-
1
-
-
9244231192
-
Revisiting phenobarbital for epilepsy
-
Kale R, Perucca E. Revisiting phenobarbital for epilepsy. BMJ 2004 Nov 20; 329 (7246): 1199-200 (Pubitemid 39551441)
-
(2004)
British Medical Journal
, vol.329
, Issue.7476
, pp. 1199-1200
-
-
Kale, R.1
Perucca, E.2
-
2
-
-
79954622504
-
The pharmacological treatment of epilepsy in adults
-
May
-
Perucca E, Tomson T. The pharmacological treatment of epilepsy in adults. Lancet Neurol 2011 May; 10 (5): 446-56
-
(2011)
Lancet Neurol
, vol.10
, Issue.5
, pp. 446-56
-
-
Perucca, E.1
Tomson, T.2
-
3
-
-
34547828792
-
Development of new antiepileptic drugs: challenges, incentives, and recent advances
-
DOI 10.1016/S1474-4422(07)70215-6, PII S1474442207702156
-
Perucca E, French J, Bialer M. Development of new antiepileptic drugs: challenges, incentives, and recent advances. Lancet Neurol 2007 Sep; 6 (9): 793-804 (Pubitemid 47243712)
-
(2007)
Lancet Neurology
, vol.6
, Issue.9
, pp. 793-804
-
-
Perucca, E.1
French, J.2
Bialer, M.3
-
4
-
-
80555147074
-
Novel pharmacotherapies for epilepsy
-
In press
-
Fattore C, Perucca E. Novel pharmacotherapies for epilepsy. Drugs. In press
-
Drugs
-
-
Fattore, C.1
Perucca, E.2
-
5
-
-
85047690079
-
An introduction to antiepileptic drugs
-
DOI 10.1111/j.0013-9580.2005.14704.x
-
Perucca E. An introduction to antiepileptic drugs. Epilepsia 2005; 46 Suppl. 4: 31-7 (Pubitemid 40847381)
-
(2005)
Epilepsia
, vol.46
, Issue.SUPPL. 4
, pp. 31-37
-
-
Perucca, E.1
-
6
-
-
3042798891
-
The neurobiology of antiepileptic drugs
-
Rogawski MA, Lö scher W. The neurobiology of antiepileptic drugs. Nat Rev Neurosci 2004 Jul; 5 (7): 553-64 (Pubitemid 38868551)
-
(2004)
Nature Reviews Neuroscience
, vol.5
, Issue.7
, pp. 553-564
-
-
Rogawski, M.A.1
Loscher, W.2
-
7
-
-
37349071555
-
The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels
-
DOI 10.1124/mol.107.039867
-
Errington AC, Stöhr T, Heers C, et al. The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels. Mol Pharmacol 2008 Jan; 73 (1): 157-69 (Pubitemid 350294207)
-
(2008)
Molecular Pharmacology
, vol.73
, Issue.1
, pp. 157-169
-
-
Errington, A.C.1
Stohr, T.2
Heers, C.3
Lees, G.4
-
8
-
-
0030668611
-
+ channels in neuronal cells
-
DOI 10.1016/S0014-2999(97)01249-1, PII S0014299997012491
-
Rundfeldt C. The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells. Eur J Pharmacol 1997 Oct 8; 336 (2-3): 243-9 (Pubitemid 27464871)
-
(1997)
European Journal of Pharmacology
, vol.336
, Issue.2-3
, pp. 243-249
-
-
Rundfeldt, C.1
-
9
-
-
79959970405
-
Perampanel: A novel orally active noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy
-
Jul
-
Hanada T, Hashizume Y, Tokuhara N, et al. Perampanel: a novel, orally active, noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy. Epilepsia 2011 Jul; 52 (7): 1331-40
-
(2011)
Epilepsia
, vol.52
, Issue.7
, pp. 1331-40
-
-
Hanada, T.1
Hashizume, Y.2
Tokuhara, N.3
-
10
-
-
0027179598
-
Lamotrigine - A review of its pharmacological properties and clinical efficacy in epilepsy
-
Goa KL, Ross SR, Chrisp P. Lamotrigine: a review of its pharmacological properties and clinical efficacy in epilepsy. Drugs 1993 Jul; 46 (1): 152-76 (Pubitemid 23232410)
