Insights into the mechanism of enhanced mobilization of hematopoietic progenitor cells and release of CXCL12 by a combination of AMD3100 and aminoglycoside-polyarginine conjugates

FEBS Journal

Volumn 278, Issue 21, 2011, Pages 4150-4165

  Berchanski, Alexander ^a   Kalinkovich, Alexander ^a   Ludin, Aya ^a   Lapidot, Tsvee ^a   Lapidot, Aviva ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

aminoglycoside polyarginine conjugates; chemokines; enhanced mobilization of hematopoietic progenitor cells; G protein coupled receptors; molecular docking

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; N ALPHA ACETYLNONA DEXTRO ARGININE; NONA DEXTRO ARGININE NEAMINE CONJUGATE; NONA DEXTRO ARGININE NEOMYCIN CONJUGATE; PLERIXAFOR; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG MECHANISM; DRUG POTENTIATION; HEMATOPOIETIC STEM CELL; LEUKOCYTE; MOLECULAR DOCKING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN PROTEIN INTERACTION; STEM CELL MOBILIZATION;

AMINOGLYCOSIDES; ANIMALS; BINDING SITES; CHEMOKINE CXCL12; HEMATOPOIETIC STEM CELLS; HETEROCYCLIC COMPOUNDS; MICE; PEPTIDES; RECEPTORS, CXCR4;

MUS;

EID: 80255132104     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2011.08348.x     Document Type: Article

References (41)

