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Volumn 7, Issue 10, 2006, Pages 882-890

Progesterone receptor antagonists

Author keywords

Asoprisnil; CDB 2914; Mifepristone; ORG 31710; ORG 33628; Proellex; Progesterone receptor antagonists; Selective progesterone receptor modulators

Indexed keywords

11BETA (4 ACETYLPHENYL) 17BETA HYDROXY 17ALPHA (1,1,2,2,2 PENTAFLUOROETHYL)ESTRA 4,9 DIEN 3 ONE; 11BETA [4 (DIMETHYLAMINO)PHENYL] 4',5' DIHYDRO 6BETA METHYLSPIRO[ESTRA 4,9 DIENE 17BETA,2'(3'H) FURAN] 3 ONE; 17ALPHA ACETOXY 11BETA (4 DIMETHYLAMINOPHENYL) 19 NORPREGNA 4,9 DIENE 3,20 DIONE; AGLEPRISTONE; ALIZINE; ANTIGESTAGEN; ASOPRISNIL; CBD 2914; CBD 4124; DESOGESTREL; ESTRADIOL; J 1042; J 596; J 956; LEUPRORELIN; LILOPRISTONE; MEDROXYPROGESTERONE ACETATE; MIFEPRISTONE; ONAPRISTONE; ORG 33628; PROELLEX; RU 46534; SELECTIVE ESTROGEN RECEPTOR MODULATOR; UNCLASSIFIED DRUG; ZK 137316; ZK 320211;

EID: 33750319343     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (32)

References (84)
  • 2
    • 0002708343 scopus 로고
    • RU38486: An original multifaceted antihormone in vivo
    • In: Agarwal M (Ed), Walter de Gruyter and Co, Berlin, Germany
    • Philibert D: RU38486: An original multifaceted antihormone in vivo. In: Adrenal Steroid Antagonism. Agarwal M (Ed), Walter de Gruyter and Co, Berlin, Germany (1984):77-101.
    • (1984) Adrenal Steroid Antagonism , pp. 77-101
    • Philibert, D.1
  • 3
    • 0024470651 scopus 로고
    • Contragestion and other clinical applications of RU486, an antiprogesterone at the receptor
    • Baulieu EE: Contragestion and other clinical applications of RU486, an antiprogesterone at the receptor. Science (1989) 246(4924):1351-1357.
    • (1989) Science , vol.246 , Issue.4924 , pp. 1351-1357
    • Baulieu, E.E.1
  • 4
    • 0023624268 scopus 로고
    • Synthesis of antiprogestational steroids
    • Wiechert R, Neef G: Synthesis of antiprogestational steroids. J Steroid Biochem (1987) 27(4-6):851-858.
    • (1987) J Steroid Biochem , vol.27 , Issue.4-6 , pp. 851-858
    • Wiechert, R.1    Neef, G.2
  • 6
    • 33750283313 scopus 로고    scopus 로고
    • Drug development update: ZK-137316, ZK-230211, Endometrion, J-956 and J-867
    • Company Communication June 19
    • Schering AG: Drug development update: ZK-230211, Endometrion, ZK-137316, J-956 and J-867. Company Communication (2001):June 19.
    • (2001)
    • Schering, A.G.1
  • 9
    • 0033656617 scopus 로고    scopus 로고
    • Endocrine pharmacological characterization of progesterone antagonists and progesterone receptor modulators with respect to PR-agonistic and antagonistic activity
    • Elger W, Bartley J, Schneider B, Kaufmann G, Schubert G, Chwalisz K: Endocrine pharmacological characterization of progesterone antagonists and progesterone receptor modulators with respect to PR-agonistic and antagonistic activity. Steroids (2000) 65(10-11):713-723.
    • (2000) Steroids , vol.65 , Issue.10-11 , pp. 713-723
    • Elger, W.1    Bartley, J.2    Schneider, B.3    Kaufmann, G.4    Schubert, G.5    Chwalisz, K.6
  • 10
    • 18844440705 scopus 로고    scopus 로고
    • Selective progesterone receptor modulator development and use in the treatment of leiomyomata and endometriosis
    • Chwalisz K, Perez MC, Demanno D, Winkel C, Schubert G, Elger W: Selective progesterone receptor modulator development and use in the treatment of leiomyomata and endometriosis. Endocr Rev (2005) 26(3):423-438.
