The effect of dehydroleucodine in adipocyte differentiation

European Journal of Pharmacology

Volumn 671, Issue 1-3, 2011, Pages 18-25

  Galvis, Adriana ^a   Marcano, Adriana ^a   Stefancin, Chad ^a   Villaverde, Nicole ^a   Priestap, Horacio A ^a   Tonn, Carlos E ^b   Lopez, Luis A ^c   Barbieri, Manuel A ^a  

^a FLORIDA INTERNATIONAL UNIVERSITY   (United States)

^b UNIVERSIDAD NACIONAL DE SAN LUIS   (Argentina)

^c Instituto de Histologia y Embriologia   (Argentina)

Author keywords

Methylene lactone function; Adipocyte; Dehydroleucodine; Transcriptional factor

Indexed keywords

11,13 DIHYDRODEHYDROLEUCODINE; CCAAT ENHANCER BINDING PROTEIN ALPHA; DEHYDROLEUCODINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ALPHA; LIPID; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE B; SESQUITERPENE LACTONE DERIVATIVE; UNCLASSIFIED DRUG;

ADIPOCYTE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME PHOSPHORYLATION; PRIORITY JOURNAL; PROADIPOCYTE; PROTEIN EXPRESSION;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; LACTONES; MICE; SESQUITERPENES; TRANSCRIPTION FACTORS;

EID: 80455160159     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.09.033     Document Type: Article

References (37)

