Biochemical pathways that regulate acetyltransferase and deacetylase activity in mammalian cells

Trends in Biochemical Sciences

Volumn 34, Issue 11, 2009, Pages 571-578

  Mellert, Hestia S ^a   McMahon, Steven B ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; ACYLTRANSFERASE; CYCLIN DEPENDENT KINASE 2; CYCLIN E; HISTONE ACETYLTRANSFERASE; HISTONE ACETYLTRANSFERASE PCAF; HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE INHIBITOR; HYDROLASE; PROTEIN MDM2; PROTEIN P53; SIRTUIN 1; VORINOSTAT;

ACETYLATION; ALZHEIMER DISEASE; CATALYSIS; CLINICAL TRIAL; CUTANEOUS T CELL LYMPHOMA; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUNTINGTON CHOREA; MOUSE MAMMARY TUMOR ONCOVIRUS; MUSCULAR DYSTROPHY; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; SUMOYLATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ACETYLATION; ACETYLTRANSFERASES; ANIMALS; CATALYSIS; HISTONE DEACETYLASES; HISTONES; HUMANS; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EUKARYOTA; MAMMALIA;

EID: 70350350917     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibs.2009.06.010     Document Type: Review

References (77)

1. Wellen K.E., et al. ATP-citrate lyase links cellular metabolism to histone acetylation. Science 324 (2009) 1076-1080
2. Legube G., and Trouche D. Regulating histone acetyltransferases and deacetylases. EMBO Rep. 4 (2003) 944-947
3. Tyteca S., et al. To die or not to die: a HAT trick. Mol. Cell 24 (2006) 807-808
4. Dokmanovic M., et al. Histone deacetylase inhibitors: overview and perspectives. Mol. Cancer. Res. 5 (2007) 981-989
5. Cheng Z., et al. Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response. Oncogene 27 (2008) 931-941
6. Chan H.M., and La Thangue N.B. p300/CBP proteins: HATs for transcriptional bridges and scaffolds. J. Cell Sci. 114 (2001) 2363-2373
7. Nakajima T., et al. The signal-dependent coactivator CBP is a nuclear target for pp90RSK. Cell 86 (1996) 465-474
8. Liu Y.Z., et al. Nerve growth factor up-regulates the transcriptional activity of CBP through activation of the p42/p44(MAPK) cascade. J. Biol. Chem. 273 (1998) 32400-32407
9. Chawla S., et al. CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV. Science 281 (1998) 1505-1509
10. Ait-Si-Ali S., et al. Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A. Nature 396 (1998) 184-186
11. Ogryzko V.V., et al. The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87 (1996) 953-959
12. Martens J.H., et al. Scaffold/matrix attachment region elements interact with a p300-scaffold attachment factor A complex and are bound by acetylated nucleosomes. Mol. Cell Biol. 22 (2002) 2598-2606
13. Hamamori Y., et al. Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A. Cell 96 (1999) 405-413
14. Thompson P.R., et al. Regulation of the p300 HAT domain via a novel activation loop. Nat. Struct. Mol. Biol. 11 (2004) 308-315
15. Kyriakis J.M., and Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev. 81 (2001) 807-869
16. Thomas T., and Voss A.K. The diverse biological roles of MYST histone acetyltransferase family proteins. Cell Cycle 6 (2007) 696-704
17. Karanam B., et al. Kinetic and mass spectrometric analysis of p300 histone acetyltransferase domain autoacetylation. J. Biol. Chem. 281 (2006) 40292-40301
18. Kim S.C., et al. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol. Cell 23 (2006) 607-618
19. Creaven M., et al. Control of the histone-acetyltransferase activity of Tip60 by the HIV-1 transactivator protein. Tat. Biochemistry 38 (1999) 8826-8830
20. Patel J.H., et al. The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60. Mol. Cell Biol. 24 (2004) 10826-10834
21. Liu Y., et al. Adenovirus E1B 55-kilodalton oncoprotein inhibits p53 acetylation by PCAF. Mol. Cell Biol. 20 (2000) 5540-5553
22. Trievel R.C., et al. Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 8931-8936
23. Yan Y., et al. The catalytic mechanism of the ESA1 histone acetyltransferase involves a self-acetylated intermediate. Nat. Struct. Biol. 9 (2002) 862-869
24. Neuwald A.F., and Landsman D. GCN5-related histone N-acetyltransferases belong to a diverse superfamily that includes the yeast SPT10 protein. Trends Biochem. Sci. 22 (1997) 154-155
25. Lill N.L., et al. Binding and modulation of p53 by p300/CBP coactivators. Nature 387 (1997) 823-827
26. Black J.C., et al. A mechanism for coordinating chromatin modification and preinitiation complex assembly. Mol. Cell 23 (2006) 809-818
27. Snowden A.W., et al. A novel transcriptional repression domain mediates p21(WAF1/CIP1) induction of p300 transactivation. Mol. Cell Biol. 20 (2000) 2676-2686
28. Girdwood D., et al. P300 transcriptional repression is mediated by SUMO modification. Mol. Cell 11 (2003) 1043-1054
29. Bouras T., et al. SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J. Biol. Chem. 280 (2005) 10264-10276
30. McKnight G.S., et al. Butyrate and related inhibitors of histone deacetylation block the induction of egg white genes by steroid hormones. Cell 22 (1980) 469-477
31. Lallemand F., et al. Direct inhibition of the expression of cyclin D1 gene by sodium butyrate. Biochem. Biophys. Res. Commun. 229 (1996) 163-169
32. Bresnick E.H., et al. Glucocorticoid receptor-dependent disruption of a specific nucleosome on the mouse mammary tumor virus promoter is prevented by sodium butyrate. Proc. Natl. Acad. Sci. U. S. A. 87 (1990) 3977-3981
