The tumor suppressor adenomatous polyposis coli controls the direction in which a cell extrudes from an epithelium

Molecular Biology of the Cell

Volumn 22, Issue 21, 2011, Pages 3962-3970

  Marshall, Thomas W ^a   Lloyd, Isaac E ^a   Delalande, Jean Marie ^a,c   Näthke, Inke ^a   Rosenblatt, Jody ^b  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; APC PROTEIN; NOCODAZOLE; PACLITAXEL;

ANIMAL CELL; ANIMAL CELL CULTURE; APOPTOSIS; ARTICLE; CELL DEATH; CELL EXTRUSION; CELL FUNCTION; COLORECTAL CARCINOMA; CONTROLLED STUDY; EPITHELIUM; GENE MUTATION; HUMAN; HUMAN CELL; MICROTUBULE; MONOLAYER CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; WILD TYPE; ZEBRA FISH;

ACTINS; ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; CELL DEATH; CELL LINE; EPIDERMIS; EPITHELIAL CELLS; GENE KNOCKDOWN TECHNIQUES; HUMANS; MICROSCOPY, CONFOCAL; MICROTUBULES; ONCOGENE PROTEINS; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECOMBINANT PROTEINS; RESPIRATORY MUCOSA; RNA INTERFERENCE; SINGLE-CELL ANALYSIS; TUBULIN; ZEBRAFISH;

DANIO RERIO;

EID: 80655128124     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E11-05-0469     Document Type: Article

References (25)

1. Aoki K, Taketo MM (2007). Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene. J Cell Sci 120, 3327-3336.
2. Bienz M, Clevers H (2000). Linking colorectal cancer to Wnt signaling. Cell 103, 311-320.
3. Cai L, Marshall TW, Uetrecht AC, Schafer DA, Bear JE (2007). Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge. Cell 128, 915-929. (Pubitemid 46341411)
4. Cozens AL, Yezzi MJ, Kunzelmann K, Ohrui T, Chin L, Eng K, Finkbeiner WE, Widdicombe JH, Gruenert DC (1994). CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells. Am J Respir Cell Mol Biol 10, 38-47.
5. Dikovskaya D, Schiffmann D, Newton IP, Oakley A, Kroboth K, Sansom O, Jamieson TJ, Meniel V, Clarke A, Näthke IS (2007). Loss of APC induced polyploidy as a result of a combination of defects in mitosis and apoptosis. J Cell Biol 176, 183-195. (Pubitemid 46143259)
6. Fodde R et al. (2001). Mutations in the APC tumour suppressor gene cause chromosomal instability. Nat Cell Biol 3, 433-438. (Pubitemid 32288454)
7. Gibson CM, Perrimon N (2005). Extrusion and death of DPP/BMP-compromised epithelial cells in the developing Drosophila wing. Science 307, 1785-1789.
8. Gu Y, Forostyan T, Sabbadini R, Rosenblatt J (2011). Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway. J Cell Biol 193, 667-676.
9. Hanahan D, Weinberg RA (2011). Hallmarks of cancer: the next generation. Cell 144, 646-674.
10. Hartenstein V, Younossi-Hartenstein A, Lekven A (1994). Delamination and division in the Drosophila neurectoderm: spatiotemporal pattern, cytoskeletal dynamics, and common control by neurogenic and segment polarity genes. Dev Biol 165, 480-499. (Pubitemid 24359812)
11. Hurlstone AF, Haramis AP, Wienholds E, Begthel H, Korving J, Van Eeden F, Cuppen E, Zivkovic D, Plasterk RH, Clevers H (2003). The Wnt/beta-catenin pathway regulates cardiac valve formation. Nature 425, 633-637. (Pubitemid 37280148)
12. Kroboth K, Newton IP, Kita K, Dikovskaya D, Zumbrunn J, Waterman-Storer CM, Näthke IS (2007). Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability. Mol Biol Cell 18, 910-918. (Pubitemid 46399496)
13. McCartney BM, Näthke IS (2008). Cell regulation by the APC protein. Curr Opin Cell Biol 20, 186.
14. Monks J, Smith-Steinhart C, Kruk ER, Fadok VA, Henson PM (2008). Epithelial cells remove apoptotic epithelial cells during postlactation involution of the mouse mammary gland. Biol Reprod 78, 586-594. (Pubitemid 351469341)
15. Moseley JB, Bartolini F, Okada K, Wen Y, Gundersen GG, Goode BL (2007). Regulated binding of adenomatous polyposis coli protein to actin. J Biol Chem 282, 12661-12668. (Pubitemid 47100645)
16. Näthke IS (2004). APC at a glance. J Cell Sci 117, 4873-4876.
17. Näthke IS, Adams CL, Polakis P, Sellin JH, Nelson WJ (1996). The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration. J Cell Biol 134, 165-179. (Pubitemid 26231528)
18. Okada K, Bartolini F, Deaconescu AM, Moseley JB, Dogic Z, Grigorieff N, Gundersen GG, Goode BL (2010). Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1. J Cell Biol 189, 1087-1096.
19. Phelps RA, Chidester S, Dehghanizadeh S, Phelps J, Sandoval IT, Rai K, Broadbent T, Sarkar S, Burt RW, Jones DA (2009). A two-step model for colon adenoma initiation and progression caused by APC loss. Cell 137, 623.
20. Reinacher-Schick A, Gumbiner BM (2001). Apical membrane localization of the adenomatous polyposis coli tumor suppressor protein and subcellular distribution of the beta-catenin destruction complex in polarized epithelial cells. J Cell Biol 152, 491-502. (Pubitemid 34280233)
21. Rosenblatt J, Raff MC, Cramer LP (2001). An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanism. Curr Biol 11, 1847-1857. (Pubitemid 33136524)
22. Shen J, Dahmann C (2005). Extrusion of cells with inappropriate Dpp signaling from Drosophila wing disc epithelia. Science 307, 1789-1790. (Pubitemid 40388622)
23. Slattum G, McGee KM, Rosenblatt J (2009). P115 RhoGEF and microtubules decide the direction apoptotic cells extrude from an epithelium. J Cell Biol 186, 693-702.
24. Westerfield M (1993). The Zebrafish: A Guide for the Laboratory Use of Zebrafish (Brachydanio reriro), Eugene, OR: Institute of Neuroscience, University of Oregon.
25. Zumbrunn J, Kinoshita K, Hyman AA, Näthke IS (2001). Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation. Curr Biol 11, 44-49. (Pubitemid 32062715)