Amine-alkyl derivatives of hydantoin: New tool to combat resistant bacteria

European Journal of Medicinal Chemistry

Volumn 46, Issue 12, 2011, Pages 5807-5816

  Handzlik, Jadwiga ^a,c   Szymańska, Ewa ^a   Chevalier, Jacqueline ^b   Otrbska, Ewa ^a   Kieć Kononowicz, Katarzyna ^a,c   Pags, Jean Marie ^b,c   Alibert, Sandrine ^b,c  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b Aix Marseille University   (France)

^c COST Action BM0701 ^*  (Belgium)

Author keywords

Antibiotic resistance; Chemosensitizer; Efflux pumps; Hydantoin derivatives

Indexed keywords

1 (3 METHYL 2,4 DIOXO 5,5 DIPHENYLIMIDAZOLIDIN 1 YL) 3 (4 PHENYLPIPERAZIN 1 YL)PROPAN 2 YL ACETATE HYDROCHLORIDE; 2 [1 [4 [4 (ETHOXYCARBONYL)PIPERAZIN 1 YL]BUTYL] 2,4 DIOXO 5,5 DIPHENYLIMIDAZOLIDIN 3-YL]ACETIC ACID; 2 [3 (3 AMINOPROPYL) 2,5 DIOXO 4,4 DIPHENYLIMIDAZOLIDIN 1 YL]ACETIC ACID HYDROCHLORIDE; 2 [3 (4 (2,3,4,6,7,8 HEXAHYDRO 1H PYRIMIDO(1,2 )PYRIMIDIN 1 YL]BUTYL] 2,5 DIOXO 4,4 DIPHENYLIMIDAZOLIDIN 1 YL]ACETIC ACID HYDROCHLORIDE; 2 [3 (4 AMINOBUTYL) 2,5 DIOXO 4,4 DIPHENYLIMIDAZOLIDIN 1 YL]ACETIC ACID HYDROCHLORIDE; 2 [3 (6 AMINOHEXYL) 2,5 DIOXO 4,4 DIPHENYLIMIDAZOLIDIN 1 YL]ACETIC ACID HYDROCHLORIDE; 2 [3 [3 [2,3,4,6,7,8 HEXAHYDRO 1H PYRIMIDO(1,2 A)PYRIMIDIN 1 YL]PROPYL] 2,5 DIOXO 4,4 DIPHENYLIMIDAZOLIDIN 1 YL]ACETIC ACID HYDROCHLORIDE; 2 [3 [4 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]BUTYL] 2,5 DIOXO 4,4 DIPHENYLIMIDAZOLIDIN 1 YL]ACETIC ACID HYDROCHLORIDE; 2 [3 [5 [2,3,4,6,7,8 HEXAHYDRO 1H PYRIMIDO(1,2 A)PYRIMIDIN 1 YL]PENTYL) 2,5 DIOXO 4,4 DIPHENYLIMIDAZOLIDIN 1 YL]ACETIC ACID HYDROCHLORIDE; 2 [3 [6 [2,3,4,6,7,8 HEXAHYDRO 1H PYRIMIDO(1,2 A)PYRIMIDIN 1 YL]HEXYL] 2,5 DIOXO 4,4 DIPHENYLIMIDAZOLIDIN 1 YL]ACETIC HYDROCHLORIDE; 4 [5 [3 (2 METHOXY 2 OXOETHYL) 2,4 DIOXO 5,5 DIPHENYLIMIDAZOLIDIN 1 YL]PENTYL]PIPERAZINE 1 CARBOXYLATE; 5,5 DIPHENYL 1 [4 (4 PHENYLPIPERAZIN 1 YL)BUTYL]IMIDAZOLIDINE 2,4 DIONE; ANTIBIOTIC AGENT; ETHYL 4 [4 [3 (2 METHOXY 2 OXOETHYL) 2,4 DIOXO 5,5 DIPHENYLIMIDAZOLIDIN 1 YL]BUTYL]PIPERAZINE 1 CARBOXYLATE; ETHYL 4 [8 [3 (2 METHOXY 2 OXOETHYL) 2,4 DIOXO 5,5 DIPHENYLIMIDAZOLIDIN 1 YL]OCTYL]PIPERAZINE 1 CARBOXYLATE; HYDANTOIN DERIVATIVE; METHYL 2 [2,4 DIOXO 5,5 DIPHENYL 1 [8 (PIPERAZIN 1 YL)OCTYL]IMIDAZOLIDIN 3 YL]ACETATE; METHYL 2 [3 [2 ACETOXY 3 (4 PHENYLPIPERAZIN 1 YL)PROPYL] 2,5 DIOXO 4,4 DIPHENYLIMIDAZOLIDIN 1 YL]ACETATE HYDROCHLORIDE; NALIDIXIC ACID; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG POTENCY; DRUG POTENTIATION; DRUG SYNTHESIS; ENTEROBACTER AEROGENES; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

AMINES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CARRIER PROTEINS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ENTEROBACTER AEROGENES; ENTEROBACTERIACEAE INFECTIONS; HUMANS; HYDANTOINS; MICROBIAL SENSITIVITY TESTS; NALIDIXIC ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80955145705     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.09.032     Document Type: Article

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