The p53-p21WAF1 checkpoint pathway plays a protective role in preventing DNA rereplication induced by abrogation of FOXF1 function

Cellular Signalling

Volumn 24, Issue 1, 2012, Pages 316-324

  Lo, Pang Kuo ^a   Lee, Ji Shin ^b   Sukumar, Saraswati ^c  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b Chonnam National University Research Institute of Medical Sciences   (South Korea)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

DNA rereplication; FOXF1; P21WAF1; P53; Tumor suppressor gene

Indexed keywords

ATM PROTEIN; ATR PROTEIN; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1; FOXF1 PROTEIN; PROTEIN P53; RETINOBLASTOMA PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ATR PROTEIN, HUMAN; CDK2 PROTEIN, HUMAN; CDKN1A PROTEIN, HUMAN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; DNA BINDING PROTEIN; FORKHEAD TRANSCRIPTION FACTOR; FOXF1 PROTEIN, HUMAN; PHOSPHOPROTEIN; PROTEIN SERINE THREONINE KINASE; TP53 PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

APOPTOSIS; ARTICLE; BREAST CANCER; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL PROTECTION; COLORECTAL CANCER; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; ENZYME INHIBITION; FOXF1 GENE; GENE FUNCTION; GENE REPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; TUMOR SUPPRESSOR GENE; WILD TYPE; BREAST TUMOR; CELL STRAIN HCT116; CELL TRANSFORMATION; COLORECTAL TUMOR; FEMALE; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; GENE INACTIVATION; GENETICS; GENOMIC INSTABILITY; METABOLISM; PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ATAXIA TELANGIECTASIA;

APOPTOSIS; BREAST NEOPLASMS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; COLORECTAL NEOPLASMS; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA REPLICATION; DNA-BINDING PROTEINS; FEMALE; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; G1 PHASE CELL CYCLE CHECKPOINTS; GENE KNOCKDOWN TECHNIQUES; GENE KNOCKOUT TECHNIQUES; GENOMIC INSTABILITY; HCT116 CELLS; HUMANS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 80755128373     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2011.09.017     Document Type: Article

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