-
(1993)
Drugs
, vol.46
, Issue.1
, pp. 152-176
-
-
Goa, K.L.1
Ross, S.R.2
Chrisp, P.3
-
11
-
-
0026443902
-
An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels
-
Nov
-
Cheung H, Kamp D, Harris E. An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels. Epilepsy Res 1992 Nov; 13 (2): 107-12
-
(1992)
Epilepsy Res
, vol.13
, Issue.2
, pp. 107-12
-
-
Cheung, H.1
Kamp, D.2
Harris, E.3
-
12
-
-
78650178478
-
Progress report on new antiepileptic drugs: A summary of the Tenth Eilat Conference (EILAT X)
-
Dec
-
Bialer M, Johannessen SI, Levy RH, et al. Progress report on new antiepileptic drugs: a summary of the Tenth Eilat Conference (EILAT X). Epilepsy Res 2010 Dec; 92 (2-3): 89-124
-
(2010)
Epilepsy Res
, vol.92
, Issue.2-3
, pp. 89-124
-
-
Bialer, M.1
Johannessen, S.I.2
Levy, R.H.3
-
14
-
-
79951683602
-
Factors determining response to antiepileptic drugs in randomized controlled trials: A systematic review and meta-analysis
-
Feb
-
Rheims S, Perucca E, Cucherat M, et al. Factors determining response to antiepileptic drugs in randomized controlled trials: a systematic review and meta-analysis. Epilepsia 2011 Feb; 52 (2): 219-33
-
(2011)
Epilepsia
, vol.52
, Issue.2
, pp. 219-33
-
-
Rheims, S.1
Perucca, E.2
Cucherat, M.3
-
15
-
-
77956059743
-
A comparison of pregabalin lamotrigine and placebo as adjunctive therapy in patients with refractory partial-onset seizures
-
Sep
-
Baulac M, Leon T, O'Brien TJ, et al. A comparison of pregabalin, lamotrigine, and placebo as adjunctive therapy in patients with refractory partial-onset seizures. Epilepsy Res 2010 Sep; 91 (1): 10-9
-
(2010)
Epilepsy Res
, vol.91
, Issue.1
, pp. 10-9
-
-
Baulac, M.1
Leon, T.2
O'Brien, T.J.3
-
16
-
-
79961212342
-
Antiepileptic drug discovery: Does mechanism of action matter?
-
Aug
-
Schmidt D. Antiepileptic drug discovery: does mechanism of action matter? Epilepsy Behav 2011 Aug; 21 (4): 342-3
-
(2011)
Epilepsy Behav
, vol.21
, Issue.4
, pp. 342-3
-
-
Schmidt, D.1
-
17
-
-
76249085581
-
Placebo-corrected efficacy of modern antiepileptic drugs for refractory epilepsy: Systematic review and meta-analysis
-
Jan
-
Beyenburg S, Stavem K, Schmidt D. Placebo-corrected efficacy of modern antiepileptic drugs for refractory epilepsy: systematic review and meta-analysis. Epilepsia 2010 Jan; 51 (1): 7-26
-
(2010)
Epilepsia
, vol.51
, Issue.1
, pp. 7-26
-
-
Beyenburg, S.1
Stavem, K.2
Schmidt, D.3
-
18
-
-
33746124186
-
ILAE treatment guidelines: Evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes
-
DOI 10.1111/j.1528-1167.2006.00585.x
-
Glauser T, Ben-Menachem E, Bourgeois B, et al. ILAE treatment guidelines: evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia 2006 Jul; 47 (7): 1094-120 (Pubitemid 44086745)
-
(2006)
Epilepsia
, vol.47
, Issue.7
, pp. 1094-1120
-
-
Glauser, T.1
Ben-Menachem, E.2
Bourgeois, B.3
Cnaan, A.4
Chadwick, D.5
Guerreiro, C.6
Kalviainen, R.7
Mattson, R.8
Perucca, E.9
Tomson, T.10
-
19
-
-
0031883148
-
Antiepileptic drugs as a cause of worsening seizures
-
DOI 10.1111/j.1528-1157.1998.tb01268.x
-
Perucca E, Gram L, Avanzini G, et al. Antiepileptic drugs as a cause of worsening seizures. Epilepsia 1998 Jan; 39 (1): 5-17 (Pubitemid 28116836)
