Thiolated chitosans: Development and in vitro evaluation of an oral tobramycin sulphate delivery system

European Journal of Pharmaceutical Sciences

Volumn 33, Issue 1, 2008, Pages 1-8

  Hombach, Juliane ^a   Hoyer, Herbert ^a   Bernkop Schnürch, Andreas ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Caco 2 cells; Chitosan NAC; Permeation enhancement; Tobramycin sulphate; Ussing type chambers

Indexed keywords

ACETYLCYSTEINE; CHITOSAN DERIVATIVE; GLUTATHIONE; TOBRAMYCIN SULFATE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; INTESTINE MUCOSA; NONHUMAN; PRIORITY JOURNAL; PROTEIN IMMOBILIZATION; RAT; SMALL INTESTINE; TABLET FORMULATION;

ACETYLCYSTEINE; ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CHITOSAN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DELAYED-ACTION PREPARATIONS; EPITHELIAL CELLS; GLUTATHIONE; HUMANS; INTESTINAL MUCOSA; INTESTINE, SMALL; MALE; MOLECULAR STRUCTURE; RATS; RATS, SPRAGUE-DAWLEY; SULFHYDRYL COMPOUNDS; TABLETS; TECHNOLOGY, PHARMACEUTICAL; TOBRAMYCIN; VERAPAMIL;

EID: 36849001337     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2007.09.001     Document Type: Article

References (33)

