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Volumn 190, Issue , 2002, Pages 53-68

Genetic diversity of the human immunoglobulin heavy chain VH region

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

EID: 0036954986     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-065X.2002.19005.x     Document Type: Review
Times cited : (28)

References (118)
  • 1
    • 0011118362 scopus 로고
    • Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions
    • Hozumi N, Tonegawa S. Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions. Proc Natl Acad Sci USA 1976;73:3628-3632.
    • (1976) Proc Natl Acad Sci USA , vol.73 , pp. 3628-3632
    • Hozumi, N.1    Tonegawa, S.2
  • 2
    • 0017885679 scopus 로고
    • Evidence for non-contiguous variable and constant region genes in both germ line and myeloma DNA
    • Rabbitts TH, Forster A. Evidence for non-contiguous variable and constant region genes in both germ line and myeloma DNA. Cell 1978;13:319-327.
    • (1978) Cell , vol.13 , pp. 319-327
    • Rabbitts, T.H.1    Forster, A.2
  • 3
    • 0018093829 scopus 로고
    • A complete immunoglobulin gene is created by somatic recombination
    • Brack C, Hirama M, Lenhard-Schuller R, Tonegawa S. A complete immunoglobulin gene is created by somatic recombination. Cell 1978;15:1-14.
    • (1978) Cell , vol.15 , pp. 1-14
    • Brack, C.1    Hirama, M.2    Lenhard-Schuller, R.3    Tonegawa, S.4
  • 4
    • 0018137706 scopus 로고
    • DNA clones containing mouse immunoglobulin kappa chain genes isolated by in vitro packaging into phage lambda coats
    • Lenhard-Schuller R, Hohn B, Brack C, Hirama M, Tonegawa S. DNA clones containing mouse immunoglobulin kappa chain genes isolated by in vitro packaging into phage lambda coats. Proc Natl Acad Sci USA 1978;75:4709-4713.
    • (1978) Proc Natl Acad Sci USA , vol.75 , pp. 4709-4713
    • Lenhard-Schuller, R.1    Hohn, B.2    Brack, C.3    Hirama, M.4    Tonegawa, S.5
  • 5
    • 0018251442 scopus 로고
    • Sequences of mouse immunoglobuhn light chain genes before and after somatic changes
    • Bernard O, Hozumi N, Tonegawa S. Sequences of mouse immunoglobuhn light chain genes before and after somatic changes. Cell 1978;15:1133-1144.
    • (1978) Cell , vol.15 , pp. 1133-1144
    • Bernard, O.1    Hozumi, N.2    Tonegawa, S.3
  • 6
    • 0018173128 scopus 로고
    • The arrangement and rearrangement of antibody genes
    • Seidman JG, Leder P. The arrangement and rearrangement of antibody genes. Nature 1978;276:790-795.
    • (1978) Nature , vol.276 , pp. 790-795
    • Seidman, J.G.1    Leder, P.2
  • 7
    • 0018627375 scopus 로고
    • Sequences at the somatic recombination sites of immunoglobulin light-chain genes
    • Sakano H, Huppi K, Heinrich G, Tonegawa S. Sequences at the somatic recombination sites of immunoglobulin light-chain genes. Nature 1979;280:288-294.
    • (1979) Nature , vol.280 , pp. 288-294
    • Sakano, H.1    Huppi, K.2    Heinrich, G.3    Tonegawa, S.4
  • 8
    • 0011088657 scopus 로고
    • Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene
    • Max EE, Seidman JG, Leder P. Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene. Proc Natl Acad Sci USA 1979;76:3450-3454.
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 3450-3454
    • Max, E.E.1    Seidman, J.G.2    Leder, P.3
  • 9
    • 0019455850 scopus 로고
    • Human immunoglobulin kappa light-chain genes are deleted or rearranged in λ-producing B cells
    • Hieter PA, Korsmeyer SJ, Waldmann TA, Leder P. Human immunoglobulin kappa light-chain genes are deleted or rearranged in λ-producing B cells. Nature 1981;290:368-372.
    • (1981) Nature , vol.290 , pp. 368-372
    • Hieter, P.A.1    Korsmeyer, S.J.2    Waldmann, T.A.3    Leder, P.4
  • 10
    • 0020534965 scopus 로고
    • Somatic generation of antibody diversity
    • Tonegawa S. Somatic generation of antibody diversity. Nature 1983;302:575-581.
    • (1983) Nature , vol.302 , pp. 575-581
    • Tonegawa, S.1
  • 11
    • 0022271336 scopus 로고
    • Origin of immune diversity: Genetic variation and selection
    • Honjo T, Habu S. Origin of immune diversity: genetic variation and selection. Annu Rev Biochem 1985;54:803-830.
    • (1985) Annu Rev Biochem , vol.54 , pp. 803-830
    • Honjo, T.1    Habu, S.2
  • 12
    • 0025836948 scopus 로고
    • Site-specific recombination in the immune system
    • Lieber MR. Site-specific recombination in the immune system. FASEB J 1991;5:2934-2944.
