Exercise: Kinetic considerations for gas exchange

Comprehensive Physiology

Volumn 1, Issue 1, 2011, Pages 203-244

  Rossiter, Harry B ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BIOLOGICAL MODEL; EXERCISE; EXERCISE TOLERANCE; HUMAN; LUNG CIRCULATION; LUNG GAS EXCHANGE; OXYGEN CONSUMPTION; PHYSIOLOGY;

EXERCISE; EXERCISE TOLERANCE; HUMANS; MODELS, BIOLOGICAL; OXYGEN CONSUMPTION; PULMONARY CIRCULATION; PULMONARY GAS EXCHANGE;

EID: 80155176344     PISSN: None     EISSN: 20404603     Source Type: Journal    
DOI: 10.1002/cphy.c090010     Document Type: Article

References (486)

1. ATS/ACCP statement on cardiopulmonary exercise testing.AmJ Respir Crit Care Med . 167, 2003, 211-277.
2. Aaron EA, Johnson BD, Seow CK, Dempsey JA. Oxygen cost of exercise hyperpnea: Measurement. J Appl Physiol . 72, 1992, 1810-1817.
3. Aliverti A, Dellaca RL, Lotti P, Bertini S, Duranti R, Scano G, Heyman J, Lo Mauro A, Pedotti A, Macklem PT. Influence of expiratory flowlimitation during exercise on systemic oxygen delivery in humans. Eur J Appl Physiol . 95, 2005, 229-242.
4. Aliverti A, Kayser B, Cautero M, Dellaca RL, di Prampero PE, Capelli C. Pulmonary [Formula: see text] kinetics at the onset of exercise is faster when actual changes in alveolar O2 stores are considered. Respir Physiol Neurobiol . 169, 2009, 78-82.
5. Aliverti A, Kayser B, Macklem PT. Breath-by-breath assessment of alveolar gas stores and exchange. J Appl Physiol . 96, 2004, 1464-1469.
6. Aliverti A, Macklem PT. The major limitation to exercise performance in COPD is inadequate energy supply to the respiratory and locomotor muscles. J Appl Physiol . 105, 2008, 749-751; discussion 755-747.
7. Allen DG, Lamb GD, Westerblad H. Skeletal muscle fatigue: Cellular mechanisms. Physiol Rev . 88, 2008, 287-332.
8. Amara CE, Shankland EG, Jubrias SA, Marcinek DJ, Kushmerick MJ, Conley KE. Mild mitochondrial uncoupling impacts cellular aging in human muscles in vivo. Proc Natl Acad Sci USA . 104, 2007, 1057-1062.
9. Arthur PG, HoganMC, Bebout DE,Wagner PD, Hochachka PW. Modeling the effects of hypoxia on ATP turnover in exercising muscle. J Appl Physiol . 73, 1992, 737-742.
10. Astrand I, Astrand PO, Christensen EH, Hedman R. Intermittent muscular work. Acta Physiol Scand . 48, 1960, 448-453.
11. Astrand I, Astrand PO, Christensen EH, Hedman R. Myohemoglobin as an oxygen-store in man. Acta Physiol Scand . 48, 1960, 454-460.
12. Babcock MA, Paterson DH, Cunningham DA, Dickinson JR. Exercise on-transient gas exchange kinetics are slowed as a function of age. Med Sci Sports Exerc . 26, 1994, 440-446.
13. Bailey SJ, Vanhatalo A, Wilkerson DP, Dimenna FJ, Jones AM. Optimizing the " priming" effect: Influence of prior exercise intensity and recovery duration on O2 uptake kinetics and severe-intensity exercise tolerance. J Appl Physiol . 107, 2009, 1743-1756.
14. Bailey SJ,Wilkerson DP, Dimenna FJ, Jones AM. Influence of repeated sprint training on pulmonary O2 uptake and muscle deoxygenation kinetics in humans. J Appl Physiol . 106, 2009, 1875-1887.
15. Bailey SJ,Winyard P, Vanhatalo A, Blackwell JR, Dimenna FJ,Wilkerson DP, Tarr J, Benjamin N, Jones A.M. Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. J Appl Physiol . 107, 2009, 1144-1155.
16. Bakkman L, Sahlin K, Holmberg HC, Tonkonogi M. Quantitative and qualitative adaptation of human skeletal muscle mitochondria to hypoxic compared with normoxic training at the same relative work rate. Acta Physiol (Oxf) . 190, 2007, 243-251.
17. Bangsbo J. Muscle oxygen uptake in humans at onset of and during intense exercise. Acta Physiol Scand . 168, 2000, 457-464.
18. Bangsbo J, Gibala MJ, Krustrup P, Gonzalez-Alonso J, Saltin B. Enhanced pyruvate dehydrogenase activity does not affect muscle O2 uptake at onset of intense exercise in humans. Am J Physiol Regul Integr Comp Physiol . 282, 2002, R273-R280.
19. Bangsbo J, Krustrup P, Gonzalez-Alonso J,Boushel R, Saltin B. Muscle oxygen kinetics at onset of intense dynamic exercise in humans. Am J Physiol Regul Integr Comp Physiol . 279, 2000, R899-R906.
20. Bangsbo J, Krustrup P, Gonzalez-Alonso J, Saltin B. ATP production and efficiency of human skeletal muscle during intense exercise: Effect of previous exercise. Am J Physiol Endocrinol Metab . 280, 2001, E956-E964.
21. Barclay CJ, Constable JK, Gibbs CL. Energetics of fast- and slowtwitch muscles of the mouse. J Physiol . 472, 1993, 61-80.
22. Barclay CJ,Weber CL. Slow skeletal muscles of themouse have greater initial efficiency than fast muscles but the same net efficiency. J Physiol . 559, 2004, 519-533.
23. Barker T, Poole DC, Noble ML, Barstow TJ. Human critical poweroxygen uptake relationship at different pedalling frequencies. Exp Physiol . 91, 2006, 621-632.
24. Barstow TJ, Casaburi R, Wasserman K. O2 uptake kinetics and the O2 deficit as related to exercise intensity and blood lactate. J Appl Physiol . 75, 1993, 755-762.
25. Barstow TJ, Jones AM, Nguyen PH, Casaburi R. Influence of muscle fiber type and pedal frequency on oxygen uptake kinetics of heavy exercise. J Appl Physiol . 81, 1996, 1642-1650.
26. Barstow TJ, Jones AM, Nguyen PH, Casaburi R. Influence of muscle fibre type and fitness on the oxygen uptake/power output slope during incremental exercise in humans. Exp Physiol . 85, 2000, 109-116.
27. Barstow TJ, Lamarra N, Whipp BJ. Modulation of muscle and pulmonary O2 uptakes by circulatory dynamics during exercise. J Appl Physiol . 68, 1990, 979-989.
28. Barstow TJ, Mole PA. Simulation of pulmonary O2 uptake during exercise transients in humans. J Appl Physiol . 63, 1987, 2253-2261.
29. Barstow TJ, Mole PA. Linear and nonlinear characteristics of oxygen uptake kinetics during heavy exercise. J Appl Physiol . 71, 1991, 2099-2106.
30. Bassett DR Jr, Howley ET. Limiting factors for maximum oxygen uptake and determinants of endurance performance. Med Sci Sports Exerc . 32, 2000, 70-84.
31. Bauer TA, Brass EP, Hiatt WR. Impaired muscle oxygen use at onset of exercise in peripheral arterial disease. J Vasc Surg . 40, 2004, 488-493.
32. Bauer TA, Brass EP, Nehler M, Barstow TJ, Hiatt WR. Pulmonary Vo2 dynamics during treadmill and arm exercise in peripheral arterial disease. J Appl Physiol . 97, 2004, 627-634.
33. Bauer TA, Regensteiner JG, Brass EP, Hiatt WR. Oxygen uptake kinetics during exercise are slowed in patients with peripheral arterial disease. J Appl Physiol . 87, 1999, 809-816.
34. Beaver WL, Lamarra N,Wasserman K. Breath-by-breath measurement of true alveolar gas exchange. J Appl Physiol . 51, 1981, 1662-1675.
35. Beaver WL, Wasserman K. Muscle RQ and lactate accumulation from analysis of the Vco2-Vo2 relationship during exercise. Clin J Sport Med 27-34, 1992.
36. Beaver WL, Wasserman K, Whipp BJ. A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol . 60, 1986, 2020-2027.
37. Behnke BJ, Delp MD, McDonough P, Spier SA, Poole DC, Musch TI. Effects of chronic heart failure on microvascular oxygen exchange dynamics in muscles of contrasting fiber type. Cardiovasc Res . 61, 2004, 325-332.
38. Behnke BJ, Kindig CA, Musch TI, Koga S, Poole DC. Dynamics of microvascular oxygen pressure across the rest-exercise transition in rat skeletal muscle. Respir Physiol . 126, 2001, 53-63.
39. Bekedam MA, van Beek-Harmsen BJ, van Mechelen W, Boonstra A, Van Der Laarse WJ. Myoglobin concentration in skeletal muscle fibers of chronic heart failure patients. J Appl Physiol 2009.
40. Belardinelli R, Barstow TJ, Nguyen P, Wasserman K. Skeletal muscle oxygenation and oxygen uptake kinetics following constant work rate exercise in chronic congestive heart failure. Am J Cardiol . 80, 1997, 1319-1324.
41. Bell C, Paterson DH, Kowalchuk JM, Cunningham DA. Oxygen uptake kinetics of older humans are slowed with age but are unaffected by hyperoxia. Exp Physiol . 84, 1999, 747-759.
42. Bell C, Paterson DH, Kowalchuk JM, Moy AP, Thorp DB, Noble EG, Taylor AW, Cunningham DA. Determinants of oxygen uptake kinetics in older humans following single-limb endurance exercise training. Exp Physiol . 86, 2001, 659-665.
43. Berger NJ, Campbell IT, Wilkerson DP, Jones AM. Influence of acute plasma volume expansion on Vo2 kinetics, Vo2 peak, and performance during high-intensity cycle exercise. J Appl Physiol . 101, 2006, 707-714.
44. Berger NJ, Jones AM. Pulmonary O2 uptake on-kinetics in sprintand endurance-trained athletes. Appl Physiol Nutr Metab . 32, 2007, 383-393.
45. Berger NJ, Rittweger J, Kwiet A, Michaelis I, Williams AG, Tolfrey K, Jones AM. Pulmonary O2 uptake on-kinetics in endurance- and sprint-trained master athletes. Int J Sports Med . 27, 2006, 1005-1012.
46. Berger NJ, Tolfrey K,Williams AG, Jones AM. Influence of continuous and interval training on oxygen uptake on-kinetics. Med Sci Sports Exerc . 38, 2006, 504-512.
47. Bergstrom J,Hermansen L, Hultman E, Saltin B. Diet, muscle glycogen and physical performance. Acta Physiol Scand . 71, 1967, 140-150.
48. Bessman SP, Geiger PJ. Transport of energy in muscle: The phosphorylcreatine shuttle. Science . 211, 1981, 448-452.
49. Billat VL, Morton RH, Blondel N, Berthoin S, Bocquet V, Koralsztein JP, Barstow TJ. Oxygen kinetics and modelling of time to exhaustion whilst running at various velocities at maximal oxygen uptake. Eur J Appl Physiol . 82, 2000, 178-187.
50. Billat VL,Mouisel E, Roblot N, Melki J. Inter- and intrastrain variation in mouse critical running speed. J Appl Physiol . 98, 2005, 1258-1263.
51. Boone J, Koppo K, Bouckaert J. The Vo2 response to submaximal ramp cycle exercise: Influence of ramp slope and training status. Respir Physiol Neurobiol . 161, 2008, 291-297.
52. Borg G, Ljunggren G, Ceci R. The increase of perceived exertion, aches and pain in the legs, heart rate and blood lactate during exercise on a bicycle ergometer. Eur J Appl Physiol Occup Physiol . 54, 1985, 343-349.
53. Borrani F, Candau R, Millet GY, Perrey S, Fuchslocher J, Rouillon JD. Is the Vo2 slow component dependent on progressive recruitment of fast-twitch fibers in trained runners? J Appl Physiol . 90, 2001, 2212-2220.
54. Brandenburg SL, Reusch JE, Bauer TA, Jeffers BW, Hiatt WR, Regensteiner JG. Effects of exercise training on oxygen uptake kinetic responses in women with type 2 diabetes. Diabetes Care . 22, 1999, 1640-1646.
55. Brittain CJ, Rossiter HB, Kowalchuk JM, Whipp BJ. Effect of prior metabolic rate on the kinetics of oxygen uptake during moderateintensity exercise. Eur J Appl Physiol . 86, 2001, 125-134.
56. Buchheit M, Laursen PB, Ahmaidi S. Effect of prior exercise on pulmonary O2 uptake and estimated muscle capillary blood flow kinetics during moderate-intensity field running in men. J Appl Physiol . 107, 2009, 460-470.
57. Buckler KJ, Vaughan-Jones RD, Peers C, Lagadic-Gossmann D, Nye PC. Effects of extracellular pH, Pco2 and HCO3 - on intracellular pH in isolated type-I cells of the neonatal rat carotid body. J Physiol . 444, 1991, 703-721.
58. Buckler KJ,WilliamsBA, Honore E. An oxygen-, acid- and anaestheticsensitive TASK-like background potassium channel in rat arterial chemoreceptor cells. J Physiol 525 Pt . 1, 2000, 135-142.
