메뉴 건너뛰기




Volumn 46, Issue 4, 2010, Pages 265-277

Recent advances in adjunctive therapy for epilepsy: Focus on sodium channel blockers as third-generation antiepileptic drugs

Author keywords

[No Author keywords available]

Indexed keywords

BRIVARACETAM; CARBAMAZEPINE; CARBAMIC ACID 2 (2 CHLOROPHENYL) 2 HYDROXYETHYL ESTER; CARISBAMATE; CLOBAZAM; DIAZEPAM; DIGOXIN; ELPETRIGINE; ESLICARBAZEPINE ACETATE; ETHOSUXIMIDE; ETIRACETAM; FELBAMATE; FLUOROFELBAMATE; FOSPHENYTOIN SODIUM; GABAPENTIN; HARKOSERIDE; LAMOTRIGINE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; RUFINAMIDE; SAFINAMIDE; SODIUM CHANNEL BLOCKING AGENT; TOLBUTAMIDE; TOPIRAMATE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALPROIC ACID; VINPOCETINE; WARFARIN; ZONISAMIDE;

EID: 77954421654     PISSN: 16993993     EISSN: 16994019     Source Type: Journal    
DOI: 10.1358/dot.2010.46.4.1445795     Document Type: Review
Times cited : (34)

References (64)
  • 1
    • 84878731348 scopus 로고    scopus 로고
    • www.who.int/mediacenter/factsheets
  • 2
    • 33745251005 scopus 로고    scopus 로고
    • New antiepileptic drugs that are second generation to existing antiepileptic drugs
    • Bialer, M. New antiepileptic drugs that are second generation to existing antiepileptic drugs. Expert Opin Investig Drugs 2006, 15(6): 637-47.
    • (2006) Expert Opin Investig Drugs , vol.15 , Issue.6 , pp. 637-647
    • Bialer, M.1
  • 3
    • 33845914088 scopus 로고    scopus 로고
    • Novel anticonvulsant drugs
    • Stefan, H., Feurstein, T.J. Novel anticonvulsant drugs. Pharmac Ther 2007, 113(1): 165-83.
    • (2007) Pharmac Ther , vol.113 , Issue.1 , pp. 165-183
    • Stefan, H.1    Feurstein, T.J.2
  • 4
    • 33645851658 scopus 로고    scopus 로고
    • Refractory epilepsy: Mechanism and solution
    • Kwan, P., Brodie, M.J. Refractory epilepsy: mechanism and solution. Expert Rev Neurothera 2006, 6(3): 397-406.
    • (2006) Expert Rev Neurothera , vol.6 , Issue.3 , pp. 397-406
    • Kwan, P.1    Brodie, M.J.2
  • 5
    • 0030938740 scopus 로고    scopus 로고
    • New antiepileptic drugs in children: Present and future
    • DOI 10.1016/S1071-9091(97)80004-6
    • Pellock, J.M., Watemberg, N. New antiepileptic drugs in children: present and children. Semin Pediatr Neurol 1997, 4(1): 9-18. (Pubitemid 27137470)
    • (1997) Seminars in Pediatric Neurology , vol.4 , Issue.1 , pp. 9-18
    • Pellock, J.M.1    Watemberg, N.2
  • 6
    • 67650215631 scopus 로고    scopus 로고
    • Third generation antiepileptic drugs: Mechanism of action, pharmacokinetics and interactions
    • Luszcki, J.J. Third generation antiepileptic drugs: mechanism of action, pharmacokinetics and interactions. Pharmac Rep 2009, 61(2): 197-16.
    • (2009) Pharmac Rep , vol.61 , Issue.2 , pp. 197-216
    • Luszcki, J.J.1
  • 7
    • 0030485569 scopus 로고    scopus 로고
    • Established antiepileptic drugs
    • Perucca, E. Established antiepileptic drugs. Baillieres Clin Neurol 1996, 5(4): 693-22.
    • (1996) Baillieres Clin Neurol , vol.5 , Issue.4 , pp. 693-722
    • Perucca, E.1
  • 8
    • 0032569248 scopus 로고    scopus 로고
    • New options for the treatment of epilepsy
    • Herman, S.T., Pedley, T.A. New options for the treatment of epilepsy. JAMA 1998, 280(8): 693-4.
