Effects of nebicapone on levodopa pharmacokinetics, catechol-O- methyltransferase activity, and motor fluctuations in patients with Parkinson disease

Clinical Neuropharmacology

Volumn 31, Issue 1, 2008, Pages 2-18

  Ferreira, Joaquim J ^a   Almeida, Luis ^b   Cunha, Luis ^c   Ticmeanu, Marina ^d   Rosa, Mário M ^a   Januário, Cristina ^c   Mitu, Cristina Elena ^d   Coelho, Miguel ^a   Correia Guedes, Leonor ^a   Morgadinho, Ana ^c   Nunes, Teresa ^b   Wright, Lyndon C ^b   Falcão, Amílcar ^e   Sampaio, Cristina ^a   Soares Da Silva, Patrício ^b  

^a INSTITUTO DE MEDICINA MOLECULAR JOÃO LOBO ANTUNES   (Portugal)

^b DEPARTMENT OF RESEARCH AND DEVELOPMENT   (Portugal)

^c CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

^d Carol Davila School of Medicine   (Romania)

^e 4Health Ltd   (Portugal)

Author keywords

Clinical trial; COMT inhibitors; Entacapone; Nebicapone; Parkinson disease

Indexed keywords

3 O METHYLDOPA; CARBIDOPA PLUS LEVODOPA; CATECHOL METHYLTRANSFERASE; CATECHOL METHYLTRANSFERASE INHIBITOR; ENTACAPONE; LEVODOPA; NEBICAPONE; PLACEBO; UNCLASSIFIED DRUG;

ADULT; AGED; AGGRESSION; AGITATION; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG HALF LIFE; DRUG TOLERABILITY; ENZYME ACTIVITY; FALLING; FEMALE; HALLUCINATION; HUMAN; HYPOMANIA; LIVER FUNCTION TEST; MALE; MOTOR PERFORMANCE; NAUSEA; PARKINSON DISEASE; PHARMACODYNAMICS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SOMNOLENCE; SWEATING; TACHYCARDIA; TREATMENT DURATION; URINE; VOMITING;

ACETOPHENONES; ADULT; AGED; ANTIPARKINSON AGENTS; CARBIDOPA; CATECHOL O-METHYLTRANSFERASE; CATECHOLS; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG INTERACTIONS; ENZYME INHIBITORS; FEMALE; HUMANS; LEVODOPA; MALE; MIDDLE AGED; MOTOR ACTIVITY; NITRILES; PARKINSON DISEASE; PLACEBOS;

EID: 40049104890     PISSN: 03625664     EISSN: None     Source Type: Journal    
DOI: 10.1097/wnf.0b013e3180645cb0     Document Type: Article

References (36)