    • (1991) FASEB J , vol.5 , pp. 2934-2944
    • Lieber, M.R.1
  • 14
    • 0027087077 scopus 로고
    • Molecular analysis of V(D)J recombination
    • Gellert M. Molecular analysis of V(D)J recombination. Annu Rev Genet 1992;26:425-446.
    • (1992) Annu Rev Genet , vol.26 , pp. 425-446
    • Gellert, M.1
  • 15
    • 0028048275 scopus 로고
    • The mechanism of V(D)J joining: Lessons from molecular, immunological, and comparative analyses
    • Lewis SM. The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses. Adv Immunol 1994;56:27-150.
    • (1994) Adv Immunol , vol.56 , pp. 27-150
    • Lewis, S.M.1
  • 16
    • 0030006070 scopus 로고    scopus 로고
    • Clonal selection and learning in the antibody system
    • Rajewsky K. Clonal selection and learning in the antibody system. Nature 1996;381:751-758.
    • (1996) Nature , vol.381 , pp. 751-758
    • Rajewsky, K.1
  • 17
    • 0024362047 scopus 로고
    • The role of somatic hypermutation in the generation of antibody diversity
    • French DL, Laskov R, Scharff MD. The role of somatic hypermutation in the generation of antibody diversity. Science 1989;244:1152-1157.
    • (1989) Science , vol.244 , pp. 1152-1157
    • French, D.L.1    Laskov, R.2    Scharff, M.D.3
  • 18
    • 0003472822 scopus 로고
    • Chromosomal location of the genes for human immunoglobulin heavy chains
    • Croce CM, et al. Chromosomal location of the genes for human immunoglobulin heavy chains. Proc Natl Acad Sci USA 1979;76:3416-3419.
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 3416-3419
    • Croce, C.M.1
  • 19
    • 0020327819 scopus 로고
    • Genes for immunoglobulin heavy chains and for α1-antitrypsin are localized to specific regions of chromosome 14q
    • Cox DW, Markovic VD, Teshima IE. Genes for immunoglobulin heavy chains and for α1-antitrypsin are localized to specific regions of chromosome 14q. Nature 1982;297:428-430.
    • (1982) Nature , vol.297 , pp. 428-430
    • Cox, D.W.1    Markovic, V.D.2    Teshima, I.E.3
  • 20
    • 0020051390 scopus 로고
    • Human immunoglobulin heavy chain genes map to a region of translocations in malignant B lymphocytes
    • Kirsch IR, Morton CC, Nakahara K, Leder P. Human immunoglobulin heavy chain genes map to a region of translocations in malignant B lymphocytes. Science 1982;216:301-303.
    • (1982) Science , vol.216 , pp. 301-303
    • Kirsch, I.R.1    Morton, C.C.2    Nakahara, K.3    Leder, P.4
  • 21
    • 0025196326 scopus 로고
    • H sequences by in situ hybridization with biotinylated probes
    • H sequences by in situ hybridization with biotinylated probes. Genes Chrom Cancer 1990;2:103-108.
    • (1990) Genes Chrom Cancer , vol.2 , pp. 103-108
    • Cherif, D.1    Berger, R.2
  • 22
    • 0031775443 scopus 로고    scopus 로고
    • The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus
    • Matsuda F, et al. The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. J Exp Med 1998;188:2151-2162.
    • (1998) J Exp Med , vol.188 , pp. 2151-2162
    • Matsuda, F.1
  • 23
    • 0025940703 scopus 로고
    • Physical map of the 3′ region of the human immunoglobulin heavy chain locus: Clustering of autoantibody-related variable segments in one haplotype
    • Shin EK, et al. Physical map of the 3′ region of the human immunoglobulin heavy chain locus: clustering of autoantibody-related variable segments in one haplotype. EMBO J 1991;10:3641-3645.
    • (1991) EMBO J , vol.10 , pp. 3641-3645
    • Shin, E.K.1
  • 24
    • 0027475327 scopus 로고
    • Structure and physical map of 64 variable segments in the 3′ 0.8-megabase region of the human immunoglobulin heavy-chain locus
    • Matsuda F, et al. Structure and physical map of 64 variable segments in the 3′ 0.8-megabase region of the human immunoglobulin heavy-chain locus. Nat Genet 1993;3:88-94.
    • (1993) Nat Genet , vol.3 , pp. 88-94
    • Matsuda, F.1
  • 25
    • 0028235295 scopus 로고
    • H locus completed by analysis of the telomeric region of chromosome 14q
    • H locus completed by analysis of the telomeric region of chromosome 14q. Nat Genet 1994;7:162-168.
