Antiatherogenic effects of oleanolic acid in apolipoprotein e knockout mice

European Journal of Pharmacology

Volumn 670, Issue 2-3, 2011, Pages 519-526

  Buus, Niels Henrik ^a,b   Hansson, Nicolaj C ^a   Rodriguez Rodriguez, Rosalia ^a,c   Stankevicius, Edgaras ^a   Andersen, Malene Rohr ^d   Simonsen, Ulf ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c UNIVERSITY OF SEVILLE   (Spain)

^d GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Apolipoprotein E knockout mouse; Atherosclerosis; Nitric oxide; Oleanolic acid

Indexed keywords

ACETYLCHOLINE; APOLIPOPROTEIN E; CHOLESTEROL; DIMETHYL SULFOXIDE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FLUINDOSTATIN; INDUCIBLE NITRIC OXIDE SYNTHASE; N(G),N(G) DIMETHYLARGININE; OLEANOLIC ACID; PHENYLEPHRINE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIATHEROGENIC EFFECT; AORTA ARCH; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BLOOD VESSEL REACTIVITY; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG STRUCTURE; ENZYME ANALYSIS; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; LONG TERM CARE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL; VASOCONSTRICTION; VASODILATATION; WEIGHT GAIN; WILD TYPE;

ACETYLCHOLINE; ANIMALS; AORTA; APOLIPOPROTEINS E; ATHEROSCLEROSIS; BODY WEIGHT; CHOLESTEROL; EATING; FATTY ACIDS, MONOUNSATURATED; GENE KNOCKOUT TECHNIQUES; INDOLES; MALE; MICE; MICE, INBRED C57BL; OLEANOLIC ACID; PHENYLEPHRINE; S-NITROSO-N-ACETYLPENICILLAMINE; TIME FACTORS; VASODILATION;

EID: 80755128493     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.09.037     Document Type: Article

References (39)

