Influence of recombinant human erythropoietin treatment on pulmonary O2 uptake kinetics during exercise in humans

Journal of Physiology

Volumn 568, Issue 2, 2005, Pages 639-652

  Wilkerson, Daryl P ^a   Rittweger, Jörn ^a   Berger, Nicolas J A ^a   Naish, Patrick F ^b   Jones, Andrew M ^a,c  

^a MANCHESTER METROPOLITAN UNIVERSITY   (United Kingdom)

^b UNIVERSITY HOSPITALS OF NORTH MIDLANDS NHS TRUST   (United Kingdom)

^c UNIVERSITY OF EXETER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; RECOMBINANT ERYTHROPOIETIN; SODIUM CHLORIDE; PLACEBO;

ADULT; ARTERIAL OXYGEN SATURATION; ARTICLE; BREATH ANALYSIS; CELL METABOLISM; CONTROLLED STUDY; CYCLING; EXERCISE; FEMALE; HEMOGLOBIN DETERMINATION; HUMAN; HUMAN EXPERIMENT; JOB PERFORMANCE; LUNG DIFFUSION; LUNG GAS EXCHANGE; MALE; NORMAL HUMAN; OXYGEN CONSUMPTION; OXYGEN TRANSPORT; PRIORITY JOURNAL; TIME; TRANSPORT KINETICS; ARTERIAL OXYGEN TENSION; EXERCISE TEST; GAS EXCHANGE; KINETICS; VELOCITY;

DOUBLE-BLIND METHOD; ERYTHROPOIETIN, RECOMBINANT; EXERCISE TEST; EXERTION; HEMATOCRIT; HEMOGLOBINS; HUMANS; KINETICS; MALE; OXYGEN CONSUMPTION; PULMONARY GAS EXCHANGE;

EID: 27644532276     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2005.089920     Document Type: Article

References (64)