59. Burnley M. Found in translation: The dependence of oxygen uptake kinetics on O2 delivery and O2 utilization. J Appl Physiol . 105, 2008, 1387-1388.
60. Burnley M, Doust JH, Jones AM. Time required for the restoration of normal heavy exercise Vo2 kinetics following prior heavy exercise. J Appl Physiol . 101, 2006, 1320-1327.
61. Burnley M, Doust JH, Vanhatalo A. A 3-min all-out test to determine peak oxygen uptake and themaximal steady state. Med Sci Sports Exerc . 38, 2006, 1995-2003.
62. Burnley M, Jones AM. Oxygen uptake kinetics as a determinant of sports performance. Eur J Sport Sci . 7, 2007, 63-79.
63. Burnley M, Jones AM, Carter H, Doust JH. Effects of prior heavy exercise on phase II pulmonary oxygen uptake kinetics during heavy exercise. J Appl Physiol . 89, 2000, 1387-1396.
64. Burnley M, Roberts CL, Thatcher R, Doust JH, Jones AM. Influence of blood donation on O2 uptake on-kinetics, peak O2 uptake and time to exhaustion during severe-intensity cycle exercise in humans. Exp Physiol . 91, 2006, 499-509.
65. Busso T, Robbins PA. Evaluation of estimates of alveolar gas exchange by using a tidally ventilated nonhomogenous lung model.JAppl Physiol . 82, 1997, 1963-1971.
66. Capelli C, Cautero M, di Prampero PE. New perspectives in breathby-breath determination of alveolar gas exchange in humans. Pflugers Arch . 441, 2001, 566-577.
67. Carlson BE, Anderson JC, Raymond GM, Dash RK, Bassingthwaighte JB.Modeling oxygen and carbon dioxide transport and exchange using a closed loop circulatory system. Adv Exp Med Biol . 614, 2008, 353-360.
68. Carter H, Jones AM, Barstow TJ, Burnley M, Williams CA, Doust JH. Oxygen uptake kinetics in treadmill running and cycle ergometry: A comparison. J Appl Physiol . 89, 2000, 899-907.
69. Carter H, Pringle JS, Boobis L, Jones AM, Doust JH. Muscle glycogen depletion alters oxygen uptake kinetics during heavy exercise. Med Sci Sports Exerc . 36, 2004, 965-972.
70. Casaburi R, Barstow TJ, Robinson T,Wasserman K. Influence of work rate on ventilatory and gas exchange kinetics. J Appl Physiol . 67, 1989, 547-555.
71. Casaburi R, Daly J, Hansen JE, Effros RM. Abrupt changes in mixed venous blood gas composition after the onset of exercise. J Appl Physiol . 67, 1989, 1106-1112.
72. Casaburi R, Storer TW, Ben-Dov I,Wasserman K. Effect of endurance training on possible determinants of Vo2 during heavy exercise. J Appl Physiol . 62, 1987, 199-207.
73. Casaburi R, Whipp BJ, Wasserman K, Beaver WL, Koyal SN. Ventilatory and gas exchange dynamics in response to sinusoidal work. J Appl Physiol . 42, 1977, 300-301.
74. Cautero M, Beltrami AP, di Prampero PE, Capelli C. Breath-by-breath alveolar oxygen transfer at the onset of step exercise in humans: Methodological implications. Eur J Appl Physiol . 88, 2002, 203-213.
75. CauteroM, di Prampero PE, Tam E, Capelli C. Alveolar oxygen uptake kinetics with step, impulse and ramp exercise in humans. Eur J Appl Physiol . 95, 2005, 474-485.
76. Cerretelli P, di Prampero PE. Gas exchange in exercise. In: Farhi LE, Tenney SM, editor. Handbook of Physiology-Section . 3, MD: American Physiological Society, 1987, p. 297-339, The Respiratory System. Bethesda.
77. Cerretelli P, Marconi C, Meyer M, Ferretti G, Grassi B. Gas exchange kinetics in heart transplant recipients. Chest . 101, 1992, 199S-205S.
78. Cerretelli P, Pendergast D, Paganelli WC, Rennie DW. Effects of specificmuscle training on Vo2 on-response and early blood lactate. J Appl Physiol . 47, 1979, 761-769.
79. Chance B, Eleff S, Leigh JS Jr, Sokolow D, Sapega A. Mitochondrial regulation of phosphocreatine/inorganic phosphate ratios in exercising human muscle: A gated 31P NMR study. Proc Natl Acad Sci USA . 78, 1981, 6714-6718.
80. Chance B, Leigh JS Jr, Clark BJ, Maris J, Kent J, Nioka S, Smith D. Control of oxidative metabolism and oxygen delivery in human skeletal muscle:Asteady-state analysis of thework/energy cost transfer function. Proc Natl Acad Sci USA . 82, 1985, 8384-8388.
81. Chance B, Williams GR. Respiratory enzymes in oxidative phosphorylation. I. Kinetics of oxygen utilization. J Biol Chem . 217, 1955, 383-393.
82. Chiappa GR, Borghi-Silva A, Ferreira LF, Carrascosa C, Oliveira CC, Maia J, Gimenes AC, Queiroga F Jr, Berton D, Ferreira EM, Nery LE, Neder JA. Kinetics of muscle deoxygenation are accelerated at the onset of heavy-intensity exercise in patients with COPD: Relationship to central cardiovascular dynamics. J Appl Physiol . 104, 2008, 1341-1350.
83. Chilibeck PD, Paterson DH, Cunningham DA. Effects of age on Vo2 kinetics during calf and cycling exercise. Adv Exp Med Biol . 393, 1995, 195-200.
84. Chilibeck PD, Paterson DH, Cunningham DA, Taylor AW, Noble EG. Muscle capillarization O2 diffusion distance, and Vo2 kinetics in old and young individuals. J Appl Physiol . 82, 1997, 63-69.
85. Chilibeck PD, Paterson DH, McCreary CR, Marsh GD, Cunningham DA, Thompson RT. The effects of age on kinetics of oxygen uptake and phosphocreatine in humans during exercise. Exp Physiol . 83, 1998, 107-117.
86. Chilibeck PD, Paterson DH, Petrella RJ, Cunningham DA. The influence of age and cardiorespiratory fitness on kinetics of oxygen uptake. Can J Appl Physiol . 21, 1996, 185-196.
87. Chin LM, Leigh RJ, Heigenhauser GJ, Rossiter HB, Paterson DH, Kowalchuk JM. Hyperventilation-induced hypocapnic alkalosis slows the adaptation of pulmonary O2 uptake during the transition to moderate-intensity exercise. J Physiol . 583, 2007, 351-364.
88. Chuang ML, Ting H, Otsuka T, Sun XG, Chiu FY, Beaver WL, Hansen JE, Lewis DA,Wasserman K. Aerobically generated CO2 stored during early exercise. J Appl Physiol . 87, 1999, 1048-1058.
89. Chuang ML, Ting H, Otsuka T, Sun XG, Chiu FY, Hansen JE,Wasserman K. Muscle deoxygenation as related to work rate. Med Sci Sports Exerc . 34, 2002, 1614-1623.
90. Cleuziou C, Perry S, Borrani F, Lecoq AM, Candau R, Courteix D, Obert P. Dynamic responses of oxygen uptake at the onset and end of moderate and heavy exercise in trained subjects. Can J Appl Physiol . 29, 2004, 32-44.
91. Cleuziou C, Perrey S, Lecoq AM, Candau R, Courteix D, Obert P. Oxygen uptake kinetics during moderate and heavy intensity exercise in humans: The influence of hypoxia and training status. Int J Sports Med . 26, 2005, 356-362.
92. Coats EM, Rossiter HB, Day JR, Miura A, Fukuba Y, Whipp BJ. Intensity-dependent tolerance to exercise after attaining V(O2max) in humans. J Appl Physiol . 95, 2003, 483-490.
93. Connett RJ. The cytosolic redox is coupled to Vo2. A working hypothesis. Adv Exp Med Biol . 222, 1988, 133-142.
94. Connett RJ, Honig CR. Regulation of Vo2 in red muscle: Do current biochemical hypotheses fit in vivo data? Am J Physiol . 256, 1989, R898-R906.
95. Connett RJ, Honig CR, Gayeski TE, Brooks GA. Defining hypoxia: A systems view of Vo2, glycolysis, energetics, and intracellular Po2. J Appl Physiol . 68, 1990, 833-842.
96. Cooper CB, Beaver WL, Cooper DM, Wasserman K. Factors affecting the components of the alveolar CO2 output-O2 uptake relationship during incremental exercise in man. Exp Physiol . 77, 1992, 51-64.
97. Coyle EF, Sidossis LS, Horowitz JF, Beltz JD. Cycling efficiency is related to the percentage of type I muscle fibers. Med Sci Sports Exerc . 24, 1992, 782-788.
98. Crow MT, Kushmerick MJ. Chemical energetics of slow- and fasttwitch muscles of the mouse. J Gen Physiol . 79, 1982, 147-166.
99. Cunningham DA, Croix CM, Paterson DH, Ö zyener F, Whipp BJ. The off-transient pulmonary oxygen uptake (VO(2)) kinetics following attainment of a particular VO(2) during heavy-intensity exercise in humans. Exp Physiol . 85, 2000, 339-347.
100. Cunningham DA, Himann JE, Paterson DH, Dickinson JR. Gas exchange dynamics with sinusoidal work in young and elderly women. Respir Physiol . 91, 1993, 43-56.
101. Dash RK, Li Y, Kim J, Beard DA, Saidel GM, Cabrera ME. Metabolic dynamics in skeletal muscle during acute reduction in blood flow and oxygen supply to mitochondria: In-silico studies using a multi-scale, top-down integrated model. PLoS One . 3, 2008, e3168.
102. Dash RK, Li Y, Kim J, Saidel GM, Cabrera ME. Modeling cellular metabolism and energetics in skeletal muscle: Large-scale parameter estimation and sensitivity analysis. IEEE Trans Biomed Eng . 55, 2008, 1298-1318.
103. Davies CT, di Prampero PE, Cerretelli P. Kinetics of cardiac output and respiratory gas exchange during exercise and recovery. J Appl Physiol . 32, 1972, 618-625.
104. Davis JA, Whipp BJ, Lamarra N, Huntsman DJ, Frank MH,Wasserman K. Effect of ramp slope on determination of aerobic parameters from the ramp exercise test. Med Sci Sports Exerc . 14, 1982, 339-343.
105. Day JR, Rossiter HB, Coats EM, Skasick A, Whipp BJ. The maximally attainableVo2 during exercise in humans: The peak vs.maximum issue. J Appl Physiol . 95, 2003, 1901-1907.
106. DeLorey DS, Kowalchuk JM, Paterson DH. Relationship between pulmonaryO2 uptake kinetics and muscle deoxygenation during moderateintensity exercise. J Appl Physiol . 95, 2003, 113-120.
107. DeLorey DS, Kowalchuk JM, Paterson DH. Adaptation of pulmonary O2 uptake kinetics and muscle deoxygenation at the onset of heavyintensity exercise in young and older adults. J Appl Physiol . 98, 2005, 1697-1704.
108. Demarie S, Sardella F, Billat V, Magini W, Faina M. The Vo2 slow component in swimming. Eur J Appl Physiol . 84, 2001, 95-99.
109. Demarle AP, Slawinski JJ, Laffite LP, Bocquet VG, Koralsztein JP, Billat VL. Decrease of O(2) deficit is a potential factor in increased time to exhaustion after specific endurance training. J Appl Physiol . 90, 2001, 947-953.
110. Dempsey JA,Wagner PD. Exercise-induced arterial hypoxemia. J Appl Physiol . 87, 1999, 1997-2006.
111. di Prampero PE, Lafortuna CL. Breath-by-breath estimate of alveolar gas transfer variability in man at rest and during exercise. J Physiol . 415, 1989, 459-475.
112. di Prampero PE, Margaria R. Relationship between O2 consumption, high energy phosphates and the kinetics of the O2 debt in exercise. Pflugers Arch . 304, 1968, 11-19.
113. Diederich ER, Behnke BJ, McDonough P, Kindig CA, Barstow TJ, Poole DC, Musch TI. Dynamics of microvascular oxygen partial pressure in contracting skeletal muscle of rats with chronic heart failure. Cardiovasc Res . 56, 2002, 479-486.
114. Douglas CG. Coordination of the respiration and circulation with variation in bodily activity. Lancet . 2, 1927, 213-230.
115. Duteil S, Bourrilhon C, Raynaud JS, Wary C, Richardson RS, Leroy-Willig A, Jouanin JC, Guezennec CY, Carlier PG. Metabolic and vascular support for the role of myoglobin in humans: A multiparametric NMR study. Am J Physiol Regul Integr Comp Physiol . 287, 2004, R1441-R1449.
116. EdwardsHT. Lactic acid in rest andwork at high altitudes. Am J Physiol . 116, 1936, 367-375.
117. Eldridge FL. Central integration of mechanisms in exercise hyperpnea. Med Sci Sports Exerc . 26, 1994, 319-327.
118. Endo M, Okada Y, Rossiter HB, Ooue A, Miura A, Koga S, Fukuba Y. Kinetics of pulmonary Vo2 and femoral artery blood flow and their relationship during repeated bouts of heavy exercise. Eur J Appl Physiol . 95, 2005, 418-430.
119. Endo M, Usui S, Fukuoka Y, Miura A, Rossiter HB, Fukuba Y. Effects of priming exercise intensity on the dynamic linearity of the pulmonary VO(2) response during heavy exercise. Eur J Appl Physiol . 91, 2004, 545-554.
