Inhibitory effects of sepiapterin on vascular endothelial growth factor-a-induced proliferation and adhesion in human umbilical vein endothelial cells

Archives of Pharmacal Research

Volumn 34, Issue 9, 2011, Pages 1571-1577

  Kim, Soo Hyeon ^a   Cho, Young Rak ^a   Kim, Myoung Dong ^a   Kim, Hyun Ju ^b   Choi, Shin Wook ^b   Seo, Dong Wan ^a  

^a Kangwon National University   (South Korea)

^b Radiant Research Institute   (South Korea)

Author keywords

Angiogenesis; Endothelial cells; Sepiapterin; Tetrahydrobiopterin; Vascular endothelial growth factor A

Indexed keywords

CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; SEPIAPTERIN; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 2;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL ADHESION; CELL CYCLE PROGRESSION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL;

ANGIOGENESIS INHIBITORS; BLOTTING, WESTERN; CELL ADHESION; CELL CULTURE TECHNIQUES; CELL MOVEMENT; CELL PROLIFERATION; DOWN-REGULATION; ENDOTHELIAL CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; NITRIC OXIDE; PTERINS; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 80755130612     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-011-0920-7     Document Type: Article

References (30)

1. O. Alper E. S. Bergmann-Leitner T. A. Bennett N. F. Hacker K. Stromberg W. G. Stetler-Stevenson 2001 Epidermal growth factor receptor signaling and the invasive phenotype of ovarian carcinoma cells J. Natl. Cancer Inst. 93 1375 1384 11562388 10.1093/jnci/93.18.1375 1:CAS:528:DC%2BD3MXns1yrt74%3D (Pubitemid 32936814)
2. A. H. Baker D. R. Edwards G. Murphy 2002 Metalloproteinase inhibitors: biological actions and therapeutic opportunities J. Cell Sci. 115 3719 3727 12235282 10.1242/jcs.00063 1:CAS:528:DC%2BD38XotFemtbs%3D (Pubitemid 35203598)
3. D. Bourboulia W. G. Stetler-Stevenson 2010 Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion Semin. Cancer Biol. 20 161 168 20470890 10.1016/j.semcancer.2010.05.002 1:CAS:528:DC%2BC3cXhtFOnt7%2FM
4. K. Brew H. Nagase 2010 The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity Biochim. Biophys. Acta 1803 55 71 20080133 10.1016/j.bbamcr.2010.01.003 1:CAS:528:DC%2BC3cXitVKitLo%3D
5. P. Carmeliet R. K. Jain 2000 Angiogenesis in cancer and other diseases Nature 407 249 257 11001068 10.1038/35025220 1:CAS:528:DC%2BD3cXmvVSls74%3D
6. L. Chen X. Zeng J. Wang S. S. Briggs E. O'Neill J. Li R. Leek D. J. Kerr A. L. Harris S. Cai 2010 Roles of tetrahydrobiopterin in promoting tumor angiogenesis Am. J. Pathol. 177 2671 2680 20847284 10.2353/ajpath.2010.100025 1:CAS:528:DC%2BC3cXhsFWgsrzF
7. S6K-dependent VEGFR-2 expression Oncol. Rep. 26 861 867 21637925 1:CAS:528:DC%2BC3MXhtF2jsbnM
8. G. Christofori 2006 New signals from the invasive front Nature 441 444 450 16724056 10.1038/nature04872 1:CAS:528:DC%2BD28XkvVyrsro%3D (Pubitemid 44050139)