    • (1998) JAMA , vol.280 , Issue.8 , pp. 693-694
    • Herman, S.T.1    Pedley, T.A.2
  • 9
    • 49549119738 scopus 로고    scopus 로고
    • Brivaracetam: A rational drug discovery success story
    • Rogawski, M.A. Brivaracetam: A rational drug discovery success story. Br J Pharmacol 2008, 154(8): 1555-7.
    • (2008) Br J Pharmacol , vol.154 , Issue.8 , pp. 1555-1557
    • Rogawski, M.A.1
  • 10
    • 53449102055 scopus 로고    scopus 로고
    • New molecular targets for antiepileptic drugs: a2d, SV2A and Kv7/ KCNQ/ M potassium channels
    • Rogawski, M.A. New molecular targets for antiepileptic drugs: a2d, SV2A and Kv7/ KCNQ/ M potassium channels. Curr Neurol Neurosci Rep 2008, 8(4): 345-52.
    • (2008) Curr Neurol Neurosci Rep , vol.8 , Issue.4 , pp. 345-352
    • Rogawski, M.A.1
  • 13
    • 33747049831 scopus 로고    scopus 로고
    • Diverse mechanisms of antiepileptic drugs in the development pipeline
    • Rogawski, M.A. Diverse mechanisms of antiepileptic drugs in the development pipeline. Epilepsy Res 2006, 69(3): 273-94.
    • (2006) Epilepsy Res , vol.69 , Issue.3 , pp. 273-294
    • Rogawski, M.A.1
  • 14
    • 0034327493 scopus 로고    scopus 로고
    • Voltage-gated sodium channels as therapeutic targets
    • Clare, J.J., Tate, S.N., Nobbs, M., Romanos, M.A. Voltage-gated sodium channels as therapeutic targets. Drug Discov Today 2000, 5(11): 506-20.
    • (2000) Drug Discov Today , vol.5 , Issue.11 , pp. 506-520
    • Clare, J.J.1    Tate, S.N.2    Nobbs, M.3    Romanos, M.A.4
  • 15
    • 63049120380 scopus 로고    scopus 로고
    • Protein-protein interactions involving voltage-gated sodium channels: Post-translational regulation, intracellular trafficking and functional expression
    • Shao, D., Okuse, K., Djamgoz, M.B.A. Protein-protein interactions involving voltage-gated sodium channels: Post-translational regulation, intracellular trafficking and functional expression. Int J Biochem Cell Biol 2009, 41(7): 1471-81.
    • (2009) Int J Biochem Cell Biol , vol.41 , Issue.7 , pp. 1471-1481
    • Shao, D.1    Okuse, K.2    Djamgoz, M.B.A.3
  • 16
    • 0031966045 scopus 로고    scopus 로고
    • Sodium channels as molecular targets for antiepileptic drugs
    • DOI 10.1016/S0165-0173(97)00054-4, PII S0165017397000544
    • Ragsdale, D.S., Avoli, M. Sodium channels as molecular targets for antiepileptic drugs. Brain Res Rev 1998, 26(1): 16-28. (Pubitemid 28179007)
    • (1998) Brain Research Reviews , vol.26 , Issue.1 , pp. 16-28
    • Ragsdale, D.S.1    Avoli, M.2
  • 17
    • 52949149762 scopus 로고    scopus 로고
    • Voltage gated sodium channel blockers.2001-2006: An overview
    • Bolcskei, H., Tarnawa, I., Kocsis, P. Voltage gated sodium channel blockers.2001-2006: An overview. Med Chem Res 2008, 17: 356-368.
    • (2008) Med Chem Res , vol.17 , pp. 356-368
    • Bolcskei, H.1    Tarnawa, I.2    Kocsis, P.3
  • 18
    • 34248396038 scopus 로고    scopus 로고
    • Blockers of voltage gated sodium channels for the treatment of CNS diseases
    • Tarnawa, I., Bolcskei, H., Kocsis, P. Blockers of voltage gated sodium channels for the treatment of CNS diseases. Recent Pat CNS Drug Discov 2007, 2(1): 57-78.