    • (2005) Endocr Rev , vol.26 , Issue.3 , pp. 423-438
    • Chwalisz, K.1    Perez, M.C.2    Demanno, D.3    Winkel, C.4    Schubert, G.5    Elger, W.6
  • 11
    • 0347627640 scopus 로고    scopus 로고
    • Pharmacological properties of CBD(VA)-2914
    • Gainer EE, Ulmann A: Pharmacological properties of CBD(VA)-2914. Steroids (2003) 68(10-13):1005-1011.
    • (2003) Steroids , vol.68 , Issue.10-13 , pp. 1005-1011
    • Gainer, E.E.1    Ulmann, A.2
  • 12
    • 33645997660 scopus 로고    scopus 로고
    • Product information
    • Repros Therapeutics Inc: Proellex. Company World Wide Web Site September 08
    • Repros Therapeutics Inc: Product information. Proellex. Company World Wide Web Site (2006):September 08.
    • (2006)
  • 14
    • 0034596105 scopus 로고    scopus 로고
    • Receptor blockers - General aspects with respect to their use in domestic animal reproduction
    • 60-61
    • Hoffmann B, Schuler G: Receptor blockers - general aspects with respect to their use in domestic animal reproduction. Anim Reprod Sci (2000) 60-61:295-312.
    • (2000) Anim Reprod Sci , pp. 295-312
    • Hoffmann, B.1    Schuler, G.2
  • 15
    • 14744298376 scopus 로고    scopus 로고
    • Nonsteroidal progesterone receptor modulators: Structure activity relationships
    • Winneker RC, Fensome A, Wrobel JE, Zhang Z, Zhang P: Nonsteroidal progesterone receptor modulators: Structure activity relationships. Semin Reprod Med (2005) 23(1):46-57.
    • (2005) Semin Reprod Med , vol.23 , Issue.1 , pp. 46-57
    • Winneker, R.C.1    Fensome, A.2    Wrobel, J.E.3    Zhang, Z.4    Zhang, P.5
  • 16
    • 0033374783 scopus 로고    scopus 로고
    • The A and B isoforms of the human progesterone receptor: Two functionally different transcription factors encoded by a single gene
    • Giangrande PH, McDonnell DP: The A and B isoforms of the human progesterone receptor: Two functionally different transcription factors encoded by a single gene. Recent Prog Horm Res (1999) 54:291-313.
    • (1999) Recent Prog Horm Res , vol.54 , pp. 291-313
    • Giangrande, P.H.1    McDonnell, D.P.2
  • 17
    • 0036917921 scopus 로고    scopus 로고
    • Mechanism of action of progesterone antagonists
    • Leonhardt SA, Edwards DP: Mechanism of action of progesterone antagonists. Exp Biol Med (2002) 227(11):969-980.
    • (2002) Exp Biol Med , vol.227 , Issue.11 , pp. 969-980
    • Leonhardt, S.A.1    Edwards, D.P.2
  • 18
    • 1442351143 scopus 로고    scopus 로고
    • Coregulator function: A key to understanding tissue specificity of selective receptor modulators
    • Smith CL, O'Malley BW: Coregulator function: A key to understanding tissue specificity of selective receptor modulators. Endocr Rev (2004) 25(1):46-71.
    • (2004) Endocr Rev , vol.25 , Issue.1 , pp. 46-71
    • Smith, C.L.1    O'Malley, B.W.2
  • 19
    • 0031910827 scopus 로고    scopus 로고
    • The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor
    • Wagner BL, Norris JD, Knotts TA, Weigel NL, McDonnell DP: The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor. Mol Cell Biol (1998) 18(3):1369-1378.
    • (1998) Mol Cell Biol , vol.18 , Issue.3 , pp. 1369-1378
    • Wagner, B.L.1    Norris, J.D.2    Knotts, T.A.3    Weigel, N.L.4    McDonnell, D.P.5
  • 20
    • 33750318332 scopus 로고    scopus 로고
    • Asoprisnil, a selective progesterone receptor modulator, displays a distinct profile in PR-mediated assays, and the ability to recruit both coactivators and corepressors may explain its failure to demonstrate antiestrogenic activity on eutopic and ectopic rat uterine tissue
    • Abs
    • Bray JD, Grygielko ET, Sulpizio AC, Pullen MA, Haimbach RE, Gu JL, Wu C, Laping NJ: Asoprisnil, a selective progesterone receptor modulator, displays a distinct profile in PR-mediated assays, and the ability to recruit both coactivators and corepressors may explain its failure to demonstrate antiestrogenic activity on eutopic and ectopic rat uterine tissue. Endocrine Society Meeting (2006) 88:Abs P1-519.