9. N. Ferrara H. P. Gerber J. LeCouter 2003 The biology of VEGF and its receptors Nat. Med. 9 669 676 12778165 10.1038/nm0603-669 1:CAS:528: DC%2BD3sXktFOnur4%3D (Pubitemid 36749215)
10. J. Folkman 2006 Angiogenesis Annu. Rev. Med. 57 1 18 16409133 10.1146/annurev.med.57.121304.131306 1:CAS:528:DC%2BD28Xis1Cksrg%3D (Pubitemid 43261975)
11. L. Gao Y. F. Pung J. Zhang P. Chen T. Wang M. Li M. Meza L. Toro H. Cai 2009 Sepiapterin reductase regulation of endothelial tetrahydrobiopterin and nitric oxide bioavailability Am. J. Physiol. Heart Circ. Physiol. 297 H331 H339 19429835 10.1152/ajpheart.00007.2009 1:CAS:528:DC%2BD1MXovVKit7c%3D
12. B. M. Gumbiner 1996 Cell adhesion: the molecular basis of tissue architecture and morphogenesis Cell 84 345 357 8608588 10.1016/S0092-8674(00) 81279-9 1:CAS:528:DyaK28XhtFWqtr4%3D (Pubitemid 26058560)
13. K. Holmes O. L. Roberts A. M. Thomas M. J. Cross 2007 Vascular endothelial growth factor receptor-2: structure, function, intracellular signaling and therapeutic inhibition Cell. Signal. 19 2003 2012 17658244 10.1016/j.cellsig.2007.05.013 1:CAS:528:DC%2BD2sXovFylsLs%3D (Pubitemid 47354167)
14. X. Jiang B. Kim H. Lin C. K. Lee J. Kim H. Kang P. Lee S. H. Jung H. M. Lee K. J. Won 2010 Tetrahydrobiopterin inhibits PDGF-stimulated migration and proliferation in rat aortic smooth muscle cells via the nitric oxide synthase-independent pathway Korean J. Physiol. Pharmacol. 14 177 183 20631891 10.4196/kjpp.2010.14.3.177 1:CAS:528:DC%2BC3cXhtVakt7nK
15. Z. S. Katusic L. V. d'Uscio K. A. Nath 2009 Vascular protection by tetrahydrobiopterin: progress and therapeutic prospects Trends Pharmacol. Sci. 30 48 54 19042039 10.1016/j.tips.2008.10.003 1:CAS:528:DC%2BD1MXktlygsQ%3D%3D
16. H. Kimura A. Weisz Y. Kurashima K. Hashimoto T. Ogura F. D'Acquisto R. Addeo M. Makuuchi H. Esumi 2000 Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide Blood 95 189 197 10607702 1:CAS:528:DC%2BD3cXhslKhtg%3D%3D (Pubitemid 30017242)
17. S. Lamy M. P. Lachambre S. Lord-Dufour R. Beliveau 2010 Propranolol suppresses angiogenesis in vitro: inhibition of proliferation, migration, and differentiation of endothelial cells Vascul. Pharmacol. 53 200 208 20732454 10.1016/j.vph.2010.08.002 1:CAS:528:DC%2BC3cXhsValtLvM
18. M. Malumbres M. Barbacid 2009 Cell cycle, CDKs and cancer: a changing paradigm Nat. Rev. Cancer 9 153 166 19238148 10.1038/nrc2602 1:CAS:528:DC%2BD1MXit1ans78%3D
19. M. Milkiewicz O. Hudlicka M. D. Brown H. Silgram 2005 Nitric oxide, VEGF, and VEGFR-2: interactions in activityinduced angiogenesis in rat skeletal muscle Am. J. Physiol. Heart Circ. Physiol. 289 H336 H343 15734877 10.1152/ajpheart.01105.2004 1:CAS:528:DC%2BD2MXmvVequr4%3D (Pubitemid 40934119)
20. J. Oh D. W. Seo T. Diaz B. Wei Y. Ward J. M. Ray Y. Morioka S. Shi H. Kitayama C. Takahashi M. Noda W. G. Stetler-Stevenson 2004 Tissue inhibitors of metalloproteinase 2 inhibits endothelial cell migration through increased expression of RECK Cancer Res. 64 9062 9069 15604273 10.1158/0008-5472.CAN-04- 1981 1:CAS:528:DC%2BD2cXhtVOmsLnL (Pubitemid 39665518)