    • (2007) Recent Pat CNS Drug Discov , vol.2 , Issue.1 , pp. 57-78
    • Tarnawa, I.1    Bolcskei, H.2    Kocsis, P.3
  • 20
    • 70449533094 scopus 로고    scopus 로고
    • Six months of post marketing experience with adjunctive lacosamide in patients with pharmacoresistant focal epilepsy at a tertiary epilepsy center in Germany
    • Wehner, T., Bauer, S., Hamer, H.M. et al. Six months of post marketing experience with adjunctive lacosamide in patients with pharmacoresistant focal epilepsy at a tertiary epilepsy center in Germany. Epilepsy Behav 2009, 16(3): 423-5.
    • (2009) Epilepsy Behav , vol.16 , Issue.3 , pp. 423-425
    • Wehner, T.1    Bauer, S.2    Hamer, H.M.3
  • 21
    • 33646911126 scopus 로고    scopus 로고
    • Seeking a mechanism of action for the novel anticonvulsant lacosamide
    • Errington, A.C., Coyne,L., Stöhr, L., Selve, N., Lees, G. Seeking a mechanism of action for the novel anticonvulsant lacosamide. Neuropharmacology 2006, 50(8): 1016-29.
    • (2006) Neuropharmacology , vol.50 , Issue.8 , pp. 1016-1029
    • Errington, A.C.1    Coyne, L.2    Stöhr, L.3    Selve, N.4    Lees, G.5
  • 22
    • 77949469954 scopus 로고    scopus 로고
    • Lacosamide as treatment for partial epilepsy: Mechanism of action, pharmacology, effects and safety
    • Kellinghaus, C. Lacosamide as treatment for partial epilepsy: mechanism of action, pharmacology, effects and safety. Ther Clin Risk Manag 2009, 5: 757-66.
    • (2009) Ther Clin Risk Manag , vol.5 , pp. 757-766
    • Kellinghaus, C.1
  • 23
    • 57449108979 scopus 로고    scopus 로고
    • Eslicarbazepine acetate
    • McCormack, P.L., Robinson, D.M. Eslicarbazepine acetate. CNS Drugs 2009, 23(1): 71-9.
    • (2009) CNS Drugs , vol.23 , Issue.1 , pp. 71-79
    • McCormack, P.L.1    Robinson, D.M.2
  • 24
    • 0035873841 scopus 로고    scopus 로고
    • Inhibition of glutamate release by BIA 2-093 and BIA 2-024, two novel derivatives of carbamazepine, due to blockade of sodium but not calcium channels
    • Ambrosio A.F., Silva, A.P., Malva, J.O., Soares-da-Silva, P., Carvalho, A.P., Carvalho, C.M. Inhibition of glutamate release by BIA 2-093 and BIA 2-024, two novel derivatives of carbamazepine, due to blockade of sodium but not calcium channels. Biochem Pharmacol 2001, 61(10): 1271-5.
    • (2001) Biochem Pharmacol , vol.61 , Issue.10 , pp. 1271-1275
    • Ambrosio, A.F.1    Silva, A.P.2    Malva, J.O.3    Soares-Da-Silva, P.4    Carvalho, A.P.5    Carvalho, C.M.6
  • 25
    • 33846184701 scopus 로고    scopus 로고
    • Eslicarbazepine acetate (BIA 2-093)
    • Almeida, L., Soares-da-Silva, P. Eslicarbazepine acetate (BIA 2-093). Neurotherapeutics 2007, 4(1): 88-96.
    • (2007) Neurotherapeutics , vol.4 , Issue.1 , pp. 88-96
    • Almeida, L.1    Soares-Da-Silva, P.2
  • 27
    • 4644301804 scopus 로고    scopus 로고
    • Progress report on new antiepileptic drugs: A summary of the Seventh Eilat Conference (EILAT VII)
    • DOI 10.1016/j.eplepsyres.2004.07.010, PII S0920121104001457
    • Bialer, M., Johannessen, S.I., Kupferberg, H.J., Levy, R.H., Perucca, E., Tomson, T. Progress report on new antiepileptic drugs: A summary of the Seventh EILAT Conference (EILAT VII). Epilepsy Res 2004, 61(1-3): 1-48. (Pubitemid 39296697)
    • (2004) Epilepsy Research , vol.61 , Issue.1-3 , pp. 1-48
    • Bialer, M.1    Johannessen, S.I.2    Kupferberg, H.J.3    Levy, R.H.4    Perucca, E.5    Tomson, T.6
  • 28
    • 57849150326 scopus 로고    scopus 로고
    • Carisbamate, a novel neuromodulator, inhibits voltage gated sodium channels and action potential firing of rat hippocampal neurons
    • Liu, Y., Yohrling, J.G., Wang, Y., Hutchinson, T.L., Brenneman, D.E., Flores, C.M., Zhao, B. Carisbamate, a novel neuromodulator, inhibits voltage gated sodium channels and action potential firing of rat hippocampal neurons. Epilepsy Res 2009, 83(1): 66-72.
