
, vol.53
, pp. 3396-3411
-
-
Kiss, L.E.1
Ferreira, H.S.2
Torrão, L.3
-
114
-
-
0031013661
-
Catechol O-methyltransferase inhibitor tolcapone has minor influence on performance in experimental memory models in rats
-
Liljequist R, Haapalinna A, Ahlander M, Li YH, Mannisto PT. Catechol O-methyltransferase inhibitor tolcapone has minor influence on performance in experimental memory models in rats. Behav Brain Res 1997; 82: 195-202.
-
(1997)
Behav Brain Res
, vol.82
, pp. 195-202
-
-
Liljequist, R.1
Haapalinna, A.2
Ahlander, M.3
Li, Y.H.4
Mannisto, P.T.5
-
115
-
-
2942614921
-
Catechol-o-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex
-
Tunbridge EM, Bannerman DM, Sharp T, Harrison PJ. Catechol-o-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex. J Neurosci 2004; 24: 5331-5.
-
(2004)
J Neurosci
, vol.24
, pp. 5331-5335
-
-
Tunbridge, E.M.1
Bannerman, D.M.2
Sharp, T.3
Harrison, P.J.4
-
116
-
-
0030663092
-
Cognitive improvement during Tolcapone treatment in Parkinson's disease
-
Gasparini M, Fabrizio E, Bonifati V, Meco G. Cognitive improvement during Tolcapone treatment in Parkinson's disease. J Neural Transm 1997; 104: 887-94.
-
(1997)
J Neural Transm
, vol.104
, pp. 887-894
-
-
Gasparini, M.1
Fabrizio, E.2
Bonifati, V.3
Meco, G.4
-
117
-
-
34247387212
-
Tolcapone improves cognition and cortical information processing in normal human subjects
-
Apud JA, Mattay V, Chen J, et al. Tolcapone improves cognition and cortical information processing in normal human subjects. Neuropsychopharmacology 2007; 32: 1011-20.
-
(2007)
Neuropsychopharmacology
, vol.32
, pp. 1011-1020
-
-
Apud, J.A.1
Mattay, V.2
Chen, J.3
-
118
-
-
57349086379
-
Improvement of prepulse inhibition and executive function by the COMT inhibitor tolcapone depends on COMT Val158Met polymorphism
-
Giakoumaki SG, Roussos P, Bitsios P. Improvement of prepulse inhibition and executive function by the COMT inhibitor tolcapone depends on COMT Val158Met polymorphism. Neuropsychopharmacology 2008; 33: 3058-68.
-
(2008)
Neuropsychopharmacology
, vol.33
, pp. 3058-3068
-
-
Giakoumaki, S.G.1
Roussos, P.2
Bitsios, P.3
-
119
-
-
70350702680
-
Tolcapone effects on gating, working memory, and mood interact with the synonymous catechol-O-methyltransferase rs4818C/G polymorphism
-
Roussos P, Giakoumaki SG, Bitsios P. Tolcapone effects on gating, working memory, and mood interact with the synonymous catechol-O-methyltransferase rs4818C/G polymorphism. Biol Psychiatry 2009; 66: 997-1004.
-
(2009)
Biol Psychiatry
, vol.66
, pp. 997-1004
-
-
Roussos, P.1
Giakoumaki, S.G.2
Bitsios, P.3
|