120. Endo MY, Kobayakawa M, Kinugasa R, Kuno S, Akima H, Rossiter HB, Miura A, Fukuba Y. Thigh muscle activation distribution and pulmonary Vo2 kinetics during moderate, heavy, and very heavy intensity cycling exercise in humans. Am J Physiol Regul Integr Comp Physiol . 293, 2007, R812-R820.
121. Essfeld D, Hoffmann U, Stegemann J. Vo2 kinetics in subjects differing in aerobic capacity: Investigation by spectral analysis. Eur J Appl Physiol Occup Physiol . 56, 1987, 508-515.
122. Essfeld D, Hoffmann U, Stegemann J. A model for studying the distortion of muscle oxygen uptake patterns by circulation parameters. Eur J Appl Physiol Occup Physiol . 62, 1991, 83-90.
123. Farhi LE, Rahn H. Gas stores of the body and the unsteady state. J Appl Physiol . 7, 1955, 472-484.
124. Fell D. Metabolic control analysis. In: Snell K, editor. Understanding the Control of Metabolism. London: Portland Press, 1997, p. 101-135.
125. Ferguson C, Rossiter HB, Whipp BJ, Cathcart AJ, Murgatroyd SR, Ward SA. Effect of recovery duration from prior exhaustive exercise on the parameters of the power-duration relationship. J Appl Phyisol . 108, 2010, 866-874.
126. Ferguson C, Whipp BJ, Cathcart AJ, Rossiter HB, Turner AP, Ward SA. Effects of prior very-heavy intensity exercise on indices of aerobic function and high-intensity exercise tolerance. J Appl Physiol . 103, 2007, 812-822.
127. Fernstrom M, Tonkonogi M, Sahlin K. Effects of acute and chronic endurance exercise on mitochondrial uncoupling in human skeletal muscle. J Physiol . 554, 2004, 755-763.
128. Ferreira LF, Harper AJ, Townsend DK, Lutjemeier BJ, Barstow TJ. Kinetics of estimated human muscle capillary blood flow during recovery from exercise. Exp Physiol . 90, 2005, 715-726.
129. Ferreira LF, Lutjemeier BJ, Townsend DK, Barstow TJ. Dynamics of skeletal muscle oxygenation during sequential bouts of moderate exercise. Exp Physiol . 90, 2005, 393-401.
130. Ferreira LF, McDonough P, Behnke BJ, Musch TI, Poole DC. Blood flow and O2 extraction as a function of O2 uptake in muscles composed of different fiber types. Respir Physiol Neurobiol . 153, 2006, 237-249.
131. Ferreira LF, Poole DC, Barstow TJ. Muscle blood flow-O2 uptake interaction and their relation to on-exercise dynamics of O2 exchange. Respir Physiol Neurobiol . 147, 2005, 91-103.
132. Ferreira LF, Townsend DK, Lutjemeier BJ, Barstow TJ. Muscle capillary blood flow kinetics estimated from pulmonary O2 uptake and near-infrared spectroscopy. J Appl Physiol . 98, 2005, 1820-1828.
133. Forbes SC, Kowalchuk JM, Thompson RT, Marsh GD. Effects of hyperventilation on phosphocreatine kinetics and muscle deoxygenation during moderate-intensity plantar flexion exercise. J Appl Physiol . 102, 2007, 1565-1573.
134. Forbes SC, Slade JM, Francis RM,Meyer RA. Comparison of oxidative capacity among leg muscles in humans using gated 31P 2-D chemical shift imaging. NMR Biomed 22(10): 1063-1071, 2009.
135. Forster HV. Exercise hyperpnea: Where do we go from here? Exerc Sport Sci Rev . 28, 2000, 133-137.
136. Francescato MP, Cettolo V, di Prampero PE. Influence of phosphagen concentration on phosphocreatine breakdown kinetics. Data from human gastrocnemius muscle. J Appl Physiol . 105, 2008, 158-164.
137. Fujihara Y, Hildebrandt J, Hildebrandt JR. Cardiorespiratory transients in exercising man. II. Linear models. J Appl Physiol . 35, 1973, 68-76.
138. Fujihara Y, Hildebrandt JR, Hildebrandt J. Cardiorespiratory transients in exercising man. I. Tests of superposition. J Appl Physiol . 35, 1973, 58-67.
139. Gaesser GA, Brooks GA. Muscular efficiency during steady-rate exercise: Effects of speed and work rate. J Appl Physiol . 38, 1975, 1132-1139.
140. Gaesser GA, Poole DC. The slow component of oxygen uptake kinetics in humans. Exerc Sport Sci Rev . 24, 1996, 35-71.
141. Gale GE, Torre-Bueno JR, Moon RE, Saltzman HA, Wagner PD. Ventilation-perfusion inequality in normal humans during exercise at sea level and simulated altitude. J Appl Physiol . 58, 1985, 978-988.
142. Gerbino A,Ward SA, Whipp BJ. Effects of prior exercise on pulmonary gas-exchange kinetics during high-intensity exercise in humans. J Appl Physiol . 80, 1996, 99-107.
143. Gibala MJ, McGee SL. Metabolic adaptations to short-term highintensity interval training: A little pain for a lot of gain? Exerc Sport Sci Rev . 36, 2008, 58-63.
144. Gladden LB. Lactate metabolism: A new paradigm for the third millennium. J Physiol . 558, 2004, 5-30.
145. Glancy B, Barstow T,Willis WT. Linear relation between time constant of oxygen uptake kinetics, total creatine, and mitochondrial content in vitro. Am J Physiol Cell Physiol . 294, 2008, C79-C87.
146. Gollnick PD, Armstrong RB, Saltin B, Saubert CWt, Sembrowich WL, Shepherd RE. Effect of training on enzyme activity and fiber composition of human skeletal muscle. J Appl Physiol . 34, 1973, 107-111.
147. Gollnick PD, Armstrong RB, Saubert CWt, Piehl K, Saltin B. Enzyme activity and fiber composition in skeletal muscle of untrained and trained men. J Appl Physiol . 33, 1972, 312-319.
148. Gonzalez-Alonso J, Calbet JA. Reductions in systemic and skeletal muscle blood flow and oxygen delivery limit maximal aerobic capacity in humans. Circulation . 107, 2003, 824-830.
149. Gonzalez-Alonso J, Quistorff B, Krustrup P, Bangsbo J, Saltin B. Heat production in human skeletal muscle at the onset of intense dynamic exercise. J Physiol 524 Pt . 2, 2000, 603-615.
150. Graham TE, Saltin B. Estimation of the mitochondrial redox state in human skeletal muscle during exercise. J Appl Physiol . 66, 1989, 561-566.
151. Grassi B. Limitation of skeletal muscle Vo2 kinetics by inertia of cellular respiration. In: Jones AM, Poole DC, editors. Oxygen Uptake Kinetics in Sport, Exercise and Medicine. London: Routledge, 2005, p. 212-219.
152. Grassi B, Gladden LB, Samaja M, Stary CM, Hogan MC. Faster adjustment of O2 delivery does not affect Vo2 on-kinetics in isolated in situ canine muscle. J Appl Physiol . 85, 1998, 1394-1403.
153. Grassi B, Hogan MC, Greenhaff PL, Hamann JJ, Kelley KM, Aschenbach WG, Constantin-Teodosiu D, Gladden LB. Oxygen uptake onkinetics in dog gastrocnemius in situ following activation of pyruvate dehydrogenase by dichloroacetate. J Physiol . 538, 2002, 195-207.
154. Grassi B, HoganMC, Kelley KM, Aschenbach WG, Hamann JJ, Evans RK, Patillo RE, Gladden LB. Role of convective O(2) delivery in determining Vo(2) on-kinetics in canine muscle contracting at peak Vo(2). J Appl Physiol . 89, 2000, 1293-1301.
155. Grassi B, HoganMC, Kelley KM, Howlett RA, Gladden LB. Effects of nitric oxide synthase inhibition by L-NAME on oxygen uptake kinetics in isolated canine muscle in situ. J Physiol . 568, 2005, 1021-1033.
156. Grassi B, Hogan MC, Rossiter HB, Howlett RA, Harris JE, Goodwin ML,Dobson JL,Gladden LB. Effects of acute creatine kinase inhibition on skeletal muscle O2 uptake kinetics. Med Sci Sports Exerc . 38, 2006, S519.
157. Grassi B, Pogliaghi S, Rampichini S, Quaresima V, Ferrari M, Marconi C, Cerretelli P. Muscle oxygenation and pulmonary gas exchange kinetics during cycling exercise on-transitions in humans. J Appl Physiol . 95, 2003, 149-158.
158. Grassi B, Poole DC, Richardson RS, Knight DR, Erickson BK,Wagner PD. Muscle O2 uptake kinetics in humans: Implications for metabolic control. J Appl Physiol . 80, 1996, 988-998.
159. Green HJ, Jones S, Ball-Burnett M, Farrance B, Ranney D. Adaptations in muscle metabolism to prolonged voluntary exercise and training. J Appl Physiol . 78, 1995, 138-145.
160. Greenhaff PL, Campbell-O'Sullivan SP, Constantin-Teodosiu D, Poucher SM, Roberts PA, Timmons JA. An acetyl group deficit limits mitochondrial ATP production at the onset of exercise. Biochem Soc Trans . 30, 2002, 275-280.
161. Grønlund J. Anewmethod for breath-to-breath determination of oxygen flux across the alveolar membrane. Eur J Appl Physiol Occup Physiol . 52, 1984, 167-172.
162. Gurd BJ, Peters SJ, Heigenhauser GJ, LeBlanc PJ, Doherty TJ, Paterson DH, Kowalchuk JM. O2 uptake kinetics, pyruvate dehydrogenase activity, and muscle deoxygenation in young and older adults during the transition to moderate-intensity exercise. Am J Physiol Regul Integr Comp Physiol . 294, 2008, R577-R584.
163. Gurd BJ, Peters SJ, Heigenhauser GJ, LeBlanc PJ, Doherty TJ, Paterson DH, Kowalchuk JM. Prior heavy exercise elevates pyruvate dehydrogenase activity and muscle oxygenation and speeds O2 uptake kinetics during moderate exercise in older adults. Am J Physiol Regul Integr Comp Physiol . 297, 2009, R877-R884.
164. Gurd BJ, Peters SJ, Heigenhauser GJ, LeBlanc PJ, Doherty TJ, Paterson DH, Kowalchuk JM. Prior heavy exercise elevates pyruvate dehydrogenase activity and speeds O2 uptake kinetics during subsequent moderate-intensity exercise in healthy young adults. J Physiol . 577, 2006, 985-996.
165. Gurd BJ, Scheuermann BW, Paterson DH,Kowalchuk JM. Prior heavyintensity exercise speeds Vo2 kinetics during moderate-intensity exercise in young adults. J Appl Physiol . 98, 2005, 1371-1378.
166. Hagberg JM, Hickson RC, Ehsani AA, Holloszy JO. Faster adjustment to and recovery from submaximal exercise in the trained state. J Appl Physiol . 48, 1980, 218-224.
167. Hagberg JM, Nagle FJ, Carlson JL. Transient O2 uptake response at the onset of exercise. J Appl Physiol . 44, 1978, 90-92.
168. Hamilton AL, Killian KJ, Summers E, Jones NL. Quantification of intensity of sensations during muscular work by normal subjects. J Appl Physiol . 81, 1996, 1156-1161.
169. Hammond MD, Gale GE, Kapitan KS, Ries A,Wagner PD. Pulmonary gas exchange in humans during exercise at sea level. J Appl Physiol . 60, 1986, 1590-1598.
170. Hansen JE, Casaburi R, Cooper DM, Wasserman K. Oxygen uptake as related to work rate increment during cycle ergometer exercise. Eur J Appl Physiol Occup Physiol . 57, 1988, 140-145.
171. Hansen JE, Sue DY, Oren A,Wasserman K. Relation of oxygen uptake to work rate in normal men and men with circulatory disorders. Am J Cardiol . 59, 1987, 669-674.
172. Hansen JE, SueDY,Wasserman K. Predicted values for clinical exercise testing. Am Rev Respir Dis . 129, 1984, S49-S55.
173. Harper AJ, Ferreira LF, Lutjemeier BJ, Townsend DK, Barstow TJ. Human femoral artery and estimated muscle capillary blood flow kinetics following the onset of exercise. Exp Physiol . 91, 2006, 661-671.
174. Harris JE, Grassi B, Rossiter HB, Hogan MC, Goodwin ML, Dobson JL, Gladden LB. Skeletal muscle function with acute creatine kinase inhibition. FASEB J . 21, 2007, 949.
175. Harris RC, Hultman E, Nordesjo LO. Glycogen, glycolytic intermediates and high-energy phosphates determined in biopsy samples of musculus quadriceps femoris of man at rest. Methods and variance of values. Scand J Clin Lab Invest . 33, 1974, 109-120.
176. Haseler LJ, Hogan MC, Richardson RS. Skeletal muscle phosphocreatine recovery in exercise-trained humans is dependent on O2 availability. J Appl Physiol . 86, 1999, 2013-2018.
177. Haseler LJ, Kindig CA, Richardson RS, Hogan MC. The role of oxygen in determining phosphocreatine onset kinetics in exercising humans. J Physiol . 558, 2004, 985-992.
178. Haseler LJ, Lin AP, Richardson RS. Skeletal muscle oxidative metabolism in sedentary humans: 31P-MRS assessment of O2 supply and demand limitations. J Appl Physiol . 97, 2004, 1077-1081.