    • (2009) Epilepsy Res , vol.83 , Issue.1 , pp. 66-72
    • Liu, Y.1    Yohrling, J.G.2    Wang, Y.3    Hutchinson, T.L.4    Brenneman, D.E.5    Flores, C.M.6    Zhao, B.7
  • 29
    • 33846185983 scopus 로고    scopus 로고
    • Rufinamide
    • Arroyo, S. Rufinamide. Neurotherapeutics 2007, 4(1): 155-62.
    • (2007) Neurotherapeutics , vol.4 , Issue.1 , pp. 155-162
    • Arroyo, S.1
  • 30
    • 63249107131 scopus 로고    scopus 로고
    • Effectiveness and tolerability of rufnamide in children and adults with refractory epilepsy: First European experience
    • Kluger, G., Kurlemann, G., Haberlandt, E. et al. Effectiveness and tolerability of rufnamide in children and adults with refractory epilepsy: First European experience. Epilepsy Behav 2009, 14(3): 491-5.
    • (2009) Epilepsy Behav , vol.14 , Issue.3 , pp. 491-495
    • Kluger, G.1    Kurlemann, G.2    Haberlandt, E.3
  • 31
    • 1842736312 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of safinamide, a neuroprotectant with antiparkinsonian and anticonvulsant activity
    • Marzo, A., Dal Bo, L., Monti, N.C. et al. Pharmacokinetics and pharmacodynamics of safinamide, a neuroprotectant with antiparkinsonian and anticonvulsant activity. Pharmacol Res 2004, 50(1): 77-85.
    • (2004) Pharmacol Res , vol.50 , Issue.1 , pp. 77-85
    • Marzo, A.1    Dal Bo, L.2    Monti, N.C.3
  • 32
    • 0033663398 scopus 로고    scopus 로고
    • Role of sodium channel inhibition in neuroprotection: Effect of vinpocetine
    • Bonoczk, P., Gulyas, B., Adam-Vizi, V. et al. Role of sodium channel inhibition in neuroprotection: Effect of vinpocetine. Brain Res Bull 2000, 53(3): 245-54.
    • (2000) Brain Res Bull , vol.53 , Issue.3 , pp. 245-254
    • Bonoczk, P.1    Gulyas, B.2    Adam-Vizi, V.3
  • 34
    • 65549137596 scopus 로고    scopus 로고
    • Neuroprotective effects of vinpocetine and its major metabolite cis-apovincaminic acid on NMDA-induced neurotoxicity in a rat entorhinal cortex lesion model
    • Nyakas, C., Felszeghy, K., Szabó, R., Keijser, J. N., Luiten, P. G., Szombathelyi, Z., Tihanyi, K. Neuroprotective effects of vinpocetine and its major metabolite cis-apovincaminic acid on NMDA-induced neurotoxicity in a rat entorhinal cortex lesion model. CNS Neurosci Ther 2009, 15(2): 89-99.
    • (2009) CNS Neurosci Ther , vol.15 , Issue.2 , pp. 89-99
    • Nyakas, C.1    Felszeghy, K.2    Szabó, R.3    Keijser, J.N.4    Luiten, P.G.5    Szombathelyi, Z.6    Tihanyi, K.7
  • 35
    • 0022515718 scopus 로고
    • Effect of Cavinton on convulsions caused by chemical substances
    • Dutov, A.A., Tolpyshev, B.A., Karpov, V.N., Petrov, A.P. Effect of Cavinton on convulsions caused by chemical substances. Farmakol Toksikol 1986, 49(4): 22-5.