    • (1994) Nat Genet , vol.7 , pp. 162-168
    • Cook, G.P.1
  • 29
    • 0032725986 scopus 로고    scopus 로고
    • IMGT locus on focus: Protein displays of the human immunoglobulin heavy, κ and λ variable and joining regions
    • Scaviner D, Barbié V, Ruiz M, Lefranc MP. IMGT locus on focus: protein displays of the human immunoglobulin heavy, κ and λ variable and joining regions. Exp Clin Immunogenet 1999;16:234-240.
    • (1999) Exp Clin Immunogenet , vol.16 , pp. 234-240
    • Scaviner, D.1    Barbié, V.2    Ruiz, M.3    Lefranc, M.P.4
  • 30
    • 0019850678 scopus 로고
    • Human immunoglobulin D segments encoded in tandem multigenic families
    • Siebenlist U, Ravetch JV, Korsmeyer S, Waldmann T, Leder P. Human immunoglobulin D segments encoded in tandem multigenic families. Nature 1981;294:631-635.
    • (1981) Nature , vol.294 , pp. 631-635
    • Siebenlist, U.1    Ravetch, J.V.2    Korsmeyer, S.3    Waldmann, T.4    Leder, P.5
  • 31
    • 0024043549 scopus 로고
    • The use of chromosomal translocations to study human immunoglobulin gene organization: Mapping DH segments within 35 kb of the C mu gene and identification of a new DH locus
    • Buluwela L, Albertson DG, Sherrington P, Rabbitts PH, Spurr N, Rabbitts TH. The use of chromosomal translocations to study human immunoglobulin gene organization: mapping DH segments within 35 kb of the C mu gene and identification of a new DH locus. EMBO J 1988;7:2003-2010.
    • (1988) EMBO J , vol.7 , pp. 2003-2010
    • Buluwela, L.1    Albertson, D.G.2    Sherrington, P.3    Rabbitts, P.H.4    Spurr, N.5    Rabbitts, T.H.6
  • 32
    • 0024293529 scopus 로고
    • Organization of human immunoglobulin heavy chain diversity gene loci
    • Ichihara Y, Matsuoka H, Kurosawa Y. Organization of human immunoglobulin heavy chain diversity gene loci. EMBO J 1988;7:4141-4150.
    • (1988) EMBO J , vol.7 , pp. 4141-4150
    • Ichihara, Y.1    Matsuoka, H.2    Kurosawa, Y.3
  • 33
    • 0031586221 scopus 로고    scopus 로고
    • Sequence of the human immunoglobulin diversity (D) segment locus: A systematic analysis provides no evidence for the use of DIR segments, inverted D segments, 'minor' D segments or D-D recombination
    • Corbett SJ, Tomlinson IM, Sonnhammer ELL, Buck D, Winter G. Sequence of the human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, in verted D segments, 'minor' D segments or D-D recombination. J Mol Biol 1997;270:587-597.
    • (1997) J Mol Biol , vol.270 , pp. 587-597
    • Corbett, S.J.1    Tomlinson, I.M.2    Sonnhammer, E.L.L.3    Buck, D.4    Winter, G.5
  • 34
    • 0033009437 scopus 로고    scopus 로고
    • IMGT Locus on Focus: The human immunoglobulin heavy diversity (IGHD) and joining (IGHJ) segments
    • Ruiz M, Pallarès N, Contet V, Barbiè V, Lefranc MP. IMGT Locus on Focus: The human immunoglobulin heavy diversity (IGHD) and joining (IGHJ) segments. Exp Clin Immunogenet 1999;16:173-184.
    • (1999) Exp Clin Immunogenet , vol.16 , pp. 173-184
    • Ruiz, M.1    Pallarès, N.2    Contet, V.3    Barbiè, V.4    Lefranc, M.P.5
  • 35
    • 0019846077 scopus 로고
    • Structure of the human immunoglobulin mu locus: Characterization of embryonic and rearranged J and D genes
    • Ravetch JV, Siebenlist U, Korsmeyer S, Waldmann T, Leder P. Structure of the human immunoglobulin mu locus: characterization of embryonic and rearranged J and D genes. Cell 1981;27:583-591.
    • (1981) Cell , vol.27 , pp. 583-591
    • Ravetch, J.V.1    Siebenlist, U.2    Korsmeyer, S.3    Waldmann, T.4    Leder, P.5
  • 36
    • 0020382551 scopus 로고
    • Arrangement of human immunoglobulin heavy chain constant region genes implies evolutionary duplication of a segment containing gamma, epsilon and alpha genes
    • Flanagan JG, Rabbitts TH. Arrangement of human immunoglobulin heavy chain constant region genes implies evolutionary duplication of a segment containing gamma, epsilon and alpha genes. Nature 1982;300:709-713.
    • (1982) Nature , vol.300 , pp. 709-713
    • Flanagan, J.G.1    Rabbitts, T.H.2
  • 37
    • 0020454947 scopus 로고
    • Inherited deletion of immunoglobulin heavy chain constant region genes in normal human individuals
    • Lefranc MP, Lefranc G, Rabbitts TH. Inherited deletion of immunoglobulin heavy chain constant region genes in normal human individuals. Nature 1982;300:760-762.
