Synthesis and antitumor evaluation of a novel series of triaminotriazine derivatives

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 4, 2007, Pages 1815-1827

  Zheng, Mingfang ^a   Xu, Chenghui ^a   Ma, Jianwei ^a   Sun, Yan ^a   Du, Feifei ^a   Liu, Hong ^a   Lin, Liping ^a   Li, Chuan ^a   Ding, Jian ^a   Chen, Kaixian ^a   Jiang, Hualiang ^a,b  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Antitumor; Colorectal cancer; Inhibitor; Triazine derivatives

Indexed keywords

2 [4 (4 METHOXYPHENYLAMINO) 6 PHENYLAMINO 1,3,5 TRIAZIN 2 YLAMINO]ETHANOL; 2 [4 [4 (4 METHOXYPHENYLAMINO) 6 PHENYLAMINO 1,3,5 TRIAZIN 2 YL]PIPERAZIN 1 YL]ETHANOL; 2 [4 [4,6 BIS(4 METHOXYPHENYLAMINO) 1,3,5 TRIAZIN 2 YL]PIPERAZIN 1 YL]ETHANOL; 2 [4 [4,6 BIS(PHENYLAMINO) 1,3,5 TRIAZIN 2 YL]PIPERAZIN 1 YL]ETHANOL; 2 [4,6 BIS(PHENYLAMINO)[1,3,5]TRIAZIN 2 YLAMINO]ETHANOL; 2,4,6 TRIS(N MORPHOLINO)[1,3,5]TRIAZINE; 4 (4 MORPHOLINO 6 PHENYLAMINO[1,3,5]TRIAZIN 2 YLAMINO)BENZAMIDE; 4 (4 MORPHOLINO 6 PHENYLAMINO[1,3,5]TRIAZIN 2 YLAMINO)BENZENESULFONAMIDE; 4 [4,6 BIS(N MORPHOLINO)[1,3,5]TRIAZIN 2 YLAMINO]BENZENESULFONAMIDE; 6 MORPHOLINO N,N' DIPHENYL[1,3,5]TRIAZINE 2,4 DIAMINE; [4,6 BIS(N MORPHOLINO)[1,3,5]TRIAZIN 2 YL] 4 FLUOROPHENYLAMINE; [4,6 BIS(N MORPHOLINO)[1,3,5]TRIAZIN 2 YL] 4 METHOXYPHENYLAMINE; [4,6 BIS(N MORPHOLINO)[1,3,5]TRIAZIN 2 YL]PHENYLAMINE; ANTINEOPLASTIC AGENT; BENZYL[4,6 BIS(N MORPHOLINO)[1,3,5]TRIAZIN 2 YL]AMINE; N (2 MORPHOLINOETHYL) N',N' DIPHENYL[1,3,5]TRIAZINE 2,4,6 TRIAMINE; N (3 METHOXYPHENYL) 6 MORPHOLINO N' PHENYL[1,3,5]TRIAZINE 2,4 DIAMINE; N (3,4 DIMETHOXYPHENYL) 6 MORPHOLINO N' PHENYL[1,3,5]TRIAZINE 2,4 DIAMINE; N (4 BROMOPHENYL) 6 MORPHOLINO N' PHENYL[1,3,5]TRIAZINE 2,4 DIAMINE; N (4 CHLOROPHENYL) 6 MORPHOLINO N' PHENYL[1,3,5]TRIAZINE 2,4 DIAMINE; N (4 METHOXYPHENYL) 6 MORPHOLINO N' PHENYL[1,3,5]TRIAZINE 2,4 DIAMINE; N (4 METHOXYPHENYL) N' (2 MORPHOLINOETHYL) N'' PHENYL[1,3,5]TRIAZINE 2,4,6 TRIAMINE; N (4 METHYLSULFANYLPHENYL) 6 MORPHOLINO N' 4 TOLYL[1,3,5]TRIAZINE 2,4 DIAMINE; N,N' BIS(4 METHOXYPHENYL) 6 MORPHOLINO[1,3,5]TRIAZINE 2,4 DIAMINE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CELL STRAIN HCT116; COLORECTAL CANCER; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG EFFECT; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; RAT; SARCOMA; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

EID: 33947122687     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.11.028     Document Type: Article

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