    • (2006) Endocrine Society Meeting , vol.88
    • Bray, J.D.1    Grygielko, E.T.2    Sulpizio, A.C.3    Pullen, M.A.4    Haimbach, R.E.5    Gu, J.L.6    Wu, C.7    Laping, N.J.8
  • 22
    • 84944495442 scopus 로고
    • The assay of progestin
    • McPhail MK: The assay of progestin. J Physiol (1934) 83:145-156.
    • (1934) J Physiol , vol.83 , pp. 145-156
    • McPhail, M.K.1
  • 23
    • 0027455310 scopus 로고
    • Reversal of activity profile in analogs of the antiprogestin RU 486: Effect of a 16 α-substituent on progestational (agonist) activity
    • Cook CE, Wani MC, Lee YW, Fail PA, Petrow V: Reversal of activity profile in analogs of the antiprogestin RU 486: Effect of a 16 α-substituent on progestational (agonist) activity. Life Sci (1993) 52(2):155-162.
    • (1993) Life Sci , vol.52 , Issue.2 , pp. 155-162
    • Cook, C.E.1    Wani, M.C.2    Lee, Y.W.3    Fail, P.A.4    Petrow, V.5
  • 24
    • 0034124343 scopus 로고    scopus 로고
    • CDB-2914: Antiprogestational/anti-glucocorticoid profile and post-coital anti-fertility activity in rats and rabbits
    • Hild SA, Reel JR, Hoffman LH, Blye RP: CDB-2914: Antiprogestational/ anti-glucocorticoid profile and post-coital anti-fertility activity in rats and rabbits. Hum Reprod (2000) 15(4):822-829.
    • (2000) Hum Reprod , vol.15 , Issue.4 , pp. 822-829
    • Hild, S.A.1    Reel, J.R.2    Hoffman, L.H.3    Blye, R.P.4
  • 25
    • 14744294392 scopus 로고    scopus 로고
    • ORG 33628 and ORG 31710 control vaginal bleeding in progestin-only contraceptive regimens
    • Verbost PM, Hanssen RGJM, Korver GHV, Mulders TMT: ORG 33628 and ORG 31710 control vaginal bleeding in progestin-only contraceptive regimens. Semin Reprod Med (2005) 23(1):101-111.
    • (2005) Semin Reprod Med , vol.23 , Issue.1 , pp. 101-111
    • Verbost, P.M.1    Hanssen, R.G.J.M.2    Korver, G.H.V.3    Mulders, T.M.T.4
  • 27
    • 0025214549 scopus 로고
    • The use of mifepristone (RU486) for cervical preparation in first trimester pregnancy termination by vacuum aspiration
    • World Health Organization Task Force on Post-ovulatory Methods for Fertility Regulation:
    • World Health Organization Task Force on Post-ovulatory Methods for Fertility Regulation: The use of mifepristone (RU486) for cervical preparation in first trimester pregnancy termination by vacuum aspiration. Br J Obstet Gynaecol. (1990) 97(3):260-266.
    • (1990) Br J Obstet Gynaecol , vol.97 , Issue.3 , pp. 260-266
  • 28
    • 0036218059 scopus 로고    scopus 로고
    • Selective progesterone receptor modulators (SPRMs): A novel therapeutic concept in endometriosis
    • Chwalisz K, Garg R, Brenner RM, Schubert G, Elger W: Selective progesterone receptor modulators (SPRMs): A novel therapeutic concept in endometriosis. Ann NY Acad Sci (2002) 955:373-88
    • (2002) Ann NY Acad Sci , vol.955 , pp. 373-388
    • Chwalisz, K.1    Garg, R.2    Brenner, R.M.3    Schubert, G.4    Elger, W.5
  • 30
    • 0031913611 scopus 로고    scopus 로고
    • Chronic treatment of cycling rhesus monkeys with low doses of the antiprogestin ZK 137 316: Morphometric assessment of the uterus and oviduct
    • Slayden OD, Zelinski-Wooten MB, Chwalisz K, Stouffer RL, Brenner RM: Chronic treatment of cycling rhesus monkeys with low doses of the antiprogestin ZK 137 316: Morphometric assessment of the uterus and oviduct. Hum Reprod (1998) 13(2):269-277.
    • (1998) Hum Reprod , vol.13 , Issue.2 , pp. 269-277
    • Slayden, O.D.1    Zelinski-Wooten, M.B.2    Chwalisz, K.3    Stouffer, R.L.4    Brenner, R.M.5
  • 31
    • 0028153640 scopus 로고
    • RU 486 action after estrogen priming in the endometrium and oviducts of rhesus monkeys (Macaca mulatta)
    • Slayden OD, Brenner RM: RU 486 action after estrogen priming in the endometrium and oviducts of rhesus monkeys (Macaca mulatta). J Clin Endocrinol Metab (1994) 78(2):440-448.
