Synthesis, structure-activity relationship of some new anti-arrhythmic 5-arylidene imidazolidine-2,4-dione derivatives

European Journal of Medicinal Chemistry

Volumn 40, Issue 3, 2005, Pages 259-269

  Pȩkala, Elzbieta ^a   Stadnicka, Katarzyna ^b   Broda, Agnieszka ^b   Zygmunt, Małgorzata ^a   Filipek, Barbara ^a   Kieć Kononowicz, Katarzyna ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

5 Arylidene imidazolidine 2,4 dione derivatives; Anti arrhythmic activity; Anticonvulsant properties; X ray structure determination

Indexed keywords

(2 BROMO)BENZYLIDENE 3 [2 [4 (HYDROXYETHYL)PIPERAZIN 1 YL] 2 OXOETHYL]IMIDAZOLIDINE 2,4 DIONE; (2 CHLORO)BENZYLIDENE 3 [2 [4 (HYDROXYETHYL)PIPERAZIN 1 YL] 2 OXOETHYL]IMIDAZOLIDINE 2,4 DIONE; (3 BROMO)BENZYLIDENE 3 [2 [4 (HYDROXYETHYL)PIPERAZIN 1 YL] 2 OXOETHYL]IMIDAZOLIDINE 2,4 DIONE; (3 CHLORO)BENZYLIDENE 3 [2 [4 (HYDROXYETHYL)PIPERAZIN 1 YL] 2 OXOETHYL]IMIDAZOLIDINE 2,4 DIONE; (4 BROMO)BENZYLIDENE 3 [2 [4 (HYDROXYETHYL)PIPERAZIN 1 YL] 2 OXOETHYL]IMIDAZOLIDINE 2,4 DIONE; (4 CHLORO)BENZYLIDENE 3 [2 [4 (HYDROXYETHYL)PIPERAZIN 1 YL] 2 OXOETHYL]IMIDAZOLIDINE 2,4 DIONE; ANTIARRHYTHMIC AGENT; BENZYLIDENE 3 [2 [4 (HYDROXYETHYL)PIPERAZIN 1 YL] 2 OXOETHYL]IMIDAZOLIDINE 2,4 DIONE; IMIDAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DRUG SYNTHESIS; ELECTROCARDIOGRAM; HEART PERFUSION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; X RAY ANALYSIS;

EID: 13844272106     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejmech.2004.11.006     Document Type: Article

References (32)

1. W.A. Catterall Annu. Rev. Biochem. 64 1995 493 531
2. G.E. Kirsch Drug Dev. Res. 33 1994 263 276
3. W.A. Catterall Ren. Physiol. Biochem. 17 1994 121 125
4. R.G. Kallen, S.A. Cohen, and R.L. Barchi Mol. Neurobiol. 7 1993 383 428
5. W.A. Catterall Science 242 1988 50 61
6. C.M. Armstrong Physiol. Rev. 72 1992 S5 S13
7. R.S. Sheldon, N.J. Cannon, and H.J. Duff Circ. Res. 61 1987 492 497
8. G.B. Brown, S.C. Tieszen, J.W. Daly, J.E. Warnick, and E.X. Albuquerque Cell. Mol. Neurobiol. 1 1981 19 40
9. W.A. Catterall Mol. Pharmacol. 30 1986 129 135
10. W.A. Catterall Trends Pharmacol. Sci. 8 1987 57 65
11. I. Zimanyi, S.R.B. Weiss, A. Lajtha, R.M. Post, and M.E. Reith Eur. J. Pharmacol. 167 1989 419 422
12. M.J. Barber, C.F. Starmer, and A.O. Grant Circ. Res. 69 1991 677 696
13. W.J. Brouillette, V.P. Jestkov, M.L. Brown, M.S. Aktar, T.M. Dlorey, and G.B. Brown J. Med. Chem. 37 1994 3289 3293
14. W.J. Brouillette, G.B. Brown, T.M. Delorey, and G. Liang J. Pharm. Sci. 79 1990 871 874
15. M.L. Brown, G.B. Brown, and W.J. Brouillette J. Med. Chem. 40 1997 602 607
16. M. Ciechanowicz-Rutkowska, K. Stadnicka, K. Kieć-Kononowicz, H. Byrtus, B. Filipek, and M. Zygmunt Arch. Pharm. Pharm. Med. Chem. 333 2000 357 364
17. K. Kieć-Kononowicz, H. Byrtus, A. Zejc, B. Filipek, and P. Chevallet Farmaco 50 1995 355 360
18. K. Kieć-Kononowicz, A. Zejc, J. Krupińska, E. Stypuła, and B. Cebo Farmaco 42 1987 727 734
19. K. Kieć-Kononowicz, K. Stadnicka, A. Mitka, E. Pȩkala, B. Filipek, and J. Sapa Eur. J. Med. Chem. 38 2003 555 566
20. PALLAS for Windows1.2, CompuDrug Chemistry Ltd., 1995.
21. M. Bernauer, and I. Ernenputsch Naunyn Schmiedebergs Arch. Pharmacol. 338 1988 88 95
22. H.G. Vogel, and W.H. Vogel Drug Discovery and Evaluation. Pharmacological Assays 1997 Springer Verlag Berlin, Heidelberg 104 118
23. M.J. Curtis, B.A. Macleod, and J.A. Walker J. Mol. Cell. Cardiol. 19 1987 399 419
24. R.R. Brooks, K.E. Miller, and J.F. Carpenter Proc. Soc. Exp. Biol. Med. 191 1989 201 209
25. O. Langendorff Pflüg. Arch. Ges. Physiol. 61 1895 291 332
26. W.F. Lubbe, and P.S. Daries Cardiovasc. Res. 12 1978 200 212
27. M.J.A. Walker, M.J. Curtis, D.J. Hearse, R.W.F. Campbell, M.J. Janse, and D.M. Yellon Cardiovasc. Res. 22 1988 447 455
28. R.L. Krall, J.K. Penry, B.G. White, H.J. Kupferberg, and E.A. Swinyard Epilepsia 19 1978 400 428
29. R.J. Porter, J.J. Cereghino, G.D. Gladding, H.J. Kupferberg, B. Scoville, and B.G. White Cleveland Clin. Q. 51 1984 293 305
30. The SHELX-97 Manual, Sheldrick G.M., University of Göttingen, Germany, 1997.
31. ORTEP-3 for Windows version 1.07, Farrugia L.J., J. Appl. Crystallogr. 30 (1997) 565.
32. Clarke's Isolation and Identification of Drugs, second ed 1986 The Pharmaceutical Press London