Use of intravenous lipid emulsion to treat ivermectin toxicosis in a Border collie

Journal of the American Veterinary Medical Association

Volumn 239, Issue 10, 2011, Pages 1328-1333

  Clarke, Dana L ^a   Lee, Justine A ^b   Murphy, Lisa A ^c   Reineke, Erica L ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Pet Poison Helpline   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHELMINTIC AGENT; ANTIDOTE; IVERMECTIN; LIPID EMULSION;

ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; DOG; DOG DISEASE; FEMALE;

ANIMALS; ANTHELMINTICS; ANTIDOTES; DOG DISEASES; DOGS; FAT EMULSIONS, INTRAVENOUS; FEMALE; IVERMECTIN;

CANIS FAMILIARIS; EQUIDAE;

EID: 80355139323     PISSN: 00031488     EISSN: None     Source Type: Journal    
DOI: 10.2460/javma.239.10.1328     Document Type: Article

References (50)

1. Mealey KL, Bentjen SA, Gay JM, et al. Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene. Pharmacogenetics 2001;11:727-733.
2. Roulet A, Puel O, Gesta S, et al. MDR-1 deficient genotype in collie dogs hypersensitive to the p-glycoprotein substrate ivermectin. Eur J Pharmacol 2003;460:85-91.
3. Mealy KL, Meurs KM. Breed distribution of the ABCB1-1 delta (multidrug sensitivity) polymorphism among dogs undergoing ABCB1 genotyping. J Am Vet Med Assoc 2008;233:921-924.
4. Neff MW, Robertson KR, Wong AK, et al. Breed distribution and history of canine mdr1-1δ, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineage. Proc Natl Acad Sci U S A 2004;101:11725-11730.
5. Nelson OL, Carsten E, Bentjen SA, et al. Ivermectin toxicity in an Australian Shepherd Dog with the MDR1 mutation associated with ivermectin sensitivity in collies. J Vet Intern Med 2003;17:354-356.
6. Azzam SI, Fleckstein L, Cheng KJ, et al. Comparison of the pharmacokinetics of moxidectin and ivermectin after oral administration to beagle dogs. Biopharm Drug Dispos 2007;28:431-438.
7. Canga AG, Prieto AM, Liebana MJ, et al. The pharmacokinetics and metabolism of ivermectin in domestic animals species. Vet J 2009;179:25-37.
8. Wolstenholme AJ, Rogers AT. Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelminthics. Parasitology 2005;131:S85-S95.
9. Martinez M, Modric S, Sharkey M, et al. The pharmacogenomics of p-glycoprotein and its role in veterinary medicine. J Vet Pharmacol Ther 2008;31:285-300.
10. Paul AJ, Tranquilli WJ, Seward RL, et al. Clinical observations in collies given ivermectin orally. Am J Vet Res 1987;48:684-685.
11. Merola V, Khan S, Gwaltney-Brant S. Ivermectin toxicosis in dogs: a retrospective study. J Am Anim Hosp Assoc 2009;45:106-111.
12. Hopper K, Aldrich J, Haskins S. Ivermectin toxicity in 17 collies. J Vet Intern Med 2002;16:89-94.
13. Hopkins KD, Marcella KL, Strecker AE. Ivermectin toxicosis in a dog. J Am Vet Med Assoc 1990;197:93-94.
14. Hadrick MK, Bunch SE, Kornegay JN. Ivermectin toxicosis in two Australian Shepherds. J Am Vet Med Assoc 1995;206:1147-1152.
15. Lewis DT, Merchant SR, Neer TM. Ivermectin toxicosis in a kitten. J Am Vet Med Assoc 1994;205:584-586.
16. Houston DM, Parent J, Matushek KJ. Ivermectin toxicosis in a dog. J Am Vet Med Assoc 1987;191:78-80.
17. Kenny PJ, Vernau KM, Puscher B, et al. Retinopathy associated with ivermectin toxicosis in two dogs. J Am Vet Med Assoc 2008;233:279-284.
18. Mealey KL. Ivermectin: macrolide antiparasitic agents. In: Peterson ME, Talcott PA, eds. Small animal toxicology. 2nd ed. St Louis: Elsevier, 2006;785-894.
19. Fassler PE, Tranquilli WJ, Paul AJ, et al. Evaluation of the safety of ivermetin administered in a beef based formulation to ivermectin sensitive collies. J Am Vet Med Assoc 1991;199:457-460.
20. Waitzberg DL, Torrinhas RS, Jacintho TM. New parenteral lipid emulsions for clinical use. J Parenter Enteral Nutr 2006;30:351-367.
21. Krieglstein J, Meffert A, Niemeyer DH. Influence of emulsified fat on chlorpromazine availability in rabbit blood. Experientia 1974;30:924-926.
22. Weinberg, GL, VadeBoncouer T, Ramaraju GA, et al. Pretreatment or resuscitation with a lipid infusion shifts the doseresponse to bupivacaine-induced asystole in rats. Anesthesiology 1998;88:1071-1075.
23. Weinberg G, Ripper R, Feinstein DL, et al. Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity. Reg Anesth Pain Med 2003;28:198-202.