1. Bangsbo J, Krustrup P, Gonzalez-Alonso J & Saltin B (2000). Muscle oxygen kinetics at onset of intense dynamic exercise in humans. Am J Physiol 279, R899-R906.
2. Berglund B & Ekblom B (1991). Ffect of recombinant human erythropoietin treatment on blood pressure and some haematological parameters in healthy men. J Intern Med 229, 125-130.
3. Birkeland KI, Stray-Gundersen J, Hemmersbach P, Hallen J, Haug E & Bahr R (2000). Effect of RhEPO administration on serum levels of sTfR and cycling performance. Med Sci Sports Exerc 32, 1238-1243.
4. Burnley M, Jones AM, Carter H & Doust JH (2000). Effect of prior heavy exercise on phase II pulmonary oxygen uptake kinetics and the slow component during heavy exercise in humans. J Appl Physiol 89, 1387-1396.
5. Cerretelli P, Rennie DW & Pendergast DP (1980). Kinetics of metabolic transients during exercise. In Exercise Bioenergetics and Gas Exchange. ed. Cerretelli P & Whipp BJ, pp. 187-209. Elsevier, Amsterdam.
6. Connes P, Perrey S, Varrat A, Prefaut C & Caillaud C (2003). Faster oxygen uptake kinetics at the onset of submaximal cycling exercise following 4 weeks recombinant human erythropoietin (r-HuEPO) treatment. Pflugers Arch 447, 231-238.
7. De Cort SC, Innes JA, Barstow TJ & Guz A (1991). Cardiac output, oxygen consumption and arteriovenous oxygen difference following a sudden rise in exercise level in humans. J Physiol 441, 501-512.
8. Delp MD & O'Leary DS (2004). Integrative control of the skeletal muscle microcirculation in the maintenance of arterial pressure during exercise. J Appl Physiol 97, 1112-1118.
9. Ekblom B & Berglund B (1991). Effect of erythropoietin administration on maximal aerobic power. Scand J Med Sci Sports 1, 88-93.
10. 2 uptake and heart rate kinetics during heavy exercise. J Appl Physiol 81, 2500-2508.
11. Evans MK, Savasi I, Heigenhauser GJ & Spriet LL (2001). Effects of acetate infusion and hyperoxia on muscle substrate phosphorylation after onset of moderate exercise. Am J Physiol 281, E1144-E1150.
12. Gerbino A, Ward SA & Whipp BJ (1996). Effects of prior exercise on pulmonary gas-exchange kinetics during high-intensity exercise in humans. J Appl Physiol 80, 99-107.
13. Gonzalez-Alonso J & Calbet JAL (2003). Reductions in systemic and skeletal muscle blood flow and oxygen delivery limit maximal aerobic capacity in humans. Circulation 107, 824-830.
14. O2 on-kinetics in isolated in situ canine muscle. J Appl Physiol 85, 1394-1403.
15. O2 on-kinetics in isolated in situ canine muscle. J Appl Physiol 85, 1404-1412.
16. O2. J Appl Physiol 89, 1293-1301.
17. 2 uptake kinetics in humans: implications for metabolic control. J Appl Physiol 80, 988-998.
18. Haseler LJ, Kindig CA, Richardson RS & Hogan MC (2004). The role of oxygen in determining phosphocreatine onset kinetics in exercising humans. J Physiol 558, 985-992.
19. 2 uptake of in situ dog muscle working maximally. J Appl Physiol 73, 2470-2475.
20. Hopkins WG, Hawley JA & Burke LM (1999). Design and analysis of research on sport performance enhancement. Med Sci Sports Exerc 31, 472-485.
21. 2 uptake kinetics at onset of supine exercise with than without lower body negative pressure. J Appl Physiol 75, 1962-1967.
22. O2 during arm exercise with circulatory occlusion of the legs. Int J Sports Med 7, 22-25.
23. Hughson RL, Schijvens H, Burrows S, Devitt D, Betik AC & Hopman MTE (2003). Blood flow and metabolic control at the onset of heavy exercise. Int J Sport Health Sci 1, 1-9.
24. Jones AM, Koppo K & Burnley M (2003a). Effects of prior exercise on metabolic and gas exchange responses to exercise. Sports Med 33, 949-971.
25. Jones AM & Poole DC (2005). Oxygen uptake dynamics: from muscle to mouth. Med Sci Sports Exerc (in press).
26. O2 kinetics. In Oxygen Uptake Kinetics in Sport, Exercise and Medicine, ed. Jones AM & Poole DC, pp. 261-293, Routledge, London
27. Jones AM, Wilkerson DP & Campbell IT (2004). Nitric oxide synthase inhibition with L-NAME, reduces maximal oxygen uptake but not gas exchange threshold during incremental cycle exercise in man. J Physiol 560, 329-338.
28. O2 kinetics in the transition to moderate-intensity exercise in man. J Physiol 552, 265-272.
29. Kindig CA, Howlett RA, Stary CM, Walsh B & Hogan MC (2005). Effects of acute creatine kinase inhibition on metabolism and tension development in isolated single myocytes. J Appl Physiol 98, 541-549.
30. Kindig CA, McDonough P, Erickson HH & Poole DC (2001). Effect of L-NAME on oxygen uptake kinetics during heavy-intensity exercise in the horse. J Appl Physiol 91, 891-896.
31. Kindig CA, McDonough P, Erickson HH & Poole DC (2002). Nitric oxide synthase inhibition speeds oxygen uptake kinetics in horses during moderate domain running. Respir Physiol Neurobiol 132, 169-178.