1. Banerjee D., and Stableforth D. The treatment of respiratory pseudomonas infection in cystic fibrosis: what drug and which way?. Drugs 60 (2000) 1053-1064
2. Banerjee S.K., Jagannath C., Hunter R.L., and Dasgupta A. Bioavailability of tobramycin after oral delivery in FVB mice using CRL-1605 copolymer, an inhibitor of P-glycoprotein. Life Sci. 67 (2000) 2011-2016
3. Barrett W.C., DeGnore J.P., Konig S., Fales H.M., Keng Y.F., Zhang Z.Y., Yim M.B., and Chock P.B. Regulation of PTP1B via glutathionylation of the active site cysteine 215. Biochemistry 38 (1999) 6699-6705
4. Bernkop-Schnürch A., and Hopf T.E. Synthesis and in vitro evaluation of chitosan-thioglycolic acid conjugates. Sci. Pharm. 69 (2001) 109-118
5. Bernkop-Schnürch A., Brandt U.M., and Clausen A.E. Synthesis and in vitro evaluation of chitosan-cysteine conjugates. Sci. Pharm. 67 (1999) 196-208
6. Bernkop-Schnürch A., Hornof M., and Zoidl T. Thiolated polymers-thiomers: synthesis and in vitro evaluation of chitosan-2-iminothiolane conjugates. Int. J. Pharm. 260 (2003) 229-237
7. Bernkop-Schnürch A., Kast C.E., and Guggi D. Permeation enhancing polymers in oral delivery of hydrophilic macromolecules: thiomer/GSH systems. J. Control. Rel. 93 (2003) 95-103
8. Bernkop-Schnürch A., Pinter Y., Guggi D., Kahlbacher H., Schoffmann G., Schuh M., Schmerold I., Del Curto M.D., D'Antonio M., Esposito P., and Huck C. The use of thiolated polymers as carrier matrix in oral peptide delivery-proof of concept. J. Control. Rel. 106 (2005) 26-33
9. Cavalli R., Bargoni A., Podio V., Muntoni E., Zara G.P., and Gasco M.R. Duodenal administration of solid lipid nanoparticles loaded with different percentages of tobramycin. J. Pharm. Sci. 92 (2003) 1085-1094
10. Clausen A.E., and Bernkop-Schnürch A. In vitro evaluation of the permeation-enhancing effect of thiolated polycarbophil. J. Pharm. Sci. 89 (2000) 1253-1261
11. Clausen A.E., Kast C.E., and Bernkop-Schnürch A. The role of glutathione in the permeation enhancing effect of thiolated polymers. Pharm. Res. 19 (2002) 602-608
12. Coupe A.J., Davis S.S., and Wilding I.R. Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects. Pharm. Res. 8 (1991) 360-364
13. Feng C.H., Lin S.J., Wu H.L., and Chen S.H. Trace analysis of tobramycin in human plasma by derivatization and high-performance liquid chromatography with ultraviolet detection. J. Chromatogr. B-Analyt. Technol. Biomed. Life Sci. 780 (2002) 349-354
14. Föger F., Schmitz T., and Bernkop-Schnürch A. In vivo evaluation of an oral delivery system for P-gp substrates based on thiolated chitosan. Biomaterials 27 (2006) 4250-4255
15. Geller D.E., Pitlick W.H., Nardella P.A., Tracewell W.G., and Ramsey B.W. Pharmacokinetics and bioavailability of aerosolized tobramycin in cystic fibrosis. Chest 122 (2002) 219-226
16. Grabovac V., Guggi D., and Bernkop-Schnürch A. Comparison of the mucoadhesive properties of various polymers. Adv. Drug Deliv. Rev. 57 (2005) 1713-1723
17. Hornof M.D., Kast C.E., and Bernkop-Schnürch A. In vitro evaluation of the viscoelastic properties of chitosan-thioglycolic acid conjugates. Eur. J. Pharm. Biopharm. 55 (2003) 185-190
18. Kafedjiiski K., Föger F., Werle M., and Bernkop-Schnürch A. Synthesis and in vitro evaluation of a novel chitosan-glutathione conjugate. Pharm. Res. 22 (2005) 1480-1488
19. Kafedjiiski K., Hoffer M., Werle M., and Bernkop-Schnürch A. Improved synthesis and in vitro characterization of chitosan-thioethylamidine conjugate. Biomaterials 27 (2006) 127-135
20. Lacombe O., Woodley J., Solleux C., Delbos J.M., Boursier-Neyret C., and Houin G. Localisation of drug permeability along the rat small intestine, using markers of the paracellular, transcellular and some transporter routes. Eur. J. Pharm. Sci. 23 (2004) 385-391
21. Langoth N., Kalbe J., and Bernkop-Schnürch A. Development of a mucoadhesive and permeation enhancing buccal delivery system for PACAP (pituitary adenylate cyclase-activating polypeptide). Int. J. Pharm. 296 (2005) 103-111
22. Langoth N., Kahlbacher H., Schoffmann G., Schmerold I., Schuh M., Franz S., Kurka P., and Bernkop-Schnürch A. Thiolated chitosans: design and in vivo evaluation of a mucoadhesive buccal peptide drug delivery system. Pharm. Res. 23 (2006) 573-579
23. Leitner V.M., Walker G.F., and Bernkop-Schnürch A. Thiolated polymers: evidence for the formation of disulphide bonds with mucus glycoproteins. Eur. J. Pharm. Biopharm. 56 (2003) 207-214
24. Lennernäs H. Gastrointestinal absorption mechanisms-a comparison between animal and human models. Eur. J. Pharm. Sci. 2 (1994) 39-43
25. Lennernäs H., Palm K., Fagerholm U., and Artursson P. Comparison between active and passive drug transport in human intestinal epithelial (Caco-2) cells in vitro and human jejunum in vivo. Int. J. Pharm. 127 (1995) 103-107
26. Lennernäs H., Nylander S., and Ungell A.L. Jejunal permeability: a comparison between the Ussing chamber technique and the single-pass perfusion in humans. Pharm. Res. 14 (1997) 667-671
27. Polli J.W., Wring S.A., Humphreys J.E., Huang L., Morgan J.B., Webster L.O., and Serabjit-Singh C.S. Rational use of in vitro P-glycoprotein assays in drug discovery. J. Pharmacol. Exp. Ther. 299 (2001) 620-628
28. Recchia J., Lurantos M.H., Amsden J.A., Storey J., and Kensil C.R. A semisynthetic Quillaja saponin as a drug delivery agent for aminoglycoside antibiotics. Pharm. Res. 12 (1995) 1917-1923
29. Rojas, M.X., Granados, C., 2006. Oral antibiotics versus parenteral antibiotics for severe pneumonia in children. Cochrane. Database. Syst. Rev. CD004979.
30. Sababi M., Borga O., and Hultkvist-Bengtsson U. The role of P-glycoprotein in limiting intestinal regional absorption of digoxin in rats. Eur. J. Pharm. Sci. 14 (2001) 21-27
31. Saitoh H., Aungst B.J., Tohyama M., Hatakeyama Y., Ohwada K., Kobayashi M., Fujisaki H., and Miyazaki K. In vitro permeation of beta-lactam antibiotics across rat jejunum and its correlation with oral bioavailability in humans. Brit. J. Clin. Pharmacol. 54 (2002) 445-448
32. Schmitz T., Gabovac V., Palmberger T.F., Hoffer M.H., and Bernkop-Schnürch A. Synthesis and characterisation of a chitosan-N-acetyl cycteine conjugate. Int. J. Pharm. 347 (2008) 79-85
33. Werle M., and Hoffer M. Glutathione and thiolated chitosan inhibit multidrug resistance P-glycoprotein activity in excised small intestine. J. Control. Rel. 111 (2006) 41-46