179. Haseler LJ, Richardson RS, Videen JS, Hogan MC. Phosphocreatine hydrolysis during submaximal exercise: The effect of Fio2. J Appl Physiol . 85, 1998, 1457-1463.
180. He ZH, Bottinelli R, Pellegrino MA, Ferenczi MA, Reggiani C. ATP consumption and efficiency of human singlemuscle fiberswith different myosin isoform composition. Biophys J . 79, 2000, 945-961.
181. Hellsten Y, Krustrup P, Iaia FM, Secher NH, Bangsbo J. Partial neuromuscular blockade in humans enhances muscle blood flow during exercise independently of muscle oxygen uptake and acetylcholine receptor blockade. Am J Physiol Regul Integr Comp Physiol . 296, 2009, R1106-R1112.
182. Hepple RT, Liu PP, Plyley MJ, Goodman JM. Oxygen uptake kinetics during exercise in chronic heart failure: Influence of peripheral vascular reserve. Clin Sci (Lond) . 97, 1999, 569-577.
183. Hermansen L, Hultman E, Saltin B. Muscle glycogen during prolonged severe exercise. Acta Physiol Scand . 71, 1967, 129-139.
184. Hernandez A, Goodwin ML, Gladden LB. Slowed convective blood flow delivery speeds the onset of fatigue in highly-oxidative skeletal muscle. FASEB J . 23, 2009, 599.
185. Heubert RA, Billat VL, Chassaing P, Bocquet V, Morton RH, Koralsztein JP, di Prampero PE. Effect of a previous sprint on the parameters of the work-time to exhaustion relationship in high intensity cycling. Int J Sports Med . 26, 2005, 583-592.
186. Hill AV, Lupton H. Muscular exercise, lactic acid and the supply and utilization of oxygen. Q J Med . 16, 1923, 135-171.
187. Hill DW, Poole DC, Smith JC. The relationship between power and the time to achieve .Vo(2max). Med Sci Sports Exerc . 34, 2002, 709-714.
188. Hogan MC. Fall in intracellular PO(2) at the onset of contractions in Xenopus single skeletal muscle fibers. J Appl Physiol . 90, 2001, 1871-1876.
189. Hogan MC, Cox RH, Welch HG. Lactate accumulation during incremental exercise with varied inspired oxygen fractions. J Appl Physiol . 55, 1983, 1134-1140.
190. Hogan MC, Nioka S, Brechue WF, Chance B. A 31P-NMR study of tissue respiration in working dog muscle during reduced O2 delivery conditions. J Appl Physiol . 73, 1992, 1662-1670.
191. Hogan MC, Richardson RS, Haseler LJ. Human muscle performance and PCr hydrolysis with varied inspired oxygen fractions: A 31P-MRS study. J Appl Physiol . 86, 1999, 1367-1373.
192. HoganMC,Welch HG. Effect of altered arterial O2 tensions on muscle metabolism in dog skeletal muscle during fatiguing work. Am J Physiol . 251, 1986, C216-C222.
193. Holian A, Owen CS, Wilson DF. Control of respiration in isolated mitochondria: Quantitative evaluation of the dependence of respiratory rates on [ATP], [ADP], and [Pi]. Arch Biochem Biophys . 181, 1977, 164-171.
194. Honig CR, Connett RJ, Gayeski TE. O2 transport and its interaction with metabolism; a systems view of aerobic capacity. Med Sci Sports Exerc . 24, 1992, 47-53.
195. Housh TJ, Devries HA, Housh DJ, Tichy MW, Smyth KD, Tichy AM. The relationship between critical power and the onset of blood lactate accumulation. J Sports Med Phys Fitness . 31, 1991, 31-36.
196. Howlett RA,Heigenhauser GJ,Hultman E, Hollidge-HorvatMG, Spriet LL. Effects of dichloroacetate infusion on human skeletal muscle metabolism at the onset of exercise. Am J Physiol . 277, 1999, E18-E25.
197. Howlett RA, Heigenhauser GJ, Spriet LL. Skeletal muscle metabolism during high-intensity sprint exercise is unaffected by dichloroacetate or acetate infusion. J Appl Physiol . 87, 1999, 1747-1751.
198. Howlett RA, Parolin ML, Dyck DJ, Hultman E, Jones NL, Heigenhauser GJ, Spriet LL. Regulation of skeletal muscle glycogen phosphorylase and PDH at varying exercise power outputs. Am J Physiol . 275, 1998, R418-R425.
199. Howlett RA, Willis WT. Fiber-type-related differences in the enzymes of a proposed substrate cycle. Biochim Biophys Acta . 1363, 1998, 224-230.
200. Hsia D, Casaburi R, Pradhan A, Torres E, Porszasz J. Physiological responses to linear treadmill and cycle ergometer exercise in COPD. Eur Respir J 34(3): 605-615, 2009.
201. Hughson RL. Regulation of Vo2 on-kinetics by O2-delivery. In: Jones AM, Poole DC, editors. Oxygen Uptake Kinetics in Sport, Exercise and Medicine. London: Routledge, 2005 p. 185-211.
202. Hughson RL, Inman MD. Oxygen uptake kinetics from ramp work tests: Variability of single test values. J Appl Physiol . 61, 1986, 373-376.
203. Hughson RL, Kowalchuk JM. Kinetics of oxygen uptake for submaximal exercise in hyperoxia, normoxia, and hypoxia. Can J Appl Physiol . 20, 1995, 198-210.
204. Hughson RL, Morrissey MA. Delayed kinetics of Vo2 in the transition from prior exercise. Evidence for O2 transport limitation of Vo2 kinetics: A review. Int J Sports Med . 4, 1983, 31-39.
205. Hughson RL, Sherrill DL, Swanson GD. Kinetics of Vo2 with impulse and step exercise in humans. J Appl Physiol . 64, 1988, 451-459.
206. Hughson RL, Xing HC, Butler GC, Northey DR. Effect of hypoxia on Vo2 kinetics during pseudorandom binary sequence exercise. Aviat Space Environ Med . 61, 1990, 236-239.
207. JackmanMR,Willis WT. Characteristics of mitochondria isolated from type I and type IIb skeletal muscle. Am J Physiol . 270, 1996, C673-C678.
208. Jeneson JA,Westerhoff HV, Kushmerick MJ. A metabolic control analysis of kinetic controls in ATP free energy metabolism in contracting skeletal muscle. Am J Physiol Cell Physiol . 279, 2000, C813-C832.
209. Jenkins DG, Quigley BM. Endurance training enhances critical power. Med Sci Sports Exerc . 24, 1992, 1283-1289.
210. Jones AM, Burnley M. Effect of exercise modality on Vo2 kinetics. In: Jones AM, Poole DC, editors. Oxygen Uptake Kinetics in Sport, Exercise and Medicine. London: Routledge, 2005, p. 95-114.
211. Jones AM, Campbell IT, Pringle JS. Influence of muscle fibre type and pedal rate on the Vo2-work rate slope during ramp exercise. Eur J Appl Physiol . 91, 2004, 238-245.
212. Jones AM, Koppo K. Effect of training on Vo2 kinetics and performance. In: Jones AM, Poole DC, editors. Oxygen Uptake Kinetics in Sport, Exercise and Medicine. London: Routledge, 2005, p. 373-397.
213. Jones AM, Koppo K, Wilkerson DP, Wilmshurst S, Campbell IT. Dichloroacetate does not speed phase-II pulmonary Vo2 kinetics following the onset of heavy intensity cycle exercise. Pflugers Arch . 447, 2004, 867-874.
214. Jones AM, Poole DC. Introduction to oxygen uptake kinetics and historical development of the discipline. In: Jones AM, Poole DC, editors. Oxygen Uptake Kinetics in Sport, Exercise and Medicine. London: Routledge, 2005, p. 3-35.
215. Jones AM, Wilkerson DP, DiMenna F, Fulford J, Poole DC. Muscle metabolic responses to exercise above and below the " critical power" assessed using 31P-MRS. Am J Physiol Regul Integr Comp Physiol . 294, 2008, R585-R593.
216. Jones AM, Wilkerson DP, Fulford J. Influence of dietary creatine supplementation on muscle phosphocreatine kinetics during knee-extensor exercise in humans. Am J Physiol Regul Integr Comp Physiol . 296, 2009, R1078-R1087.
217. Jones AM, Wilkerson DP, Koppo K, Wilmshurst S, Campbell IT. Inhibition of nitric oxide synthase by L-NAME speeds phase II pulmonary.Vo2 kinetics in the transition to moderate-intensity exercise in man. J Physiol . 552, 2003, 265-272.
218. Jones NL. An obsession with CO2. Appl Physiol Nutr Metab . 33, 2008, 641-650.
219. Jones NL, Killian KJ. Exercise limitation in health and disease. N Engl J Med . 343, 2000, 632-641.
220. Jones NL, Makrides L, Hitchcock C, Chypchar T, McCartney N. Normal standards for an incremental progressive cycle ergometer test. Am Rev Respir Dis . 131, 1985, 700-708.
221. Jones S, Elliott PM, Sharma S, McKenna WJ, Whipp BJ. Cardiopulmonary responses to exercise in patients with hypertrophic cardiomyopathy. Heart . 80, 1998, 60-67.
222. Joyner MJ, Saltin B. Exercise physiology and human performance: Systems biology before systems biology! J Physiol . 586, 2008, 9.
223. Jue T, Tran TK, Mole P, Chung Y, Sailasuta N, Hurd R, Kreutzer U, Kuno S. Myoglobin and O2 consumption in exercising human gastrocnemius muscle. Adv Exp Med Biol . 471, 1999, 289-294.
224. Katz A, Sahlin K. Effect of decreased oxygen availability on NADH and lactate contents in human skeletal muscle during exercise. Acta Physiol Scand . 131, 1987, 119-127.
225. Kearon MC, Summers E, Jones NL, Campbell EJ, Killian KJ. Effort and dyspnoea duringwork of varying intensity and duration. Eur Respir J . 4, 1991, 917-925.
226. Kemp G. Physiological implications of linear kinetics of mitochondrial respiration in vitro. Am J Physiol Cell Physiol . 295, 2008, C844-C846; author reply C847-C848.
227. Kemp GJ, Meyerspeer M, Moser E. Absolute quantification of phosphorus metabolite concentrations in human muscle in vivo by 31PMRS: A quantitative review. NMR Biomed . 20, 2007, 555-565.
228. Kemps HM, De Vries WR, Hoogeveen AR, Zonderland ML, Thijssen EJ, Schep G. Reproducibility of onset and recovery oxygen uptake kinetics in moderately impaired patients with chronic heart failure. Eur J Appl Physiol . 100, 2007, 45-52.
229. Kemps HM, Prompers JJ, Wessels B, de Vries WR, Zonderland ML, Thijssen EJ, Nicolay K, Schep G, Doevendans PA. Skeletal muscle metabolic recovery following submaximal exercise in chronic heart failure is limited more by O2 delivery than O2 utilization. Clin Sci (Lond) 118(3): 203-210, 2009.
230. Kemps HM, Schep G, Zonderland ML, Thijssen EJ, De Vries WR, Wessels B, Doevendans PA, Wijn PF. Are oxygen uptake kinetics in chronic heart failure limited by oxygen delivery or oxygen utilization? Int J Cardiol 142(2): 138-144, 2010.
231. Kindig CA, Gallatin LL, Erickson HH, Fedde MR, Poole DC. Cardiorespiratory impact of the nitric oxide synthase inhibitor L-NAME in the exercising horse. Respir Physiol . 120, 2000, 151-166.
232. Kindig CA, Howlett RA, Stary CM, Walsh B, Hogan MC. Effects of acute creatine kinase inhibition on metabolism and tension development in isolated single myocytes. J Appl Physiol . 98, 2005, 541-549.
233. KindigCA, McDonough P, Erickson HH, PooleDC. Effect of L-NAME on oxygen uptake kinetics during heavy-intensity exercise in the horse. J Appl Physiol . 91, 2001, 891-896.
234. Kindig CA, Musch TI, Basaraba RJ, Poole DC. Impaired capillary hemodynamics in skeletal muscle of rats in chronic heart failure. J Appl Physiol . 87, 1999, 652-660.
235. Kindig CA, Poole DC. A comparison of the microcirculation in the rat spinotrapezius and diaphragm muscles. Microvasc Res . 55, 1998, 249-259.
236. Kindig CA, Sexton WL, Fedde MR, Poole DC. Skeletal muscle microcirculatory structure and hemodynamics in diabetes. Respir Physiol . 111, 1998, 163-175.
237. Knight DR, Poole DC, Schaffartzik W, Guy HJ, Prediletto R, Hogan MC, Wagner PD. Relationship between body and leg Vo2 during maximal cycle ergometry. J Appl Physiol . 73, 1992, 1114-1121.
238. Knuttgen HG. Oxygen debt, lactate, pyruvate, and excess lactate after muscular work. J Appl Physiol . 17, 1962, 639-644.
239. Koga S, Poole DC, Ferreira LF, Whipp BJ, Kondo N, Saitoh T, Ohmae E, Barstow TJ. Spatial heterogeneity of quadriceps muscle deoxygenation kinetics during cycle exercise. J Appl Physiol . 103, 2007, 2049-2056.
240. Koga S, Poole DC, Shiojiri T, Kondo N, Fukuba Y, Miura A, Barstow TJ. Comparison of oxygen uptake kinetics during knee extension and cycle exercise. Am J Physiol Regul Integr Comp Physiol . 288, 2005, R212-R220.