1. S. Acín, M.A. Navarro, J.S. Perona, J.M. Arbonés-Mainar, J.C. Surra, M.A. Guzmán, R. Carnicer, C. Arnal, I. Orman, J.C. Segovia, J. Osada, and V. Ruiz-Gutiérrez Olive oil preparation determines the atherosclerotic protection in apolipoprotein E knockout mice J. Nutr. Biochem. 18 2007 418 424 (Pubitemid 46727042)
2. N.K. Andrikopoulos, A.C. Kaliora, A.N. Assimopoulou, and V.P. Papageorgiou Inhibitory activity of minor polyphenolic and nonpolyphenolic constituents of olive oil against in vitro low-density lipoprotein oxidation J. Med. Food 5 2002 1 7 (Pubitemid 34462795)
3. P. Chew, Y.C. Derek, P. Koh, N. Stefanovic, M.A. Febbraio, I. Kola, M.E. Cooper, and J.B. de Haan Site-specific antiatherogenic effect of the antioxidant ebselen in the diabetic apolipoprotein E-deficient mouse Arterioscler. Thromb. Vasc. Biol. 29 2009 823 830
4. H.M. Crauwels, C.E. VanHove, P. Holvoet, A.G. Herman, and H. Bult Plaque-associated endothelial dysfunction in apolipoprotein E-deficient mice on a regular diet. Effect of human apolipoprotein AI Cardiovasc. Res. 59 2003 189 199 (Pubitemid 36776385)
5. L.V. d'Uscio, T.A. Baker, C.B. Mantilla, L. Smith, D. Weiler, G.C. Sieck, and Z.S. Katusic Mechanisms of endothelial dysfunction in apolipoprotein E-deficient mice Arterioscler. Thromb. Vasc. Biol. 21 2001 1017 1022 (Pubitemid 34168662)
6. J. Davignon Beneficial cardiovascular pleiotropic effects of statins Circulation 109 2004 III39 III43
7. M. de Lorgeril, S. Renaud, P. Salen, I. Monjaud, N. Mamelle, J.L. Martin, J. Guidollet, P. Touboul, and J. Delaye Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease Lancet 343 1994 1454 1459 (Pubitemid 24176333)
8. C.L. de Melo, M.G. Queiroz, S.G. Fonseca, A.M. Bizerra, T.L. Lemos, T.S. Melo, F.A. Santos, and V.S. Rao Oleanolic acid, a natural triterpenoid improves blood glucose tolerance in normal mice and ameliorates visceral obesity in mice fed a high-fat diet Chem. Biol. Interact. 185 2010 59 65
9. P.A. Detmers, M. Hernandez, J. Mudgett, H. Hassing, C. Burton, S. Mundt, S. Chun, D. Fletcher, D.J. Card, J. Lisnock, R. Weikel, J.D. Bergstrom, D.E. Shevell, A. Hermanowski-Vosatka, C.P. Sparrow, Y.S. Chao, D.J. Rader, S.D. Wright, and E. Pure Deficiency in inducible nitric oxide synthase results in reduced atherosclerosis in apolipoprotein E-deficient mice J. Immunol. 165 2000 3430 3435
10. S.N. El, and S. Karakaya Olive tree (Olea europaea) leaves: potential beneficial effects on human health Nutr. Rev. 67 2009 632 638
11. M. Fitó, R. de la Torre, and M.I. Covas Olive oil and oxidative stress Mol. Nutr. Food Res. 51 2007 1215 1224 (Pubitemid 350013169)
12. M. Gervais, S. Pons, A. Nicoletti, C. Cosson, J.F. Giudicelli, and C. Richer Fluvastatin prevents renal dysfunction and vascular NO deficit in apolipoprotein E-deficient mice Arterioscler. Thromb. Vasc. Biol. 23 2003 183 189 (Pubitemid 36231926)
13. C.L. Ha, C.Y. Weng, L. Wang, T.W. Lian, and M.J. Wu Immunomodulatory effect of Glossogyne tenuifolia in murine peritoneal macrophages and splenocytes J. Ethnopharmacol. 107 2006 116 125 (Pubitemid 44038821)
14. R. Hernanz, M.J. Alonso, H. Zibrandtsen, Y. Alvarez, M. Salaices, and U. Simonsen Measurements of nitric oxide concentrations and hyporeactivity in rat superior mesenteric artery exposed to endotoxin Cardiovasc. Res. 62 2004 202 211 (Pubitemid 38326826)
15. K. Husain, E. Suarez, A. Isidro, and L. Ferder Effects of paricalcitol and enalapril on atherosclerotic injury in mouse aortas Am. J. Nephrol. 32 2010 296 304
16. J.K. Ibengwe, and H. Suzuki Changes in mechanical responses of vascular smooth muscles to acetylcholine, noradrenaline and high potassium solution in hypercholesterolemic rabbits Br. J. Pharmacol. 87 1986 395 402 (Pubitemid 17178569)
17. J. Johnson, K. Carson, H. Williams, S. Karanam, A. Newby, G. Angelini, S. George, and C. Jackson Plaque rupture after short periods of fat feeding in the apolipoprotein E-knockout mouse: model characterization and effects of pravastatin treatment Circulation 111 2005 1422 1430 (Pubitemid 40396809)
18. P.J. Kuhlencordt, J. Chen, F. Han, J. Astern, and P.L. Huang Genetic deficiency of inducible nitric oxide synthase reduces atherosclerosis and lowers plasma lipid peroxides in apolipoprotein E-knockout mice Circulation 103 2001 3099 3104 (Pubitemid 32587858)
19. J. Liu Pharmacology of oleanolic acid and ursolic acid J. Ethnopharmacol. 49 1995 57 68 (Pubitemid 26010740)