1. Pelus LM, &, Fukuda S, (2008) Chemokine-mobilized adult stem cells; defining a better hematopoietic graft. Leukemia 22, 466-473. (Pubitemid 351386716)
2. Wright DE, Wagers AJ, Gulati AP, Johnson FL, &, Weissman IL, (2001) Physiological migration of hematopoietic stem and progenitor cells. Science 294, 1933-1936. (Pubitemid 33101591)
3. Lapidot T, &, Petit I, (2002) Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells. Exp Hematol 30, 973-981. (Pubitemid 35286613)
4. Dar A, Kollet O, &, Lapidot T, (2006) Mutual, reciprocal SDF-1/CXCR4 interactions between hematopoietic and bone marrow stromal cells regulate human stem cell migration and development in NOD/SCID chimeric mice. Exp Hematol 34, 967-975. (Pubitemid 44080383)
5. Broxmeyer HE, Orschell CM, Clapp DW, Hangoc G, Cooper S, Plett PA, Liles WC, Li X, Graham-Evans B, Campbell TB, et al. (2005) Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist. J Exp Med 201, 1307-1318. (Pubitemid 40629073)
6. Larochelle A, Krouse A, Metzger M, Orlic D, Donahue RE, Fricker S, Bridger G, Dunbar CE, &, Hematti P, (2006) AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates. Blood 107, 3772-3778.
7. Devine SM, Vij R, Rettig M, Todt L, McGlauchlen K, Fisher N, Devine H, Link DC, Calandra G, Bridger G, et al. (2008) Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction. Blood 112, 990-998.
8. Liles WC, Rodger E, Broxmeyer HE, Dehner C, Badel K, Calandra G, Christensen J, Wood B, Price TH, &, Dale DC, (2005) Augmented mobilization and collection of CD34+ hematopoietic cells from normal human volunteers stimulated with granulocyte-colony-stimulating factor by single-dose administration of AMD3100, a CXCR4 antagonist. Transfusion 45, 295-300. (Pubitemid 40389423)
9. Abraham M, Biyder K, Begin M, Wald H, Weiss ID, Galun E, Nagler A, &, Peled A, (2007) Enhanced unique pattern of hematopoietic cell mobilization induced by the CXCR4 antagonist 4F-benzoyl-TN14003. Stem Cells 25, 2158-2166. (Pubitemid 47480473)
10. Dar A, Schajnovitz A, Lapid K, Kalinkovich A, Itkin T, Ludin A, Kao WM, Battista M, Tesio M, Kollet O, et al. (2011) Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells. Leukemia 25, 1286-1296.
11. Hegde R, Borkow G, Berchanski A, &, Lapidot A, (2007) Structure-function relationship of novel X4 HIV-1 entry inhibitors-l- and d-arginine peptide-aminoglycoside conjugates. FEBS J 274, 6523-6536. (Pubitemid 350215940)
12. Lapidot A, Berchanski A, &, Borkow G, (2008) Insight into the mechanisms of aminoglycoside derivatives interaction with HIV-1 entry steps and viral gene transcription. FEBS J 275, 5236-5257.
13. Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC, et al. (2010) Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science 330, 1066-1071.
14. Brelot A, Heveker N, Montes M, and, Alizon M, (2000) Identification of residues of CXCR4 critical for human immunodeficiency virus coreceptor and chemokine receptor activities. J Biol Chem 275, 23736-23744. (Pubitemid 30624660)
15. Crump MP, Gong JH, Loetscher P, Rajarathnam K, Amara A, Arenzana-Seisdedos F, Virelizier JL, Baggiolini M, Sykes BD, &, Clark-Lewis I, (1997) Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1. EMBO J 16, 6996-7007. (Pubitemid 27520800)
16. Kofuku Y, Yoshiura C, Ueda T, Terasawa H, Hirai T, Tominaga S, Hirose M, Maeda Y, Takahashi H, Terashima Y, et al. (2009) Structural basis of the interaction between chemokine stromal cell-derived factor-1/CXCL12 and its G-protein-coupled receptor CXCR4. J Biol Chem 284, 35240-35250.
17. Cashen A, Lopez S, Gao F, Calandra G, MacFarland R, Badel K, &, DiPersio J, (2008) A phase II study of plerixafor (AMD3100) plus G-CSF for autologous hematopoietic progenitor cell mobilization in patients with Hodgkin lymphoma. Biol Blood Marrow Transplant 14, 1253-1261.
18. Tigue CC, McKo JM, Evens AM, Trifilio SM, Tallman MS, &, Bennett CL, (2007) Granulocyte-colony stimulating factor administration to healthy individuals and persons with chronic neutropenia or cancer: an overview of safety considerations from the Research on Adverse Drug Events and Reports project. Bone Marrow Transplant 40, 185-192. (Pubitemid 47108460)
19. Tian S, Choi WT, Liu D, Pesavento J, Wang Y, An J, Sodroski JG, &, Huang Z, (2005) Distinct functional sites for human immunodeficiency virus type 1 and stromal cell-derived factor 1alpha on CXCR4 transmembrane helical domains. J Virol 79, 12667-12673. (Pubitemid 41433186)
20. Rosenkilde MM, Gerlach LO, Hatse S, Skerlj RT, Schols D, Bridger GJ, &, Schwartz TW, (2007) Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor. J Biol Chem 282, 27354-27365. (Pubitemid 47501954)
