The sesquiterpene lactone dehydroleucodine (DhL) affects the growth of cultured epimastigotes of Trypanosoma cruzi

Journal of Parasitology

Volumn 86, Issue 2, 2000, Pages 407-412

  Brengio, Silvia D ^a   Belmonte, Silvia A ^a   Guerreiro, Eduardo ^a,b   Giordano, Oscar S ^a,b   Pietrobon, Elisa O ^a   Sosa, Miguel A ^a  

^a Instituto de Histologia y Embriologia   (Argentina)

^b Área de Química Analítica   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

SESQUITERPENE LACTONE DEHYDROLEUCODINE; SESQUITERPENE LACTONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; FLAGELLATE; GROWTH INHIBITION; GROWTH REGULATION; NONHUMAN; TRYPANOSOMA CRUZI;

INVERTEBRATA; MASTIGOPHORA (FLAGELLATES); PROTOZOA; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 0034127868     PISSN: 00223395     EISSN: None     Source Type: Journal    
DOI: 10.1645/0022-3395(2000)086[0407:tsldda]2.0.co;2     Document Type: Article

References (20)

1. BEEKMAN, A. C., H. J. WOERDENBAG, W. VAN UDEN, N. PRAS, A. W. T. KONINGS, V. H. WIKTSROM, AND T. J. SCHMIDT. 1997. Structure-cytotoxicity relationship of some helenanolide-type sesquiterpene lactones. Journal of Natural Products 60: 252-257.
2. BRENKR, Z. 1973. Biology of Trypanosoma cruzi. Annual Review of Microbiology 27: 347-382.
3. CHIARI, E., A. B. DE OLIVHIRA, D. S. RASLAN, A. A. MESQUITA, AND K. G. TAVARKS. 1991. Screening in vitro of natural products against blood forms of Trypanosoma cruzi. Transactions of the Royal Society of Tropical Medicine and Hygiene 85: 372-374.
4. DE SOUZA, W. 1984. Cell biology of Trypanosoma cruzi. International Review of Cytology 186: 197-283.
5. DOCAMPO, R., AND S. N. J. MORENO. 1984. Free radicals metabolites in the mode of action of chemotherapeutic agents and phagocytic cells on Trypanosoma cruzi. Review of Infectious Disease 6: 223-238.
6. FOURNHT, A., A. ANGELO, V. MUN̄OZ, R. ROBLOT, R. HOCQUEMILLER, AND A. CAVE. 1992. Biological and chemical studies of Perabenensis a Bolivian plant used in folk medicine as a treatment of cutaneous Leishmaniasis. Journal of Ethnopharmacology 37: 159-164.
7. GIORDANO, O. S., E. GUERREIRO, M. J. PETSCHANKER, J.GUZMAN, D. PASTOR, AND T. GUARDIA. 1990. The gastric cytoprotective effect of several sesquiterpene lactones. Journal of Natural Products 53: 803-809.
8. ISOLA, E. L. D., H. M. LAMMEL, V. J. KATZIN, AND S. M. GONZALEZ-CAPPA. 1981. Trypanosoma cruzi morhogenesis: Preliminary purification of an active fraction from hemolymph and intestinal homogenate of Triatoma infestons. Journal of Parasitology 67: 53-58.
9. JISAKA, M., M. KAWANAKA, H. SUGIYAMA, K. TAKEGAWA, M. A. HUFFMAN, H. OHIGASHI, AND K. KOSHIMIZU. 1992. Antischistosomal activities of sesquiterpene lactones and steroid glucosides from Vernonia amygdalina, possibly used by wild chimpanzees against parasite-related diseases. Bioscience, Biotechnology and Biochemistry 56: 845-846.
10. JOCKERS-SCHERUBL, M. C., R. H. SCHIRMER, AND R. L. KRAUTH-SIEGEL. 1989. Trypanothione reductase from Trypanosoma cruzi. Catalytic properties of the enzyme and inhibition studies with trypanocidal compounds. European Journal of Biochemistry 180: 267-272.
11. KUPCHAN, S. M., M. A. EAKIN, AND A. M. THOMAS. 1971. Tumor inhibitors. Structure-cytotoxicity relationships among the sesquiterpene lactones. Journal of Medicinal Chemistry 14(12): 1147-1152.
12. _, D. C. FESSLER, M. A. EAKIN, AND T. J. GIACOBBE. 1970. Reactions of α-methylene lactone tumor inhibitors with model biological nucleophiles. Science 168: 376-378.
13. LAMMEL, E. M., D. TURYN, AND E. L. D. ISOEA. 1992. Trypanosoma cruzi: Incorporation of macromolecule precursors during morphogenic process. Revista Argentina de Microbiología 24: 81-85.
14. LEE, K. H., I. H. HALL, E. C. MAR, C. O. STARNES, S. A. ELGEBALY, T. G. WADDELL, R. I. HADGRAFT, C. G. RUFFNER, AND I. WEIDNER. 1977. Sesquiterpene antitumor agents: Inhibitors of cellular metabolism. Science 196: 533-535.
15. MORELLO, A. 1988. The biochemistry of the mode of action of drugs and the detoxication mechanisms in Trypanosoma cruzi. Comparative Biochemistry and Physiology 90C: 1-12.
16. PENKETH, P. G., W. P. K. KENNEDY, C. L. PATTON, AND A. C. SARTORELLI. 1987. Trypanosomatid hydrogen peroxide metabolism. FEBS Letters 221: 427-431.
17. PICMAN, A. K. 1986. Biological activities of sesquiterpene lactones. Biochemical Systematics and Ecology 14:255-281.
18. RODRIGUEZ, E., G. H. N. TOWERS, AND J. C. MITCHELL. 1976. BIOLOGICAL ACTIVITIES OF SESQUITERPENE LACTONES. PHYTOCHEMISTRY 15: 1573-1580.
19. SEPÚLVEDA-BOZA, S., AND B. K. CASSELS. 1996. Plant metabolites active against Trypanosoma cruzi. Planta Medica 62: 98-105.
20. WOERDENBAG, H. J., I. MERFORT, C. M. PASSREITER, T. J. SCHMIDT, G. WILLUHN, W. VAN UDEN, N. PRAS, H. KAMPINGA, AND A. W. T. KONINGS. 1994. Cytotoxicity of flavonoids and sesquiterpene lactones from Arnica species against the GLC4 and COLO 320 cell lines. Planta Medica 60: 434-437.