    • (1986) Farmakol Toksikol , vol.49 , Issue.4 , pp. 22-25
    • Dutov, A.A.1    Tolpyshev, B.A.2    Karpov, V.N.3    Petrov, A.P.4
  • 36
    • 26844513020 scopus 로고    scopus 로고
    • Eburnamine derivatives and the brain
    • Vas, A., Gulyás, B. Eburnamine derivatives and the brain. Med Res Rev 2005, 25(6): 737-57.
    • (2005) Med Res Rev , vol.25 , Issue.6 , pp. 737-757
    • Vas, A.1    Gulyás, B.2
  • 37
    • 33747624158 scopus 로고    scopus 로고
    • 2+ and glutamate release in hippocampal isolated nerve endings
    • 2+ and glutamate release in hippocampal isolated nerve endings. Neurochem Int 2006, 49(1): 55-61.
    • (2006) Neurochem Int , vol.49 , Issue.1 , pp. 55-61
    • Sitges, M.1    Chiu, L.M.2    Nekrassov, V.3
  • 38
    • 33846204772 scopus 로고    scopus 로고
    • Brivaracetam (UCB-34714)
    • Von Rosenstiel, P. Brivaracetam (UCB-34714). Neurotherapeutics 2007, 4(1): 84-7.
    • (2007) Neurotherapeutics , vol.4 , Issue.1 , pp. 84-87
    • Von Rosenstiel, P.1
  • 40
    • 33747047760 scopus 로고    scopus 로고
    • A new drug, RWJ-333369, displays potent antiepileptic properties in genetic models of absence and audiogenic epilepsy
    • Abst 2638
    • Nehlig, A., Rigoulot, M.A., Boehrer, A. A new drug, RWJ-333369, displays potent antiepileptic properties in genetic models of absence and audiogenic epilepsy. Epilepsia 2005, 46(Suppl. 8): Abst 2638.
    • (2005) Epilepsia , vol.46 , Issue.SUPPL. 8
    • Nehlig, A.1    Rigoulot, M.A.2    Boehrer, A.3
  • 41
    • 51449116680 scopus 로고    scopus 로고
    • A new potential AED, carisbamate, substantially reduces spontaneous motor seizures in rats with kainate-induced epilepsy
    • Grabenstatter, H.L., Dudek, F.E. A new potential AED, carisbamate, substantially reduces spontaneous motor seizures in rats with kainate-induced epilepsy. Epilepsia 2008, 49(10): 1787-94.
    • (2008) Epilepsia , vol.49 , Issue.10 , pp. 1787-1794
    • Grabenstatter, H.L.1    Dudek, F.E.2
  • 42
    • 49449094989 scopus 로고    scopus 로고
    • Anticonvulsive and antiepileptic properties of brivaracetam (UCB 34714), a high affinity synaptic vesicle protein SV2A ligand
    • Matagne, A., Margineanu, D.G., Kenda, B., Michel, P., Klitgaard, H. Anticonvulsive and antiepileptic properties of brivaracetam (UCB 34714), a high affinity synaptic vesicle protein SV2A ligand. Br J Pharmacol 2008, 154(8): 1662-71.
    • (2008) Br J Pharmacol , vol.154 , Issue.8 , pp. 1662-1671
    • Matagne, A.1    Margineanu, D.G.2    Kenda, B.3    Michel, P.4    Klitgaard, H.5
  • 43
    • 0036799687 scopus 로고    scopus 로고
    • Anticonvulsant and antiepileptogenic effects of fluorofelbamate in experimental status epilepticus
    • Mazarati, A.M., Sofia, R.D., Wasterlain, C.G. Anticonvulsant and antiepileptogenic effects of fluorofelbamate in experimental status epilepticus. Seizure 2002, 11(7): 423-30.
    • (2002) Seizure , vol.11 , Issue.7 , pp. 423-430
    • Mazarati, A.M.1    Sofia, R.D.2    Wasterlain, C.G.3
  • 44
    • 33846194013 scopus 로고    scopus 로고
    • Progress report on new antiepileptic drugs: A summary of the Eight EILAT Conference (EILAT VIII)
    • Bialer, M., Johannessen, S.I., Kupferberg, H.J., Levy, R.H., Perucca, E., Tomson, T. Progress report on new antiepileptic drugs: A summary of the Eight EILAT Conference (EILAT VIII). Epilepsy Res 2007, 73(1): 1-52.