241. Koga S, Shiojiri T, Shibasaki M, Fukuba Y, Fukuoka Y, Kondo N. Kinetics of oxygen uptake and cardiac output at onset of arm exercise. Respir Physiol . 103, 1996, 195-202.
242. Koppo K, Bouckaert J. The effect of prior high-intensity cycling exercise on the Vo2 kinetics during high-intensity cycling exercise is situated at the additional slow component. Int J Sports Med . 22, 2001, 21-26.
243. Koppo K, Bouckaert J, JonesAM. Effects of training status and exercise intensity on phase II Vo2 kinetics. Med Sci Sports Exerc . 36, 2004, 225-232.
244. Koppo K, Whipp BJ, Jones AM, Aeyels D, Bouckaert J. Overshoot in Vo2 following the onset of moderate-intensity cycle exercise in trained cyclists. Eur J Appl Physiol . 93, 2004, 366-373.
245. Koppo K, Wilkerson DP, Bouckaert J, Wilmshurst S, Campbell IT, Jones AM. Influence of DCA on pulmonary (.-)V(O2) kinetics during moderate-intensity cycle exercise. Med Sci Sports Exerc . 36, 2004, 1159-1164.
246. Korzeniewski B. Oxygen consumption and metabolite concentrations during transitions between different work intensities in heart. Am J Physiol Heart Circ Physiol . 291, 2006, H1466-H1474.
247. Korzeniewski B. Regulation of oxidative phosphorylation through parallel activation. Biophys Chem . 129, 2007, 93-110.
248. Krogh A, Lindhard J. The regulation of respiration and circulation during the initial stages of muscular work. J Physiol . 47, 1913, 112-136.
249. Krogh A, Lindhard J. The changes in respiration at the transition from work to rest. J Physiol . 53, 1920, 431-437.
250. Krustrup P, Ferguson RA,Kjaer M, Bangsbo J. ATP and heat production in human skeletal muscle during dynamic exercise: Higher efficiency of anaerobic than aerobic ATP resynthesis. J Physiol . 549, 2003, 255-269.
251. Krustrup P, Jones AM,Wilkerson DP, Calbet JA, Bangsbo J. Muscular and pulmonary O2 uptake kinetics during moderate- and high-intensity sub-maximal knee-extensor exercise in humans. J Physiol . 587, 2009, 1843-1856.
252. Krustrup P, Secher NH, Relu MU, Hellsten Y, Soderlund K, Bangsbo J. Neuromuscular blockade of slow twitch muscle fibres elevates muscle oxygen uptake and energy turnover during submaximal exercise in humans. J Physiol . 586, 2008, 6037-6048.
253. Krustrup P, Soderlund K, Mohr M, Bangsbo J. Slow-twitch fiber glycogen depletion elevates moderate-exercise fast-twitch fiber activity and O2 uptake. Med Sci Sports Exerc . 36, 2004, 973-982.
254. Krustrup P, Soderlund K, Mohr M, Bangsbo J. The slow component of oxygen uptake during intense, sub-maximal exercise in man is associated with additional fibre recruitment. Pflugers Arch . 447, 2004, 855-866.
255. Krustrup P, Soderlund K, Mohr M, Gonzalez-Alonso J, Bangsbo J. Recruitment of fibre types and quadriceps muscle portions during repeated, intense knee-extensor exercise in humans. Pflugers Arch . 449, 2004, 56-65.
256. Kushmerick MJ, Meyer RA, Brown TR. Regulation of oxygen consumption in fast- and slow-twitch muscle. Am J Physiol . 263, 1992, C598-C606.
257. Lador F, Azabji Kenfack M, Moia C, Cautero M, Morel DR, Capelli C, Ferretti G. Simultaneous determination of the kinetics of cardiac output, systemic O2 delivery, and lung O2 uptake at exercise onset in men. Am J Physiol Regul Integr Comp Physiol . 290, 2006, R1071-R1079.
258. Lador F, Tam E, Azabji Kenfack M, Cautero M, Moia C, Morel DR, Capelli C, Ferretti G. Phase I dynamics of cardiac output, systemic O2 delivery, and lung O2 uptake at exercise onset in men in acute normobaric hypoxia. Am J Physiol Regul Integr Comp Physiol . 295, 2008, R624-R632.
259. Lai N, Camesasca M, Saidel GM, Dash RK, Cabrera ME. Linking pulmonary oxygen uptake, muscle oxygen utilization and cellular metabolism during exercise. Ann Biomed Eng . 35, 2007, 956-969.
260. Lai N, Saidel GM, Iorio M, Cabrera ME. Non-invasive estimation of metabolic flux and blood flowinworking muscle: Effect of blood-tissue distribution. Adv Exp Med Biol . 645, 2009, 155-160.
261. Lai N, Syed N, Saidel GM, Cabrera ME. Muscle oxygen uptake differs from consumption dynamics during transients in exercise. Adv Exp Med Biol . 614, 2008, 325-332.
262. Lai N, Zhou H, Saidel G.M. Wolf M, McCully K, Gladden L.B, Cabrera M.E. Modeling oxygenation in venous blood and skeletal muscle in response to exercise using near-infrared spectroscopy. J Appl Physiol . 106, 2009, 1858-1874.
263. Lamarra N. Variables, constants, and parameters: Clarifying the system structure. Med Sci Sports Exerc . 22, 1990, 88-95.
264. Lamarra N, Ward SA, Whipp BJ. Model implications of gas exchange dynamics on blood gases in incremental exercise. J Appl Physiol . 66, 1989, 1539-1546.
265. Lamarra N, Whipp BJ, Blumenberg M, Wasserman K. Model-order estimation of cardiorespiratory dynamics during moderate exercise. In: Whipp BJ, Wiberg DM, editors. Modelling and Control of Breathing. Oxford, UK: Elsevier Biomedical, 1983, p. 338-345.
266. Lamarra N, Whipp BJ,Ward SA,Wasserman K. The effect of hyperoxia on the coupling of ventilatory and gas-exchange dynamics in response to impulse exercise testing. In: Benchetrit G, Baconnier P, Demongeot J, editors. Concepts and Formalizations in the Control of Breathing. Manchester, UK: Manchester University Press, 1987, p. 87-100.
267. Lamarra N, Whipp BJ, Ward SA, Wasserman K. Effect of interbreath fluctuations on characterizing exercise gas exchange kinetics. J Appl Physiol . 62, 1987, 2003-2012.
268. Langsetmo I, Weigle GE, Fedde MR, Erickson HH, Barstow TJ, Poole DC. Vo2 kinetics in the horse during moderate and heavy exercise. J Appl Physiol . 83, 1997, 1235-1241.
269. Larsen FJ, Weitzberg E, Lundberg JO, Ekblom B. Effects of dietary nitrate on oxygen cost during exercise. Acta Physiol (Oxf) . 191, 2007, 59-66.
270. Larsen FJ, Weitzberg E, Lundberg JO, Ekblom B. Dietary nitrate reduces maximal oxygen consumption while maintaining work performance in maximal exercise. Free Radic Biol Med . 48, 2010, 342-347.
271. Lauderdale MA,HinchcliffKW. Hyperbolic relationship between timeto-fatigue and workload. Equine Vet J Suppl . 30, 1999, 586-590.
272. Laver DR, Lenz GK, Dulhunty AF. Phosphate ion channels in sarcoplasmic reticulum of rabbit skeletal muscle. J Physiol . 535, 2001, 715-728.
273. Lawler JM, Powers SK, Van Dijk H, Visser T, Kordus MJ, Ji LL. Metabolic and antioxidant enzyme activities in the diaphragm: Effects of acute exercise. Respir Physiol . 96, 1994, 139-149.
274. Lawler JM, Powers SK, Visser T, Van Dijk H, Kordus MJ, Ji LL. Acute exercise and skeletal muscle antioxidant and metabolic enzymes: Effects of fiber type and age. Am J Physiol . 265, 1993, R1344-R1350.
275. Le Chevalier JM, Vandewalle H, Thepaut-Mathieu C, Stein JF, Caplan L. Local critical power is an index of local endurance. Eur J Appl Physiol . 81, 2000, 120-127.
276. Le VV, Mitiku T, Hadley D, Myers J, Froelicher V. Exercise capacity at submaximal heart rate and prognosis. Int J Cardiol 142(2): 145-151, 2010.
277. Leek BT, Mudaliar SR, Henry R, Mathieu-Costello O, Richardson RS. Effect of acute exercise on citrate synthase activity in untrained and trained human skeletal muscle. Am J Physiol Regul Integr Comp Physiol . 280, 2001, R441-R447.
278. Liguzinski P, Korzeniewski B. Metabolic control over the oxygen consumption flux in intact skeletal muscle: In silico studies. Am J Physiol Cell Physiol . 291, 2006, C1213-C1224.
279. Liguzinski P, Korzeniewski B. Oxygen delivery by blood determines the maximal Vo2 and work rate during whole body exercise in humans: In silico studies. Am J Physiol Heart Circ Physiol . 293, 2007, H343-H353.
280. Linnarsson D. Dynamics of pulmonary gas exchange and heart rate changes at start and end of exercise. Acta Physiol Scand Suppl . 415, 1974, 1-68.
281. Linnarsson D, Karlsson J, Fagraeus L, Saltin B. Muscle metabolites and oxygen deficit with exercise in hypoxia and hyperoxia. J Appl Physiol . 36, 1974, 399-402.
282. Linnarsson D, Lindborg B. Breath-by-breath measurement of respiratory gas exchange using on-line analog computation. Scand J Clin Lab Invest . 34, 1974, 219-224.
283. Long CNH. Muscular exercise, lactic acid, and the supply and utilisation of oxygen: The relation between the oxygen intake during exercise and the lactic acid content of the muscles. Proc R Soc Lond . 99, 1925, 167-172.
284. MacPhee SL, Shoemaker JK, Paterson DH, Kowalchuk JM. Kinetics of O2 uptake, leg blood flow, and muscle deoxygenation are slowed in the upper compared with lower region of the moderate-intensity exercise domain. J Appl Physiol . 99, 2005, 1822-1834.
285. Mahler M. The relationship between initial creatine phosphate breakdown and recovery oxygen consumption for a single isometric tetanus of the frog sartorius muscle at 20 degrees C. J Gen Physiol . 73, 1979, 159-174.
286. Mahler M. First-order kinetics of muscle oxygen consumption, and an equivalent proportionality between Qo2 and phosphorylcreatine level. Implications for the control of respiration. J Gen Physiol . 86, 1985, 135-165.
287. MalagutiC,Nery LE, DalCorso S, De Fuccio MB, Lerario MC,Cendon S, Neder JA. Alternative strategies for exercise critical power estimation in patients with COPD. Eur J Appl Physiol . 96, 2006, 59-65.
288. Mallory LA, Scheuermann BW, Hoelting BD, Weiss ML, McAllister RM, Barstow TJ. Influence of peak Vo2 and muscle fiber type on the efficiency of moderate exercise. Med Sci Sports Exerc . 34, 2002, 1279-1287.
289. Marconi C, Pendergast D, Krasney JA, Rennie DW, Cerretelli P. Dynamic and steady-state metabolic changes in running dogs. Respir Physiol . 50, 1982, 93-110.
290. Margaria R,EdwardsHT, Dill DB. The possible mechanism of contracting and paying the oxygen debt and the role of lactic acid in muscular contraction. Am J Physiol . 106, 1933, 689-715.
291. Markovitz GH, Sayre JW, Storer TW, Cooper CB. On issues of confidence in determining the time constant for oxygen uptake kinetics. Br J Sports Med . 38, 2004, 553-560; discussion 553-560.
292. McCartney N, Heigenhauser GJ, Jones NL. Power output and fatigue of human muscle in maximal cycling exercise. J Appl Physiol . 55, 1983, 218-224.
293. McCully KK, Fielding RA, Evans WJ, Leigh JS, Jr., Posner JD. Relationships between in vivo and in vitro measurements of metabolism in young and old human calf muscles. J Appl Physiol . 75, 1993, 813-819.
294. McDonough P, Behnke BJ, Musch TI, Poole DC. Effects of chronic heart failure in rats on the recovery of microvascular Po2 after contractions in muscles of opposing fibre type. Exp Physiol . 89, 2004, 473-485.
295. McDonough P, Behnke BJ, Padilla DJ,Musch TI, Poole DC. Control of microvascular oxygen pressures in rat muscles comprised of different fibre types. J Physiol . 563, 2005, 903-913.
296. McKay BR, Paterson DH, Kowalchuk JM. Effect of short-term highintensity interval training vs. continuous training on O2 uptake kinetics, muscle deoxygenation, and exercise performance. J Appl Physiol . 107, 2009, 128-138.
297. McLellan TM, Cheung KS. A comparative evaluation of the individual anaerobic threshold and the critical power. Med Sci Sports Exerc . 24, 1992, 543-550.
298. Meakins J, Long CNH. Oxygen consumption, oxygen debt and lactic acid in circulatory failure. J Clin Invest . 4, 1927, 273-293.
299. Medbo JI,Mohn AC, Tabata I, Bahr R, Vaage O, Sejersted OM. Anaerobic capacity determined by maximal accumulated O2 deficit. J Appl Physiol . 64, 1988, 50-60.
300. Meyer K, Schwaibold M, Hajric R, Westbrook S, Ebfeld D, Leyk D, Roskamm H. Delayed Vo2 kinetics during ramp exercise: A criterion for cardiopulmonary exercise capacity in chronic heart failure. Med Sci Sports Exerc . 30, 1998, 643-648.
