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Volumn 7, Issue 11, 2008, Pages 1575-1579

Does the absence of ABCC6 (multidrug resistance protein 6) in patients with Pseudoxanthoma elasticum prevent the liver from providing sufficient vitamin K to the periphery?

Author keywords

ABC transporters; ABCC6; Glutathione; Menadione; MRP6; Pseudoxanthoma elasticum; Vitamin K

Indexed keywords

ABCC6 PROTEIN; ANTIVITAMIN K; GLUCURONIDE; GLUTATHIONE; MENADIONE; MULTIDRUG RESISTANCE PROTEIN 6; VITAMIN K DEPENDENT CARBOXYLASE; VITAMIN K GROUP;

EID: 45849111436     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.7.11.6005     Document Type: Review
Times cited : (66)

References (43)
  • 1
    • 0023744791 scopus 로고
    • Pseudoxanthoma elasticum
    • Neldner KH. Pseudoxanthoma elasticum. Clin Dermatol 1988; 6:1-159.
    • (1988) Clin Dermatol , vol.6 , pp. 1-159
    • Neldner, K.H.1
  • 4
    • 0034705145 scopus 로고    scopus 로고
    • Pseudoxanthoma elasticum: Mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter
    • Ringpfeil F, Lebwohl MG, Christiano AM, Uitto J. Pseudoxanthoma elasticum: mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter. Proc Natl Acad Sci USA 2000; 97:6001-6.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 6001-6006
    • Ringpfeil, F.1    Lebwohl, M.G.2    Christiano, A.M.3    Uitto, J.4
  • 6
    • 24344480438 scopus 로고    scopus 로고
    • Klement JF, Matsuzaki Y, Jiang QJ, Terlizzi J, Choi HY, Fujimoto N, Li K, Pulkkinen l, Birk DE, Sundberg JP, Uitto J. Targeted ablation of the abcc6 gene results in ectopic mineralization of connective tissues. Mol Cell Biol 2005; 25:8299-310.
    • Klement JF, Matsuzaki Y, Jiang QJ, Terlizzi J, Choi HY, Fujimoto N, Li K, Pulkkinen l, Birk DE, Sundberg JP, Uitto J. Targeted ablation of the abcc6 gene results in ectopic mineralization of connective tissues. Mol Cell Biol 2005; 25:8299-310.
  • 7
    • 1242335471 scopus 로고    scopus 로고
    • The MRP-related and BCRP/ABCG2 multidrug resistance proteins: Biology, substrate specificity and regulation
    • Haimeur A, Conseil G, Deeley RG, Cole SP. The MRP-related and BCRP/ABCG2 multidrug resistance proteins: biology, substrate specificity and regulation. Curr Drug Metab 2004; 5:21-53.
    • (2004) Curr Drug Metab , vol.5 , pp. 21-53
    • Haimeur, A.1    Conseil, G.2    Deeley, R.G.3    Cole, S.P.4
  • 8
    • 0036074018 scopus 로고    scopus 로고
    • Mammalian ABC transporters in health and disease
    • Richardson CC, Kornberg R, Raetz CHR, Thorstensen K, eds
    • Borst P, Oude Elferink R. Mammalian ABC transporters in health and disease. In: Richardson CC, Kornberg R, Raetz CHR, Thorstensen K, eds. Ann Rev Biochem California: Science 2002; 537-92.
    • (2002) Ann Rev Biochem California: Science , pp. 537-592
    • Borst, P.1    Oude Elferink, R.2
  • 9
    • 0036829109 scopus 로고    scopus 로고
    • Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6)
    • Belinsky MG, Chen ZS, Shchaveleva I, Zeng H, Kruh GD. Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). Cancer Res 2002; 62:6172-7.
    • (2002) Cancer Res , vol.62 , pp. 6172-6177
    • Belinsky, M.G.1    Chen, Z.S.2    Shchaveleva, I.3    Zeng, H.4    Kruh, G.D.5