    • (1994) J Clin Endocrinol Metab , vol.78 , Issue.2 , pp. 440-448
    • Slayden, O.D.1    Brenner, R.M.2
  • 32
    • 33646067165 scopus 로고    scopus 로고
    • A novel selective progesterone receptor modulator asoprisnil (J867) inhibits proliferation and induces apoptosis in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells
    • Chen W, Ohara N, Wang J, Xu Q, Liu J, Morikawa A, Sasaki H, Yoshida S, Demanno DA, Chwalisz K, Maruo T: A novel selective progesterone receptor modulator asoprisnil (J867) inhibits proliferation and induces apoptosis in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells. J Clin Endocrinol Metab (2006) 91(4):1296-1304.
    • (2006) J Clin Endocrinol Metab , vol.91 , Issue.4 , pp. 1296-1304
    • Chen, W.1    Ohara, N.2    Wang, J.3    Xu, Q.4    Liu, J.5    Morikawa, A.6    Sasaki, H.7    Yoshida, S.8    Demanno, D.A.9    Chwalisz, K.10    Maruo, T.11
  • 33
    • 33745855890 scopus 로고    scopus 로고
    • A novel selective progesterone receptor modulator asoprisnil (J867) down-regulates the expression of EGF, IGF-I, TGFβ3 and their receptors in cultured uterine leiomyoma cells
    • Wang J, Ohara N, Wang Z, Chen W, Morikawa A, Sasaki H, DeManno DA, Chwalisz K, Maruo T: A novel selective progesterone receptor modulator asoprisnil (J867) down-regulates the expression of EGF, IGF-I, TGFβ3 and their receptors in cultured uterine leiomyoma cells. Hum Reprod (2006) 21(7):1869-1877.
    • (2006) Hum Reprod , vol.21 , Issue.7 , pp. 1869-1877
    • Wang, J.1    Ohara, N.2    Wang, Z.3    Chen, W.4    Morikawa, A.5    Sasaki, H.6    DeManno, D.A.7    Chwalisz, K.8    Maruo, T.9
  • 35
    • 0027481262 scopus 로고
    • Effects of continuous treatment with low dose mifepristone throughout one menstrual cycle
    • Croxatto HB, Salvatierra AM, Croxatto HO, Fuentealba B: Effects of continuous treatment with low dose mifepristone throughout one menstrual cycle. Hum Reprod (1993) 8(2):201-207.
    • (1993) Hum Reprod , vol.8 , Issue.2 , pp. 201-207
    • Croxatto, H.B.1    Salvatierra, A.M.2    Croxatto, H.O.3    Fuentealba, B.4
  • 37
    • 18744409835 scopus 로고    scopus 로고
    • The effects of 1-month administration of asoprisnil (J867), a selective progesterone receptor modulator, in healthy premenopausal women
    • Chwalisz K, Elger W, Stickler T, Mattia-Goldberg C, Larsen L: The effects of 1-month administration of asoprisnil (J867), a selective progesterone receptor modulator, in healthy premenopausal women. Hum Reprod (2005) 20(4):1090-1099.
    • (2005) Hum Reprod , vol.20 , Issue.4 , pp. 1090-1099
    • Chwalisz, K.1    Elger, W.2    Stickler, T.3    Mattia-Goldberg, C.4    Larsen, L.5
  • 38
    • 0023579662 scopus 로고
    • Effects of the antiprogesterone RU 486 in normal women. II. Administration in the late follicular phase
    • Shoupe D, Mishell DR Jr, Page MA, Madkour H, Spitz IM, Lobo RA: Effects of the antiprogesterone RU 486 in normal women. II. Administration in the late follicular phase. Am J Obstet Gynecol (1987) 157(6):1421-1426.
    • (1987) Am J Obstet Gynecol , vol.157 , Issue.6 , pp. 1421-1426
    • Shoupe, D.1    Mishell Jr., D.R.2    Page, M.A.3    Madkour, H.4    Spitz, I.M.5    Lobo, R.A.6
  • 40
    • 0029940788 scopus 로고    scopus 로고
    • Antiprogestin and/or gonadotropin-releasing hormone agonist for endometriosis treatment and bone maintenance: A 1-year primate study
    • Grow DR, Williams RF, Hsiu JG, Hodgen GD: Antiprogestin and/or gonadotropin-releasing hormone agonist for endometriosis treatment and bone maintenance: A 1-year primate study. J Clin Endocrinol Metab (1996) 81(5):1933-1939.
