Discovery of a novel mechanism of steroid receptor antagonism: WAY-255348 modulates progesterone receptor cellular localization and promoter interactions

Biochemical Pharmacology

Volumn 82, Issue 11, 2011, Pages 1709-1719

  Yudt, Matthew R ^a   Russo, Louise A ^b   Berrodin, Thomas J ^a   Jelinsky, Scott A ^a   Ellis, Debra ^a   Cohen, Jeff C ^a   Cooch, Neil ^a   Haglund, Elizabeth ^b   Unwalla, Raymond J ^a   Fensome, Andrew ^a   Wrobel, Jay ^a   Zhang, Zhiming ^a,c   Nagpal, Sunil ^a   Winneker, Richard C ^a  

^a PFIZER INC   (United States)

^b VILLANOVA UNIVERSITY   (United States)

^c Johnson and Johnson Pharmaceutical   (United States)

Author keywords

Chromatin immunoprecipitation; Nonsteroidal selective progesterone receptor modulator (SPRM); Nuclear localization; Peptide profiling; Transcriptional regulation

Indexed keywords

ANTIGESTAGEN; NUCLEAR RECEPTOR COACTIVATOR; PROGESTERONE; PROGESTERONE RECEPTOR; UNCLASSIFIED DRUG; WAY 255348;

ARTICLE; CELLULAR DISTRIBUTION; COMPETITIVE INHIBITION; CONTROLLED STUDY; DNA BINDING; DRUG BINDING; DRUG CONFORMATION; DRUG STRUCTURE; GENE EXPRESSION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

ACTIVE TRANSPORT, CELL NUCLEUS; BINDING, COMPETITIVE; CELL LINE, TUMOR; CELL NUCLEUS; CHROMATIN IMMUNOPRECIPITATION; CO-REPRESSOR PROTEINS; DRUG PARTIAL AGONISM; HUMANS; INDOLES; MODELS, MOLECULAR; NUCLEAR RECEPTOR COACTIVATORS; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN CONFORMATION; PYRROLES; RADIOLIGAND ASSAY; RECEPTORS, PROGESTERONE;

EID: 80255136231     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.08.006     Document Type: Article

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