-
(1998)
Epilepsia
, vol.39
, Issue.1
, pp. 5-17
-
-
Perucca, E.1
Gram, L.2
Avanzini, G.3
Dulac, O.4
-
20
-
-
79952170654
-
Management of seizures in Lennox-Gastaut syndrome
-
Apr 1
-
Crumrine PK. Management of seizures in Lennox-Gastaut syndrome. Pediatr Drugs 2011 Apr 1; 13 (2): 107-18
-
(2011)
Pediatr Drugs
, vol.13
, Issue.2
, pp. 107-18
-
-
Crumrine, P.K.1
-
21
-
-
0033051765
-
Lamictal (lamotrigine) monotherapy for typical absence seizures in children
-
DOI 10.1111/j.1528-1157.1999.tb00805.x
-
Frank LM, Enlow T, Holmes GL, et al. Lamictal (lamotrigine) monotherapy for typical absence seizures in children. Epilepsia 1999 Jul; 40 (7): 973-9 (Pubitemid 29316053)
-
(1999)
Epilepsia
, vol.40
, Issue.7
, pp. 973-979
-
-
Frank, L.M.1
Enlow, T.2
Holmes, G.L.3
Manasco, P.4
Concannon, S.5
Chen, C.6
Womble, G.7
Casale, E.J.8
-
22
-
-
77954421654
-
Recent advances in adjunctive therapy for epilepsy: Focus on sodium channel blockers as third-generation antiepileptic drugs
-
Apr
-
Vohora D, Saraogi P, Yazdani MA, et al. Recent advances in adjunctive therapy for epilepsy: focus on sodium channel blockers as third-generation antiepileptic drugs. Drugs Today (Barc) 2010 Apr; 46 (4): 265-77
-
(2010)
Drugs Today (Barc)
, vol.46
, Issue.4
, pp. 265-77
-
-
Vohora, D.1
Saraogi, P.2
Yazdani, M.A.3
-
23
-
-
79955702777
-
Immuno-and antiinflammatory therapies in epileptic disorders
-
May
-
Özkara Ç, Vigevano F. Immuno-and antiinflammatory therapies in epileptic disorders. Epilepsia 2011 May; 52 Suppl. 3: 45-51
-
(2011)
Epilepsia
, vol.52
, Issue.SUPPL. 3
, pp. 45-51
-
-
Özkara, Ç.1
Vigevano, F.2
-
24
-
-
80555135235
-
GLUT1 deficiency syndrome in clinical practice
-
Mar 5
-
Klepper J. GLUT1 deficiency syndrome in clinical practice. Epilepsy Res. Epub 2011 Mar 5
-
(2011)
Epilepsy Res. Epub
-
-
Klepper, J.1
-
25
-
-
80052699025
-
Glucose transporter 1 deficiency as a treatable cause of myoclonic astatic epilepsy
-
May 9
-
Mullen SA, Marini C, Suls A, et al. Glucose transporter 1 deficiency as a treatable cause of myoclonic astatic epilepsy. Arch Neurol. Epub 2011 May 9
-
(2011)
Arch Neurol. Epub
-
-
Mullen, S.A.1
Marini, C.2
Suls, A.3
-
26
-
-
0031947590
-
Lamotrigine and seizure aggravation in severe myoclonic epilepsy
-
DOI 10.1111/j.1528-1157.1998.tb01413.x
-
Guerrini R, Dravet C, Genton P, et al. Lamotrigine and seizure aggravation in severe myoclonic epilepsy. Epilepsia 1998 May; 39 (5): 508-12 (Pubitemid 28221807)
-
(1998)
Epilepsia
, vol.39
, Issue.5
, pp. 508-512
-
-
Guerrini, R.1
Dravet, C.2
Genton, P.3
Belmonte, A.4
Kaminska, A.5
Dulac, O.6
-
27
-
-
33748115786
-
Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy
-
DOI 10.1038/nn1754, PII NN1754
-
Yu FH, Mantegazza M, Westenbroek RE, et al. Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy. Nat Neurosci 2006 Sep; 9 (9): 1142-9 (Pubitemid 44306307)
-
(2006)
Nature Neuroscience
, vol.9
, Issue.9
, pp. 1142-1149
-
-
Yu, F.H.1
Mantegazza, M.2
Westenbroek, R.E.3
Robbins, C.A.4
Kalume, F.5
Burton, K.A.6
Spain, W.J.7
McKnight, G.S.8
Scheuer, T.9
Catterall, W.A.10
-
28
-
-
80051547306
-
Antiepileptic drug therapy: Does mechanism of action matter?