33. Mulholland N.M., et al. Inhibition of MMTV transcription by HDAC inhibitors occurs independent of changes in chromatin remodeling and increased histone acetylation. Oncogene 22 (2003) 4807-4818
34. Qiu Y., et al. HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription. Mol. Cell 22 (2006) 669-679
35. Becker M., et al. Dynamic behavior of transcription factors on a natural promoter in living cells. EMBO Rep. 3 (2002) 1188-1194
36. Reid G., et al. Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor alpha, in response to deacetylase inhibition by valproic acid and trichostatin A. Oncogene 24 (2005) 4894-4907
37. Cho Y., et al. Individual histone deacetylases in Drosophila modulate transcription of distinct genes. Genomics 86 (2005) 606-617
38. Chang S., and Pikaard C.S. Transcript profiling in Arabidopsis reveals complex responses to global inhibition of DNA methylation and histone deacetylation. J. Biol. Chem. 280 (2005) 796-804
39. Berdeaux R., et al. SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes. Nat. Med. 13 (2007) 597-603
40. Thomas E.A., et al. The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 15564-15569
41. Green K.N., et al. Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau. J. Neurosci. 28 (2008) 11500-11510
42. Keedy K.S., et al. A limited group of class I histone deacetylases acts to repress human immunodeficiency virus type 1 expression. J. Virol. 83 (2009) 4749-4756
43. Allard S., et al. NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. EMBO J. 18 (1999) 5108-5119
44. Clarke A.S., et al. Esa1p is an essential histone acetyltransferase required for cell cycle progression. Mol. Cell. Biol. 19 (1999) 2515-2526
45. Kamine J., et al. Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator. Virology 216 (1996) 357-366
46. Yamamoto T., and Horikoshi M. Novel substrate specificity of the histone acetyltransferase activity of HIV-1-Tat interactive protein Tip60. J. Biol. Chem. 272 (1997) 30595-30598
47. Ikura T., et al. Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Cell 102 (2000) 463-473
48. Squatrito M., et al. Tip60 in DNA damage response and growth control: many tricks in one HAT. Trends Cell Biol. 16 (2006) 433-442
49. Sun Y., et al. A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 13182-13187
50. Gupta A., et al. Involvement of human MOF in ATM function. Mol. Cell Biol. 25 (2005) 5292-5305
51. Kusch T., et al. Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions. Science 306 (2004) 2084-2087
52. Legube G., et al. Role of the histone acetyl transferase Tip60 in the p53 pathway. J. Biol. Chem. 279 (2004) 44825-44833
53. Sykes S.M., et al. Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol. Cell 24 (2006) 841-851
54. Tang Y., et al. Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol. Cell 24 (2006) 827-839
55. Legube G., et al. Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation. EMBO J. 21 (2002) 1704-1712
56. Bhoumik A., et al. Regulation of TIP60 by ATF2 modulates ATM activation. J. Biol. Chem. 283 (2008) 17605-17614
57. Lemercier C., et al. Tip60 acetyltransferase activity is controlled by phosphorylation. J. Biol. Chem. 278 (2003) 4713-4718
58. Kim J.H., et al. Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes. Nature 434 (2005) 921-926
59. Gorrini C., et al. Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response. Nature 448 (2007) 1063-1067
60. Sasaki T., et al. Phosphorylation regulates SIRT1 function. PLoS ONE 3 (2008) e4020
61. Yang Y., et al. SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress. Nat. Cell Biol. 9 (2007) 1253-1262
62. Chen L., and Chen J. MDM2-ARF complex regulates p53 sumoylation. Oncogene 22 (2003) 5348-5357
63. Kornek G., and Selzer E. Targeted therapies in solid tumours: pinpointing the tumour's Achilles heel. Curr. Pharm. Des. 15 (2009) 207-242
64. Pavlovsky C., et al. First-line therapy for chronic myeloid leukemia: Past, present, and future. Am. J. Hematol. (2009)
65. Gu W., and Roeder R.G. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90 (1997) 595-606
66. Boyes J., et al. Regulation of activity of the transcription factor GATA-1 by acetylation. Nature 396 (1998) 594-598
67. Costanzo A., et al. DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes. Mol. Cell 9 (2002) 175-186
68. Luo J., et al. Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature 408 (2000) 377-381
69. Ito A., et al. MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. EMBO J. 21 (2002) 6236-6245
70. Gaughan L., et al. Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor. J. Biol. Chem. 277 (2002) 25904-25913
71. Mal A., et al. A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program. EMBO J. 20 (2001) 1739-1753
72. Langley E., et al. Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J. 21 (2002) 2383-2396
73. Vaziri H., et al. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107 (2001) 149-159
74. Luo J., et al. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107 (2001) 137-148
75. Fu M., et al. Hormonal control of androgen receptor function through SIRT1. Mol. Cell. Biol. 26 (2006) 8122-8135
76. Rajamohan S.B., et al. SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly (ADP-ribose) polymerase 1. Mol. Cell. Biol 29 (2009) 4116-4129
77. Wang L., et al. Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and function. Curr. Opin. Struct. Biol. 18 (2008) 741-747