Organ-specific enhancement of metastasis by spontaneous ploidy duplication and cell size enlargement

Cell Research

Volumn 20, Issue 9, 2010, Pages 1012-1022

  Lu, Xin ^a   Lu, Xuemin ^a   Kang, Yibin ^a,b  

^a PRINCETON UNIVERSITY   (United States)

^b RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

breast cancer; cell size; hyperploidy; metastasis; organotropism

Indexed keywords

ANEUPLOIDY; ANIMAL; ARTICLE; BREAST TUMOR; CELL SIZE; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; KARYOTYPING; METABOLISM; METASTASIS; MOUSE; PATHOLOGY; TUMOR CELL LINE; XENOGRAFT;

ANEUPLOIDY; ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL SIZE; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KARYOTYPING; MICE; NEOPLASM METASTASIS; TRANSPLANTATION, HETEROLOGOUS;

EID: 77956341942     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2010.93     Document Type: Article

References (37)

1. Gupta GP, Massague J. Cancer metastasis: building a framework. Cell 2006; 127:679-695.
2. Lu X, Kang Y. Organotropism of breast cancer metastasis. J Mammary Gland Biol Neoplasia 2007; 12:153-162.
3. Rajagopalan H, Lengauer C. Aneuploidy and cancer. Nature 2004; 432:338-341.
4. Coulson P, Thornthwaite J, Woolley T, Sugarbaker E, Seck-inger D. Prognostic indicators including DNA histogram type, receptor content, and staging related to human breast cancer patient survival. Cancer Res 1984; 44:4187-4196.
5. Kallioniemi OP, Blanco G, Alavaikko M, et al. Improving the prognostic value of DNA fow cytometry in breast cancer by combining DNA index and S-phase fraction. A proposed clas-sifcation of DNA histograms in breast cancer. Cancer 1988; 62:2183-2190.
6. Dutrillaux B, Gerbault-Seureau M, Remvikos Y, Zafrani B, Prieur M. Breast cancer genetic evolution: I. Data from cy-togenetics and DNA content. Breast Cancer Res Treat 1991; 19:245-255.
7. Lu X, Kang Y. Cell fusion as a hidden force in tumor progression. Cancer Res 2009; 69:8536-8539.
8. Singec I, Snyder EY. Infammation as a matchmaker: revisiting cell fusion. Nat Cell Biol 2008; 10:503-505.
9. Storchova Z, Pellman D. From polyploidy to aneuploidy, genome instability and cancer. Nat Rev Mol Cell Biol 2004; 5:45-54.
10. Abdalla F, Boder J, Markus R, Hashmi H, Buhmeida A, Col-lan Y. Correlation of nuclear morphometry of breast cancer in histological sections with clinicopathological features and prognosis. Anticancer Res 2009; 29:1771-1776.
11. Van Bogaert LJ, De Muylder C, Maldague P, Maisin H. Prognostic implications of mean nuclear diameter in breast cancer. Br J Cancer 1980; 42:537-541.
12. Zajdela A, De LaRiva LS, Ghossein NA. The relation of prognosis to the nuclear diameter of breast cancer cells obtained by cytologic aspiration. Acta Cytologica 1979; 23:75-80.
13. Khan MA, Walsh PC, Miller MC, et al. Quantitative alterations in nuclear structure predict prostate carcinoma distant metastasis and death in men with biochemical recurrence after radical prostatectomy. Cancer 2003; 98:2583-2591.
14. Blom JH, Ten Kate FJ, Schroeder FH, Van Der Heul RO. Mor-phometrically estimated variation in nuclear size. A useful tool in grading prostatic cancer. Urol Res 1990; 18:93-99.
15. Mossbacher U, Knollmayer S, Binder M, Steiner A, Wolff K, Pehamberger H. Increased nuclear volume in metastasizing 'thick' melanomas. J Invest Dermatol 1996; 106:437-440.
16. Minn AJ, Gupta GP, Siegel PM, et al. Genes that mediate breast cancer metastasis to lung. Nature 2005; 436:518-524.
17. Kang Y, Siegel PM, Shu W, et al. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 2003; 3:537-549.
18. Bos PD, Zhang XHF, Nadal C, et al. Genes that mediate breast cancer metastasis to the brain. Nature 2009; 459:1005-1009.
19. Lu X, Kang Y. Effcient acquisition of dual metastasis organ-otropism to bone and lung through stable spontaneous fusion between MDA-MB-231 variants. Proc Natl Acad Sci USA 2009; 106:9385-9390.
20. Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profles. Proc Natl Acad Sci USA 2005; 102:15545-15550.
21. Mootha VK, Lindgren CM, Eriksson KF, et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 2003; 34:267-273.
22. Galitski T, Saldanha AJ, Styles CA, Lander ES, Fink GR. Ploidy regulation of gene expression. Science 1999; 285:251-254.
23. Watanabe S. The metastasizability of tumor cells. Cancer 1954; 7:215-223.
24. Zeidman I. The fate of circulating tumor cells: I. Passage of cells through capillaries. Cancer Res 1961; 21:38-39.
25. Koike A. Mechanism of blood-borne metastases. I. Some factors affecting lodgment and growth of tumor cells in the lungs. Cancer 1964; 17:450-460.
26. Nguyen DX, Bos PD, Massague J. Metastasis: from dissemination to organ-specifc colonization. Nat Rev Cancer 2009; 9:274-284.
27. Kang Y. Functional genomic analysis of cancer metastasis: biologic insights and clinical implications. Expert Rev Mol Diagn 2005; 5:385-395.
28. Paget S. Distribution of secondary growths in cancer of the breast. Lancet 1889; 1:571-573.
29. Padua D, Zhang XH, Wang Q, et al. TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell 2008; 133:66-77.
30. Kimura H, Hayashi K, Yamauchi K, et al. Real-time imaging of single cancer-cell dynamics of lung metastasis. J Cell Bio-chem 2010; 109:58-64.
31. Ganem NJ, Storchova Z, Pellman D. Tetraploidy, aneuploidy and cancer. Curr Opin Genet Dev 2007; 17:157-162.
32. Kang Y. Analysis of cancer stem cell metastasis in xenograft animal models. Methods Mol Biol 2009; 568:7-19.
33. Lu X, Kang Y. Chemokine (C-C motif) ligand 2 engages CCR2+ stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone. J Biol Chem 2009; 284:29087-29096.
34. Yang J, Mani SA, Donaher JL, et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 2004; 117:927-939.
35. Lu X, Wang Q, Hu G, et al. ADAMTS1 and MMP1 prote-olytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis. Genes Dev 2009; 23:1882-1894.
36. Sauer KA, Scholtes P, Karwot R, Finotto S. Isolation of CD4+ T cells from murine lungs: a method to analyze ongoing immune responses in the lung. Nat Protoc 2007; 1:2870-2875.
37. Mootha VK, Lindgren CM, Eriksson K-F, et al. PGC-1[alpha]-responsive genes involved in oxidative phosphoryla-tion are coordinately downregulated in human diabetes. Nat Genet 2003; 34:267-273.