    • (1982) Nature , vol.300 , pp. 760-762
    • Lefranc, M.P.1    Lefranc, G.2    Rabbitts, T.H.3
  • 38
    • 18344409944 scopus 로고
    • Instability of the human immunoglobulin heavy chain constant region locus indicated by different inherited chromosomal deletions
    • Lefranc M, et al. Instability of the human immunoglobulin heavy chain constant region locus indicated by different inherited chromosomal deletions. J Mol Biol Med 1983;1:207-217.
    • (1983) J Mol Biol Med , vol.1 , pp. 207-217
    • Lefranc, M.1
  • 39
    • 0019841554 scopus 로고
    • Human immunoglobulin heavy chain genes, evolutionary comparisons of Cμ, Cδ and Cγ genes and associated switch sequences
    • Rabbitt H, Forste A, Milstei P. Human immunoglobulin heavy chain genes, evolutionary comparisons of Cμ, Cδ and Cγ genes and associated switch sequences. Nucl Acids Res 1981;9:4509-4524.
    • (1981) Nucl Acids Res , vol.9 , pp. 4509-4524
    • Rabbitt, H.1    Forste, A.2    Milstei, P.3
  • 41
    • 0022623585 scopus 로고
    • Sequence of a human immunoglobulin γ 3 heavy chain constant region gene: Comparison with the other human C gamma genes
    • Huck S, Fort P, Crawford DH, Lefranc MP, Lefranc G. Sequence of a human immunoglobulin γ 3 heavy chain constant region gene: comparison with the other human C gamma genes. Nucl Acids Res 1986;14:1779-1789.
    • (1986) Nucl Acids Res , vol.14 , pp. 1779-1789
    • Huck, S.1    Fort, P.2    Crawford, D.H.3    Lefranc, M.P.4    Lefranc, G.5
  • 42
    • 0024434169 scopus 로고
    • A human immunoglobulin IGHG3 allele (Gmb0,b1,c3,c5,u) with an IGHG4 converted region and three hinge exons
    • Huck S, Lefranc G, Lefranc MP. A human immunoglobulin IGHG3 allele (Gmb0,b1,c3,c5,u) with an IGHG4 converted region and three hinge exons. Immunogenetics 1989;30:250-257.
    • (1989) Immunogenetics , vol.30 , pp. 250-257
    • Huck, S.1    Lefranc, G.2    Lefranc, M.P.3
  • 43
    • 0020479274 scopus 로고
    • The nucleotide sequence of a human immunoglobulin Cγ1 gene
    • Ellison JW, Berson BJ, Hood LE. The nucleotide sequence of a human immunoglobulin Cγ1 gene. Nucl Acids Res 1982;10:4071-4079.
    • (1982) Nucl Acids Res , vol.10 , pp. 4071-4079
    • Ellison, J.W.1    Berson, B.J.2    Hood, L.E.3
  • 44
    • 0020317363 scopus 로고
    • Duplication and deletion in the human immunoglobulin ε genes
    • Max EE, Battey J, Ney R, Kirsch IR, Leder P. Duplication and deletion in the human immunoglobulin ε genes. Cell 1982;29:691-699.
    • (1982) Cell , vol.29 , pp. 691-699
    • Max, E.E.1    Battey, J.2    Ney, R.3    Kirsch, I.R.4    Leder, P.5
  • 45
    • 0024284254 scopus 로고
    • The human immunoglobulin pseudo-γ IGHGP gene shows no major structural defect
    • Bensmana M, Huck S, Lefranc G, Lefranc MP. The human immunoglobulin pseudo-γ IGHGP gene shows no major structural defect. Nucl Acids Res 1988;16:3108.
    • (1988) Nucl Acids Res , vol.16 , pp. 3108
    • Bensmana, M.1    Huck, S.2    Lefranc, G.3    Lefranc, M.P.4
  • 46
    • 0019982096 scopus 로고
    • Linkage and sequence homology of two human immunoglobulin γ heavy chain constant region genes
    • Ellison JW, Hood LE. Linkage and sequence homology of two human immunoglobulin γ heavy chain constant region genes. Proc Natl Acad Sci USA 1982;79:1984-1988.
    • (1982) Proc Natl Acad Sci USA , vol.79 , pp. 1984-1988
    • Ellison, J.W.1    Hood, L.E.2
  • 47
    • 0019748856 scopus 로고
    • Nucleotide sequence of a human immunoglobulin Cγ4 gene
    • Ellison JW, Buxbaum J, Hood L. Nucleotide sequence of a human immunoglobulin Cγ4 gene. DNA 1981;1:11-18.
    • (1981) DNA , vol.1 , pp. 11-18
    • Ellison, J.W.1    Buxbaum, J.2    Hood, L.3
  • 48
    • 0020339799 scopus 로고
    • The sequence of a human immunoglobulin ε heavy chain constant region gene, and evidence for three non-allelic genes
    • Flanagan JG, Rabbitts TH. The sequence of a human immunoglobulin ε heavy chain constant region gene, and evidence for three non-allelic genes. EMBO J 1982;1:655-660.
