Vitamin K supplementation increases vitamin K tissue levels but fails to counteract ectopic calcification in a mouse model for pseudoxanthoma elasticum

Journal of Molecular Medicine

Volumn 89, Issue 11, 2011, Pages 1125-1135

  Gorgels, Theo G M F ^a   Waarsing, Jan H ^b   Herfs, Marjolein ^c   Versteeg, Daniëlle ^a   Schoensiegel, Frank ^d   Sato, Toshiro ^e   Schlingemann, Reinier O ^f   Ivandic, Boris ^d   Vermeer, Cees ^c   Schurgers, Leon J ^c   Bergen, Arthur A B ^a,f  

^a NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c MAASTRICHT UNIVERSITY   (Netherlands)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e J Oil Mills Inc   (Japan)

^f ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

ABC transporter; Calcium metabolism; Cardiovascular; Connective tissue; Ectopic calcification; Mouse models; Pseudoxanthoma elasticum; Vascular calcification; Vitamin K; Vitamins

Indexed keywords

MENAQUINONE 7; UNCLASSIFIED DRUG; VITAMIN K GROUP;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CLOTTING; BLOOD VESSEL CALCIFICATION; CELL MEMBRANE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; GENOTYPE; HISTOLOGY; IN VIVO STUDY; LIVER CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PSEUDOXANTHOMA ELASTICUM; TISSUE LEVEL; VITAMIN BLOOD LEVEL; VITAMIN K TISSUE LEVEL; VITAMIN SUPPLEMENTATION;

ANIMALS; CALCINOSIS; DISEASE MODELS, ANIMAL; HEMOSTATICS; HUMANS; MICE; MICE, KNOCKOUT; PSEUDOXANTHOMA ELASTICUM; VITAMIN K 2; VITAMINS;

EID: 80755139715     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-011-0782-y     Document Type: Article

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