    • (1996) J Clin Endocrinol Metab , vol.81 , Issue.5 , pp. 1933-1939
    • Grow, D.R.1    Williams, R.F.2    Hsiu, J.G.3    Hodgen, G.D.4
  • 41
    • 0142205817 scopus 로고    scopus 로고
    • Progesterone antagonists and progesterone receptor modulators: An overview
    • Spitz IM: Progesterone antagonists and progesterone receptor modulators: An overview. Steroids (2003) 68(10-13):981-993.
    • (2003) Steroids , vol.68 , Issue.10-13 , pp. 981-993
    • Spitz, I.M.1
  • 43
    • 0028944184 scopus 로고
    • The anti-progestin CDB 2914 has no antifertility effect in male rats
    • Wang C, Sinha-Hikim A, Leung A: The anti-progestin CDB 2914 has no antifertility effect in male rats. Contraception (1995) 51(3):215-218.
    • (1995) Contraception , vol.51 , Issue.3 , pp. 215-218
    • Wang, C.1    Sinha-Hikim, A.2    Leung, A.3
  • 45
    • 0344334020 scopus 로고    scopus 로고
    • Comparison of three single doses of mifepristone as emergency contraception: A randomized trial
    • Task Force on Postovulatory Methods of Fertility Regulation
    • Comparison of three single doses of mifepristone as emergency contraception: A randomized trial. Task Force on Postovulatory Methods of Fertility Regulation. Lancet (1999) 353(9154):697-702.
    • (1999) Lancet , vol.353 , Issue.9154 , pp. 697-702
  • 47
    • 3042570806 scopus 로고    scopus 로고
    • Systematic review of mifepristone for the treatment of uterine leiomyomata
    • Steinauer J, Pritts EA, Jackson R, Jacoby AF: Systematic review of mifepristone for the treatment of uterine leiomyomata. Obstet Gynecol (2004) 103(6):1331-1336.
    • (2004) Obstet Gynecol , vol.103 , Issue.6 , pp. 1331-1336
    • Steinauer, J.1    Pritts, E.A.2    Jackson, R.3    Jacoby, A.F.4
  • 48
    • 0036149959 scopus 로고    scopus 로고
    • Daily low-dose mifepristone has contraceptive potential by suppressing ovulation and menstruation: A double-blind randomized control trial of 2 and 5 mg per day for 120 days
    • Brown A, Cheng L, Lin S, Baird DT: Daily low-dose mifepristone has contraceptive potential by suppressing ovulation and menstruation: A double-blind randomized control trial of 2 and 5 mg per day for 120 days. J Clin Endocrinol Metab (2002) 87(1):63-70.
    • (2002) J Clin Endocrinol Metab , vol.87 , Issue.1 , pp. 63-70
    • Brown, A.1    Cheng, L.2    Lin, S.3    Baird, D.T.4
  • 49
    • 2942693992 scopus 로고    scopus 로고
    • Effect of intermittent treatment with mifepristone on bleeding patterns in Norplant implant users
    • Massai MR, Pavez M, Fuentealba B, Croxatto HB, d'Arcangues C: Effect of intermittent treatment with mifepristone on bleeding patterns in Norplant implant users. Contraception (2004) 70(1):47-54.
    • (2004) Contraception , vol.70 , Issue.1 , pp. 47-54
    • Massai, M.R.1    Pavez, M.2    Fuentealba, B.3    Croxatto, H.B.4    d'Arcangues, C.5
  • 50
    • 29144462031 scopus 로고    scopus 로고
    • A pilot study to assess the effect of three short-term treatments on frequent and/or prolonged bleeding compared to placebo in women using Implanon
    • Weisberg E, Hickey M, Palmer D, O'Connor V, Salamonsen LA, Findlay JK, Fraser IS: A pilot study to assess the effect of three short-term treatments on frequent and/or prolonged bleeding compared to placebo in women using Implanon. Hum Reprod (2006) 21(1):295-302.
    • (2006) Hum Reprod , vol.21 , Issue.1 , pp. 295-302
    • Weisberg, E.1    Hickey, M.2    Palmer, D.3    O'Connor, V.4    Salamonsen, L.A.5    Findlay, J.K.6    Fraser, I.S.7
  • 51
    • 0034052080 scopus 로고    scopus 로고
    • Single monthly administration of the anti-progestagen Org 31710 in users of the 75 microg desogestrel progestagen-only pill: Effects on pituitary-ovarian activity
    • van Heusden AM, Killick SR, Coelingh Bennink HJ, Fauser BC: Single monthly administration of the anti-progestagen Org 31710 in users of the 75 microg desogestrel progestagen-only pill: Effects on pituitary-ovarian activity. Hum Reprod (2000) 15(3):629-636.