    • (1982) EMBO J , vol.1 , pp. 655-660
    • Flanagan, J.G.1    Rabbitts, T.H.2
  • 49
    • 0020317803 scopus 로고
    • Structure of human immunoglobulin γ genes: Implications for evolution of a gene family
    • Takahashi N, Ueda S, Obata M, Nikaido T, Nakai S, Honjo T. Structure of human immunoglobulin γ genes: implications for evolution of a gene family. Cell 1982;29:671-679.
    • (1982) Cell , vol.29 , pp. 671-679
    • Takahashi, N.1    Ueda, S.2    Obata, M.3    Nikaido, T.4    Nakai, S.5    Honjo, T.6
  • 50
    • 0021247949 scopus 로고
    • Mechanisms of divergence and convergence of the human immunoglobulin α 1 and α 2 constant region gene sequences
    • Flanagan JG, Lefranc MP, Rabbitts TH. Mechanisms of divergence and convergence of the human immunoglobulin α 1 and α 2 constant region gene sequences. Cell 1984;36:681-688.
    • (1984) Cell , vol.36 , pp. 681-688
    • Flanagan, J.G.1    Lefranc, M.P.2    Rabbitts, T.H.3
  • 51
    • 0024670006 scopus 로고
    • Pulsed-field gel analysis of human immunoglobulin heavy-chain constant region gene deletions reveals the extent of unmapped regions within the locus
    • Bottaro A, de Marchi M, Migone N, Carbonara AO. Pulsed-field gel analysis of human immunoglobulin heavy-chain constant region gene deletions reveals the extent of unmapped regions within the locus. Genomics 1989;4:505-508.
    • (1989) Genomics , vol.4 , pp. 505-508
    • Bottaro, A.1    De Marchi, M.2    Migone, N.3    Carbonara, A.O.4
  • 52
    • 0026033192 scopus 로고
    • Sequence of the CH1 and hinge-CH2 exons of the human immunoglobulin IGHA2 A2m (2) allele: Comparison with the nonallelic and allelic IGHA genes
    • Bensmana M, Chuchana P, Lefranc G, Lefranc MP. Sequence of the CH1 and hinge-CH2 exons of the human immunoglobulin IGHA2 A2m (2) allele: comparison with the nonallelic and allelic IGHA genes. Cytogenet Cell Genet 1991;56:128.
    • (1991) Cytogenet Cell Genet , vol.56 , pp. 128
    • Bensmana, M.1    Chuchana, P.2    Lefranc, G.3    Lefranc, M.P.4
  • 53
  • 54
    • 0028100960 scopus 로고
    • Recent translocation of variable and diversity segments of the human immunoglobulin heavy chain from chromosome 14 to chromosomes 15 and 16
    • Nagaoka H, et al. Recent translocation of variable and diversity segments of the human immunoglobulin heavy chain from chromosome 14 to chromosomes 15 and 16. Genomics 1994;22:189-197.
    • (1994) Genomics , vol.22 , pp. 189-197
    • Nagaoka, H.1
  • 55
    • 0023268717 scopus 로고
    • A novel family of variable region genes of the human immunoglobulin heavy chain
    • Lee KH, Matsuda F, Kinashi T, Kodaira M, Honjo T. A novel family of variable region genes of the human immunoglobulin heavy chain. J Mol Biol 1987;195:761-768.
    • (1987) J Mol Biol , vol.195 , pp. 761-768
    • Lee, K.H.1    Matsuda, F.2    Kinashi, T.3    Kodaira, M.4    Honjo, T.5
  • 57
    • 0023976188 scopus 로고
    • H locus
    • H locus. EMBO J 1988;7:727-738.
    • (1988) EMBO J , vol.7 , pp. 727-738
    • Berman, J.E.1
  • 58
    • 0018894548 scopus 로고
    • Contribution of immunoglobulin heavychain variable-region genes to antibody diversity
    • Rabbitts TH, Matthyssens G, Hamlyn PH. Contribution of immunoglobulin heavychain variable-region genes to antibody diversity. Nature 1980;84:238-243.
    • (1980) Nature , vol.84 , pp. 238-243
    • Rabbitts, T.H.1    Matthyssens, G.2    Hamlyn, P.H.3
  • 61
    • 0024165482 scopus 로고
    • H gene is located within 95 Kb of the human immunoglobulin heavy chain constant region genes
    • H gene is located within 95 Kb of the human immunoglobulin heavy chain constant region genes. Eur J Immunol 1988;18:1843-1845.
    • (1988) Eur J Immunol , vol.18 , pp. 1843-1845
    • Buluwela, L.1    Rabbitts, T.H.2
  • 64
    • 0026592314 scopus 로고
    • H clan and family identity predicts variable domain structure and may influence antigen binding
    • H clan and family identity predicts variable domain structure and may influence antigen binding. EMBO J 1992;11:603-609.