-
Aug
-
Brodie M, Covanis T, Gil-Nagel A, et al. Antiepileptic drug therapy: does mechanism of action matter? Epilepsy Behav 2011 Aug; 21 (4): 331-41
-
(2011)
Epilepsy Behav
, vol.21
, Issue.4
, pp. 331-41
-
-
Brodie, M.1
Covanis, T.2
Gil-Nagel, A.3
-
29
-
-
80053312809
-
Synaptic vesicle protein 2A predicts response to levetiracetam in patients with glioma
-
Aug 9
-
De Groot M, Aronica E, Heimans JJ, et al. Synaptic vesicle protein 2A predicts response to levetiracetam in patients with glioma. Neurology 2011 Aug 9; 77 (6): 532-9
-
(2011)
Neurology
, vol.77
, Issue.6
, pp. 532-9
-
-
De Groot, M.1
Aronica, E.2
Heimans, J.J.3
-
30
-
-
0031883784
-
Carbamazepine toxicity with lamotrigine: Pharmacokinetic or pharmacodynamic interaction?
-
DOI 10.1111/j.1528-1157.1998.tb01356.x
-
Besag FM, Berry DJ, Pool F, et al. Carbamazepine toxicity with lamotrigine: pharmacokinetic or pharmacodynamic interaction? Epilepsia 1998 Feb; 39 (2): 183-7 (Pubitemid 28074354)
-
(1998)
Epilepsia
, vol.39
, Issue.2
, pp. 183-187
-
-
Besag, F.M.C.1
Berry, D.J.2
Pool, F.3
Newbery, J.-E.4
Subel, B.5
-
31
-
-
0034535858
-
Oxcarbazepine placebo-controlled, dose-ranging trial in refractory partial epilepsy
-
BarcsG,Walker EB, Elger CE, et al. Oxcarbazepine placebocontrolled, dose-ranging trial in refractory partial epilepsy. Epilepsia 2000 Dec; 41 (12): 1597-607 (Pubitemid 32002734)
-
(2000)
Epilepsia
, vol.41
, Issue.12
, pp. 1597-1607
-
-
Barcs, G.1
Walker, E.B.2
Elger, C.E.3
Scaramelli, A.4
Stefan, H.5
Sturm, Y.6
Moore, A.7
Flesch, G.8
Kramer, L.9
D'Souza, J.10
-
32
-
-
77952118055
-
-
Eisai Ltd [online] [Accessed 2011 May 8]
-
Eisai Ltd. Zebinix: summary of product characteristics [online]. Available from URL: http://www.medicines.org.uk/emc/medicine/22376/SPC/[Accessed 2011 May 8]
-
Zebinix: Summary of Product Characteristics
-
-
-
33
-
-
78649357007
-
A pooled analysis of lacosamide clinical trial data grouped by mechanism of action of concomitant antiepileptic drugs
-
Dec 1
-
Sake JK, Hebert D, Isojärvi J, et al. A pooled analysis of lacosamide clinical trial data grouped by mechanism of action of concomitant antiepileptic drugs. CNS Drugs 2010 Dec 1; 24 (12): 1055-68
-
(2010)
CNS Drugs
, vol.24
, Issue.12
, pp. 1055-68
-
-
Sake, J.K.1
Hebert, D.2
Isojärvi, J.3
-
34
-
-
78651251889
-
Lacosamide neurotoxicity associated with concomitant use of sodium channel-blocking antiepileptic drugs: A pharmacodynamic interaction?
-
Jan
-
Novy J, Patsalos PN, Sander JW, et al. Lacosamide neurotoxicity associated with concomitant use of sodium channel-blocking antiepileptic drugs: a pharmacodynamic interaction? Epilepsy Behav 2011 Jan; 20 (1): 20-3
-
(2011)
Epilepsy Behav
, vol.20
, Issue.1
, pp. 20-3
-
-
Novy, J.1
Patsalos, P.N.2
Sander, J.W.3
-
35
-
-
68149096743
-
Rufinamide for the adjunctive treatment of partial seizures in adults and adolescents: A randomized placebo-controlled trial
-
Aug
-
Brodie MJ, Rosenfeld WE, Vazquez B, et al. Rufinamide for the adjunctive treatment of partial seizures in adults and adolescents: a randomized placebo-controlled trial. Epilepsia 2009 Aug; 50 (8): 1899-909
-
(2009)
Epilepsia
, vol.50
, Issue.8
, pp. 1899-909
-
-
Brodie, M.J.1
Rosenfeld, W.E.2
Vazquez, B.3
-
36
-
-
0033761218
-
Selection of antiepileptic drug polytherapy based on mechanisms of action: The evidence reviewed
-
Nov
-
