MCF-7 cells as a three-dimensional model for the study of human breast cancer

Tissue Engineering - Part C: Methods

Volumn 17, Issue 11, 2011, Pages 1097-1107

  Do Amaral, Jônatas Bussador ^a   Rezende Teixeira, Paula ^a   Freitas, Vanessa Morais ^a   MacHado Santelli, Gláucia Maria ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; CELL DEATH; TUMORS;

3-D ENVIRONMENTS; ADENOCARCINOMA CELLS; AUTOPHAGY; CELL DIFFERENTIATION; CELL SURVIVAL; E-CADHERIN EXPRESSION; HUMAN BREAST CANCER; IN-VITRO; IN-VIVO; MCF-7 CELLS; MICROENVIRONMENTS; MULTICELLULAR TUMOR SPHEROIDS; THREE-DIMENSIONAL (3D); THREE-DIMENSIONAL MODEL; TUMOR PHYSIOLOGY;

THREE DIMENSIONAL;

CADHERIN; CDH1 PROTEIN, HUMAN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B;

ACTIN FILAMENT; APOPTOSIS; ARTICLE; AUTOPHAGY; BIOLOGICAL MODEL; BREAST TUMOR; CELL CYCLE; CELL PROLIFERATION; CELL SHAPE; CHEMICAL PHENOMENA; ENZYMOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MULTICELLULAR SPHEROID; PATHOLOGY; PHOSPHORYLATION; PLOIDY; TIME; TUMOR CELL LINE;

ACTIN CYTOSKELETON; APOPTOSIS; AUTOPHAGY; BREAST NEOPLASMS; CADHERINS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SHAPE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, BIOLOGICAL; PHOSPHORYLATION; PLOIDIES; PROTO-ONCOGENE PROTEINS C-AKT; RNA, MESSENGER; SPHEROIDS, CELLULAR; TIME FACTORS;

EID: 80455168283     PISSN: 19373384     EISSN: 19373392     Source Type: Journal    
DOI: 10.1089/ten.tec.2011.0260     Document Type: Article

References (58)