  • 10
    • 0037053355 scopus 로고    scopus 로고
    • Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6)
    • Ilias A, Urban Z, Seidl TL, Le Saux O, Sinko E, Boyd CD, Sarkadi B, Varadi A. Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6). J Biol Chem 2002; 277:16860-7.
    • (2002) J Biol Chem , vol.277 , pp. 16860-16867
    • Ilias, A.1    Urban, Z.2    Seidl, T.L.3    Le Saux, O.4    Sinko, E.5    Boyd, C.D.6    Sarkadi, B.7    Varadi, A.8
  • 12
    • 0038648741 scopus 로고    scopus 로고
    • The distribution of Abcc6 in normal mouse tissues suggests multiple functions for this ABC transporter
    • Beck K, Hayashi K, Nishiguchi B, Le Saux O, Hayashi M, Boyd CD. The distribution of Abcc6 in normal mouse tissues suggests multiple functions for this ABC transporter. J Histochem Cytochem 2003; 51:887-902.
    • (2003) J Histochem Cytochem , vol.51 , pp. 887-902
    • Beck, K.1    Hayashi, K.2    Nishiguchi, B.3    Le Saux, O.4    Hayashi, M.5    Boyd, C.D.6
  • 16
    • 33847016921 scopus 로고    scopus 로고
    • Pseudoxanthoma elasticum-like phenotypes: More diseases than one
    • Uitto J, Jiang Q. Pseudoxanthoma elasticum-like phenotypes: more diseases than one. J Invest Dermatol 2007; 127:507-10.
    • (2007) J Invest Dermatol , vol.127 , pp. 507-510
    • Uitto, J.1    Jiang, Q.2
  • 17
    • 0034478001 scopus 로고    scopus 로고
    • Uitto J, Pulkkinen l, Ringpfeil F. Molecular genetics of Pseudoxanthoma elasticum: a metabolic disorder at the environment-genome interface? Trends Molecular Medicine 2001;7:13-7.
    • Uitto J, Pulkkinen l, Ringpfeil F. Molecular genetics of Pseudoxanthoma elasticum: a metabolic disorder at the environment-genome interface? Trends Molecular Medicine 2001;7:13-7.
  • 18
    • 45849136594 scopus 로고    scopus 로고
    • Aberrant mineralization of connective tissues in Pseudoxanthoma elasticum: A mouse grafting model
    • Jiang Q, Endo M, Udagawa N, Li Q, Uitto J. Aberrant mineralization of connective tissues in Pseudoxanthoma elasticum: A mouse grafting model. J Invest Dermatol 2008; 127.
    • (2008) J Invest Dermatol , pp. 127
    • Jiang, Q.1    Endo, M.2    Udagawa, N.3    Li, Q.4    Uitto, J.5
  • 19
    • 45849134386 scopus 로고    scopus 로고
    • Cell-based therapy for Pseudoxanthoma elasticum: Reduction of connective tissue mineralization in a mouse model (Abcc6-/-) by transplantation of wild-type hepatocytes
    • Jiang Q, Dibra F, Wang K, Uitto J. Cell-based therapy for Pseudoxanthoma elasticum: reduction of connective tissue mineralization in a mouse model (Abcc6-/-) by transplantation of wild-type hepatocytes. J Invest Dermatol 2008.
    • (2008) J Invest Dermatol
    • Jiang, Q.1    Dibra, F.2    Wang, K.3    Uitto, J.4
  • 21
    • 34447521886 scopus 로고    scopus 로고
    • Vitamin K: The coagulation vitamin that became omnipotent
    • Cranenburg EC, Schurgers LJ, Vermeer C. Vitamin K: the coagulation vitamin that became omnipotent. Thromb Haemost 2007; 98:120-5.
    • (2007) Thromb Haemost , vol.98 , pp. 120-125
    • Cranenburg, E.C.1    Schurgers, L.J.2    Vermeer, C.3
  • 24
    • 33947578745 scopus 로고    scopus 로고
    • Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats
    • Schurgers LJ, Spronk HM, Soute BA, Schiffers PM, DeMey JG, Vermeer C. Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats. Blood 2007; 109:2823-31.
    • (2007) Blood , vol.109 , pp. 2823-2831
    • Schurgers, L.J.1    Spronk, H.M.2    Soute, B.A.3    Schiffers, P.M.4    DeMey, J.G.5    Vermeer, C.6
  • 25
  • 26
    • 34147137917 scopus 로고    scopus 로고
    • Vitamin Kcontaining dietary supplements: Comparison of synthetic vitamin K1 and natto-derived menaquinone-7
    • Schurgers LJ, Teunissen KJ, Hamulyak K, Knapen MH, Vik H, Vermeer C. Vitamin Kcontaining dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood 2007; 109:3279-83.
    • (2007) Blood , vol.109 , pp. 3279-3283
    • Schurgers, L.J.1    Teunissen, K.J.2    Hamulyak, K.3    Knapen, M.H.4    Vik, H.5    Vermeer, C.6
  • 27
    • 0442293394 scopus 로고    scopus 로고
    • Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarintreated rats
    • Spronk HM, Soute BA, Schurgers LJ, Thijssen HH, De Mey JG, Vermeer C. Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarintreated rats. J Vasc Res 2003; 40:531-7.
    • (2003) J Vasc Res , vol.40 , pp. 531-537
    • Spronk, H.M.1    Soute, B.A.2    Schurgers, L.J.3    Thijssen, H.H.4    De Mey, J.G.5    Vermeer, C.6
  • 28
    • 33847053974 scopus 로고    scopus 로고
    • Aberrant mineralization of connective tissues in a mouse model of pseudoxanthoma elasticum: Systemic and local regulatory factors
    • Jiang Q, Li Q, Uitto J. Aberrant mineralization of connective tissues in a mouse model of pseudoxanthoma elasticum: systemic and local regulatory factors. J Invest Dermatol 2007; 127:1392-402.
    • (2007) J Invest Dermatol , vol.127 , pp. 1392-1402
    • Jiang, Q.1    Li, Q.2    Uitto, J.3
  • 30
    • 0029978364 scopus 로고    scopus 로고
    • Chemistry, nutritional sources, tissue distribution and metabolism of vitamin K with special reference to bone health
    • Shearer MJ, Bach A, Kohlmeier M. Chemistry, nutritional sources, tissue distribution and metabolism of vitamin K with special reference to bone health. J Nutr 1996; 126:1181-6.
    • (1996) J Nutr , vol.126 , pp. 1181-1186
    • Shearer, M.J.1    Bach, A.2    Kohlmeier, M.3
  • 31
    • 45849118924 scopus 로고    scopus 로고
    • Metabolism and cell biology of vitamin K
    • in press
    • Shearer MJ, Newman P. Metabolism and cell biology of vitamin K. Thromb Haemost 2008; (in press).
    • (2008) Thromb Haemost
    • Shearer, M.J.1    Newman, P.2
  • 32
    • 0030932090 scopus 로고    scopus 로고
    • Menaquinone-4 accumulation in various tissues after an oral administration of phylloquinone in Wistar rats
    • Yamamoto R, Komai M, Kojima K, Furukawa Y, Kimura S. Menaquinone-4 accumulation in various tissues after an oral administration of phylloquinone in Wistar rats. J Nutr Sci Vitaminol (Tokyo) 1997; 43:133-43.
    • (1997) J Nutr Sci Vitaminol (Tokyo) , vol.43 , pp. 133-143
    • Yamamoto, R.1    Komai, M.2    Kojima, K.3    Furukawa, Y.4    Kimura, S.5
  • 34
    • 45549105720 scopus 로고    scopus 로고
    • Conversion of phylloquinone (vitamin K1) into menaquinone-4 (vitamin K2) in mice: Two possible routes for menaquinone-4 accumulation in cerebra of mice