Deckers CL, Czuczwar SJ,Hekster YA, et al. Selection of antiepileptic drug polytherapy based on mechanisms of action: the evidence reviewed. Epilepsia 2000 Nov; 41 (11): 1364-74
-
(2000)
Epilepsia
, vol.41
, Issue.11
, pp. 1364-74
-
-
Deckers, C.L.1
Czuczwar, S.J.2
Hekster, Y.A.3
-
37
-
-
49149103455
-
Adverse effects of antiepileptic drugs
-
Jul
-
Toledano R, Gil-Nagel A. Adverse effects of antiepileptic drugs. Semin Neurol 2008 Jul; 28 (3): 317-27
-
(2008)
Semin Neurol
, vol.28
, Issue.3
, pp. 317-27
-
-
Toledano, R.1
Gil-Nagel, A.2
-
38
-
-
36649019378
-
Weight issues for people with epilepsy - A review
-
DOI 10.1111/j.1528-1167.2007.01402.x
-
Ben-Menachem E. Weight issues for people with epilepsy: a review. Epilepsia 2007; 48 Suppl. 9: 42-5 (Pubitemid 350198229)
-
(2007)
Epilepsia
, vol.48
, Issue.SUPPL. 9
, pp. 42-45
-
-
Ben-Menachem, E.1
-
39
-
-
80051551477
-
Zonisamide versus topiramate in migraine prophylaxis: A doubleblind randomized clinical trial
-
Jul-Aug
-
Mohammadianinejad SE, Abbasi V, Sajedi SA, et al. Zonisamide versus topiramate in migraine prophylaxis: a doubleblind randomized clinical trial. Clin Neuropharmacol 2011 Jul-Aug; 34 (4): 174-7
-
(2011)
Clin Neuropharmacol
, vol.34
, Issue.4
, pp. 174-7
-
-
Mohammadianinejad, S.E.1
Abbasi, V.2
Sajedi, S.A.3
-
40
-
-
0036798013
-
Kidney stones, carbonic anhydrase inhibitors, and the ketogenic diet
-
DOI 10.1046/j.1528-1157.2002.11302.x
-
Kossoff EH, Pyzik PL, Furth SL, et al. Kidney stones, carbonic anhydrase inhibitors, and the ketogenic diet. Epilepsia 2002 Oct; 43 (10): 1168-71 (Pubitemid 35176123)
-
(2002)
Epilepsia
, vol.43
, Issue.10
, pp. 1168-1171
-
-
Kossoff, E.H.1
Pyzik, P.L.2
Furth, S.L.3
Hladky, H.D.4
Freeman, J.M.5
Vining, E.P.G.6
-
41
-
-
79955480833
-
Metabolic acidosis with topiramate and zonisamide: An assessment of its severity and predictors
-
May
-
Mirza NS, Alfirevic A, Jorgensen A, et al. Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors. Pharmacogenet Genomics 2011 May; 21 (5): 297-302
-
(2011)
Pharmacogenet Genomics
, vol.21
, Issue.5
, pp. 297-302
-
-
Mirza, N.S.1
Alfirevic, A.2
Jorgensen, A.3
-
42
-
-
33645732506
-
Hyponatremia from oxcarbazepine and carbamazepine
-
DOI 10.1212/01.wnl.0000188819.45330.90, PII 0000611420051227000030
-
Dong X, Leppik IE, White J, et al. Hyponatremia from oxcarbazepine and carbamazepine. Neurology 2005 Dec 27; 65 (12): 1976-8 (Pubitemid 43970125)
-
(2005)
Neurology
, vol.65
, Issue.12
, pp. 1976-1978
-
-
Dong, X.1
Leppik, I.E.2
White, J.3
Rarick, J.4
-
43
-
-
77953536118
-
Functional effects of the KCNQ modulators retigabine and XE991 in the rat urinary bladder
-
Jul 25
-
Rode F, Svalø J, Sheykhzade M, et al. Functional effects of the KCNQ modulators retigabine and XE991 in the rat urinary bladder. Eur J Pharmacol 2010 Jul 25; 638 (1-3): 121-7
-
(2010)
Eur J Pharmacol
, vol.638
, Issue.1-3
, pp. 121-7
-
-
Rode, F.1
Svalø, J.2
Sheykhzade, M.3
-
44
-
-
79955592696
-
RESTORE 1/Study 301 Investigators. Randomized, double-blind, placebo-controlled trial of ezogabine (retigabine) in partial epilepsy
-
May 3
-
French JA, Abou-Khalil BW, Leroy RF, et al., RESTORE 1/Study 301 Investigators. Randomized, double-blind, placebo-controlled trial of ezogabine (retigabine) in partial epilepsy. Neurology 2011 May 3; 76 (18): 1555-63
-
(2011)
Neurology
, vol.76
, Issue.18
, pp. 1555-63
-
-
French, J.A.1
Abou-Khalil, B.W.2
Leroy, R.F.3
|