301. Meyer RA. A linear model of muscle respiration explains monoexponential phosphocreatine changes. Am J Physiol . 254, 1988, C548-C553.
302. Meyer RA. Linear dependence of muscle phosphocreatine kinetics on total creatine content. Am J Physiol . 257, 1989, C1149-C1157.
303. Milsum JH. Biological Control Systems Analysis. New York:McGraw-Hill, 1966.
304. Mitchell GS, Babb TG. Layers of exercise hyperpnea: Modulation and plasticity. Respir Physiol Neurobiol . 151, 2006, 251-266.
305. Miyamoto Y, Nakazono Y, Hiura T, Abe Y. Cardiorespiratory dynamics during sinusoidal and impulse exercise in man. Jpn J Physiol . 33, 1983, 971-986.
306. Miyamoto Y. Kinetics of respiratory and circulatory responses to step, impulse, sinusoidal and ramp forcings of exercise load in humans. Front Med Biol Eng . 4, 1992, 3-18.
307. Mogensen M, BaggerM, Pedersen PK, FernstromM, Sahlin K. Cycling efficiency in humans is related to low UCP3 content and to type I fibres but not to mitochondrial efficiency. J Physiol . 571, 2006, 669-681.
308. Mole PA, Chung Y, Tran TK, Sailasuta N, Hurd R, Jue T. Myoglobin desaturation with exercise intensity in human gastrocnemius muscle. Am J Physiol . 277, 1999, R173-R180.
309. Mole PA, Hoffmann JJ. Vo(2) kinetics of mild exercise are altered by RER. J Appl Physiol . 87, 1999, 2097-2106.
310. Monod H, Scherrer J. The work capacity of a synergic muscle group. Ergonomics . 8, 1965, 399-350.
311. Moritani T, Nagata A, deVries HA, Muro M. Critical power as a measure of physical work capacity and anaerobic threshold. Ergonomics . 24, 1981, 339-350.
312. Mortensen SP, Dawson EA,Yoshiga CC, DalsgaardMK, DamsgaardR, Secher NH, Gonzalez-Alonso J. Limitations to systemic and locomotor limb muscle oxygen delivery and uptake during maximal exercise in humans. J Physiol . 566, 2005, 273-285.
313. Murciano D, Ferretti A, Boczkowski J, Sleiman C, Fournier M, Milic-Emili J. Flow limitation and dynamic hyperinflation during exercise in COPD patients after single lung transplantation. Chest . 118, 2000, 1248-1254.
314. Murgatroyd SR, Ferguson C, Ward SA, Whipp BJ, Rossiter HB. Oxygen uptake kinetics as a determinant of very-heavy intensity exercise tolerance. FASEB J . 22, 2008, 1176.
315. Murphy MP, Brand MD. The control of electron flux through cytochrome oxidase. Biochem J . 243, 1987, 499-505.
316. Myers J. Exercise capacity and prognosis in chronic heart failure. Circulation 119(25): 3165-3167, 2009.
317. Neder JA, Jones PW, Nery LE, Whipp BJ. Determinants of the exercise endurance capacity in patients with chronic obstructive pulmonary disease. The power-duration relationship. Am J Respir Crit Care Med . 162, 2000, 497-504.
318. Neder JA, Jones PW, Nery LE, Whipp BJ. The effect of age on the power/duration relationship and the intensity-domain limits in sedentary men. Eur J Appl Physiol . 82, 2000, 326-332.
319. Neder JA, Nery LE, Castelo A, Andreoni S, LerarioMC, Sachs A, Silva AC, Whipp BJ. Prediction of metabolic and cardiopulmonary responses to maximum cycle ergometry: A randomised study. Eur Respir J . 14, 1999, 1304-1313.
320. Nery LE,Wasserman K, Andrews JD, Huntsman DJ,Hansen JE, Whipp BJ. Ventilatory and gas exchange kinetics during exercise in chronic airways obstruction. J Appl Physiol . 53, 1982, 1594-1602.
321. Newsholme EA, Gevers W. Control of glycolysis and gluconeogenesis in liver and kidney cortex. Vitam Horm . 25, 1967, 1-87.
322. Nielsen OB, de Paoli F, Overgaard K. Protective effects of lactic acid on force production in rat skeletal muscle. J Physiol . 536, 2001, 161-166.
323. Noakes TD. Testing for maximum oxygen consumption has produced a brainless model of human exercise performance. Br J Sports Med . 42, 2008, 551-555.
324. Oga T, Nishimura K, Tsukino M, Hajiro T, Ikeda A, Izumi T. The effects of oxitropium bromide on exercise performance in patients with stable chronic obstructive pulmonary disease. A comparison of three different exercise tests. Am J Respir Crit Care Med . 161, 2000, 1897-1901.
325. Overend TJ, Cunningham DA, Paterson DH, Smith WD. Physiological responses of young and elderly men to prolonged exercise at critical power. Eur J Appl Physiol Occup Physiol . 64, 1992, 187-193.
326. Owen CS, Wilson DF. Control of respiration by the mitochondrial phosphorylation state. Arch Biochem Biophys . 161, 1974, 581-591.
327. Ozcelik O, Ward SA, Whipp BJ. Effect of altered body CO2 stores on pulmonary gas exchange dynamics during incremental exercise in humans. Exp Physiol . 84, 1999, 999-1011.
328. Ö zyener F, Rossiter HB, Ward SA, Whipp BJ. Influence of exercise intensity on the on- and off-transient kinetics of pulmonary oxygen uptake in humans. J Physiol . 533, 2001, 891-902.
329. Ö zyener F, Rossiter HB, Ward SA, Whipp BJ. Negative accumulated oxygen deficit during heavy and very heavy intensity cycle ergometry in humans. Eur J Appl Physiol . 90, 2003, 185-190.
330. Palange P,Ward SA, Carlsen KH, Casaburi R, Gallagher CG, Gosselink R, O'Donnell DE, Puente-Maestu L, Schols AM, Singh S, Whipp BJ. Recommendations on the use of exercise testing in clinical practice. Eur Respir J . 29, 2007, 185-209.
331. Paterson DH, Whipp BJ. Asymmetries of oxygen uptake transients at the on- and offset of heavy exercise in humans. J Physiol . 443, 1991, 575-586.
332. Paterson ND, Kowalchuk JM, Paterson DH. Kinetics of.Vo2 and femoral artery blood flow during heavy-intensity, knee-extension exercise. J Appl Physiol . 99, 2005, 683-690.
333. Pedersen PK, Sorensen JB, Jensen K, Johansen L, Levin K. Muscle fiber type distribution and nonlinear.Vo(2)-power output relationship in cycling. Med Sci Sports Exerc . 34, 2002, 655-661.
334. Perrey S, Candau R, Rouillon JD, Hughson RL. The effect of prolonged submaximal exercise on gas exchange kinetics and ventilation during heavy exercise in humans. Eur J Appl Physiol . 89, 2003, 587-594.
335. Phillips SM, Green HJ, MacDonald MJ, Hughson RL. Progressive effect of endurance training on Vo2 kinetics at the onset of submaximal exercise. J Appl Physiol . 79, 1995, 1914-1920.
336. Poole DC, Barstow TJ, Gaesser GA, Willis WT, Whipp BJ. Vo2 slow component: Physiological and functional significance. Med Sci Sports Exerc . 26, 1994, 1354-1358.
337. Poole DC, Ferreira LF. Oxygen exchange in muscle of young and old rats: Muscle-vascular-pulmonary coupling. Exp Physiol . 92, 2007, 341-346.
338. Poole DC, Ferreira LF, Behnke BJ, Barstow TJ, Jones AM. The final frontier: Oxygen flux into muscle at exercise onset. Exerc Sport Sci Rev . 35, 2007, 166-173.
339. Poole DC, Henson LC. Effect of acute caloric restriction on work efficiency. Am J Clin Nutr . 47, 1988, 15-18.
340. Poole DC, Jones AM. Towards an understanding of the mechanistic bases of Vo2 kinetics. In: Jones AM, Poole DC, editors. Oxygen Uptkae Kinetics in Sport, Exercise and Medicine. London, New York: Routledge, 2005, p. 294-328.
341. Poole DC, Schaffartzik W, Knight DR, Derion T, Kennedy B, Guy HJ, Prediletto R, Wagner PD. Contribution of exercising legs to the slow component of oxygen uptake kinetics in humans. J Appl Physiol . 71, 1991, 1245-1260.
342. Poole DC, Wagner PD, Wilson DF. Diaphragm microvascular plasma Po2 measured in vivo. J Appl Physiol . 79, 1995, 2050-2057.
343. Poole DC, Ward SA, Gardner GW, Whipp BJ. Metabolic and respiratory profile of the upper limit for prolonged exercise in man. Ergonomics . 31, 1988, 1265-1279.
344. Poole DC,Ward SA, Whipp BJ. The effects of training on the metabolic and respiratory profile of high-intensity cycle ergometer exercise. Eur J Appl Physiol Occup Physiol . 59, 1990, 421-429.
345. Porszasz J, EmtnerM, Goto S, Somfay A, Whipp BJ, Casaburi R. Exercise training decreases ventilatory requirements and exercise-induced hyperinflation at submaximal intensities in patients with COPD. Chest . 128, 2005, 2025-2034.
346. Powers SK, Dodd S, Beadle RE. Oxygen uptake kinetics in trained athletes differing in Vo2max. Eur J Appl Physiol Occup Physiol . 54, 1985, 306-308.
347. Pringle JS, Doust JH, Carter H, Tolfrey K, Campbell IT, Sakkas GK, Jones AM. Oxygen uptake kinetics during moderate, heavy and severe intensity " submaximal" exercise in humans: The influence of muscle fibre type and capillarisation. Eur J Appl Physiol . 89, 2003, 289-300.
348. Pringle JS, Jones AM. Maximal lactate steady state, critical power and EMG during cycling. Eur J Appl Physiol . 88, 2002, 214-226.
349. Puente-Maestu L, SantaCruz A, Vargas T, Martinez-Abad Y, Whipp BJ. Effects of training on the tolerance to high-intensity exercise in patients with severe COPD. Respiration . 70, 2003, 367-370.
350. Puente-Maestu L, Sanz ML, Sanz P, Nunez A, Gonzalez F, Whipp BJ. Reproducibility of the parameters of the on-transient cardiopulmonary responses during moderate exercise in patients with chronic obstructive pulmonary disease. Eur J Appl Physiol . 85, 2001, 434-441.
351. Puente-Maestu L, Tena T, Trascasa C, Perez-Parra J, Godoy R, Garcia MJ, Stringer WW. Training improves muscle oxidative capacity and oxygenation recovery kinetics in patients with chronic obstructive pulmonary disease. Eur J Appl Physiol . 88, 2003, 580-587.
352. Radegran G, Saltin B. Muscle blood flow at onset of dynamic exercise in humans. Am J Physiol . 274, 1998, H314-H322.
353. Rausch SM,Whipp BJ,Wasserman K, Huszczuk A. Role of the carotid bodies in the respiratory compensation for the metabolic acidosis of exercise in humans. J Physiol . 444, 1991, 567-578.
354. Regensteiner JG, Bauer TA, Reusch JE, Brandenburg SL, Sippel JM, Vogelsong AM, Smith S, Wolfel EE, Eckel RH, Hiatt WR. Abnormal oxygen uptake kinetic responses in women with type II diabetes mellitus. J Appl Physiol . 85, 1998, 310-317.
355. Ren JM, Henriksson J, Katz A, Sahlin K. NADH content in type I and type II human muscle fibres after dynamic exercise. Biochem J . 251, 1988, 183-187.
356. Richardson RS, Newcomer SC, Noyszewski EA. Skeletal muscle intracellular PO(2) assessed bymyoglobin desaturation: Response to graded exercise. J Appl Physiol . 91, 2001, 2679-2685.
357. Richardson RS, Noyszewski EA, Kendrick KF, Leigh JS, Wagner PD. Myoglobin O2 desaturation during exercise. Evidence of limited O2 transport. J Clin Invest . 96, 1995, 1916-1926.
358. Riggs DS. Control Theory and Physiological Feedback Mechanisms. New York: Krieger, 1976.
359. RileyM,Wasserman K, Fu PC,Cooper CB. Muscle substrate utilization from alveolar gas exchange in trained cyclists. Eur J Appl PhysiolOccup Physiol . 72, 1996, 341-348.
360. Roberts PA, Loxham SJ, Poucher SM, Constantin-Teodosiu D, Greenhaff PL. Acetyl-CoA provision and the acetyl group deficit at the onset of contraction in ischemic canine skeletal muscle. Am J Physiol Endocrinol Metab . 288, 2005, E327-E334.
361. Roca J, Hogan MC, Story D, Bebout DE, Haab P, Gonzalez R, Ueno O, Wagner PD. Evidence for tissue diffusion limitation of Vo2max in normal humans. J Appl Physiol . 67, 1989, 291-299.
362. Roman BB, Meyer RA, Wiseman RW. Phosphocreatine kinetics at the onset of contractions in skeletal muscle ofMMcreatine kinase knockout mice. Am J Physiol Cell Physiol . 283, 2002, C1776-C1783.
363. Rossi-Fanelli A, Antonini E. Studies on the oxygen and carbon monoxide equilibria of human myoglobin. Arch Biochem Biophys . 77, 1958, 478-492.
