NOX2 activated by α 1-adrenoceptors modulates hepatic metabolic routes stimulated by β-adrenoceptors

Free Radical Research

Volumn 45, Issue 11-12, 2011, Pages 1366-1378

  Diaz Cruz, Antonio ^a   Vilchis Landeros, Maria Magdalena ^b   Guinzberg, Raquel ^b   Villalobos Molina, Rafael ^a   Piña, Enrique ^b  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

Adrenaline; Gluconeogenesis; H 2O 2; NADPH oxidase; Ureagenesis

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLYCOPROTEIN GP 91; GUANOSINE TRIPHOSPHATE; HYDROGEN PEROXIDE; PROTEIN P22; PROTEIN P40; PROTEIN P47; PROTEIN P67; RAC1 PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2;

ARTICLE; GLUCONEOGENESIS; LIVER CELL; LIVER CELL MEMBRANE; MALE; METABOLISM; NONHUMAN; PROTEIN FUNCTION; RAT; UREA CYCLE;

ADRENERGIC ALPHA-1 RECEPTOR AGONISTS; ANIMALS; AQUAPORINS; CELL MEMBRANE; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GLUCONEOGENESIS; GUANOSINE TRIPHOSPHATE; HEPATOCYTES; HYDROGEN PEROXIDE; LIVER; MALE; MEMBRANE GLYCOPROTEINS; METABOLIC NETWORKS AND PATHWAYS; MULTIPROTEIN COMPLEXES; NADP; NADPH OXIDASE; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, ADRENERGIC, BETA-1; UREA;

EID: 80555144296     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715762.2011.627920     Document Type: Article

References (58)

1. Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev 1979;59:527-605. (Pubitemid 9236599)
2. Bayne AC, Mockett RJ, Orr WC, Sohal RS. Enhanced catabolism of mitochondrial superoxide/hydrogen peroxide and aging in transgenic Drosophila. Biochem J 2005;391:277-284. (Pubitemid 41532424)
3. Giorgio M, Trinei M, Migliaccio E, Pelicci PG. Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals? Nat Rev Mol Cell Biol 2007;8:722-728. (Pubitemid 47312827)
4. Trinei M, Giorgio M, Cicalese A, Barozzi S, Ventura A, Migliaccio E, et al. A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis. Oncogene 2002; 21: 3872-3878. (Pubitemid 34620855)
5. Pinton P, Rimessi A, Marchi S, Orsini F, Migliaccio E, Giorgio M, et al. Protein kinase C βand prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66 Shc . Science 2007;315:659-663. (Pubitemid 46214712)
6. Giorgio M, Migliaccio E, Orsini F, Paolucci D, Moroni M, Contursi C, et al. Electron transfer between cytochrome c and p66 Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell 2005;122:221-233. (Pubitemid 41032986)
7. Bedard K, Krause KH. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 2007;87:245-313. (Pubitemid 46209993)
8. Brown DI, Griendling KK. Nox proteins in signal transduction. Free Radic Biol Med 2009;47:1239-1253.
9. Babior BM, Lambeth JD, Nauseef W. The neutrophil NADPH oxidase. Arch Biochem Biophys 2002;397:342-344. (Pubitemid 34852301)
10. Groemping Y, Rittinger K. Activation and assembly of the NADPH oxidase: a structural perspective. Biochem J 2005;386:401-416. (Pubitemid 40445864)
11. Fisher AB. Redox signaling across cell membranes. Antioxid Redox Signal 2009;11:1349-1356.
12. Winterbourn CC, Metodiewa D. Reactivity of biologically important thiol compounds with superoxide and hydrogen peroxide. Free Radic Biol Med 1999;27:322-328. (Pubitemid 29395424)
13. Zentella de Piñ a MZ, Vazquez-Meza H, Pardo JP, Rendon JL, Villalobos-Molina R, Riveros-Rosas H, Pi ñ a E. Signaling the signal, cyclic AMP-dependent protein kinase inhibition by insulin-formed H 2 O 2 and reactivation by thioredoxin. J Biol Chem 2008;283:12373-12386.
14. Stone JR, Yang S. Hydrogen peroxide: a signaling messenger. Antioxid Redox Signal 2006;8:243-270. (Pubitemid 43741296)
15. Passos JF, Von Zglinicki T. Oxygen free radicals in cell senescence: are they signal transducers? Free Radic Res 2006; 40:1277-1283. (Pubitemid 44698277)
16. Guichard C, Moreau R, Pessayre D, Epperson TK, Krause KH. NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes? Biochem Soc Trans 2008;36:920-929.
17. Reinehr R, Becker S, Eberle A, Grether-Beck S, Haussinger D. Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosis. J Biol Chem 2005;280:27179-27194. (Pubitemid 41040757)
18. Reinehr R, Becker S, Braun J, Eberle A, Grether-Beck S, Haussinger D. Endosomal acidifi cation and activation of NADPH oxidase isoforms are upstream events in hyperosmolarity-induced hepatocyte apoptosis. J Biol Chem 2006;281: 23150-23166.
19. Becker S, Reinehr R, Graf D, vom Dahl S, Haussinger D. Hydrophobic bile salts induce hepatocyte shrinkage via NADPH oxidase activation. Cell Physiol Biochem 2007; 19:89-98.
20. Carmona-Cuenca I, Herrera B, Ventura JJ, Roncero C, Fernandez M, Fabregat I. EGF blocks NADPH oxidase activation by TGF-beta in fetal rat hepatocytes, impairing oxidative stress, and cell death. J Cell Physiol 2006;207:322-330.
21. Carmona-Cuenca I, Roncero C, Sancho P, Caja L, Fausto N, Fernandez M, Fabregat I. Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity. J Hepatol 2008;49:965-976.
22. Sancho P, Bertran E, Caja L, Carmona-Cuenca I, Murillo MM, Fabregat I. The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-beta-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms. Biochim Biophys Acta 2009;1793: 253-263.
23. Caja L, Sancho P, Bertran E, Iglesias-Serret D, Gil J, Fabregat I. Overactivation of the MEK/ERK pathway in liver tumor cells confers resistance to TGF-βinduced cell death through impairing up-regulation of the NADPH oxidase NOX4. Cancer Res 2009;69:7595-7602.
24. Sancho P, Fabregat I. NADPH oxidase NOX1 controls autocrine growth of liver tumor cells through up-regulation of the epidermal growth factor receptor pathway. J Biol Chem 2010;285:24815-24824.
25. Li L, He Q, Huang X, Man Y, Zhou Y, Wang S, Wang J, Li J. NOX3-derived reactive oxygen species promote TNFalpha-induced reductions in hepatocyte glycogen levels via a JNK pathway. FEBS Lett 2010;584:995-1000.
26. Gao D, Nong S, Huang X, Lu Y, Zhao H, Lin Y, Man Y, Wan S, Yang J, Li J. The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways. J Biol Chem 2010;285:29965-29973.
27. Diaz-Cruz A, Guinzberg R, Guerra R, Vilchis M, Carrasco D, Garcia-Vazquez FJ, Pi ñ a E. Adrenaline stimulates H 2 O 2 generation in liver via NADPH oxidase. Free Radic Res 2007;41:663-672. (Pubitemid 46845587)
28. Guinzberg R, Laguna I, Zentella A, Guzman R, Pina E. Effect of adenosine and inosine on ureagenesis in hepatocytes. Biochem J 1987;245:371-374.