1. Friedman, M., and Friedland, G.W. Medicine's 10 Greatest Discoveries. New Haven: Yale University Press, 2000.
2. Kim, J., Stein, R., and O'Hare, M. Three-dimensional in vitro tissue culture models of breast cancer-a review. Breast Cancer Res Treat 85, 281, 2004.
3. Lin, R.-Z., Chu, W.-C., Chiang, C.-C., Lai, C.-H., and Chang, H.-Y. Magnetic reconstruction of three-dimensional tissues from multicellular spheroids. Tissue Eng Part C 14, 197, 2008.
4. Lin, R.-Z., and Chang, H.-Y. Recent advances in three-dimensional multicellular spheroid culture for biomedical research. Biotechnol J 3, 1172, 2008.
5. Rangarajan, A., Hong, S.J., Gifford, A., and Weinberg, R.A. Species-and cell type-specific requirements for cellular transformation. Cancer Cell 6, 171, 2004.
6. Hebner, C., Weaver, V.M., and Debnath, J. Modeling morphogenesis and oncogenesis in three-dimensional breast epithelial cultures. Annu Rev Pathol 3, 313, 2008.
7. Burdett, E., Kasper, K., Mikos, A., and Ludwig, J.A. Engineering tumors: a tissue engineering perspective in cancer biology. Tissue Eng Part B 16, 351, 2010.
8. do Amaral, J.B., and Machado-Santelli, G.M. A cultura de células em 3 dimensões e a sua aplicação em estudos re-lacionados a formação do lúmen. Naturalia 34, 1, 2011.
9. Byrnes, W.M. Ernest Everett Just, Johannes Holtfreter, and the origin of certain concepts in embryo morphogenesis. Mol Reprod Dev 76, 912, 2009.
10. Holtfreter, J. A study of the mechanics of gastrulation. J Exp Zool 95, 171, 1944.
11. Moscona, A. Cell suspensions from organ rudiments of chick embryos. Exp Cell Res 3, 535, 1952.
12. Moscona, A. Formation of lentoids by dissociated retinal cells of the chick embryo. Science 125, 598, 1957.
13. Leighton, J. A sponge matrix method for tissue culture. Formation of organized aggregates of cell in vitro. J Natl Cancer Inst 12, 545, 1951.
14. Schaeffer, W.I. In memorium-a tribute to Dr. Joseph Leighton. Methods Cell Sci 21, 1, 1999.
15. Inch, W., McCredie, J., and Sutherland, R. Growth of nodular carcinomas in rodents compared with multi-cell spheroids in tissue culture. Growth 34, 271, 1970.
16. Sutherland, R.M., McCredie, J.A., and Inch, W.R. Growth of multicell spheroids in tissue culture as a model of nodular carcinomas. J Natl Cancer Inst 46, 113, 1971.
17. Acker, H., Carlsson, J., Durand, R.E., and Sutherland, R. Spheroids in Cancer Research. Berlin Heidelberg: Springer-Verlag, 1984.
18. Mueller-Klieser, W. Tumor biology and experimental therapeutics. Crit Rev Oncol Hematol 36, 123, 2000.
19. Friedrich, J., Ebner, R., and Kunz-Schughart, L.A. Experimental anti-tumor therapy in 3-D: spheroids-old hat or new challenge? Int J Radiat Biol 83, 849, 2007.
20. Debnath, J. The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell 111, 29, 2002.
21. Debnath, J., Muthuswamy, S., and Brugge, J. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 30, 256, 2003.
22. Dhimolea, E., Maffini, M.V., Soto, A.M., and Sonnenschein, C. The role of collagen reorganization on mammary epithelial morphogenesis in a 3D culture model. Biomaterials 31, 3622, 2010.
23. Kenny, P.A., Lee, G.Y., Myers, C.A., Neve, R.M., Semeiks, J.R., Spellman, P.T., et al. The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression. Mol Oncol 1, 84, 2007.
24. do Amaral, J.B., Urabayashi, M.S., and Machado-Santelli, G.M. Cell death and lumen formation in spheroids of MCF-7 cells. Cell Biol Int 34, 267, 2010.
25. Lubarsky, B., and Krasnow, M.A. Tube morphogenesis: making and shaping biological tubes. Cell 112, 19, 2003.
26. Martín-Belmonte, F., Yu, W., Rodríguez-Fraticelli, A.E., Ewald, A., Werb, Z., Alonso, M.A., et al. Cell-polarity dynamics controls the mechanism of lumen formation in epithelial morphogenesis. Curr Biol 18, 507, 2008.
27. Anderson, L.R., Sutherland, R.L., and Butt, A.J. BAG-1 overexpression attenuates luminal apoptosis in MCF-10A mammary epithelial cells through enhanced RAF-1 activation. Oncogene 29, 527, 2009.
28. Freitas, V.M., Rangel, M., Bisson, L.F., Jaeger, R.G., and Machado-Santelli, G.M. The geodiamolide H, derived from brazilian sponge Geodia corticostylifera, regulates actin cy-toskeleton, migration and invasion of breast cancer cells cultured in three-dimensional environment. J Cell Physiol 216, 583, 2008.
29. Kleinman, H.K., and Martin, G.R. Matrigel: basement membrane matrix with biological activity. Semin Cancer Biol 15, 378, 2005.
30. Petersen, O., Ronnov-Jessen, L., Howlett, A., and Bissell, M. Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells. Proc Natl Acad Sci USA 89, 9064, 1992.
31. Weaver, V., Petersen, O., Wang, F., Larabell, C., Briand, P., Damsky, C., et al. Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J Cell Biol 137, 231, 1997.
