Retinopathy associated with ivermectin toxicosis in two dogs

Journal of the American Veterinary Medical Association

Volumn 233, Issue 2, 2008, Pages 279-284

  Kenny, Patrick J ^a,c   Vernau, Karen M ^b   Puschner, Birgit ^a   Maggs, David J ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c QUEEN MOTHER HOSPITAL FOR ANIMALS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INSECTICIDE; IVERMECTIN;

ANIMAL; ANIMAL DISEASE; ARTICLE; BLINDNESS; BLOOD; CASE REPORT; CENTRAL NERVOUS SYSTEM DISEASE; CHEMICALLY INDUCED DISORDER; DIFFERENTIAL DIAGNOSIS; DOG; DOG DISEASE; FEMALE; INFESTATION;

ANIMALS; BLINDNESS; CENTRAL NERVOUS SYSTEM DISEASES; DIAGNOSIS, DIFFERENTIAL; DOG DISEASES; DOGS; FEMALE; INSECTICIDES; IVERMECTIN; MITE INFESTATIONS;

CANIS FAMILIARIS;

EID: 48049086792     PISSN: 00031488     EISSN: None     Source Type: Journal    
DOI: 10.2460/javma.233.2.279     Document Type: Article

References (25)

1. Paradis M, Laperriere E. Efficacy of daily ivermectin treatment in a dog with amitraz-resistant generalized demodicosis. Vet Dermatol 1992;3:85-88.
2. Paul AK. Clinical experience with pancuronium in paediatric anaesthesia. J Indian Med Assoc 1987;85:358-361.
3. Houston DM, Parent J, Matushek KJ. Ivermectin toxicosis in a dog. J Am Vet Med Assoc 1987;191:78-80.
4. Hopkins KD, Marcella KL, Strecker AE. Ivermectin toxicosis in a dog. J Am Vet Med Assoc 1990;197:93-94.
5. Hadrick MK, Bunch SE, KornegayJN. Ivermectin toxicosis in two Australian shepherds. J Am Vet Med Assoc 1995;206:1147-1150.
6. Hopper K, Aldrich J, Haskins SC. Ivermectin toxicity in 17 collies. J Vet Intern Med 2002;16:89-94.
7. Nelson OL, Carsten E, Bentjen SA, et al. Ivermectin toxicity in an Australian Shepherd dog with the MDR1 mutation associated with ivermectin sensitivity in Collies. J Vet Intern Med 2003;17:354-356.
8. Ketring K. Presumed ocular toxicity of ivermectin, in Proceedings. 13th Annu Kal Kan Symp 1989;109-110.
9. Wolfer J, Grahn B, Lane S. Diagnostic ophthalmology. Can Vet J 1997;38:729-730.
10. Plummer CE, Kallberg ME, Ollivier FJ, et al. Suspected ivermectin toxicosis in a miniature mule foal causing blindness. Vet Ophthalmol 2006;9:29-32.
11. Lovell RA. Ivermectin and piperazine toxicoses in dogs and cats. Vet Clin North Am Small Anim Pract 1990;20:453-468.
12. Foster AC, Kemp JA. Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol 2006;6:7-17.
13. Harrison NL. Mechanisms of sleep induction by GABA(A) receptor agonists. J Clin Psychiatry 2007;68(suppl 5):6-12.
14. Mealey KL, Bentjen SA, Gay JM, et al. Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene. Pharmacogenetics 2001;11:727-733.
15. Fink DW, Porras AG. Pharmacokinetics of ivermectin in animals and humans. In: Campbell WC. ed. Iivermectin and abamectin. New York: Springer-Verlag Inc. 1989:113-130.
16. Kitzman D, Wei SY, Fleckenstein L. Liquid chromatographic assay of ivermectin in human plasma for application to clinical pharmacokinetic studies. J Pharm Biomed Anal 2006,40:1013-1020.
17. Fujiwara M, Muramatsu I. Gamma-aminobutyric acid receptor on vascular smooth muscle of dog cerebral arteries. Br J Pharmacol 1975;55:561-562.
18. Krause DN, Wong E, Degener P, et al. GABA receptors in bovine cerebral blood vessels: binding studies with [3H]muscimol. Brain Res 1980;185:51-57.
19. Alborch E, Torregrosa G, Terrasa JC. et al. GABA receptors mediate cerebral vasodilation in the unanesthetized goat. Brain Res 1984;321:103-110.
20. Robin LN, Kalloniatis M. Interrelationship between retinal ischaemic damage and turnover and metabolism of putative amino acid neurotransmitters, glutamate and GABA. Doc Ophthalmol 1992;80:273-300.
21. Yang XL. Characterization of receptors for glutamate and GABA in retinal neurons. Prog Neurobiol 2004:73:127-150.
22. Daurio CP, Cheung EN, Jeffcoat AR, et al. Bioavailability of ivermectin administered orally to dogs. Vet Res Commun 1992;16:125-130.
23. Klotz U, Ogbuokiri JE, Okonkwo PO. Ivermectin binds avidly to plasma proteins. Eur J Clin Pharmacol 1990:39:607-608.
24. Neff MW, Robertson KR, Wong AK. et al. Breed distribution and history of canine mdr1-1Delta, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineage. Proc Natl Acad Sci USA 2004;101:11725-11730.
25. Schinkel AH, Wagenaar E, Mol CA, et al. P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J Clin Invest 1996;97:2517-2524.