29. Davies R, Cain K, Edwards RE, Snowden RT, Legg RF, Neal GE. The preparation of highly enriched fractions of binucleated rat hepatocytes by centrifugal elutriation and fl ow cytometry. Anal Biochem 1990;190:266-270. (Pubitemid 20371964)
30. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-254.
31. Fioravanti CF, Reisig JM. Mitochondrial hydrogen peroxide formation and the fumarate reductase of Hymenolepis diminuta. J Parasitol 1990;76:457-463. (Pubitemid 20299293)
32. Sambrook J, Fritsch EF, Maniatis TA. 1989. Detection and analysis of proteins expressed from cloned genes. In: Laboratory Manual. 2nd ed. New York: Cold Spring Harbor Laboratory Press. p 18.60-18.69.
33. Taylor SJ, Shalloway D. Cell cycle-dependent activation of Ras. Curr Biol 1996;6:1621-1627. (Pubitemid 27050229)
34. Fales FW. Glucose (enzymatic). Stand Methods. Clin Chem 1963;4:101-112.
35. Gutman I, Bergmeyer HU. 1974. Determination of urea. In: Methods of Enzymatic Analysis (Bermeyer HU., ed), vol 4, New York and London: Academic Press, p. 1791-1794.
36. Bokoch GM, Diebold BA. Current molecular models for NADPH oxidase regulation by Rac GTPase. Blood 2002;100: 2692-2696.
37. Riobo NA, Manning DR. Receptors coupled to heterotrimeric G proteins of the G 12 family. Trends Pharmacol Sci 2005;26: 146-154. (Pubitemid 40313594)
38. Yuan J, Rey O, Rozengurt E. Activation of protein kinase D3 by signaling through Rac and the alpha subunits of the heterotrimeric G proteins G 12 and G 13 . Cell Signal 2006;18: 1051-1062.
39. Sumimoto H, Miyano K, Takeya R. Molecular composition and regulation of the Nox family NAD(P)H oxidases. Biochem Biophys Res Commun 2005;338:677-686. (Pubitemid 41540615)
40. Cheng G, Diebold BA, Hughes Y, Lambeth JD. Nox1-dependent reactive oxygen generation is regulated by Rac1. J Biol Chem 2006;281:17718-17726. (Pubitemid 44035570)
41. Hordijk PL. Regulation of NADPH oxidases: the role of Rac proteins. Circ Res 2006;98:453-462.
42. Reyes-Salcido V, Villalobos-Molina R. Patterns of adrenoceptor change during liver regeneration of the Wistar Kyoto rat: a binding study. Arch Med Res 1999;30:89-92. (Pubitemid 29255680)
43. Huerta-Bahena J, Villalobos-Molina R, Garcia-Sainz JA. Roles of alpha 1-and beta-adrenergic receptors in adrenergic responsiveness of liver cells formed after partial hepatectomy. Biochim Biophys Acta 1983;763:112-119.
44. Niemietz CM, Tyerman SD. New potent inhibitors of aquaporins: silver and gold compounds inhibit aquaporins of plant and human origin. FEBS Lett 2002;531:443-447. (Pubitemid 35336066)
45. Bienert GP, Moller AL, Kristiansen KA, Schulz A, Moller IM, Schjoerring JK, Jahn TP. Specifi c aquaporins facilitate the diffusion of hydrogen peroxide across membranes. J Biol Chem 2007;282:1183-1192. (Pubitemid 47076557)
46. 2+channel Cav1.2. Science 2001;293:98-101. (Pubitemid 32625503)
47. 1B-adrenoceptors) and ethanol stimulate OH radical production in isolated rat hepatocytes. Life Sci 2002;71:2469-2474. (Pubitemid 35247956)
48. Matute JD, Arias AA, Dinauer MC, Patino PJ. p40phox: the last NADPH oxidase subunit. Blood Cells Mol Dis 2005;35: 291-302. (Pubitemid 41267062)
49. Nishida M, Tanabe S, Maruyama Y, Mangmool S, Urayama K, Nagamatsu Y, et al. G alpha 12/13-and reactive oxygen species-dependent activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase by angiotensin receptor stimulation in rat neonatal cardiomyocytes. J Biol Chem 2005;280:18434-18441. (Pubitemid 41389093)
50. Li JM, Shah AM. Intracellular localization and preassembly of the NADPH oxidase complex in cultured endothelial cells. J Biol Chem 2002;277:19952-19960. (Pubitemid 34967517)
51. Xiao K, McClatchy DB, Shukla AK, Zhao Y, Chen M, Shenoy SK, et al. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proc Natl Acad Sci USA 2007;104:12011-12016. (Pubitemid 47185621)
52. Shukla AK, Kim J, Ahn S, Xiao K, Shenoy SK, Liedtke W, Lefkowitz RJ. Arresting a transient receptor potential (TRP) channel: β-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV 4 . J Biol Chem 2010; 285:30115-30125.
53. Zhang J, Hupfeld CJ, Taylor SS, Olefsky JM, Tsien RY. Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes. Nature 2005;437:569-573. (Pubitemid 41613556)
54. Kreutz B, Hajicek N, Yau DM, Nakamura S, Kozasa T. Distinct regions of Gα13 participate in its regulatory interactions with RGS homology domain-containing RhoGEFs. Cell Signal 2007;19:1681-1689. (Pubitemid 46935425)
55. Dessauer CW. Adenylyl cyclase-A-kinase anchoring protein complexes: the next dimension in cAMP signaling. Mol Pharmacol 2009;76:935-941.
56. Skarpen E, Thoresen GH, Tasken K, Samuelsen JT, Jahnsen T, Schwarze PE, Huitfeldt HS. Localization of cAMP-dependent signal transducers in early rat liver carcinogenesis. Histochem Cell Biol 1998;109:203-209. (Pubitemid 28114284)
57. Masyuk AI, LaRusso NF. Aquaporins in the hepatobiliary system. Hepatology 2006;43:S75-S81.
58. Wong W, Scott JD. AKAP signalling complexes: focal points in space and time. Nat Rev Mol Cell Biol 2004;5:959-970. (Pubitemid 39611533)