Synthesis and in vitro evaluation of analogues of avocado-produced toxin (+)-(R)-persin in human breast cancer cells

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 23, 2011, Pages 7033-7043

  Brooke, Darby G ^a   Shelley, Elizabeth J ^b   Roberts, Caroline G ^b   Denny, William A ^a   Sutherland, Robert L ^b,c   Butt, Alison J ^b,c  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Hydroxyketone; Anti cancer agent; Avocado; Breast cancer; Estrogen receptor; Persin

Indexed keywords

1,2 DIHYDROXY 3,3 DIMETHYLHENICOS 4 ONE; 2 HYDROXY 3,3 DIMETHYL 4 OXOHENICOSYL ACETATE; 2 HYDROXY 4 OXODECYL ACETATE; 2 HYDROXY 4 OXOHENICOSA 12,15 DIEN 1 YL 4 BROMOBENZOATE; 2 HYDROXY 4 OXOHENICOSA 12,15 DIEN 1 YL ACETATE PERSIN; 2 HYDROXY 4 OXOHENICOSA 12,15 DIEN 1 YL BENZOATE; 2 HYDROXY 4 OXOHENICOSA 12,15 DIEN 1 YL ISONICOTINATE; 2 HYDROXY 4 OXOHENICOSYL ACETATE TETRAHYDROPERSIN; 2 METHYL 2 (OXIRAN 2 YL)ICOSAN 3 ONE; 3,3 DIMETHYLHENICOS 1 EN 4 OL; 3,3 DIMETHYLHENICOS 1 EN 4 ONE; 4 OXOHENICOSA 12,15 DIENE 1,2 DIYL BIS (4 BROMOBENZOATE); 4 OXOHENICOSA 12,15 DIENE 1,2 DIYL BIS (4 NITROBENZOATE); 4 OXOHENICOSA 12,15 DIENE 1,2 DIYL DIBENZOATE; 4 OXOHENICOSA 2,12,15 TRIEN 1 YL 4 NITRO BENZOATE; 4 PYRIDINYL DERIVATIVE; ACETOXYACETALDEHYDE; ALPHA DIMETHYLTETRAHYDROPERSIN; ANTINEOPLASTIC AGENT; NATURAL PRODUCT; PERSIN; TETRAHYDROPERSIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AVOCADO; BREAST CANCER; CANCER CELL; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; PHYTOCHEMISTRY; TUMOR CELL DESTRUCTION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BREAST NEOPLASMS; CELL LINE, TUMOR; FATTY ALCOHOLS; FEMALE; HUMANS; PERSEA; PLANT EXTRACTS; STRUCTURE-ACTIVITY RELATIONSHIP;

PERSEA AMERICANA;

EID: 80655123134     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.10.006     Document Type: Article

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