Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system

Bioscience Reports

Volumn 31, Issue 5, 2011, Pages 429-437

  Cui, Jie ^a   Yu, Mei ^a,b   Niu, Jingwen ^a   Yue, Zhenyu ^c   Xu, Zhiheng ^a  

^a INSTITUTE OF GENETICS AND DEVELOPMENTAL BIOLOGY   (China)

^b SHANDONG UNIVERSITY   (China)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Leucine rich repeat kinase 2 (LRRK2); Mitochondria; Parkinson's disease (PD); Permeability transition pore complex (PTPC)

Indexed keywords

ADENINE NUCLEOTIDE TRANSLOCASE; LEUCINE RICH REPEAT KINASE 2; MITOCHONDRIAL CREATINE KINASE; MUTANT PROTEIN; VOLTAGE DEPENDENT ANION CHANNEL; LRRK2 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE;

ARTICLE; CELL CULTURE; CELL DEATH; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; EMBRYO; ENZYME MODIFICATION; ENZYME REPRESSION; HUMAN; HUMAN CELL; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL MEMBRANE POTENTIAL; NERVE CELL NECROSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; UBIQUITINATION; WILD TYPE; APOPTOSIS; CHEMISTRY; ENZYMOLOGY; GENE EXPRESSION; GENETICS; HEK293 CELL LINE; METABOLISM; NERVE CELL; PARKINSON DISEASE; PATHOLOGY; PHYSIOLOGY; PROTEIN DOMAIN; PROTEIN PROCESSING; TUMOR CELL LINE;

APOPTOSIS; CELL LINE, TUMOR; CREATINE KINASE, MITOCHONDRIAL FORM; GENE EXPRESSION; HEK293 CELLS; HUMANS; MITOCHONDRIAL ADP, ATP TRANSLOCASES; NEURONS; PARKINSON DISEASE; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-SERINE-THREONINE KINASES; VOLTAGE-DEPENDENT ANION CHANNELS;

EID: 80155187926     PISSN: 01448463     EISSN: None     Source Type: Journal    
DOI: 10.1042/BSR20100127     Document Type: Article

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