    • (1992) EMBO J , vol.11 , pp. 603-609
    • Kirkham, P.M.1    Mortari, F.2    Newton, J.A.3    Schroeder H.W., Jr.4
  • 67
    • 0021129784 scopus 로고
    • The immunoglobulin heavy chain variable region (IgH-V. locus in the mouse. I. One hundred IgH-V genes comprise seven families of homologous genes
    • Brodeur PH, Riblet R. The immunoglobulin heavy chain variable region (IgH-V. locus in the mouse. I. One hundred IgH-V genes comprise seven families of homologous genes. Eur J Immunol 1984;14:922-930.
    • (1984) Eur J Immunol , vol.14 , pp. 922-930
    • Brodeur, P.H.1    Riblet, R.2
  • 68
    • 0022773519 scopus 로고
    • H replacement during pre-B differentiation: Non-random usage of gene segments
    • H replacement during pre-B differentiation: non-random usage of gene segments. EMBO J 1986;5:2131-2138.
    • (1986) EMBO J , vol.5 , pp. 2131-2138
    • Reth, M.G.1    Jackson, S.2    Alt, F.W.3
  • 70
    • 0023162439 scopus 로고
    • H region genes of the mouse are organized in overlapping clusters
    • H region genes of the mouse are organized in overlapping clusters. Eur J Immunol 1987;17:1351-1357.
    • (1987) Eur J Immunol , vol.17 , pp. 1351-1357
    • Blankenstein, T.1    Krawinkel, U.2
  • 71
    • 0022450491 scopus 로고
    • Organization and evolution of variable region genes of the human immunoglobulin heavy chain
    • Kodaira M, et al. Organization and evolution of variable region genes of the human immunoglobulin heavy chain. J Mol Biol 1986;190:529-541.
    • (1986) J Mol Biol , vol.190 , pp. 529-541
    • Kodaira, M.1
  • 72
    • 0025184433 scopus 로고
    • The physical organization of the human immunoglobulin heavy chain gene complex
    • Walter MA, Surti U, Hofker MH, Cox DW. The physical organization of the human immunoglobulin heavy chain gene complex. EMBO J 1990;9:3303-3313.
    • (1990) EMBO J , vol.9 , pp. 3303-3313
    • Walter, M.A.1    Surti, U.2    Hofker, M.H.3    Cox, D.W.4
  • 73
    • 0035024972 scopus 로고    scopus 로고
    • Nomenclature of the human immunoglobulin heavy (IGH) genes
    • Lefranc MP. Nomenclature of the human immunoglobulin heavy (IGH) genes. Exp Clin Immunogenet 2001;18:100-116.
    • (2001) Exp Clin Immunogenet , vol.18 , pp. 100-116
    • Lefranc, M.P.1
  • 74
    • 0023988952 scopus 로고
    • Dispersed localization of D segments in the human immunoglobulin heavy-chain locus
    • Matsuda F, et al. Dispersed localization of D segments in the human immunoglobulin heavy-chain locus. EMBO J 1988;7:1047-1051.
    • (1988) EMBO J , vol.7 , pp. 1047-1051
    • Matsuda, F.1
  • 75
    • 0026540473 scopus 로고
    • H4) using deletional analysis and pulsed field gel electrophoresis
    • H4) using deletional analysis and pulsed field gel electrophoresis. J Immunol 1992;148:2923-2931.
    • (1992) J Immunol , vol.148 , pp. 2923-2931
    • Van Dijk, K.W.1    Milner, L.A.2    Milner, E.C.3
  • 77
    • 0032167853 scopus 로고    scopus 로고
    • Determination of gene organization in individual haplotypes by analyzing single DNA fragments from individual spermatozoa
    • Cui X, Li H. Determination of gene organization in individual haplotypes by analyzing single DNA fragments from individual spermatozoa. Proc Natl Acad Sci USA 1998;95:10791-10796.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 10791-10796
    • Cui, X.1    Li, H.2
  • 78
    • 0344212391 scopus 로고
    • Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region
    • Matthyssens G, Rabbitts TH. Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region. Proc Natl Acad Sci USA 1980;77:6561-6565.
    • (1980) Proc Natl Acad Sci USA , vol.77 , pp. 6561-6565
    • Matthyssens, G.1    Rabbitts, T.H.2
  • 86
    • 0025942731 scopus 로고
    • Nonuniform linkage disequilibrium within a 1,500-kb region of the human immunoglobulin heavy-chain complex
    • Walter MA, Cox DW. Nonuniform linkage disequilibrium within a 1,500-kb region of the human immunoglobulin heavy-chain complex. Am J Hum Genet 1991;49:917-931.