    • in press
    • Okano T, Shimomura Y, Yamane M, Suhara Y, Kamao M, Sugiura M, Nakagawa K. Conversion of phylloquinone (vitamin K1) into menaquinone-4 (vitamin K2) in mice: Two possible routes for menaquinone-4 accumulation in cerebra of mice. J Biol Chem 2007; (in press).
    • (2007) J Biol Chem
    • Okano, T.1    Shimomura, Y.2    Yamane, M.3    Suhara, Y.4    Kamao, M.5    Sugiura, M.6    Nakagawa, K.7
  • 35
    • 0014436352 scopus 로고
    • Metabolic studies of vitamin K1-14C and menadione-14C in the normal and hepatectomized rats
    • Losito R, Owen CA Jr, Flock EV. Metabolic studies of vitamin K1-14C and menadione-14C in the normal and hepatectomized rats. Thromb Diath Haemorrh 1968; 19:383-8.
    • (1968) Thromb Diath Haemorrh , vol.19 , pp. 383-388
    • Losito, R.1    Owen Jr, C.A.2    Flock, E.V.3
  • 36
    • 33747159665 scopus 로고    scopus 로고
    • Comparative uptake, metabolism, and utilization of menaquinone-4 and phylloquinone in human cultured cell lines
    • Suhara Y, Murakami A, Nakagawa K, Mizuguchi Y, Okano T. Comparative uptake, metabolism, and utilization of menaquinone-4 and phylloquinone in human cultured cell lines. Bioorg Med Chem 2006; 14:6601-7.
    • (2006) Bioorg Med Chem , vol.14 , pp. 6601-6607
    • Suhara, Y.1    Murakami, A.2    Nakagawa, K.3    Mizuguchi, Y.4    Okano, T.5
  • 38
    • 0023889781 scopus 로고
    • Inhibition of biliary taurocholate excretion during menadione metabolism in perfused rat liver
    • Akerboom T, Bultmann T, Sies H. Inhibition of biliary taurocholate excretion during menadione metabolism in perfused rat liver. Arch Biochem Biophys 1988; 263:10-8.
    • (1988) Arch Biochem Biophys , vol.263 , pp. 10-18
    • Akerboom, T.1    Bultmann, T.2    Sies, H.3
  • 39
    • 34447135471 scopus 로고    scopus 로고
    • Excretion of the urinary 5C- and 7C-aglycone metabolites of vitamin K by young adults responds to changes in dietary phylloquinone and dihydrophylloquinone intakes
    • Harrington DJ, Booth SL, Card DJ, Shearer MJ. Excretion of the urinary 5C- and 7C-aglycone metabolites of vitamin K by young adults responds to changes in dietary phylloquinone and dihydrophylloquinone intakes. J Nutr 2007; 137:1763-8.
    • (2007) J Nutr , vol.137 , pp. 1763-1768
    • Harrington, D.J.1    Booth, S.L.2    Card, D.J.3    Shearer, M.J.4
  • 40
    • 0021671419 scopus 로고
    • Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes
    • Di Monte D, Ross D, Bellomo G, Eklow L, Orrenius S. Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes. Arch Biochem Biophys 1984; 235:334-42.
    • (1984) Arch Biochem Biophys , vol.235 , pp. 334-342
    • Di Monte, D.1    Ross, D.2    Bellomo, G.3    Eklow, L.4    Orrenius, S.5
  • 41
    • 31844450741 scopus 로고    scopus 로고
    • On the putative co-transport of drugs by multidrug resistance proteins
    • Borst P, Zelcer N, Van de Wetering K, Poolman B. On the putative co-transport of drugs by multidrug resistance proteins. FEBS Letters 2006; 580:1085-93.
    • (2006) FEBS Letters , vol.580 , pp. 1085-1093
    • Borst, P.1    Zelcer, N.2    Van de Wetering, K.3    Poolman, B.4


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