    • (2007) Epilepsy Res , vol.73 , Issue.1 , pp. 1-52
    • Bialer, M.1    Johannessen, S.I.2    Kupferberg, H.J.3    Levy, R.H.4    Perucca, E.5    Tomson, T.6
  • 45
  • 47
    • 54149084727 scopus 로고    scopus 로고
    • Comparison of acute, chronic and post-treatment effects of carbamazepine and vinpocetine on hearing loss and seizures induced by 4-aminopyridine
    • Nekrassov, V., Sitges, M. Comparison of acute, chronic and post-treatment effects of carbamazepine and vinpocetine on hearing loss and seizures induced by 4-aminopyridine. Clin Neurophysiol 2008, 119(11): 2608-14.
    • (2008) Clin Neurophysiol , vol.119 , Issue.11 , pp. 2608-2614
    • Nekrassov, V.1    Sitges, M.2
  • 48
    • 33747069013 scopus 로고    scopus 로고
    • The anticonvulsant profile and tolerability of rufinamide in mice and rats
    • Abst 3088
    • White, H.S., Schmutz, M., Pozza, M., Wolf, H., Stables, J., Kupferberg, H. The anticonvulsant profile and tolerability of rufinamide in mice and rats. Epilepsia 2005, 46(Suppl. 8): Abst 3088.
    • (2005) Epilepsia , vol.46 , Issue.SUPPL. 8
    • White, H.S.1    Schmutz, M.2    Pozza, M.3    Wolf, H.4    Stables, J.5    Kupferberg, H.6
  • 49
    • 0023433387 scopus 로고
    • Vinpocetine effects on cognitive impairments produced by flunitrazepam
    • Bhatti, J.Z., Hindmarch, I. Vinpocetine effects on cognitive impairments produced by flunitrazepam. Int Clin Psychopharmacol 1987, 2(4): 325-31.
    • (1987) Int Clin Psychopharmacol , vol.2 , Issue.4 , pp. 325-331
    • Bhatti, J.Z.1    Hindmarch, I.2
  • 51
    • 41949140586 scopus 로고    scopus 로고
    • In vivo pharmacological effects of elpetrigine, a novel anticonvulsant, in models for anticonvulsant, antimania and antidepressant activity
    • Foreman, M.M., Hanania, T., Stratton, S.C., Wilcox, K.S., Steve White, H., Stables, J.P., Eller, M. In vivo pharmacological effects of elpetrigine, a novel anticonvulsant, in models for anticonvulsant, antimania and antidepressant activity. Pharmacol Biochem Behav 2008, 89(4): 523-34.
    • (2008) Pharmacol Biochem Behav , vol.89 , Issue.4 , pp. 523-534
    • Foreman, M.M.1    Hanania, T.2    Stratton, S.C.3    Wilcox, K.S.4    Steve White, H.5    Stables, J.P.6    Eller, M.7
  • 52
    • 70349972675 scopus 로고    scopus 로고
    • Efficacy and safety of 800 and 1200 mg Eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures
    • Nagel, A. G., Lopes-lima, J., Almeida, L., Soares-da-silva, P. Efficacy and safety of 800 and 1200 mg Eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures. Acta Neurol Scand 2009, 120(5): 281-7.
    • (2009) Acta Neurol Scand , vol.120 , Issue.5 , pp. 281-287
    • Nagel, A.G.1    Lopes-Lima, J.2    Almeida, L.3    Soares-Da-Silva, P.4
  • 53
    • 23944448566 scopus 로고    scopus 로고
    • Single-dose and steady-state pharmacokinetics of eslicarbazepine acetate (BIA 2-093) in healthy elderly and young subjects
    • Almeida, L., Falcao, A., Maia, J., Mazur, D., Gellert, M., Soares-da-Silva, P. Single-dose and steady-state pharmacokinetics of eslicarbazepine acetate (BIA 2-093) in healthy elderly and young subjects. J Clin Pharmacol 2005, 45(9): 1062-66.