    • (2000) Hum Reprod , vol.15 , Issue.3 , pp. 629-636
    • van Heusden, A.M.1    Killick, S.R.2    Coelingh Bennink, H.J.3    Fauser, B.C.4
  • 52
    • 0347627633 scopus 로고    scopus 로고
    • Mifepristone for the prevention of breakthrough bleeding in new starters of depo-medroxyprogesterone acetate
    • Jain JK, Nicosia AF, Nucatola DL, Lu JJ, Kuo J, Felix JC: Mifepristone for the prevention of breakthrough bleeding in new starters of depo-medroxyprogesterone acetate. Steroids (2003) 68(10-13):1115-1119.
    • (2003) Steroids , vol.68 , Issue.10-13 , pp. 1115-1119
    • Jain, J.K.1    Nicosia, A.F.2    Nucatola, D.L.3    Lu, J.J.4    Kuo, J.5    Felix, J.C.6
  • 53
    • 0033811828 scopus 로고    scopus 로고
    • Once a month administration of mifepristone improves bleeding patterns in women using subdermal contraceptive implants releasing levonorgestrel
    • Cheng L, Zhu H, Wang A, Ren F, Chen J, Glasier A: Once a month administration of mifepristone improves bleeding patterns in women using subdermal contraceptive implants releasing levonorgestrel. Hum Reprod (2000) 15(9):1969-1972.
    • (2000) Hum Reprod , vol.15 , Issue.9 , pp. 1969-1972
    • Cheng, L.1    Zhu, H.2    Wang, A.3    Ren, F.4    Chen, J.5    Glasier, A.6
  • 54
  • 58
    • 0036672759 scopus 로고    scopus 로고
    • Slowing the progression of cognitive decline in Alzheimer's disease using mifepristone
    • Belanoff JK, Jurik J, Schatzberg LD, DeBattista C, Schatzberg AF: Slowing the progression of cognitive decline in Alzheimer's disease using mifepristone. J Mol Neurosci (2002) 19(1-2):201-206.
    • (2002) J Mol Neurosci , vol.19 , Issue.1-2 , pp. 201-206
    • Belanoff, J.K.1    Jurik, J.2    Schatzberg, L.D.3    DeBattista, C.4    Schatzberg, A.F.5
  • 60
    • 3242783282 scopus 로고    scopus 로고
    • Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder
    • Young AH, Gallagher P, Watson S, Del-Estal D, Owen BM, Ferrier IN: Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder. Neuropsychopharmacology (2004) 29(8):1538-1545.
    • (2004) Neuropsychopharmacology , vol.29 , Issue.8 , pp. 1538-1545
    • Young, A.H.1    Gallagher, P.2    Watson, S.3    Del-Estal, D.4    Owen, B.M.5    Ferrier, I.N.6
  • 62
    • 0034084465 scopus 로고    scopus 로고
    • Phase II study of mifepristone (RU486) in refractory ovarian cancer
    • Rocereto TF, Saul HM, Aikins JA Jr, Paulson J: Phase II study of mifepristone (RU486) in refractory ovarian cancer. Gynecol Oncol (2000) 77(3):429-432.
    • (2000) Gynecol Oncol , vol.77 , Issue.3 , pp. 429-432
    • Rocereto, T.F.1    Saul, H.M.2    Aikins Jr., J.A.3    Paulson, J.4
  • 63
    • 0033661349 scopus 로고    scopus 로고
    • Progesterone antagonists and progesterone receptor modulators in the treatment of breast cancer
    • Klijn JG, Setyono-Han B, Foekens JA: Progesterone antagonists and progesterone receptor modulators in the treatment of breast cancer. Steroids (2000) 66(10-11):825-830.
    • (2000) Steroids , vol.66 , Issue.10-11 , pp. 825-830
    • Klijn, J.G.1    Setyono-Han, B.2    Foekens, J.A.3
  • 66
    • 1842514450 scopus 로고    scopus 로고
    • Mifepristone-induced secretion of transforming growth factor β1-induced apoptosis in prostate cancer cells
    • Liang Y, Eid MA, El Etreby F, Lewis RW, Kumar MV: Mifepristone-induced secretion of transforming growth factor β1-induced apoptosis in prostate cancer cells. Int J Oncol (2002) 21(6):1259-1267.