32. 2 supply and utilization in men. J Appl Physiol 75, 2586-2594.
33. Koga S, Shiojiri T, Shibasaki M, Kondo N, Fukuba Y & Barstow TJ (1999). Kinetics of oxygen uptake during supine and upright heavy exercise. J Appl Physiol 87, 253-260.
34. O2 kinetics during high-intensity cycling exercise is situated at the additional slow component. Int J Sports Med 22, 21-26.
35. O2 kinetics during arm exercise above the heart level. Med Sci Sports Exerc 37, 613-619.
36. O2 kinetics. Med sci Sports Exerc 36, 225-232.
37. Krustrup P, Gonzalez-Alonso J, Quistorff B & Bangsbo J (2001). Muscle heat production and anaerobic energy turnover during repeated intense dynamic exercise in humans. J Physiol 536, 947-956.
38. Lamarra N, Whipp BJ, Ward SA & Wasserman K (1987). Effect of interbreath fluctuations on characterizing exercise gas exchange kinetics. J Appl Physiol 62.
39. Linde T, Sandhagen B, Danielson BG & Wikstrom B (1992). Impaired erythrocyte fluidity during treatment of renal anaemia with erythropoietin. J Intern Med 231, 601-606.
40. O2 kinetics in heavy submaximal exercise by hyperoxia and prior high-intensity exercise. J Appl Physiol 83, 1318-1325.
41. MacDonald MJ, Shoemaker JK, Tschakovsky ME & Hughson RL (1998). Uveolar oxygen uptake and femoral artery blood flow dynamics in upright and supine leg exercise in humans. J Appl Physiol 85, 1622-1628.
42. MacDonald MJ, Tarnopolsky MA & Hughson RL (2000). Effect of hyperoxia and hypoxia on leg blood flow and pulmonary and leg oxygen uptake at the onset of kicking exercise. Can J Physiol Pharmacol 78, 67-74.
43. 2 transport during exercise in patients with chronic renal failure. J Clin Invest 97, 2092-2100.
44. O2 kinetics during intense exercise. J Appl Physiol 90, 1057-1064.
45. Parisotto R, Gore CJ, Emslie KR, Ashenden MJ, Brugnara C, Howe C, Martin DT, Trout GJ & Hahn AG (2000). A novel method utilising markers of altered erythropoiesis for the detection of recombinant human erythropoietin abuse in athletes. Haematologica 85, 564-572.
46. O2 kinetics. In Oxygen Uptake Kinetics in Sport, Exercise and Medicine, ed. Jones AM & Poole DC, pp. 298-328. Routledge, London.
47. O2 kinetics in different disease states. In Oxygen Uptake Kinetics in Sport, Exercise and Medicine, ed. Jones AM & Poole DC, pp. 298-328. Routledge, London.
48. Reid MB (1998). Role of nitric oxide in skeletal muscle: synthesis, distribution and functional importance. Acta Physiol Scand 162, 401-409.
49. 2 uptake between the on- and off-transients of moderate- and high-intensity exercise in humans. J Physiol 541, 991-1002.
50. Russell G, Gore CJ, Ashenden MJ, Parisotto R & Hahn AG (2002). Effects of prolonged low doses of recombinant human erythropoietin during submaximal and maximal exercise. Eur J Appl Physiol 86, 442-449.
51. Saltin B & Strange S (1992). Maximal oxygen uptake: 'old' and 'new' arguments for a cardiovascular limitation. Med Sci Sports Exerc 24, 30-37.
52. Savasi I, Evans MK, Heigenhauser GJ & Spriet LL (2002). Skeletal muscle metabolism is unaffected by DCA infusion and hyperoxia after onset of intense aerobic exercise. Am J Physiol 283, E108-E115.
53. Tordi N, Perrey S, Harvey A & Hughson RL (2003). Oxygen uptake kinetics during two bouts of heavy cycling separated by fatiguing sprint exercise in humans. J Appl Physiol 94, 533-541.
54. Tschakovsky ME & Hughson RL (1999). Interaction of factors determining oxygen uptake at the onset of exercise. J Appl Physiol 86, 1101-1113.
55. Wagner PD (1996). Determinants of maximal oxygen transport and utilization. Annu Rev Physiol 58, 21-50.
56. O2max. Exerc Sport Sci Rev 28, 10-14.
57. Wasserman K, Hansen JE, Sue DY, Whipp BJ & Casaburi R (1994). Principles of Exercise Testing and Prescription. Lea & Febiger, Philadelphia.
58. Welch HG, Bonde-Petersen F, Graham T, Klausen K & Secher N (1977). Effects of hyperoxia on leg blood flow and metabolism during exercise. J Appl Physiol 42, 385-390.
59. Whipp BJ, Davis JA, Torres F & Wasserman K (1981). A test to determine parameters of aerobic function during exercise. J Appl Physiol 50, 217-221.
60. Whipp BJ & Mahler M (1980). Dynamics of pulmonary gas exchange during exercise. In Pulmonary Gas Exchange, ed. West JB, pp. 33-96. Academic Press, New York.
61. Whipp BJ & Rossiter HB (2005). The kinetics of oxygen uptake: physiological inferences from the parameters. In Oxygen Uptake Kinetics in Sport, Exercise and Medicine, ed. Jones AM & Poole DC, pp. 62-114. Routledge, London.
62. Whipp BJ & Wasserman K (1972). Oxygen uptake kinetics for various intensities of constant-load work. J Appl Physiol 33, 351-356.
63. 2 uptake kinetics during supra-maximal exercise in humans. J Physiol 561, 623-635.
64. 2 uptake kinetics following the onset of perimaximal exercise. J Appl Physiol 97, 1227-1236.