Breed distribution of the ABCB1-1Δ (multidrug sensitivity) polymorphism among dogs undergoing ABCB1 genotyping

Journal of the American Veterinary Medical Association

Volumn 233, Issue 6, 2008, Pages 921-924

  Mealey, Katrina L ^a   Meurs, Kathryn M ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN P; VETERINARY DRUG;

ALLELE; ANIMAL; ARTICLE; BREEDING; CHEMICALLY INDUCED DISORDER; CROSS-SECTIONAL STUDY; DOG; DOG DISEASE; FEMALE; GENE; GENE DELETION; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; MALE; MULTIDRUG RESISTANCE;

ALLELES; ANIMALS; BREEDING; CROSS-SECTIONAL STUDIES; DOG DISEASES; DOGS; DRUG RESISTANCE, MULTIPLE; FEMALE; GENE DELETION; GENE FREQUENCY; GENES, MDR; GENOTYPE; MALE; P-GLYCOPROTEIN; POLYMORPHISM, GENETIC; VETERINARY DRUGS;

ANIMALIA; CANIS FAMILIARIS;

EID: 53049101740     PISSN: 00031488     EISSN: None     Source Type: Journal    
DOI: 10.2460/javma.233.6.921     Document Type: Article

References (16)

1. Fujita K, Sasaki Y. Pharmacogenomics in drug-metabolizing enzymes catalyzing anticancer drugs for personalized cancer chemotherapy. Curr Drug Metab 2007;8:554-562.
2. Court MH, Hay-Kraus BL, Hill DW, et al. Propofol hydroxylation by dog liver microsomes: assay development and dog breed differences. Drug Metab Dispos 1999;27:1293-1299.
3. Hay Kraus BL, Greenblatt DJ, Venkatakrishnan K, et al. Evidence for propofol hydroxylation by cytochrome P4502B11 in canine liver microsomes: breed and gender differences. Xenobi otica 2000;30:575-588.
4. Niimi Y, Inoue-Murayama M, Kato K, et al. Breed differences in allele frequency of the dopamine receptor D4 gene in dogs. J Hered 2001;92:433-436.
5. Mealey KL, Bentjen SA, Gay JM, et al. Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene. Pharmacogenetics 2001;11:727-733.
6. Sartor LL, Bentjen SA, Trepanier L, et al. Loperamide toxicity in a collie with the MDR1 mutation associated with ivermectin sensitivity. J Vet Intern Med 2004;18:117-118.
7. Revolution [package insert], Groton, Conn: Pfizer, 2008.
8. Tranquilli WJ, Paul AJ, Todd KS. Assessment of toxicosis induced by high-dose administration of milbemycin oxime in Collies. Am J Vet Res 1991;52:1170-1172.
9. Mealey KL, Northrup NC, Bentjen SA. Increased toxicity of P-glycoprotein-substrate chemotherapeutic agents in a dog with the MDR1 deletion mutation associated with ivermectin sensitivity. J Am Vet Med Assoc 2003;223:1434,1453-5.
10. Mealey KL, Munyard KA, Bentjen SA. Frequency of the mutant MDR1 allele associated with multidrug sensitivity in a sample of herding breed dogs living in Australia. Vet Parasitol 2005;131:193-196.
11. Mealey KL, Bentjen SA, Waiting DK. Frequency of the mutant MDR1 allele associated with ivermectin sensitivity in a sample population of Collies from the northwestern United States. Am J Vet Res 2002;63:479-481.
12. Neff MW, Robertson KR, Wong AK, et al. Breed distribution and history of canine mdr1-1Δ, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineage. Proc Natl Acad Sci U S A 2004;101:11725-11730.
13. Hugnet C, Bentjen SA, Mealey KL. Frequency of the mutant MDR1 allele associated with multidrug sensitivity in a sample of collies from France. J Vet Pharmacol Ther 2004;27:227-229.
14. Henik RA, Kellum HB, Bentjen SA, et al. Digoxin and mexiletine sensitivity in a Collie with the MDR1 mutation. J Vet Intern Med 2006;20:415-417.
15. Geyer J, Döring B, Godoy JR, et al. Frequency of the nt230 (del4) MDR1 mutation in Collies and related dog breeds in Germany. J Vet Pharmacol Ther 2005;28:545-551.
16. Mealey KL, Gay JM, Martin LG, et al. Comparison of the hypothalamic-pituitary-adrenal axis in MDR1-1Ä and MDR1 wildtype dogs. J Vet Emerg Crit Care 2007;17:61-66.