20. M. Marquez-Martin, R. De La Puerta, A. Fernandez-Arche, V. Ruiz-Gutierrez, and P. Yaqoob Modulation of cytokine secretion by pentacyclic triterpenes from olive pomace oil in human mononuclear cells Cytokine 36 2006 211 217 (Pubitemid 46546652)
21. R.P. Mason, M.F. Walter, and R.F. Jacob Effects of HMG-CoA reductase inhibitors on endothelial function: role of microdomains and oxidative stress Circulation 109 2004 II34 II41
22. L. Estergaard, U. Simonsen, Y. Eskildsen-Helmond, H. Vorum, N. Uldbjerg, B. Honoré, and M.J. Mulvany Proteomics reveals lowering oxygen alters cytoskeletal and endoplasmatic stress proteins in human endothelial cells Proteomics 9 2009 4457 4467
23. J.S. Perona, R. Cabello-Moruno, and V. Ruiz-Gutierrez The role of virgin olive oil components in the modulation of endothelial function J. Nutr. Biochem. 17 2006 429 445 (Pubitemid 43867255)
24. R. Rodriguez-Rodriguez, M.D. Herrera, J.S. Perona, and V. Ruiz-Gutiérrez Potential vasorelaxant effects of oleanolic acid and erythrodiol, two triterpenoids contained in 'orojo' olive oil, on rat aorta Br. J. Nutr. 92 2004 635 642 (Pubitemid 39409557)
25. R. Rodriguez-Rodriguez, M.D. Herrera, M.A. de Sotamayor, and V. Ruiz-Gutierrez Pomace olive oil improves endothelial function in spontaneously hypertensive rats by increasing endothelial nitric oxide synthase expression Am. J. Hypertens. 20 2007 728 734 (Pubitemid 46936165)
26. R. Rodriguez-Rodriguez, E. Stankevicius, M.D. Herrera, L. Estergaard, M.R. Andersen, V. Ruiz-Gutierrez, and U. Simonsen Oleanolic acid induces relaxation and calcium-independent release of endothelium-derived nitric oxide Br. J. Pharmacol. 155 2008 535 546
27. R. Rodriguez-Rodriguez, M.D. Herrera, M.A. de Sotomayor, and V. Ruiz-Gutierrez Effects of pomace olive oil-enriched diets on endothelial function of small mesenteric arteries from spontaneously hypertensive rats Br. J. Nutr. 102 2009 1435 1444
28. M. Rosenblat, N. Volkova, R. Coleman, Y. Almagor, and M. Aviram Antiatherogenicity of extra virgin olive oil and its enrichment with green tea polyphenols in the atherosclerotic apolipoprotein-E-deficient mice: enhanced macrophage cholesterol efflux J. Nutr. Biochem. 19 2008 514 523 (Pubitemid 351952321)
29. U. Simonsen, D. Prieto, M.J. Mulvany, E. Ehrnrooth, N. Korsgaard, and N.C. Nyborg Effect of induced hypercholesterolemia in rabbits on functional responses of isolated large proximal and small distal coronary arteries Arterioscler. Thromb. 12 1992 380 392
30. G.B. Singh, S. Singh, S. Bani, B.D. Gupta, and S.K. Banerjee Anti-inflammatory activity of oleanolic acid in rats and mice J. Pharm. Pharmacol. 44 1992 456 458
31. L.O. Somova, A. Nadar, P. Rammanan, and F.O. Shode Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension Phytomedicine 10 2003 115 121 (Pubitemid 36433204)
32. L.I. Somova, F.O. Shode, P. Ramnanan, and A. Nadar Antihypertensive, antiatherosclerotic and antioxidant activity of triterpenoids isolated from Olea europaea, subspecies africana leaves J. Ethnopharmacol. 84 2003 299 305 (Pubitemid 36329158)
33. C.P. Sparrow, C.A. Burton, M. Hernandez, S. Mundt, H. Hassing, S. Patel, R. Rosa, A. Hermanowski-Vosatka, P.R. Wang, D. Zhang, L. Peterson, P.A. Detmers, Y.S. Chao, and S.D. Wright Simvastatin has anti-inflammatory and antiatherosclerotic activities independent of plasma cholesterol lowering Arterioscler. Thromb. Vasc. Biol. 21 2001 115 121 (Pubitemid 32061935)
34. A. Trichopoulou, T. Costacou, C. Bamia, and D. Trichopoulos Adherence to a Mediterranean diet and survival in a Greek population N. Engl. J. Med. 348 2003 2599 2608 (Pubitemid 36741587)
35. T.J. Verbeuren, E. Bonhomme, M. Laubie, and S. Simonet Evidence for induction of nonendothelial NO synthase in aortas of cholesterol-fed rabbits J. Cardiovasc. Pharmacol. 21 1993 841 845 (Pubitemid 23121886)
36. J.N. Wilcox, R.R. Subramanian, C.L. Sundell, W.R. Tracey, J.S. Pollock, D.G. Harrison, and P.A. Marsden Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels Arterioscler. Thromb. Vasc. Biol. 17 1997 2479 2488 (Pubitemid 28015984)
37. W. Xu, L. Liu, I.G. Charles, and S. Moncada Nitric oxide induces coupling of mitochondrial signalling with the endoplasmatic reticulum stress response Nature Cell Biol. 6 2004 1129 1134 (Pubitemid 39468015)
38. Y. Yun, S. Han, E. Park, D. Yim, S. Lee, C.K. Lee, K. Cho, and K. Kim Immunomodulatory activity of betulinic acid by producing pro-inflammatory cytokines and activation of macrophages Arch. Pharm. Res. 26 2003 1087 1095
39. S.H. Zhang, R.L. Reddick, J.A. Piedrahita, and N. Maeda Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E Science 258 1992 468 471