Low serum vitamin K in PXE results in defective carboxylation of mineralization inhibitors similar to the GGCX mutations in the PXE-like syndrome

Laboratory Investigation

Volumn 90, Issue 6, 2010, Pages 895-905

  Vanakker, Olivier M ^a   Martin, Ludovic ^b   Schurgers, Leon J ^c   Quaglino, Daniela ^d   Costrop, Laura ^a   Vermeer, Cees ^c   Pasquali Ronchetti, Ivonne ^d   Coucke, Paul J ^a   De Paepe, Anne ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b UNIVERSITÉ D'ANGERS   (France)

^c MAASTRICHT UNIVERSITY   (Netherlands)

^d UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Elastic fibers; Fetuin A; Mineralization; Pseudoxanthoma elasticum; Vitamin K; Vitamin K dependent proteins

Indexed keywords

CALCIUM BINDING PROTEIN; GRANULOMA PROTEIN, MOUSE; MATRIX GLA PROTEIN; MENADIONE EPOXIDASE; MIXED FUNCTION OXIDASE; PROTEIN; SCLEROPROTEIN; VITAMIN K GROUP;

ADULT; AGED; ANIMAL; ARTICLE; BLOOD; CALCINOSIS; GENETICS; HUMAN; METABOLISM; MIDDLE AGED; MOUSE; MOUSE MUTANT; MUTATION; PATHOPHYSIOLOGY; PSEUDOXANTHOMA ELASTICUM; SYNDROME; VITAMIN K DEFICIENCY;

ADULT; AGED; ANIMALS; CALCINOSIS; CALCIUM-BINDING PROTEINS; EXTRACELLULAR MATRIX PROTEINS; HUMANS; MICE; MICE, KNOCKOUT; MIDDLE AGED; MIXED FUNCTION OXYGENASES; MUTATION; PROTEINS; PSEUDOXANTHOMA ELASTICUM; SYNDROME; VITAMIN K; VITAMIN K DEFICIENCY;

EID: 77954588638     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2010.68     Document Type: Article

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