21. Veldkamp CT, Seibert C, Peterson FC, De la Cruz NB, Haugner JC III, Basnet H, Sakmar TP, &, Volkman BF, (2008) Structural basis of CXCR4 sulfotyrosine recognition by the chemokine SDF-1/CXCL12. Sci Signal 1, ra4, 1- 9.
22. Gerlach LO, Skerlj RT, Bridger GJ, &, Schwartz TW, (2001) Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor. J Biol Chem 276, 14153-14160.
23. Hatse S, Princen K, Bridger G, De Clercq E, &, Schols D, (2002) Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4. FEBS Lett 527, 255-262. (Pubitemid 35253875)
24. Fricker SP, Anastassov V, Cox J, Darkes MC, Grujic O, Idzan SR, Labrecque J, Lau G, Mosi RM, Nelson KL, et al. (2006) Characterization of the molecular pharmacology of AMD3100: a specific antagonist of the G-protein coupled chemokine receptor CXCR4. Biochem Pharmacol 72, 588-596. (Pubitemid 44163295)
25. Wong RS, Bodart V, Metz M, Labrecque J, Bridger G, &, Fricker SP, (2008) Comparison of the potential multiple binding modes of bicyclam, monocylam, and noncyclam small-molecule CXC chemokine receptor 4 inhibitors. Mol Pharmacol 74, 1485-1495.
26. Juarez J, Bradstock KF, Gottlieb DJ, &, Bendall LJ, (2003) Effects of inhibitors of the chemokine receptor CXCR4 on acute lymphoblastic leukemia cells in vitro. Leukemia 17, 1294-1300. (Pubitemid 36857336)
27. Spiegel A, Kollet O, Peled A, Abel L, Nagler A, Bielorai B, Rechavi G, Vormoor J, &, Lapidot T, (2004) Unique SDF-1-induced activation of human precursor-B ALL cells as a result of altered CXCR4 expression and signaling. Blood 103, 2900-2907. (Pubitemid 38451658)
28. Pettersson S, Perez-Nueno VI, Mena MP, Clotet B, Este JA, Borrel JI, &, Teixido J, (2010) Novel monocyclam derivatives as HIV entry inhibitors: design, synthesis, anti-HIV evaluation, and their interaction with the CXCR4 co-receptor. ChemMedChem 5, 1272-1281.
29. Lam AR, Bhattacharya S, Patel K, Hall SE, Mao A, &, Vaidehi N, (2011) Importance of receptor flexibility in binding of cyclam compounds to the chemokine receptor CXCR4. J Chem Inf Model 51, 139-147.
30. Trent JO, Wang ZX, Murray JL, Shao W, Tamamura H, Fujii N, &, Peiper SC, (2003) Lipid bilayer simulations of CXCR4 with inverse agonists and weak partial agonists. J Biol Chem 278, 47136-47144. (Pubitemid 37452300)
31. Doranz BJ, Filion LG, Diaz-Mitoma F, Sitar DS, Sahai J, Baribaud F, Orsini MJ, Benovic JL, Cameron W, &, Doms RW, (2001) Safe use of the CXCR4 inhibitor ALX40-4C in humans. AIDS Res Hum Retroviruses 17, 475-486. (Pubitemid 32692330)
32. Sweeney EA, Lortat-Jacob H, Priestley GV, Nakamoto B, &, Papayannopoulou T, (2002) Sulfated polysaccharides increase plasma levels of SDF-1 in monkeys and mice: involvement in mobilization of stem/progenitor cells. Blood 99, 44-51.
33. Hidalgo A, Peired AJ, Weiss LA, Katayama Y, &, Frenette PS, (2004) The integrin alphaMbeta2 anchors hematopoietic progenitors in the bone marrow during enforced mobilization. Blood 104, 993-1001. (Pubitemid 39038018)
34. Albanese P, Caruelle D, Frescaline G, Delbe J, Petit-Cocault L, Huet E, Charnaux N, Uzan G, Papy-Garcia D, &, Courty J, (2009) Glycosaminoglycan mimetics-induced mobilization of hematopoietic progenitors and stem cells into mouse peripheral blood: structure/function insights. Exp Hematol 37, 1072-1083.
35. Petit I, Szyper-Kravitz M, Nagler A, Lahav M, Peled A, Habler L, Ponomaryov T, Taichman RS, Arenzana-Seisdedos F, Fujii N, et al. (2002) G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat Immunol 3, 687-694. (Pubitemid 34752479)
36. Kalinkovich A, Tavor S, Avigdor A, Kahn J, Brill A, Petit I, Goichberg P, Tesio M, Netzer N, Naparstek E, et al. (2006) Functional CXCR4-expressing microparticles and SDF-1 correlate with circulating acute myelogenous leukemia cells. Cancer Res 66, 11013-11020. (Pubitemid 44877001)
37. Berchanski A, &, Lapidot A, (2007) Prediction of HIV-1 entry inhibitors neomycin-arginine conjugates interaction with the CD4-gp120 binding site by molecular modeling and multistep docking procedure. Biochim Biophys Acta 1768, 2107-2119. (Pubitemid 47379603)
38. Berchanski A, &, Lapidot A, (2009) Computer-based design of novel HIV-1 entry inhibitors: neomycin conjugated to arginine peptides at two specific sites. J Mol Model 15, 281-294.
39. Heifetz A, Katchalski-Katzir E, &, Eisenstein M, (2002) Electrostatics in protein-protein docking. Protein Sci 11, 571-587. (Pubitemid 34171262)
40. Berchanski A, Shapira B, &, Eisenstein M, (2004) Hydrophobic complementarity in protein-protein docking. Proteins 56, 130-142. (Pubitemid 38720845)
41. Honig B, &, Nicholls A, (1995) Classical electrostatics in biology and chemistry. Science 268, 1144-1149.