24. Zausig YA, Zink W, Keil M, et al. Lipid emulsion improves recovery from bupivacaine-induced cardiac arrest, but not from ropivacaineor mepivacaine-induced cardiac arrest. Anesth Analg 2009;109:1323-1326.
25. Spence AG. Lipid reversal of central nervous system symptoms f bupivacaine toxicity. Anesthesiology 2007;107:516-517.
26. Marwick PC, Levin AI, Coetzee AR. Recurrence of cardiotoxicity after lipid rescue from bupivacaine-induced cardiac arrest. Anesth Analg 2009;108:1344-1346.
27. Rosenblatt MA, Abel M, Fischer GW, et al. Successful use of 20% lipid emulsion to resuscitate a patient after presumed bupivacaine-related cardiac arrest. Anesthesiology 2006;105:217-218.
28. Foxall G, McCahon R, Lamb J, et al. Levobupivacaine-inducted seizures and cardiovascular collapse treated with intralipid. Anaesthesia 2007;62:516-518.
29. Tebbutt S, Harvey M, Nicholson T, et al. Intralipid prolongs survival in a rat model of verapamil toxicity. Acad Emerg Med 2006;13:134-139.
30. Bania TC, Chu J, Perex E, et al. Hemodynamic effects of intravenous fat emulsion in an animal model of severe verapamil toxicity resuscitated with atropine, calcium, and saline. Acad Emerg Med 2007;14:105-111.
31. Harvey M, Cave G. Intralipid outperforms sodium bicarbonate in a rabbit model of clomipramine toxicity. Ann Emerg Med 2007;49:178-185.
32. Harvey MG, Cave GR. Intralipid infusion ameliorates propanolol-induced hypotension in rabbits. J Med Toxicol 2008;4:71-76.
33. Charbonneau H, Marcou TA, Mazoit JX, et al. Early use of lipid emulsion to treat incipient mepivacaine intoxication. Reg Anesth Pain Med 2009;34:277-278.
34. Weinberg G, Di Gregorio G, Hiller D, et al. Reversal of haloperidol-induced cardiac arrest by using lipid emulsion. Ann Intern Med 2009;150:737-738.
35. Sirianni AJ, Osterhoudt KC, Calello DP, et al. Use of lipid emulsion in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of buproprion and lamotrigene. Ann Emerg Med 2008;51:412-415.
36. Finn SD, Uncles DR, Willers J, et al. Early treatment of a quetiapine and sertraline overdose with Intralipid. Anaesthesia 2009;64:191-194.
37. Carr D, Boone A, Hoffman RS, et al. Successful resuscitation of a doxepin overdose using intravenous fat emulsion (IFE). Clin Toxicol 2009;47:710.
38. West PL, McKeown NJ, Hendrickson RG. Iatrogenic lipid emulsion overdose in a case of amlodipine poisoning. Clin Toxicol 2010;48:393-396.
39. Stellpflug SJ, Harris CR, Engebretsen KM, et al. Intentional overdose with cardiac arrest treated with intravenous fat emulsion and high-dose insulin. Clin Toxicol 2010;48:227-229.
40. DiGregorio G, Schwartz D, Ripper R, et al. Lipid emulsion is superior to vasopressin in a rodent model of resuscitation from toxin induced cardiac arrest. Crit Care Med 2009;37:993-999.
41. Weinberg GL. Lipid infusion therapy: translation to clinical practice. Anesth Analg 2008;106:1340-1342.
42. Weinberg GL. Limits to lipid in the literature and lab: what we know, what we don't know. Anesth Analg 2009;108:1062-1064.
43. Tuner-Lawrence DE, Kerns W. Intravenous fat emulsion: a potential novel antidote. J Med Toxicol 2008;4:109-114.
44. Cave G, Harvey M. Intravenous lipid emulsion as antidote beyond local anesthetic toxicity: a systematic review. Acad Emerg Med 2009;16:815-824.
45. Mazoit JX, Le Guen R, Boleil H, et al. Binding of long-lasting local anesthetics to lipid emulsions. Anesthesiology 2009;110:380-386.
46. Harvey M, Cave G, Hoggett K. Correlation of plasma and peritoneal dialysate clompramine concentration with hemodynamic recovery after intralipid infusion in rabbits. Acad Emerg Med 2009;16:151-156.
47. Driscoll DF. Lipid injectable emulsions: pharmacopeial and safety issues. Pharm Res 2006;23:1959-1969.
48. Sonsino DH, Fischler M. Immediate intravenous lipid infusion in the successful resuscitation of ropivacaine-induced cardiac arrest after infraclavicular brachial plexus block. Reg Anesth Pain Med 2009;34:276-277.
49. Weinberg G. Lipid rescue resuscitation from local anaesthetic cardiac toxicity. Toxicol Rev 2006;25:139-145.
50. Crandell DE, Weinberg GL. Moxidectin toxicosis in a puppy successfully treated with intravenous lipids. J Vet Emerg Crit Care 2009;19:181-186.