32. Debnath, J., and Brugge, J. Modelling glandular epithelial cancers in three-dimensional cultures. Nat Rev Cancer 5, 675, 2005.
33. Mailleux, A.A., Overholtzer, M., and Brugge, J.S. Lumen formation during mammary epithelial morphogenesis: insights from in vitro and in vivo models. Cell Cycle 7, 57, 2008.
34. Lacroix, M., and Leclercq, G. Relevance of breast cancer cell lines as models for breast tumours: an update. Breast Cancer Res Treat 83, 249, 2004.
35. Soule, H.D., Vazguez, J., Long, A., Albert, S., and Brennan, M. A human cell line from a pleural effusion derived from a breast carcinoma. J Natl Cancer Inst 51, 1409, 1973.
36. Fischbach, C., Chen, R., Matsumoto, T., Schmelzle, T., Brugge, J.S., Polverini, P.J., et al. Engineering tumors with 3D scaffolds. Nat Methods 4, 855, 2007.
37. Dhiman, H.K., Ray, A.R., and Panda, A.K. Three-dimensional chitosan scaffold-based MCF-7 cell culture for the determination of the cytotoxicity of tamoxifen. Biomaterials 26, 979, 2005.
38. Kirshner, J., Chen, C.J., Liu, P., Huang, J., and Shively, J.E. CEACAM1-4S, a cell-cell adhesion molecule, mediates apo-ptosis and reverts mammary carcinoma cells to a normal morphogenic phenotype in a 3D culture. Proc Natl Acad Sci USA 100, 521, 2003.
39. Chen, C.-J., Nguyen, T., and Shively, J.E. Role of calpain-9 and PKC-[delta] in the apoptotic mechanism of lumen formation in CEACAM1 transfected breast epithelial cells. Exp Cell Res 316, 638, 2010.
40. Krause, S., Maffini, M., Soto, A., and Sonnenschein, C. The microenvironment determines the breast cancer cells' phe-notype: organization of MCF7 cells in 3D cultures. BMC Cancer 10, 263, 2010.
41. Burdall, S., Hanby, A., Lansdown, M., and Speirs, V. Breast cancer cell lines: friend or foe? Breast Cancer Res 5, 89, 2003.
42. Fillmore, C., and Kuperwasser, C. Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy. Breast Cancer Res 10, R25, 2008.
43. Grimshaw, M., Cooper, L., Papazisis, K., Coleman, J., Boh-nenkamp, H., Chiapero-Stanke, L., et al. Mammosphere culture of metastatic breast cancer cells enriches for tumor-igenic breast cancer cells. Breast Cancer Res 10, R52, 2008.
44. Calcagno, A.M., Salcido, C.D., Gillet, J.-P., Wu, C.-P., Fostel, J.M., Mumau, M.D., et al. Prolonged drug selection of breast cancer cells and enrichment of cancer stem cell characteristics. J Natl Cancer Inst 102, 1637, 2010.
45. Lu, X., Lu, X., and Kang, Y. Organ-specific enhancement of metastasis by spontaneous ploidy duplication and cell size enlargement. Cell Res 20, 1012, 2010.
46. Yan, J., Luo, D., Luo, Y., Gao, X., and Zhang, G. Induction of G1 arrest and differentiation in MDA-MB-231 breast cancer cell by boehmeriasin A, a novel compound from plant. Int J Gynecol Cancer 16, 165, 2006.
47. Baranwal, S., and Alahari, S.K. Molecular mechanisms controlling E-cadherin expression in breast cancer. Biochem Biophys Res Commun 384, 6, 2009.
48. Kashiwagi, S., Yashiro, M., Takashima, T., Nomura, S., Noda, S., Kawajiri, H., et al. Significance of E-cadherin expression in triple-negative breast cancer. Br J Cancer 103, 249, 2010.
49. Onder, T., Gupta, P., Mani, S., Yang, J., Lander, E., and Weinberg, R. Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res 68, 3645, 2008.
50. Debnath, J., Mills, K.R., Collins, N.L., Reginato, M.J., Mu-thuswamy, S.K., and Brugge, J. The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell 111, 29, 2002.
51. Mills, K.R., Reginato, M., Debnath, J., Queenan, B., and Brugge, J.S. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro. Proc Natl Acad Sci USA 101, 3438, 2004.
52. Mizushima, N., and Yoshimori, T. How to interpret LC3 immunoblotting. Autophagy 3, 542, 2007.
53. Kolch, W. Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Bio-chem J 351, 289, 2000.
54. O'Connor, L., Strasser, A., O'Reilly, L.A., Hausmann, G., Adams, J.M., Cory, S., et al. Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J 17, 384, 1998.
55. Carnero, A., Blanco-Aparicio, C., Renner, O., Link, W., and Leal, J.F. The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications. Curr Cancer Drug Targets 8, 187, 2008.
56. Bellacosa, A., Chan, T.O., Ahmed, N.N., Datta, K., Mal-strom, S., Stokoe, D., et al. Akt activation by growth factors is a multiple-step process: the role of the PH domain. Oncogene 17, 313, 1998.
57. Testa, J.R., and Bellacosa, A. AKT plays a central role in tumorigenesis. Proc Natl Acad Sci USA 98, 10983, 2001.
58. Debnath, J., Walker, S.J., and Brugge, J.S. AKT activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner. J Cell Biol 163, 315, 2003.