    • (1991) Am J Hum Genet , vol.49 , pp. 917-931
    • Walter, M.A.1    Cox, D.W.2
  • 87
    • 0025195883 scopus 로고
    • H genes detected with oligonucleotide probes from the complementarity-determining regions
    • H genes detected with oligonucleotide probes from the complementarity-determining regions. J Immunol 1990;145:1934-1945.
    • (1990) J Immunol , vol.145 , pp. 1934-1945
    • Guillaume, T.1
  • 91
    • 0030861903 scopus 로고    scopus 로고
    • The use of a genetic map of biallelic markers in linkage studies
    • Kruglyak L. The use of a genetic map of biallelic markers in linkage studies. Nat Genet 1997;17:21-24.
    • (1997) Nat Genet , vol.17 , pp. 21-24
    • Kruglyak, L.1
  • 92
    • 0031834225 scopus 로고    scopus 로고
    • It's raining SNPs, hallelujah?
    • Chakravarti A. It's raining SNPs, hallelujah? Nat Genet 1998;19:216-217.
    • (1998) Nat Genet , vol.19 , pp. 216-217
    • Chakravarti, A.1
  • 93
    • 17344364213 scopus 로고    scopus 로고
    • DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene
    • Nickerson DA, et al. DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene. Nat Genet 1998;19:233-240.
    • (1998) Nat Genet , vol.19 , pp. 233-240
    • Nickerson, D.A.1
  • 94
    • 0032991552 scopus 로고    scopus 로고
    • Characterization of singlenucleotide polymorphisms in coding regions of human genes
    • Cargill M, et al. Characterization of singlenucleotide polymorphisms in coding regions of human genes. Nat Genet 1999;22:231-238.
    • (1999) Nat Genet , vol.22 , pp. 231-238
    • Cargill, M.1
  • 95
    • 0032990407 scopus 로고    scopus 로고
    • Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis
    • Halushka MK, et al. Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nat Genet 1999;22:239-247.
    • (1999) Nat Genet , vol.22 , pp. 239-247
    • Halushka, M.K.1
  • 96
    • 0012487923 scopus 로고    scopus 로고
    • Direct detection of insertion/deletion polymorphism in an autosomal region by analyzing individual haplotypes in spermatoza with high-density markers
    • in press
    • Pramanik S, Li H. Direct detection of insertion/deletion polymorphism in an autosomal region by analyzing individual haplotypes in spermatoza with high-density markers. Am J Hum Genet, in press.
    • Am J Hum Genet
    • Pramanik, S.1    Li, H.2
  • 98
    • 0025186353 scopus 로고
    • Possible deletion of a developmentally regulated heavy-chain variable region gene in autoimmune diseases
    • Yang PM, et al. Possible deletion of a developmentally regulated heavy-chain variable region gene in autoimmune diseases. Proc Natl Acad Sci USA 1990;87:7907-7911.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 7907-7911
    • Yang, P.M.1
  • 105
    • 0033621672 scopus 로고    scopus 로고
    • H4 sequences resolved by population-based analysis after enzymatic amplification and denaturing gradient gel electrophoresis
    • H4 sequences resolved by population-based analysis after enzymatic amplification and denaturing gradient gel electrophoresis. Eur J Immunogenet 2000;27:37-46.
    • (2000) Eur J Immunogenet , vol.27 , pp. 37-46
    • Cui, X.1    Li, H.2
  • 106
    • 0030872569 scopus 로고    scopus 로고
    • H4 sequences by analyzing single spermatozoa
    • H4 sequences by analyzing single spermatozoa. Hum Genet 1997;100:96-100.
    • (1997) Hum Genet , vol.100 , pp. 96-100
    • Cui, X.1    Li, H.2
  • 107
    • 0019050871 scopus 로고
    • Separation of random fragments of DNA according to properties of their sequences
    • Fischer SG, Lerman LS. Separation of random fragments of DNA according to properties of their sequences. Proc Natl Acad Sci USA 1980;77:4420-4424.
    • (1980) Proc Natl Acad Sci USA , vol.77 , pp. 4420-4424
    • Fischer, S.G.1    Lerman, L.S.2
  • 108
    • 0001430252 scopus 로고
    • DNA fragments differing by single base-pair substitutions are separated in denaturing gradient gels: Correspondence with melting theory
    • Fischer SG, Lerman LS. DNA fragments differing by single base-pair substitutions are separated in denaturing gradient gels: correspondence with melting theory. Proc Natl Acad Sci USA 1983;80:1579-1583.
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 1579-1583
    • Fischer, S.G.1    Lerman, L.S.2
  • 109
    • 0022422690 scopus 로고
    • Modification of the melting properties of duplex DNA by attachment of a GC-rich DNA sequence as determined by denaturing gradient gel electrophoresis
    • Myers RM, Fischer SG, Maniatis T, Lerman LS. Modification of the melting properties of duplex DNA by attachment of a GC-rich DNA sequence as determined by denaturing gradient gel electrophoresis. Nucl Acids Res 1985;13:3111-3129.