    • (2002) Int J Oncol , vol.21 , Issue.6 , pp. 1259-1267
    • Liang, Y.1    Eid, M.A.2    El Etreby, F.3    Lewis, R.W.4    Kumar, M.V.5
  • 67
    • 0028040033 scopus 로고
    • Termination of early pregnancy with ZK 98,734: Pharmacokinetic behaviour and clinical effect
    • Swahn ML, Kovacs L, Cekan SZ, Aedo AR, Westlund P: Termination of early pregnancy with ZK 98,734: Pharmacokinetic behaviour and clinical effect. Hum Reprod (1994) 9(1):57-63.
    • (1994) Hum Reprod , vol.9 , Issue.1 , pp. 57-63
    • Swahn, M.L.1    Kovacs, L.2    Cekan, S.Z.3    Aedo, A.R.4    Westlund, P.5
  • 68
    • 0023640532 scopus 로고
    • Endometrial and myometrial effects of progesterone antagonists in pregnant guinea pigs
    • Elger W, Fahnrich M, Beier S, Qing SS, Chwalisz K: Endometrial and myometrial effects of progesterone antagonists in pregnant guinea pigs. Am J Obstet Gynecol (1987) 157(4 Pt 2):1065-1074.
    • (1987) Am J Obstet Gynecol , vol.157 , Issue.4 PART 2 , pp. 1065-1074
    • Elger, W.1    Fahnrich, M.2    Beier, S.3    Qing, S.S.4    Chwalisz, K.5
  • 69
    • 0026096890 scopus 로고
    • Two types of antiprogestins identified by their differential action in transcriptionally active extracts from T47D cells
    • Klein-Hitpass L, Cato AC, Henderson D, Ryffel GU: Two types of antiprogestins identified by their differential action in transcriptionally active extracts from T47D cells. Nucleic Acids Res (1991) 19(6):1227-1234.
    • (1991) Nucleic Acids Res , vol.19 , Issue.6 , pp. 1227-1234
    • Klein-Hitpass, L.1    Cato, A.C.2    Henderson, D.3    Ryffel, G.U.4
  • 70
    • 0028233852 scopus 로고
    • The use of progesterone, antagonists for cervical ripening and as an adjunct to labour and delivery
    • Chwalisz K: The use of progesterone, antagonists for cervical ripening and as an adjunct to labour and delivery. Hum Reprod (1994) 9(Suppl 1): 131-161.
    • (1994) Hum Reprod , vol.9 , Issue.SUPPL. 1 , pp. 131-161
    • Chwalisz, K.1
  • 71
  • 73
    • 0037251493 scopus 로고    scopus 로고
    • Low-dose antiprogestin treatment prevents pregnancy in rhesus monkeys and is reversible after 1 year of treatment
    • Borman SM, Schwinof KM, Niemeyer C, Chwalisz K, Stouffer RL, Zelinski-Wooten MB: Low-dose antiprogestin treatment prevents pregnancy in rhesus monkeys and is reversible after 1 year of treatment. Hum Reprod (2003) 18(1):69-76.
    • (2003) Hum Reprod , vol.18 , Issue.1 , pp. 69-76
    • Borman, S.M.1    Schwinof, K.M.2    Niemeyer, C.3    Chwalisz, K.4    Stouffer, R.L.5    Zelinski-Wooten, M.B.6
  • 74
    • 0034893862 scopus 로고    scopus 로고
    • Reversible suppression of menstruation with progesterone antagonists in rhesus macaques
    • Slayden OD, Chwalisz K, Brenner RM: Reversible suppression of menstruation with progesterone antagonists in rhesus macaques. Hum Reprod (2001) 16(8)1562-1574.
    • (2001) Hum Reprod , vol.16 , Issue.8 , pp. 1562-1574
    • Slayden, O.D.1    Chwalisz, K.2    Brenner, R.M.3
  • 75
    • 14744299922 scopus 로고    scopus 로고
    • Treatment of endometriosis with the novel selective progesterone receptor modulator (SPRM) asoprisnil
    • Chwalisz K, Mattia-Goldberg K, Lee M, Elger W, Edmonds A: Treatment of endometriosis with the novel selective progesterone receptor modulator (SPRM) asoprisnil. Fertil Steril (2004) 82:S83.
    • (2004) Fertil Steril , vol.82
    • Chwalisz, K.1    Mattia-Goldberg, K.2    Lee, M.3    Elger, W.4    Edmonds, A.5
  • 76
    • 13344259374 scopus 로고    scopus 로고
    • Effects of the novel selective progesterone receptor modulator (SPRM) asoprisnil on bleeding patterns in subjects with leiomyomata
    • Abs 728
    • Chwalisz K, Larsen L, McCrary K, Edmonds A: Effects of the novel selective progesterone receptor modulator (SPRM) asoprisnil on bleeding patterns in subjects with leiomyomata. J Soc Gynecol Invest (2004) 11(2 Suppl):Abs 728.