    • (2005) J Clin Pharmacol , vol.45 , Issue.9 , pp. 1062-1066
    • Almeida, L.1    Falcao, A.2    Maia, J.3    Mazur, D.4    Gellert, M.5    Soares-Da-Silva, P.6
  • 55
    • 37549020621 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism of 14C-brivaracetam, a novel SV2A ligand, in healthy subjects
    • Sargentini-Maier, M.L., Espié, P., Coquette, A., Stockis, A. Pharmacokinetics and metabolism of 14C-brivaracetam, a novel SV2A ligand, in healthy subjects. Drug Metab Dispos 2008, 36(1): 36-45.
    • (2008) Drug Metab Dispos , vol.36 , Issue.1 , pp. 36-45
    • Sargentini-Maier, M.L.1    Espié, P.2    Coquette, A.3    Stockis, A.4
  • 56
    • 44949208728 scopus 로고    scopus 로고
    • The pharmacokinetics, CNS pharmacodynamics and adverse event profile of brivaracetam after multiple increasing oral doses in healthy men
    • Rolan, P., Sargentini-Maler, M.L., Plgeolet, E., Stockls, A. The pharmacokinetics, CNS pharmacodynamics and adverse event profile of brivaracetam after multiple increasing oral doses in healthy men. Br J Clin Pharmacol 2008, 66(1): 71-5.
    • (2008) Br J Clin Pharmacol , vol.66 , Issue.1 , pp. 71-75
    • Rolan, P.1    Sargentini-Maler, M.L.2    Plgeolet, E.3    Stockls, A.4
  • 57
    • 34047122100 scopus 로고    scopus 로고
    • The absorption, metabolism and excretion of the novel neuromodulator RWJ-333369 in humans
    • Mannes, G.S., Hendrick, J., Janssen, C.G. et al. The absorption, metabolism and excretion of the novel neuromodulator RWJ-333369 in humans. Drug Metab Dispos 2007, 35(4): 554-65.
    • (2007) Drug Metab Dispos , vol.35 , Issue.4 , pp. 554-565
    • Mannes, G.S.1    Hendrick, J.2    Janssen, C.G.3
  • 58
    • 33750960656 scopus 로고    scopus 로고
    • Pharmacokinetic interaction study between the new antiepileptic and CNS drug RWJ-333369 and carbamazepine in healthy subjects
    • Chien, S., Bialer, M., Solanki, B. Pharmacokinetic interaction study between the new antiepileptic and CNS drug RWJ-333369 and carbamazepine in healthy subjects. Epilepsia 2006, 47(11): 1830-9.
    • (2006) Epilepsia , vol.47 , Issue.11 , pp. 1830-1839
    • Chien, S.1    Bialer, M.2    Solanki, B.3
  • 60
    • 0026645586 scopus 로고
    • Bioavailability of vinpocetine and interference of the time of application with food intake
    • Lohmann, A., Dingler, E., Sommer, W., Schaffler, K., Wober, W., Schmidt, W. Bioavailability of vinpocetine and interference of the time of application with food intake. Arzneimittelforschung 1992, 42(7): 914-7.
    • (1992) Arzneimittelforschung , vol.42 , Issue.7 , pp. 914-917
    • Lohmann, A.1    Dingler, E.2    Sommer, W.3    Schaffler, K.4    Wober, W.5    Schmidt, W.6
  • 61
    • 0036598021 scopus 로고    scopus 로고
    • Vinpocetine
    • Vinpocetine. Altern Med Rev 2002, 7(3): 240-3.
    • (2002) Altern Med Rev , vol.7 , Issue.3 , pp. 240-243
  • 63
    • 0034935392 scopus 로고    scopus 로고
    • The mechanisms of action of commonly used antiepileptic drugs
    • Kwan, P., Sills, G.J., Brodie, M.J. The mechanisms of action of commonly used antiepileptic drugs. Pharmacol Ther 2001, 90(1): 21-34.
    • (2001) Pharmacol Ther , vol.90 , Issue.1 , pp. 21-34
    • Kwan, P.1    Sills, G.J.2    Brodie, M.J.3
  • 64
    • 0031126348 scopus 로고    scopus 로고
    • A pharmacological and clinical review on topiramate, a new antiepileptic drug
    • Perucca, E. A pharmacological and clinical review on topiramate, a new antiepileptic drug. Pharmacol Res 1997, 35(4): 241-56.
    • (1997) Pharmacol Res , vol.35 , Issue.4 , pp. 241-256
    • Perucca, E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.