Dietary magnesium, not calcium, prevents vascular calcification in a mouse model for pseudoxanthoma elasticum

Journal of Molecular Medicine

Volumn 88, Issue 5, 2010, Pages 467-475

  Gorgels, Theo G M F ^a   Waarsing, Jan H ^b   De Wolf, Anneke ^a   Ten Brink, Jacoline B ^a   Loves, Willem J P ^a   Bergen, Arthur A B ^a,c  

^a NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

ABC transporter; ABCC6; Calcium; Calcium metabolism; Cardiovascular; Connective tissue; Diet; Histopathology; Magnesium; PXE; Vascular calcification

Indexed keywords

ABC TRANSPORTER; CALCIUM; MAGNESIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL CALCIFICATION; CALCIUM INTAKE; CONTROLLED STUDY; DIETARY INTAKE; DISEASE SEVERITY; HEART CALCIFICATION; KIDNEY BLOOD VESSEL; KIDNEY CALCIFICATION; MICRO-COMPUTED TOMOGRAPHY; MINERAL INTAKE; MOUSE; NONHUMAN; PROPHYLAXIS; PROTEIN FUNCTION; PSEUDOXANTHOMA ELASTICUM; SOFT TISSUE CALCIFICATION;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BLOOD VESSELS; CALCINOSIS; CALCIUM; DIETARY SUPPLEMENTS; GENE DELETION; KIDNEY; MAGNESIUM; MICE; MICE, INBRED C57BL; MYOCARDIUM; PSEUDOXANTHOMA ELASTICUM;

EID: 77954562710     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-010-0596-3     Document Type: Article

References (32)