364. Rossiter HB, Howe FA, Ward SA. Intramuscular phosphate and pulmonary Vo2 kinetics during exercise: Implications for control of skeletal muscle O2 consumption. In: Jones AM, and Poole DC, editors. Oxygen Uptake Kinetics in Sport, Exercise and Medicine. London: Routledge, 2005, p. 154-184.
365. Rossiter HB, Howe FA,Ward SA, Kowalchuk JM, Griffiths JR, Whipp BJ. Intersample fluctuations in phosphocreatine concentration determined by 31P-magnetic resonance spectroscopy and parameter estimation of metabolic responses to exercise in humans. J Physiol 528Pt . 2, 2000, 359-369.
366. Rossiter HB, Howlett RA, Holcombe HH, Entin PL,Wagner HE,Wagner PD. Age is no barrier to muscle structural, biochemical and angiogenic adaptations to training up to 24 months in female rats. J Physiol . 565, 2005, 993-1005.
367. Rossiter HB, Ward SA, Doyle VL, Howe FA, Griffiths JR, Whipp BJ. Inferences from pulmonary O2 uptake with respect to intramuscular [phosphocreatine] kinetics during moderate exercise in humans. J Physiol 518(pt 3): 921-932, 1999.
368. Rossiter HB, Ward SA, Howe FA, Kowalchuk JM, Griffiths JR, Whipp BJ. Dynamic inter-relationships between intramuscular PCr metabolism and pulmonary Vo2 during quadriceps exercise in man: Testing superposition using impulse and square-wave inputs. Magn Reson Mater Biol Phys Med . 14, 2002, 175-176.
369. Rossiter HB,Ward SA, Howe FA, Kowalchuk JM, Griffiths JR, Whipp BJ. Dynamics of intramuscular 31P-MRS P(i) peak splitting and the slow components of PCr and O2 uptake during exercise. J Appl Physiol . 93, 2002, 2059-2069.
370. Rossiter HB,Ward SA, Howe FA,Wood DM, Kowalchuk JM, Griffiths JR, Whipp BJ. Effects of dichloroacetate on Vo2 and intramuscular 31P metabolite kinetics during high-intensity exercise in humans. J Appl Physiol . 95, 2003, 1105-1115.
371. Rossiter HB,Ward SA, Kowalchuk JM, Howe FA, Griffiths JR,Whipp BJ. Effects of prior exercise on oxygen uptake and phosphocreatine kinetics during high-intensity knee-extension exercise in humans. J Physiol . 537, 2001, 291-303.
372. Rossiter HB,Ward SA, Kowalchuk JM, Howe FA, Griffiths JR,Whipp BJ. Dynamic asymmetry of phosphocreatine concentration and O(2) uptake between the on- and off-transients of moderate- and high-intensity exercise in humans. J Physiol . 541, 2002, 991-1002.
373. Roussel M, Mattei JP, Le Fur Y, Ghattas B, Cozzone PJ, Bendahan D. Metabolic determinants of the onset of acidosis in exercising human muscle: A 31P-MRS study. J Appl Physiol . 94, 2003, 1145-1152.
374. Rumsey WL,Vanderkooi JM,Wilson DF. Imaging of phosphorescence: A novel method for measuring oxygen distribution in perfused tissue. Science . 241, 1988, 1649-1651.
375. Sahlin K. NADH in human skeletal muscle during short-term intense exercise. Pflugers Arch . 403, 1985, 193-196.
376. Sahlin K, Sorensen JB, Gladden LB, Rossiter HB, Pedersen PK. Prior heavy exercise eliminates Vo2 slow component and reduces efficiency during submaximal exercise in humans. J Physiol . 564, 2005, 765-773.
377. Saitoh T, Ferreira LF, Barstow TJ, Poole DC, Ooue A, Kondo N, Koga S. Effects of prior heavy exercise on heterogeneity of muscle deoxygenation kinetics during subsequent heavy exercise. Am J Physiol Regul Integr Comp Physiol . 297, 2009, R615-R621.
378. Saks VA, Kaambre T, Sikk P, Eimre M, Orlova E, Paju K, Piirsoo A, Appaix F, Kay L, Regitz-Zagrosek V, Fleck E, Seppet E. Intracellular energetic units in red muscle cells. Biochem J . 356, 2001, 643-657.
379. Saltin B, Calbet JA. Point: In health and in a normoxic environment, Vo2max is limited primarily by cardiac output and locomotor muscle blood flow. J Appl Physiol . 100, 2006, 744-745.
380. Schantz PG, Henriksson J. Enzyme levels of the NADH shuttle systems: Measurements in isolated muscle fibres from humans of differing physical activity. Acta Physiol Scand . 129, 1987, 505-515.
381. Schenkman KA, Marble DR, Burns DH, Feigl EO. Myoglobin oxygen dissociation by multiwavelength spectroscopy. J Appl Physiol . 82, 1997, 86-92.
382. Scheuermann BW, Barstow TJ. O2 uptake kinetics during exercise at peak O2 uptake. J Appl Physiol . 95, 2003, 2014-2022.
383. Scheuermann BW, Hoelting BD, Noble ML, Barstow TJ. The slow component of O(2) uptake is not accompanied by changes in muscle EMG during repeated bouts of heavy exercise in humans. J Physiol . 531, 2001, 245-256.
384. Scheuermann BW, Kowalchuk JM. Attenuated respiratory compensation during rapidly incremented ramp exercise. Respir Physiol . 114, 1998, 227-238.
385. Scheuermann BW, Tripse McConnell JH, Barstow TJ. EMG and oxygen uptake responses during slow and fast ramp exercise in humans. Exp Physiol . 87, 2002, 91-100.
386. Shinohara M, Moritani T. Increase in neuromuscular activity and oxygen uptake during heavy exercise. Ann Physiol Anthropol . 11, 1992, 257-262.
387. Shoemaker JK, Hughson RL. Adaptation of blood flow during the rest to work transition in humans. Med Sci Sports Exerc . 31, 1999, 1019-1026.
388. Sietsema KE, Ben-Dov I, Zhang YY, Sullivan C, Wasserman K. Dynamics of oxygen uptake for submaximal exercise and recovery in patients with chronic heart failure. Chest . 105, 1994, 1693-1700.
389. Sietsema KE, Cooper DM, Perloff JK, Rosove MH, Child JS, Canobbio MM, Whipp BJ, Wasserman K. Dynamics of oxygen uptake during exercise in adults with cyanotic congenital heart disease. Circulation . 73, 1986, 1137-1144.
390. Sietsema KE, Daly JA, Wasserman K. Early dynamics of O2 uptake and heart rate as affected by exercise work rate. J Appl Physiol . 67, 1989, 2535-2541.
391. Smith JC,Dangelmaier BS,Hill D.W. Critical power is related to cycling time trial performance. Int J Sports Med . 20, 1999, 374-378.
392. Somfay A, Porszasz J, Lee SM, Casaburi R. Dose-response effect of oxygen on hyperinflation and exercise endurance in nonhypoxaemic COPD patients. Eur Respir J . 18, 2001, 77-84.
393. Somfay A, Porszasz J, Lee SM, Casaburi R. Effect of hyperoxia on gas exchange and lactate kinetics following exercise onset in nonhypoxemic COPD patients. Chest . 121, 2002, 393-400.
394. Sperandio PA, Borghi-Silva A, Barroco A, Nery LE, Almeida DR, Neder JA. Microvascular oxygen delivery-to-utilization mismatch at the onset of heavy-intensity exercise in optimally treated patients with CHF. Am J Physiol Heart Circ Physiol . 297, 2009, H1720-H1728.
395. Stirling JR, Zakynthinaki MS, Saltin B. A model of oxygen uptake kinetics in response to exercise: Including a means of calculating oxygen demand/deficit/debt. Bull Math Biol . 67, 2005, 989-1015.
396. Stringer W, Wasserman K, Casaburi R. The Vco2/Vo2 relationship during heavy, constant work rate exercise reflects the rate of lactic acid accumulation. Eur J Appl Physiol Occup Physiol . 72, 1995, 25-31.
397. Swanson GD, Hughson RL. On the modeling and interpretation of oxygen uptake kinetics from ramp work rate tests. J Appl Physiol . 65, 1988, 2453-2458.
398. Swanson GD, Sherrill DL. A model evaluation of estimates of breathto-breath alveolar gas exchange. J Appl Physiol . 55, 1983, 1936-1941.
399. Tevald MA, Foulis SA, Lanza IR, Kent-Braun JA. Lower energy cost of skeletal muscle contractions in older humans. Am J Physiol Regul Integr Comp Physiol 298(3): R729-R739, 2010.
400. Tevald MA, Lanza IR, Befroy DE, Kent-Braun JA. Intramyocellular oxygenation during ischemic muscle contractions in vivo. Eur J Appl Physiol . 106, 2009, 333-343.
401. Tevald MA, Lanza IR, Befroy DE, Kent-Braun JA. Intramyocellular oxygenation during ischemic muscle contractions in vivo. Eur J Appl Physiol 106(3): 333-343, 2009.
402. Timmons JA, Constantin-Teodosiu D, Poucher SM, Greenhaff PL. Acetyl group availability influences phosphocreatine degradation even during intense muscle contraction. J Physiol . 561, 2004, 851-859.
403. Timmons JA, Gustafsson T, Sundberg CJ, Jansson E, Greenhaff PL. Muscle acetyl group availability is amajor determinant of oxygen deficit in humans during submaximal exercise. Am J Physiol . 274, 1998, E377-E380.
404. Timmons JA, Poucher SM, Constantin-Teodosiu D, Worrall V, Macdonald IA, Greenhaff PL. Increased acetyl group availability enhances contractile function of canine skeletal muscle during ischemia. J Clin Invest . 97, 1996, 879-883.
405. Tonkonogi M, Harris B, Sahlin K. Increased activity of citrate synthase in human skeletal muscle after a single bout of prolonged exercise. Acta Physiol Scand . 161, 1997, 435-436.
406. Tordi N, Perrey S, Harvey A, Hughson RL. Oxygen uptake kinetics during two bouts of heavy cycling separated by fatiguing sprint exercise in humans. J Appl Physiol . 94, 2003, 533-541.
407. Toyofuku M, Takaki H, Sugimachi M, Kawada T, Goto Y, Sunagawa K. Reduced oxygen uptake increase to work rate increment (deltaVo2/deltaWR) is predictable by Vo2 response to constant work rate exercise in patients with chronic heart failure. Eur J Appl Physiol . 90, 2003, 76-82.
408. Tran TK, Sailasuta N, Hurd R, Jue T. Spatial distribution of deoxymyoglobin in human muscle: An index of local tissue oxygenation. NMR Biomed . 12, 1999, 26-30.
409. Tran TK, Sailasuta N, Kreutzer U, Hurd R, Chung Y, Mole P, Kuno S, Jue T. Comparative analysis of NMR and NIRS measurements of intracellular Po2 in human skeletal muscle. Am J Physiol . 276, 1999, R1682-R1690.
410. TschakovskyME, Hughson RL. Interaction of factors determining oxygen uptake at the onset of exercise. J Appl Physiol . 86, 1999, 1101-1113.
411. Tschakovsky ME, Rogers AM, Pyke KE, Saunders NR, Glenn N, Lee SJ, Weissgerber T, Dwyer EM. Immediate exercise hyperemia in humans is contraction intensity dependent: Evidence for rapid vasodilation. J Appl Physiol . 96, 2004, 639-644.
412. TschakovskyME, Shoemaker JK, Hughson RL. Vasodilation and muscle pump contribution to immediate exercise hyperemia. Am J Physiol . 271, 1996, H1697-H1701.
413. Turner AP, Cathcart AJ, Parker ME, Butterworth C, Wilson J, Ward SA. Oxygen uptake and muscle desaturation kinetics during intermittent cycling. Med Sci Sports Exerc . 38, 2006, 492-503.
414. van Deursen J, Heerschap A, Oerlemans F, Ruitenbeek W, Jap P, ter Laak H, Wieringa B. Skeletal muscles of mice deficient in muscle creatine kinase lack burst activity. Cell . 74, 1993, 621-631.
415. Vanhatalo A, Doust JH, Burnley M. Robustness of a 3 min all-out cycling test to manipulations of power profile and cadence in humans. Exp Physiol . 93, 2008, 383-390.
416. Vanhatalo A, Fulford J, Dimenna F, Jones AM. Influence of hyperoxia on muscle metabolic responses and the power-duration relationship during severe-intensity exercise in humans: A 31P-MRS study. Exp Physiol 95(4): 528-540, 2010.
417. Vogiatzis I, Zakynthinos S, Georgiadou O, Golemati S, Pedotti A, Macklem PT, Roussos C, Aliverti A. Oxygen kinetics and debt during recovery from expiratory flow-limited exercise in healthy humans. Eur J Appl Physiol . 99, 2007, 265-274.
418. Wackerhage H, Hoffmann U, Essfeld D, Leyk D, Mueller K, Zange J. Recovery of free ADP, Pi, and free energy of ATP hydrolysis in human skeletal muscle. J Appl Physiol . 85, 1998, 2140-2145.
419. Wagner PD. Determinants of maximal oxygen transport and utilization. Annu Rev Physiol . 58, 1996, 21-50.
420. Wagner PD. New ideas on limitations to Vo2max. Exerc Sport Sci Rev . 28, 2000, 10-14.
421. Wagner PD. Skeletal muscles in chronic obstructive pulmonary disease: Deconditioning, or myopathy? Respirology . 11, 2006, 681-686.
