Human homolog of Drosophila tumor suppressor Scribble negatively regulates cell-cycle progression from G1 to S phase by localizing at the basolateral membrane in epithelial cells

Cancer Science

Volumn 97, Issue 11, 2006, Pages 1217-1225

  Nagasaka, Kazunori ^a   Nakagawa, Shunsuke ^a   Yano, Tetsu ^a   Takizawa, Shin ^a   Matsumoto, Yoko ^a   Tsuruga, Tetsushi ^a   Nakagawa, Keiichi ^a   Minaguchi, Takeo ^a   Oda, Katsutoshi ^a   Hiraike Wada, Osamu ^a   Ooishi, Hajime ^a   Yasugi, Toshiharu ^a   Taketani, Yuji ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; CYCLIN A; CYCLIN D1; DROSOPHILA PROTEIN; LEUCINE; PROTEIN SCRIBBLE; SMALL INTERFERING RNA; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BASOLATERAL MEMBRANE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL GROWTH; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; BLOTTING, WESTERN; CELL MEMBRANE; CELL PROLIFERATION; COLONY-FORMING UNITS ASSAY; DROSOPHILA MELANOGASTER; EPITHELIAL CELLS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; G1 PHASE; GENES, TUMOR SUPPRESSOR; GREEN FLUORESCENT PROTEINS; HUMANS; MEMBRANE PROTEINS; MICE; NIH 3T3 CELLS; RECOMBINANT FUSION PROTEINS; RNA, SMALL INTERFERING; S PHASE; TUMOR SUPPRESSOR PROTEINS;

EID: 33748933901     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2006.00315.x     Document Type: Article

References (29)

1. Bilder D. Epithelial polarity and proliferation control: Links from the Drosophila neoplastic tumor suppressors. Genes Dev 2004; 18: 1909-25.
2. Bissell MJ, Radisky D. Putting tumours in context. Nat Rev Cancer 2001; 1: 46-54.
3. Greaves S. Growth and polarity: The case for scribble. Nat Cell Biol 2000; 2: E140.
4. Muller HA, Bossinger O. Molecular networks controlling epithelial cell polarity in development. Mech Dev 2003; 120: 1231-56.
5. Bilder D, Perrimon N. Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature 2000; 403: 676-80.
6. Bilder D, Li M, Perrimon N. Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science 2000; 289: 113-6.
7. Brumby A, Secombe J, Horsfield J et al. A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in Drosophila. Genetics 2004; 168: 227-51.
8. Nakagawa S, Huibregtse JM. Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase. Mol Cell Biol 2000; 20: 8244-53.
9. Kiyono T, Hiraiwa A, Fujita M, Hayashi Y, Akiyama T, Ishibashi M. Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein. Proc Natl Acad Sci USA 1997; 94: 11612-6.
10. Matsumine A, Ogai A, Senda T et al. Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. Science 1996; 272: 1020-3.
11. Nakagawa S, Yano T, Nakagawa K et al. Analysis of the expression and localisation of a LAP protein, human scribble, in the normal and neoplastic epithelium of uterine cervix. Br J Cancer 2004; 90: 194-9.
12. Bilder D, Birnbaum D, Borg JP et al. Collective nomenclature for LAP proteins. Nat Cell Biol 2000; 2: E114.
13. Borg JP, Marchetto S, Le Bivic A et al. ERBIN: A basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor. Nat Cell Biol 2000; 2: 407-14.
14. Bryant PJ, Huwe A. LAP proteins: What's up with epithelia? Nat Cell Biol 2000; 2: E141-3.
15. Audebert S, Navarro C, Nourry C et al. Mammalian Scribble forms a tight complex with the betaPIX exchange factor. Curr Biol 2004; 14: 987-95.
16. Jaulin-Bastard F, Saito H, Le Bivic A et al. The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins. J Biol Chem 2001; 276: 15256-63.
17. Laprise P, Viel A, Rivard N. Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells. J Biol Chem 2004; 279: 10157-66.
18. Takizawa S, Nagasaka K, Nakagawa S et al. Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli. Genes Cells 2006; 11: 453-64.
19. Bilder D, Schober M, Perrimon N. Integrated activity of PDZ protein complexes regulates epithelial polarity. Nat Cell Biol 2003; 5: 53-8.
20. Ekholm SV, Reed SI. Regulation of G (1) cyclin-dependent kinases in the mammalian cell cycle. Curr Opin Cell Biol 2000; 12: 676-84.
21. Sherr CJ, Roberts JM. CDK inhibitors: Positive and negative regulators of G1-phase progression. Genes Dev 1999; 13: 1501-12.
22. Dow LE, Brumby AM, Muratore R et al. hScrib is a functional homologue of the Drosophila tumour suppressor Scribble. Oncogene 2003; 22: 9225-30.
23. Morais Cabral JH, Petosa C, Sutcliffe MJ et al. Crystal structure of a PDZ domain. Nature 1996; 382: 649-52.
24. Heinen CD, Goss KH, Cornelius JR et al. The APC tumor suppressor controls entry into S-phase through its ability to regulate the cyclin D/ RB pathway. Gastroenterology 2002; 123: 751-63.
25. Kobe B, Deisenhofer J. A structural basis of the interactions between leucine-rich repeats and protein ligands. Nature 1995; 374: 183-6.
26. Legouis R, Jaulin-Bastard F, Schott S, Navarro C, Borg JP, Labouesse M. Basolateral targeting by leucine-rich repeat domains in epithelial cells. EMBO Rep 2003; 4: 1096-102.
27. Albertson R, Chabu C, Sheehan A, Doe CQ. Scribble protein domain mapping reveals a multistep localization mechanism and domains necessary for establishing cortical polarity. J Cell Sci 2004; 117: 6061-70.
28. Zeitler J, Hsu CP, Dionne H, Bilder D. Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor Scribble. J Cell Biol 2004; 167: 1137-46.
29. Ishidate T, Matsumine A, Toyoshima K, Akiyama T. The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase. Oncogene 2000; 19: 365-72.