21. M. Pannirselvam W. B. Wiehler T. Anderson C. R. Triggle 2005 Enhanced vascular reactivity of small mesenteric arteries from diabetic mice is associated with enhanced oxidative stress and cyclooxygenase products Br. J. Pharmacol. 144 953 960 15685205 10.1038/sj.bjp.0706121 1:CAS:528: DC%2BD2MXivVOisrY%3D (Pubitemid 40593021)
22. D. W. Seo H. Li L. Guedez P. T. Wingfield T. Diaz R. Salloum B. Y. Wei W. G. Stetler-Stevenson 2003 TIMP-2 mediated inhibition of angiogenesis: an MMPindependent mechanism Cell 114 171 180 12887919 10.1016/S0092-8674(03)00551-8 1:CAS:528:DC%2BD3sXlvFCgu7k%3D (Pubitemid 36936911)
23. D. W. Seo H. Li C. K. Qu J. Oh Y. S. Kim T. Diaz B. Wei J. W. Han W. G. Stetler-Stevenson 2006 Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells J. Biol. Chem. 281 3711 3721 16326706 10.1074/jbc.M509932200 1:CAS:528: DC%2BD28XhtFSmtL4%3D (Pubitemid 43845989)
24. D. W. Seo S. H. Kim S. H. Eom H. J. Yoon Y. R. Cho P. H. Kim Y. K. Kim J. W. Han T. Diaz B. Y. Wei W. G. Stetler-Stevenson 2008 TIMP-2 disrupts FGF-2-induced downstream signaling pathways Microvasc. Res. 76 145 151 18721821 10.1016/j.mvr.2008.07.003 1:CAS:528:DC%2BD1cXht1Kgsr%2FP
25. W. A. Spannuth A. K. Sood R. L. Coleman 2008 Angiogenesis as a strategic target for ovarian cancer therapy Nat. Clin. Pract. Oncol. 5 194 204 18268546 10.1038/ncponc1051 1:CAS:528:DC%2BD1cXktVWmsbc%3D (Pubitemid 351493679)
26. W. G. Stetler-Stevenson D. W. Seo 2005 TIMP-2: an endogenous inhibitor of angiogenesis Trends Mol. Med. 11 97 103 15760767 10.1016/j.molmed.2005.01.007 1:CAS:528:DC%2BD2MXit1eqsrw%3D (Pubitemid 40348986)
27. Stetler-Stevenson, W. G., Tissue inhibitors of metalloproteinases in cell signaling: metalloproteinase-independent biological activities. Sci. Signal., 1, re6 (2008).
28. B. Thony G. Auerbach N. Blau 2000 Tetrahydrobiopterin biosynthesis, regeneration and functions Biochem. J. 347Pt1 1 16 10.1042/0264-6021:3470001 (Pubitemid 30199034)
29. P. T. Wingfield J. K. Sax S. J. Stahl J. Kaufman I. Palmer V. Chung M. L. Corcoran D. E. Kleiner W. G. Stetler-Stevenson 1999 Biophysical and functional characterization of full-length, recombinant human tissue inhibitor of metalloproteinases-2 (TIMP-2) produced in Escherichia coli. Comparison of wild type and amino-terminal alanine appended variant with implications for the mechanism of TIMP functions J. Biol. Chem. 274 21362 21368 10409697 10.1074/jbc.274.30.21362 1:CAS:528:DyaK1MXkvVKrt7k%3D (Pubitemid 29350610)
30. M. Ziche L. Morbidelli R. Choudhuri H. T. Zhang S. Donnini H. J. Granger R. Bicknell 1997 Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factorinduced angiogenesis J. Clin. Invest. 99 2625 2634 9169492 10.1172/JCI119451 1:CAS:528:DyaK2sXjs1Knurs%3D (Pubitemid 27259809)