422. Wagner PD. Counterpoint: In health and in normoxic environment Vo2max is limited primarily by cardiac output and locomotor muscle blood flow. J Appl Physiol . 100, 2006, 745-747; discussion 747-748.
423. Wagner PD,West JB. Effects of diffusion impairment on O 2 and CO 2 time courses in pulmonary capillaries. J Appl Physiol . 33, 1972, 62-71.
424. Wakayoshi K, Ikuta K, Yoshida T, Udo M, Moritani T, Mutoh Y, Miyashita M. Determination and validity of critical velocity as an index of swimming performance in the competitive swimmer. Eur J Appl Physiol Occup Physiol . 64, 1992, 153-157.
425. Wallimann T, Wyss M, Brdiczka D, Nicolay K, Eppenberger HM. Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: The " phosphocreatine circuit" for cellular energy homeostasis. Biochem J 281(pt 1): 21-40, 1992.
426. Walsh B, Tonkonogi M, Soderlund K, Hultman E, Saks V, Sahlin K. The role of phosphorylcreatine and creatine in the regulation of mitochondrial respiration in human skeletal muscle. J Physiol . 537, 2001, 971-978.
427. Ward SA, Whipp BJ. Influence of body CO2 store on ventilatorymetabolic coupling during exercise. In: Honda Y, Mijamoto Y, Konno K, Widdicombe JG, editors. Control of Breathing and Its Modelling Perspective. New York: Plenum Press, 1992, p. 425-443.
428. Ward SA, Whipp BJ, Koyal S, Wasserman K. Influence of body CO2 stores on ventilatory dynamics during exercise. J Appl Physiol . 55, 1983, 742-749.
429. Wasserman K. Breath-by-breath determination of alveolar gas exchange. J Appl Physiol . 54, 1983, 599.
430. Wasserman K, Hansen JE, Sue DY, Stringer WW, Whipp BJ. Principles of Exercise Testing and Interpretation: Including Pathophysiology and Clinical Applications. Philadelphia, PA: Lippincott Williams & Wilkins, 2005, p. 1-585.
431. Wasserman K, McIlroy MB. Detecting the threshold of anaerobic metabolism in cardiac patients during exercise. Am J Cardiol . 14, 1964, 844-852.
432. Wasserman K, Sue DY. Coupling of external to cellular respiration. In: Wasserman K, editor. Exercise Gas Exchange in Heart Disease. Armonk, NY: Futura, 1996, p. 1-15.
433. Wasserman K, Van Kessel AL, Burton GG. Interaction of physiological mechanisms during exercise. J Appl Physiol . 22, 1967, 71-85.
434. Wasserman K, Whipp BJ. Exercise physiology in health and disease (state of the art). Am Rev Respir Dis . 112, 1975, 219-249.
435. Wasserman K, Whipp BJ, Casaburi R. Respiratory control during exercise. In: Macklem PT, Mead J, editors. Handbook of Physiology, The Respiratory System II. Bethesda, MD: The American Physiology Society, 1986, p. 595-619.
436. Wasserman K, Whipp BJ, Casaburi R, Beaver WL. Carbon dioxide flow and exercise hyperpnea. Cause and effect. Am Rev Respir Dis . 115, 1977, 225-237.
437. Wasserman K, Whipp BJ, Casaburi R, Beaver WL, and Brown HV. CO2 flow to the lungs and ventilatory control. In: Dempsey JA, Reed CE, editors. Muscular Exercise and the Lung.Madison, WI: University of Wisconsin Press, 1977, p. 105-135.
438. Weissman ML, Jones PW, Oren A, Lamarra N, Whipp BJ, Wasserman K. Cardiac output increase and gas exchange at start of exercise. J Appl Physiol . 52, 1982, 236-244.
439. Wessel HU, Stout RL, Bastanier CK, Paul MH. Breath-by-breath variation of FRC: Effect on Vo2 and Vco2 measured at the mouth. J Appl Physiol . 46, 1979, 1122-1126.
440. Whipp BJ. The control of exercise hyperpnea. In: Hornbein T, editor. Regulation of Breathing. New York: Dekker Inc, 1981, p. 1069-1139.
441. Whipp BJ. Dynamics of pulmonary gas exchange. Circulation . 76, 1987, VI18-VI28.
442. Whipp BJ. Domains of aerobic function and their limiting parameters. In: Steinacker JM, Ward SA, editors. The Physiology and Pathophysiology of Exercise Tolerance. New York: Plenum, 1996, p. 83-89.
443. WhippBJ. Exercise physiology. In:AkayM, editor.Wiley Encyclopedia of Bio-Medical Engineering. Hoboken, NJ: Wiley, 2006.
444. Whipp BJ. Physiological mechanisms dissociating pulmonary CO2 and O2 exchange dynamics during exercise in humans. Exp Physiol . 92, 2007, 347-355.
445. Whipp BJ. Control of the exercise hyperpnea: The unanswered question. Adv Exp Med Biol . 605, 2008, 16-21.
446. Whipp BJ, Agostoni P. Noninvasive estimation of the lactate threshold in a subject with dissociated ventilatory and pulmonary gas exchange indices: A case report. Chest . 132, 2007, 1994-1997.
447. Whipp BJ, Davis JA, Torres F, Wasserman K. A test to determine parameters of aerobic function during exercise. J Appl Physiol . 50, 1981, 217-221.
448. Whipp BJ, Lamarra N,Ward SA. Required characteristics of pulmonary gas exchange dynamics for non-invasive determination of the anaerobic threshold. In: Benchetrit G, Baconnier P, Demongeot J, editors. Concepts and Formulations in the Control of Breathing. Manchester, UK: Manchester University Press, 1987, p. 185-200.
449. Whipp BJ, Lamarra N, Ward SA. Obligatory anaerobiosis resulting from oxygen uptake-to-blood flow ratio dispersion in skeletal muscle: A model. Eur J Appl Physiol Occup Physiol . 71, 1995, 147-152.
450. Whipp BJ, Mahler M. Dynamics of pulmonary gas exchange during exercise. In: West JB, editor. Pulmonary Gas Exchange. New York: Academic Press, 1980, p. 33-96.
451. Whipp BJ, Rossiter HB. The kinetics of oxygen uptake: Physiological inferences from the parameters. In: Jones AM, Poole DC, editors. Oxygen Uptake Kinetics in Sport, Exercise and Medicine. London: Routledge, 2005, p. 62-94.
452. Whipp BJ, Rossiter HB, Ward SA. Exertional oxygen uptake kinetics: A stamen of stamina? Biochem Soc Trans . 30, 2002, 237-247.
453. Whipp BJ, Rossiter HB, Ward SA, Avery D, Doyle VL, Howe FA, Griffiths JR. Simultaneous determination of muscle 31P and O2 uptake kinetics during whole body NMR spectroscopy. J Appl Physiol . 86, 1999, 742-747.
454. Whipp BJ, Stirling JR, Zakynthinaki MS. Point: Counterpoint " The kinetics of oxygen uptake during muscular exercise do/do not manifest time-delayed phases." J Appl Physiol 107(5): 1674, 2009.
455. Whipp BJ, Ward SA. Control of ventilatory dynamics during exercise. Int J Sport Sci . 1, 1981, 146-159.
456. Whipp BJ,Ward SA. Cardiopulmonary coupling during exercise. J Exp Biol . 100, 1982, 175-193.
457. Whipp BJ, Ward SA. The coupling of ventilation to pulmonary gas exchange during exercise. In: Whipp BJ, Wasserman K, editors. Pulmonary Physiology and Pathophysiology of Exercise. New York: Dekker, 1991, p. 271-307.
458. Whipp BJ,Ward SA. Pulmonary gas exchange dynamics and the tolerance to muscular exercise: Effects of fitness and training. Ann Physiol Anthropol . 11, 1992, 207-214.
459. Whipp BJ, Ward SA. Respiratory responses of athletes to exercise. In: Harries M, Williams C, Stanish WD, Micheli LJ, editors. Oxford Textbook of Sports Medicine. Oxford, UK: Oxford University Press, 1994, p. 13-26.
460. Whipp BJ, Ward SA. Quantifying intervention-related improvements in exercise tolerance. Eur Respir J . 33, 2009, 1254-1260.
461. Whipp BJ, Ward SA, Lamarra N, Davis JA, Wasserman K. Parameters of ventilatory and gas exchange dynamics during exercise. J Appl Physiol . 52, 1982, 1506-1513.
462. Whipp BJ, Ward SA, Rossiter HB. Pulmonary O2 uptake during exercise: Conflatingmuscular and cardiovascular responses. Med Sci Sports Exerc . 37, 2005, 1574-1585.
463. Whipp BJ, Ward SA, Wasserman K. Respiratory markers of the anaerobic threshold. Adv Cardiol . 35, 1986, 47-64.
464. WhippBJ,Wasserman K. Oxygen uptake kinetics for various intensities of constant-load work. J Appl Physiol . 33, 1972, 351-356.
465. Whipp BJ, Wasserman K. Exercise. In: Murray JF, Nadel JA, editors. Textbook of Respiratory Medicine. Philadelphia: WB Saunders, 1996, p. 219-250.
466. Wilkerson DP, Campbell IT, Jones AM. Influence of nitric oxide synthase inhibition on pulmonaryO2 uptake kinetics during supra-maximal exercise in humans. J Physiol . 561, 2004, 623-635.
467. Wilkerson DP, Rittweger J, Berger NJ, Naish PF, Jones AM. Influence of recombinant human erythropoietin treatment on pulmonary O2 uptake kinetics during exercise in humans. J Physiol . 568, 2005, 639-652.
468. Wilson DF. Factors affecting the rate and energetics of mitochondrial oxidative phosphorylation. Med Sci Sports Exerc . 26, 1994, 37-43.
469. Wilson DF, ErecinskaM, Drown C, Silver IA. Effect of oxygen tension on cellular energetics. Am J Physiol . 233, 1977, C135-C140.
470. Wilson DF, Erecinska M, Drown C, Silver IA. The oxygen dependence of cellular energy metabolism. Arch Biochem Biophys . 195, 1979, 485-493.
471. Wilson DF, Rumsey WL. Factors modulating the oxygen dependence of mitochondrial oxidative phosphorylation. Adv Exp Med Biol . 222, 1988, 121-131.
472. Wilson DF, Rumsey WL, Green TJ, Vanderkooi JM. The oxygen dependence of mitochondrial oxidative phosphorylation measured by a new optical method for measuring oxygen concentration. J Biol Chem . 263, 1988, 2712-2718.
473. Wilson JR, Mancini DM, McCully K, Ferraro N, Lanoce V, Chance B. Noninvasive detection of skeletal muscle underperfusion with nearinfrared spectroscopy in patients with heart failure. Circulation . 80, 1989, 1668-1674.
474. Wu F, Jeneson JA, Beard DA. Oxidative ATP synthesis in skeletal muscle is controlled by substrate feedback. Am J Physiol Cell Physiol . 292, 2007, C115-C124.
475. Wust RC, Aliverti A, Capelli C, Kayser B. Breath-by-breath changes of lung oxygen stores at rest and during exercise in humans. Respir Physiol Neurobiol . 164, 2008, 291-299.
476. Xu L, Poole DC, Musch TI. Effect of heart failure on muscle capillary geometry: Implications for O2 exchange. Med Sci Sports Exerc . 30, 1998, 1230-1237.
477. Yamamoto WS. A mathematical simulation of the hyperpneas of metabolic CO2 production and inhalation. Am J Physiol . 235, 1978, R265-R278.
478. Yamashiro SM, Yamashiro PK, Glenny RW, Robertson HT. Non-linear dynamics of cardiopulmonary responses during exercise. In: Honda Y, Mijamoto Y, Konno K, editors. Control of Breathing and its Modelling Perspective. New York: Plenum Press, 1992, p. 271-274.
479. Yano T, Yunoki T, Ogata H. Relationship between the slow component of oxygen uptake and the potential reduction in maximal power output during constant-load exercise. J Sports Med Phys Fitness . 41, 2001, 165-169.
480. Yoshida T, Whipp BJ. Dynamics of the pulmonary O2 uptake to blood flow ratio (Vo2/Q) during and following constant-load exercise. Adv Exp Med Biol . 393, 1995, 207-211.
481. Zhang YY, Johnson MC II, Chow N,Wasserman K. The role of fitness on Vo2 and Vco2 kinetics in response to proportional step increases in work rate. Eur J Appl Physiol Occup Physiol . 63, 1991, 94-100.
482. Zhang YY,Wasserman K, Sietsema KE, Ben-Dov I, Barstow TJ,Mizumoto G, Sullivan CS. O2 uptake kinetics in response to exercise. A measure of tissue anaerobiosis in heart failure. Chest . 103, 1993, 735-741.
483. Zhou H, Lai N, Saidel GM, Cabrera ME. Multi-scale model of O2 transport and metabolism: Response to exercise. Ann NY Acad Sci . 1123, 2008, 178-186.
484. Zoladz JA, Duda K, Majerczak J. Oxygen uptake does not increase linearly at high power outputs during incremental exercise test in humans. Eur J Appl Physiol Occup Physiol . 77, 1998, 445-451.
485. Zoladz JA, Gladden LB, HoganMC, Nieckarz Z, Grassi B. Progressive recruitment of muscle fibers is not necessary for the slow component of Vo2 kinetics. J Appl Physiol . 105, 2008, 575-580.
486. Zoladz JA, Rademaker AC, Sargeant AJ. Non-linear relationship between O2 uptake and power output at high intensities of exercise in humans. J Physiol 488(pt 1): 211-217, 1995.