    • (2004) J Soc Gynecol Invest , vol.11 , Issue.2 SUPPL.
    • Chwalisz, K.1    Larsen, L.2    McCrary, K.3    Edmonds, A.4
  • 77
    • 0034093491 scopus 로고    scopus 로고
    • A single mid-follicular dose of CDB-2914, a new antiprogestin, inhibits folliculogenesis and endometrial differentiation in normally cycling women
    • Stratton P, Hartog B, Hajizadeh N, Piquion J, Sutherland D, Merino M, Lee YJ, Nieman LK: A single mid-follicular dose of CDB-2914, a new antiprogestin, inhibits folliculogenesis and endometrial differentiation in normally cycling women. Hum Reprod (2000) 15(5):1092-1099.
    • (2000) Hum Reprod , vol.15 , Issue.5 , pp. 1092-1099
    • Stratton, P.1    Hartog, B.2    Hajizadeh, N.3    Piquion, J.4    Sutherland, D.5    Merino, M.6    Lee, Y.J.7    Nieman, L.K.8
  • 78
    • 33750363886 scopus 로고    scopus 로고
    • Progesterone receptor modulators and the endometrium - Changes and consequences
    • NIH Meeting, Bethesda, MD, USA
    • Progesterone receptor modulators and the endometrium - changes and consequences. NIH Meeting, Bethesda, MD, USA (2006).
    • (2006)
  • 79
    • 0033823905 scopus 로고    scopus 로고
    • Heterogeneity of progesterone receptors A and B expression in human endometrial glands and stroma
    • Mote PA, Balleine RL, McGowan EM, Clarke CL: Heterogeneity of progesterone receptors A and B expression in human endometrial glands and stroma. Hum Reprod (2000) 15(Suppl 3):48-56.
    • (2000) Hum Reprod , vol.15 , Issue.SUPPL. 3 , pp. 48-56
    • Mote, P.A.1    Balleine, R.L.2    McGowan, E.M.3    Clarke, C.L.4
  • 80
    • 1642344635 scopus 로고    scopus 로고
    • Subnuclear distribution of progesterone receptors A and B in normal and malignant endometrium
    • Arnett-Mansfield RL, DeFazio A, Mote PA, Clarke CL: Subnuclear distribution of progesterone receptors A and B in normal and malignant endometrium. J Clin Endocrinol Metab (2004) 89(3):1429-1442.
    • (2004) J Clin Endocrinol Metab , vol.89 , Issue.3 , pp. 1429-1442
    • Arnett-Mansfield, R.L.1    DeFazio, A.2    Mote, P.A.3    Clarke, C.L.4
  • 81
    • 1342284431 scopus 로고    scopus 로고
    • Effect of progesterone receptor a predominance on breast cancer cell migration into bone marrow fibroblasts
    • McGowan EM, Saad S, Bendall LJ, Bradstock KF, Clarke CL: Effect of progesterone receptor a predominance on breast cancer cell migration into bone marrow fibroblasts. Breast Cancer Res Treat (2004) 83(3):211-220.
    • (2004) Breast Cancer Res Treat , vol.83 , Issue.3 , pp. 211-220
    • McGowan, E.M.1    Saad, S.2    Bendall, L.J.3    Bradstock, K.F.4    Clarke, C.L.5
  • 82
    • 0033587687 scopus 로고    scopus 로고
    • Development of gene-switch transgenic mice that inducibly express transforming growth factor β1 in the epidermis
    • Wang XJ, Liefer KM, Tsai S, O'Malley BW, Roop DR: Development of gene-switch transgenic mice that inducibly express transforming growth factor β1 in the epidermis. Proc Natl Acad Sci USA (1999) 96(15):8483-8488.
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.15 , pp. 8483-8488
    • Wang, X.J.1    Liefer, K.M.2    Tsai, S.3    O'Malley, B.W.4    Roop, D.R.5
  • 84
    • 0033995555 scopus 로고    scopus 로고
    • Advances in plasmid gene delivery and expression in skeletal muscle
    • Smith LC, Nordstrom JL: Advances in plasmid gene delivery and expression in skeletal muscle. Curr Opin Mol Ther (2000) 2(2):150-154.
    • (2000) Curr Opin Mol Ther , vol.2 , Issue.2 , pp. 150-154
    • Smith, L.C.1    Nordstrom, J.L.2


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