1. Hu X, Plomp AS, van Soest S, Wijnholds J, de Jong PT, Bergen AA (2003) Pseudoxanthoma elasticum: a clinical, histopatholog-ical, and molecular update. Surv Ophthalmol 48:424-438 (Pubitemid 36798130)
2. Finger RP, Charbel IP, Ladewig MS, Gotting C, Szliska C, Scholl HP, Holz FG (2009) Pseudoxanthoma elasticum: genetics, clinical manifestations and therapeutic approaches. Surv Ophthalmol 54:272-285
3. Gheduzzi D, Sammarco R, Quaglino D, Bercovitch L, Terry S, Taylor W, Ronchetti IP (2003) Extracutaneous ultrastructural alterations in pseudoxanthoma elasticum. Ultrastruct Pathol 27:375-384
4. Chassaing N, Martin L, Calvas P, Le Bert M, Hovnanian A (2005) Pseudoxanthoma elasticum: a clinical, pathophysiological and genetic update including 11 novel ABCC6 mutations. J Med Genet 42:881-892
5. Plomp AS, Hu X, de Jong PT, Bergen AA (2004) Does autosomal dominant pseudoxanthoma elasticum exist? Am J Med Genet 126A: 403-412
6. Bergen AA, Plomp AS, Schuurman EJ, Terry S, Breuning M, Dauwerse H, Swart J, Kool M, van Soest S, Baas F, ten Brink JB, de Jong PT (2000) Mutations in ABCC6 cause pseudoxanthoma elasticum. Nat Genet 25:228-231
7. Le Saux O, Urban Z, Tschuch C, Csiszar K, Bacchelli B, Quaglino D, Pasquali-Ronchetti I, Pope FM, Richards A, Terry S, Bercovitch L, De Paepe A, Boyd CD (2000) Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum. Nat Genet 25:223-227
8. Hu X, Peek R, Plomp A, ten Brink J, Scheffer G, van Soest S, Leys A, de Jong PT, Bergen AA (2003) Analysis of the frequent R1141X mutation in the ABCC6 gene in pseudoxanthoma elasticum. Invest Ophthalmol Vis Sci 44:1824-1829
9. Hu X, Plomp A, Wijnholds J, ten Brink J, van Soest S, van den Born LI, Leys A, Peek R, de Jong PT, Bergen AA (2003) ABCC6/MRP6 mutations: further insight into the molecular pathology of pseudoxanthoma elasticum. Eur J Hum Genet 11:215-224
10. Ilias A, Urban Z, Seidl TL, Le Saux O, Sinko E, Boyd CD, Sarkadi B, Varadi A (2002) Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6). J Biol Chem 277:16860-16867
11. Scheffer GL, Hu X, Pijnenborg AC, Wijnholds J, Bergen AA, Scheper RJ (2002) MRP6 (ABCC6) detection in normal human tissues and tumors. Lab Invest 82:515-518
12. Uitto J, Pulkkinen L, Ringpfeil F (2001) Molecular genetics of pseudoxanthoma elasticum: a metabolic disorder at the environment-genome interface? Trends Mol Med 7:13-17
13. Gorgels TG, Hu X, Scheffer GL, van der Wal AC, Toonstra J, de Jong PT, van Kuppevelt TH, Levelt CN, de Wolf A, Loves WJ, Scheper RJ, Peek R, Bergen AA (2005) Disruption of Abcc6 in the mouse: novel insight in the pathogenesis of pseudoxanthoma elasticum. Hum Mol Genet 14:1763-1773
14. Klement JF, Matsuzaki Y, Jiang QJ, Terlizzi J, Choi HY, Fujimoto N, Li K, Pulkkinen L, Birk DE, Sundberg JP, Uitto J (2005) Targeted ablation of the abcc6 gene results in ectopic mineralization of connective tissues. Mol Cell Biol 25:8299-8310
15. Renie WA, Pyeritz RE, Combs J, Fine SL (1984) Pseudoxan-thoma elasticum: high calcium intake in early life correlates with severity. Am J Med Genet 19:235-244
16. Martinez-Hernandez A, Huffer WE, Neldner K, Gordon S, Reeve EB (1978) Resolution and repair of elastic tissue calcification in pseudoxanthoma elasticum. Arch Pathol Lab Med 102:303-305
17. Sapadin AN, Lebwohl MG, Teich SA, Phelps RG, DiCostanzo D, Cohen SR (1998) Periumbilical pseudoxanthoma elasticum associated with chronic renal failure and angioid streaks-apparent regression with hemodialysis. J Am Acad Dermatol 39:338-344
18. Dorfman K (2002) Pseudoxanthoma elasticum: what to do while waiting for progress in research. PXE International, Washington
19. Subcommittee on Laboratory Animal Nutrition CoANBoANRC (2009) Nutrient Requirements of Laboratory Animals, Fourth Revised Edition, 1995. http://www.napedu/openbookphp?isbn=0309051266&page=8080-102
20. Li Q, Jiang Q, Pfendner E, Varadi A, Uitto J (2009) Pseudox-anthoma elasticum: clinical phenotypes, molecular genetics and putative pathomechanisms. Exp Dermatol 18:1-11
21. Korff S, Riechert N, Schoensiegel F, Weichenhan D, Autschbach F, Katus HA, Ivandic BT (2006) Calcification of myocardial necrosis is common in mice. Virchows Arch 448:630-638
22. Aherrahrou Z, Doehring LC, Ehlers EM, Liptau H, Depping R, Linsel-Nitschke P, Kaczmarek PM, Erdmann J, Schunkert H (2008) An alternative splice variant in Abcc6, the gene causing dystrophic calcification, leads to protein deficiency in C3H/He mice. J Biol Chem 283:7608-7615
23. Tzanakis IP, Oreopoulos DG (2009) Beneficial effects of magnesium in chronic renal failure: a foe no longer. Int Urol Nephrol 41:363-371
24. LaRusso J, Li Q, Jiang Q, Uitto J (2009) Elevated dietary magnesium prevents connective tissue mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6 (-/-)). J Invest Dermatol 129:1388-1394
25. van den Broek FA, Beynen AC (1998) The influence of dietary phosphorus and magnesium concentrations on the calcium content of heart and kidneys of DBA/2 and NMRI mice. Lab Anim 32:483-491
26. Blumenthal NC (1989) Mechanisms of inhibition of calcification. Clin Orthop Relat Res 247:279-289
27. LaRusso J, Jiang Q, Li Q, Uitto J (2008) Ectopic mineralization of connective tissue in Abcc6-/-mice: effects of dietary modifications and a phosphate binder-a preliminary study. Exp Dermatol 17:203-207
28. Sherer DW, Singer G, Uribarri J, Phelps RG, Sapadin AN, Freund KB, Yanuzzi L, Fuchs W, Lebwohl M (2005) Oral phosphate binders in the treatment of pseudoxanthoma elasticum. J Am Acad Dermatol 53:610-615
29. van den Broek FA, Ritskes-Hoitinga J, Beynen AC (2000) Influence of excessive fluoride consumption on the severity of dystrophic cardiac calcification in DBA/2 mice. Biol Trace Elem Res 78:191-203
30. van den Broek FA, Beynen AC (1998) Effect of dietary fat level on the calcium content of heart and kidney in DBA/2 and C57BL/6 mice. Lab Anim 32:206-213
31. Eaton GJ, Custer RP, Johnson FN, Stabenow KT (1978) Dystrophic cardiac calcinosis in mice: genetic, hormonal, and dietary influences. Am J Pathol 90:173-186
32. Everitt JI, Olson LM, Mangum JB, Visek WJ (1988) High mortality with severe dystrophic cardiac calcinosis in C3H/OUJ mice fed high fat purified diets. Vet Pathol 25:113-118