1. C.A. Auld, R.G. Hopkins, K.M. Fernandes, and R.F. Morrison Novel effect of helenalin on Akt signaling and Skp2 expression in 3T3-L1 preadipocytes Biochem. Biophys. Res. Commun. 346 2006 314 320 (Pubitemid 43866000)
2. A.C. Beekman, H.J. Woerdenbag, W. van Uden, N. Pras, A.W. Konings, H.V. Wikstrom, and T.J. Schmidt Structure-cytotoxicity relationships of some helenanolide-type sesquiterpene lactones J. Nat. Prod. 60 1997 252 257 (Pubitemid 27146459)
3. J.G. Blanco, R.R. Gil, C.I. Alvarez, L.C. Patrito, S. Genti-Raimondi, and A. Flury A novel activity for a group of sesquiterpene lactones: inhibition of aromatase FEBS Lett. 409 1997 396 400 (Pubitemid 27285893)
4. F. Bohlmann, and C. Zdero Zwei neue Sesquiterpen-lactone aus Lidbeckia pectinata Berg. und Pentzia elegans DC Tetrahedron Lett. 13 1972 621 624
5. F. Bost, M. Aouadi, L. Caron, and B. Binetruy The role of MAPKs in adipocyte differentiation and obesity Biochimie 87 2005 51 56 (Pubitemid 40298765)
6. S.D. Brengio, S.A. Belmonte, E. Guerreiro, O.S. Giordano, E.O. Pietrobon, and M.A. Sosa The sesquiterpene lactone dehydroleucodine (DhL) affects the growth of cultured epimastigotes of Trypanosoma cruzi J. Parasitol. 86 2000 407 412 (Pubitemid 30208404)
7. C.H. Cheng, B. Costall, M. Hamburger, K. Hostettmann, R.J. Naylor, Y. Wang, and P. Jenner Toxic effects of solstitialin A 13-acetate and cynaropicrin from Centaurea solstitialis L. (Asteraceae) in cell cultures of foetal rat brain Neuropharmacology 31 1992 271 277
8. O. Galal Nutrition-related health patterns in the Middle East Asia Pac. J. Clin. Nutr. 12 2003 337 343 (Pubitemid 38880721)
9. O.S. Giordano, E. Guerreiro, M.J. Pestchanker, J. Guzman, D. Pastor, and T. Guardia The gastric cytoprotective effect of several sesquiterpene lactones J. Nat. Prod. 53 1990 803 809 (Pubitemid 20334537)
10. O.S. Giordano, M.J. Pestchanker, E. Guerreiro, J.R. Saad, R.D. Enriz, A.M. Rodriguez, E.A. Jauregui, J. Guzman, A.O. Maria, and G.H. Wendel Structure-activity relationship in the gastric cytoprotective effect of several sesquiterpene lactones J. Med. Chem. 35 1992 2452 2458
11. A.J. Hay, M. Hamburger, K. Hostettmann, and J.R. Hoult Toxic inhibition of smooth muscle contractility by plant-derived sesquiterpenes caused by their chemically reactive alpha-methylenebutyrolactone functions Br. J. Pharmacol. 112 1994 9 12 (Pubitemid 24151695)
12. K. Hayashi, T. Hayashi, K. Ujita, and Y. Takaishi Characterization of antiviral activity of a sesquiterpene, triptofordin C-2 J. Antimicrob. Chemother. 37 1996 759 768 (Pubitemid 26135347)
13. S.P. Hehner, M. Heinrich, P.M. Bork, M. Vogt, F. Ratter, V. Lehmann, K. Schulze-Osthoff, W. Droge, and M.L. Schmitz Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta J. Biol. Chem. 273 1998 1288 1297 (Pubitemid 28133643)
14. M. Heinrich, M. Robles, J.E. West, B.R. Ortiz de Montellano, and E. Rodriguez Ethnopharmacology of Mexican asteraceae (Compositae) Annu. Rev. Pharmacol. Toxicol. 38 1998 539 565 (Pubitemid 28231505)
15. D. Hwang, N.H. Fischer, B.C. Jang, H. Tak, J.K. Kim, and W. Lee Inhibition of the expression of inducible cyclooxygenase and proinflammatory cytokines by sesquiterpene lactones in macrophages correlates with the inhibition of MAP kinases Biochem. Biophys. Res. Commun. 226 1996 810 818 (Pubitemid 26348552)
16. B.E. Kemp, D. Stapleton, D.J. Campbell, Z.P. Chen, S. Murthy, M. Walter, A. Gupta, J.J. Adams, F. Katsis, B. van Denderen, I.G. Jennings, T. Iseli, B.J. Michell, and L.A. Witters AMP-activated protein kinase, super metabolic regulator Biochem. Soc. Trans. 31 2003 162 168 (Pubitemid 36241420)
17. A. Koppen, and E. Kalkhoven Brown vs white adipocytes: the PPARgamma coregulator story FEBS Lett. 584 2008 3250 3259
18. F. Lagra, K. Karastergiou, I. Delithanasis, E. Koutsika, I. Katsikas, and P. Papadopoulou-Zekeridou Obesity and colorectal cancer Tech. Coloproctol. 8 Suppl. 1 2004 s161 s163
19. G. Lyss, A. Knorre, T.J. Schmidt, H.L. Pahl, and I. Merfort The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65 J. Biol. Chem. 273 1998 33508 33516 (Pubitemid 29005734)
20. D. Meisse, M. Van de Casteele, C. Beauloye, I. Hainault, B.A. Kefas, M.H. Rider, F. Foufelle, and L. Hue Sustained activation of AMP-activated protein kinase induces c-Jun N-terminal kinase activation and apoptosis in liver cells FEBS Lett. 526 2002 38 42 (Pubitemid 35245688)
21. A.J. Mendez, C. Cabeza, and S.L. Hsia A fluorometric method for the determination of triglycerides in nanomolar quantities Anal. Biochem. 156 1986 386 389 (Pubitemid 16051775)
22. A.B. Penissi, T.H. Fogal, J.A. Guzman, and R.S. Piezzi Gastroduodenal mucosal protection induced by dehydroleucodine: mucus secretion and role of monoamines Dig. Dis. Sci. 43 1998 791 798 (Pubitemid 28176469)
23. N.B. Perry, and L.M. Foster Sesquiterpene/quinol from a New Zealand liverwort, Riccardia crassa J. Nat. Prod. 58 1995 1131 1135
24. F.X. Pi-Sunyer The obesity epidemic: pathophysiology and consequences of obesity Obes. Res. 10 Suppl. 2 2002 97S 104S (Pubitemid 41132563)
25. L.M. Polo, C.M. Castro, M.C. Cruzado, C.J. Collino, F.D. Cuello-Carrion, D.R. Ciocca, O.S. Giordano, M. Ferrari, and L.A. Lopez 11,13-Dihydro- dehydroleucodine, a derivative of dehydroleucodine with an inactivated alkylating function conserves the anti-proliferative activity in G2 but does not cause cytotoxicity Eur. J. Pharmacol. 556 2007 19 26 (Pubitemid 46073997)
26. D.L. Roberts, C. Dive, and A.G. Renehan Biological mechanisms linking obesity and cancer risk: new perspectives Annu. Rev. Med. 61 2010 301 316
27. M. Robles, M. Aregullin, J. West, and E. Rodriguez Recent studies on the zoopharmacognosy, pharmacology and neurotoxicology of sesquiterpene lactones Planta Med. 61 1995 199 203
28. E.D. Rosen, and B.M. Spiegelman Molecular regulation of adipogenesis Annu. Rev. Cell Dev. Biol. 16 2000 145 171 (Pubitemid 32037503)
29. E.D. Rosen, C.J. Walkey, P. Puigserver, and B.M. Spiegelman Transcriptional regulation of adipogenesis Genes Dev. 14 2000 1293 1307 (Pubitemid 30397073)
30. P. Sartipy, and D.J. Loskutoff Monocyte chemoattractant protein 1 in obesity and insulin resistance Proc. Natl. Acad. Sci. U.S.A. 100 2003 7265 7270 (Pubitemid 36706427)
31. R.J. Shaw, M. Kosmatka, N. Bardeesy, R.L. Hurley, L.A. Witters, R.A. DePinho, and L.C. Cantley The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress Proc. Natl. Acad. Sci. U.S.A. 101 2004 3329 3335 (Pubitemid 38338195)
32. N.F. Sheard Cow's milk, diabetes, and infant feeding Nutr. Rev. 51 1993 79 81
33. X.M. Song, M. Fiedler, D. Galuska, J.W. Ryder, M. Fernstrom, A.V. Chibalin, H. Wallberg-Henriksson, and J.R. Zierath 5-Aminoimidazole-4- carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) mice Diabetologia 45 2002 56 65 (Pubitemid 34118543)
34. B.M. Spiegelman, L. Choy, G.S. Hotamisligil, R.A. Graves, and P. Tontonoz Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes J. Biol. Chem. 268 1993 6823 6826 (Pubitemid 23105553)
35. T. Tanaka, N. Yoshida, T. Kishimoto, and S. Akira Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene EMBO J. 16 1997 7432 7443 (Pubitemid 28010503)
36. M.R. Wofford, M.E. Andrew, A. Brown, D. King, R.A. Pickett, J. Stevens, S. Wyatt, and D.W. Jones Obesity hypertension in the atherosclerosis risk in communities cohort: implications of obesity guidelines J. Clin. Hypertens. 1 1999 27 32
37. J.W. Yun Possible anti-obesity therapeutics from nature-a review Phytochemistry 71 2010 1625 1641