    • (1985) Nucl Acids Res , vol.13 , pp. 3111-3129
    • Myers, R.M.1    Fischer, S.G.2    Maniatis, T.3    Lerman, L.S.4
  • 110
    • 0022422655 scopus 로고
    • Nearly all single base substitutions in DNA fragments joined to a GC-clamp can be detected by denaturing gradient gel electrophoresis
    • Myers RM, Fischer SG, Lerman LS, Maniatis T. Nearly all single base substitutions in DNA fragments joined to a GC-clamp can be detected by denaturing gradient gel electrophoresis. Nucl Acids Res 1985;13:3131-3145.
    • (1985) Nucl Acids Res , vol.13 , pp. 3131-3145
    • Myers, R.M.1    Fischer, S.G.2    Lerman, L.S.3    Maniatis, T.4
  • 111
    • 0000023099 scopus 로고
    • Attachment of a 40-base-pair G + C-rich sequence (GC-clamp) to genomic DNA fragments by the polymerase chain reacnon results in improved detection of single-base changes
    • Sheffield VC, Cox DR, Lerman LS, Myers RM. Attachment of a 40-base-pair G + C-rich sequence (GC-clamp) to genomic DNA fragments by the polymerase chain reacnon results in improved detection of single-base changes. Proc Natl Acad Sci USA 1989;86:232-236.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 232-236
    • Sheffield, V.C.1    Cox, D.R.2    Lerman, L.S.3    Myers, R.M.4
  • 112
    • 0030002989 scopus 로고    scopus 로고
    • Multiplex genotype determination at a large number of gene loci
    • Lin Z, Cui X, Li H. Multiplex genotype determination at a large number of gene loci. Proc Natl Acad Sci USA 1996;93:2582-2587.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2582-2587
    • Lin, Z.1    Cui, X.2    Li, H.3
  • 113
    • 0034139460 scopus 로고    scopus 로고
    • Multiplexgenotype analysis of invasive carcinomaand accompanying proliferative lesions microdissected from breast tissue
    • Cui X, Feiner H, Lin Z, Li H. Multiplexgenotype analysis of invasive carcinomaand accompanying proliferative lesions microdissected from breast tissue. J Mol Diagn 2000;2:29-36.
    • (2000) J Mol Diagn , vol.2 , pp. 29-36
    • Cui, X.1    Feiner, H.2    Lin, Z.3    Li, H.4
  • 114
    • 0036667668 scopus 로고    scopus 로고
    • Multiplex loss of heterozygosity analysis by using single or very few cells
    • Cui X, Feiner H, Li H. Multiplex loss of heterozygosity analysis by using single or very few cells. J Mol Diagn 2002;4:172-177.
    • (2002) J Mol Diagn , vol.4 , pp. 172-177
    • Cui, X.1    Feiner, H.2    Li, H.3
  • 115
    • 0025762748 scopus 로고
    • Susceptibility to multiple sclerosis is associated with the proximal immunoglobulin heavy chain variable region
    • Walter MA, Gibson WT, Ebers GC, Cox DW. Susceptibility to multiple sclerosis is associated with the proximal immunoglobulin heavy chain variable region. J Clin Invest 1991;87:1266-1273.
    • (1991) J Clin Invest , vol.87 , pp. 1266-1273
    • Walter, M.A.1    Gibson, W.T.2    Ebers, G.C.3    Cox, D.W.4
  • 116
    • 0028808578 scopus 로고
    • Susceptibility to multiple sclerosis and the immunoglobulin heavy chain variable region
    • Wood NW, et al. Susceptibility to multiple sclerosis and the immunoglobulin heavy chain variable region. J Neurol 1995;242:677-682.
    • (1995) J Neurol , vol.242 , pp. 677-682
    • Wood, N.W.1
  • 117
    • 0029791677 scopus 로고    scopus 로고
    • The immunoglobulin heavy-chain variable region in insulin-dependent diabetes mellitus. Affected-sib-pair analysis and association studies
    • Veijola R, Knip M, Puukka R, Reijonen H, Cox DW, Ilonen J. The immunoglobulin heavy-chain variable region in insulin-dependent diabetes mellitus. affected-sib-pair analysis and association studies. Am J Hum Genet 1996;59:462-470.
    • (1996) Am J Hum Genet , vol.59 , pp. 462-470
    • Veijola, R.1    Knip, M.2    Puukka, R.3    Reijonen, H.4    Cox, D.W.5    Ilonen, J.6
  • 118
    • 0036100801 scopus 로고    scopus 로고
    • H gene V1-69 affects susceptibility to rheumatoid arthritis in subjects lacking the HLA-DRB1 shared epitope
    • H gene V1-69 affects susceptibility to rheumatoid arthritis in subjects lacking the HLA-DRB1 shared epitope. Rheumatology (Oxford) 2002;41:401-410.
    • (2002) Rheumatology (Oxford) , vol.41 , pp. 401-410
    • Vencovsky, J.1


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