Covalently stabilized trimethyl chitosan-hyaluronic acid nanoparticles for nasal and intradermal vaccination

Journal of Controlled Release

Volumn 156, Issue 1, 2011, Pages 46-52

  Verheul, Rolf J ^a   Slütter, Bram ^b   Bal, Suzanne M ^b   Bouwstra, Joke A ^b   Jiskoot, Wim ^b   Hennink, Wim E ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Hyaluronic acid; Nasal intradermal immunization; PEGylation; Stabilized nanoparticles; Thiolation; Trimethyl chitosan

Indexed keywords

CHITOSAN; GELATION; IMMUNIZATION; NANOPARTICLES; ORGANIC ACIDS; PARTICLE SIZE; POLYELECTROLYTES; STABILIZATION; SULFUR COMPOUNDS; VACCINES; ZETA POTENTIAL;

INTRADERMAL VACCINATION; LOADING EFFICIENCY; PARTICULATE SYSTEMS; PEGYLATION; PHYSIOLOGICAL CONDITION; STABILIZED NANOPARTICLES; THIOLATION; TRIMETHYL CHITOSAN;

HYALURONIC ACID;

CHITOSAN DERIVATIVE; DISULFIDE; DITHIOTHREITOL; HYALURONIC ACID; IMMUNOGLOBULIN G; MACROGOL; MALEIMIDE; NANOPARTICLE; OVALBUMIN; THIOL; TRIMETHYL CHITOSAN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG STABILITY; FEMALE; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; INCUBATION TEMPERATURE; MOUSE; NONHUMAN; PARTICLE SIZE; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; ZETA POTENTIAL;

EID: 80855138149     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.07.014     Document Type: Article

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