Oxygen uptake kinetics during exercise are slowed in patients with peripheral arterial disease

Journal of Applied Physiology

Volumn 87, Issue 2, 1999, Pages 809-816

  Bauer, Timothy A ^a   Regensteiner, Judith G ^a,b   Brass, Eric P ^c   Hiatt, William R ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

Heart rate; Muscle metabolism; Oxygen consumption

Indexed keywords

OXYGEN;

ADULT; ARTERY DISEASE; ARTERY OCCLUSION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EXERCISE; GAS EXCHANGE; HUMAN; MUSCLE METABOLISM; OXYGEN CONSUMPTION; PRIORITY JOURNAL; SKELETAL MUSCLE;

EID: 0032841029     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1999.87.2.809     Document Type: Article

References (38)

1. Arfvidsson, B., A. Wennmalm, J. Gelin, A. G. Dahllof, B. Hallgren, and K. Lundholm. Co-variation between walking ability and circulatory alterations in patients with intermittent claudication. Eur. J. Vasc. Surg. 6: 642-646, 1992.
2. Auchincloss, J. H., K. Ashutosh, S. Rana, D. Peppi, L. W. Johnson, and R. Gilbert. Effect of cardiac, pulmonary, and vascular disease on one-minute oxygen uptake. Chest 70: 486-493, 1976.
3. Auchincloss, J. H. J., J. W. Meade, R. Gilbert, and B. E. Chamberlain. One minute oxygen uptake in peripheral ischemic vascular disease. Ann. Surg. 191: 203-206, 1980.
4. Babcock, M. A., D. H. Paterson, and D. A. Cunningham. Effects of aerobic endurance training on gas exchange kinetics of older men. Med. Sci. Sports Exerc. 26, 447-452, 1994.
5. Barstow, T. J., S. Buchthal, S. Zanconato, and D. M. Cooper. Muscle energetics and pulmonary oxygen uptake kinetics during moderate exercise. J. Appl. Physiol. 77: 1742-1749, 1994.
6. Barstow, T. J., and P. A. Molé. Linear and nonlinear characteristics of oxygen uptake kinetics during heavy exercise. J. Appl. Physiol. 71: 2099-2106, 1991.
7. 2 uptake during exercise transients in humans. J. Appl. Physiol. 63: 2253-2261, 1987.
8. Belardinelli, R., Y. Y. Zhang, K. Wasserman, A. Purcaro, and P. G. Agostoni. A four-minute submaximal constant work rate exercise test to assess cardiovascular functional class in chronic heart failure. Am. J. Cardiol. 81: 1210-1214, 1998.
9. Bhat, H. K., W. R. Hiatt, C. L. Hoppel, and E. P. Brass. Skeletal muscle mitochondrial DNA injury in patients with unilateral peripheral arterial disease. Circulation 99: 807-812, 1999.
10. Brass, E. P. Skeletal muscle metabolism as a target for drug therapy in peripheral arterial disease. Vasc. Med. 1: 55-59, 1996.
11. Bruce, R. A., F. Kusumi, and D. Hosmer. Maximal oxygen intake and nomographic assessment of functional aerobic impairment in cardiovascular disease. Am. Heart J. 85: 546-562, 1973.
12. Bylund-Fellenius, A. C., P. M. Walker, A. Elander, and T. Schersten. Peripheral vascular disease. Am. Rev. Respir. Dis. 129: S65-S67, 1984.
13. Carlson, L. A., and B. Pernow. Studies on the peripheral circulation and metabolism in man. II. Oxygen utilization and lactate-pyruvate formation in the legs at rest and during exercise in patients with arteriosclerosis obliterans. Acta Med. Scand. 171: 311-323, 1962.
14. Drexler, H., U. Riede, T. Munzel, H. Konig, E. Funke, and H. Just. Alterations of skeletal muscle in chronic heart failure. Circulation 85: 1751-1759, 1992.
15. Gardner, A. W., J. S. Skinner, N. R. Vaughan, C. X. Bryant, and L. K. Smith. Comparison of three progressive exercise protocols in peripheral vascular occlusive disease. Angiology 43: 661-671, 1992.
16. 2 uptake in humans: implications for metabolic control. J. Appl. Physiol. 80: 988-998, 1996.
17. Hansen, J. E., D. Y. Sue, A. Oren, and K. Wasserman. Relation of oxygen uptake to work rate in normal men and men with circulatory disorders. Am. J. Cardiol. 59: 669-674, 1987.
18. Hiatt, W. R., D. Nawaz, and E. P. Brass. Carnitine metabolism during exercise in patients with peripheral vascular disease. J. Appl. Physiol. 62: 2383-2387, 1987.
19. Hiatt, W. R., J. G. Regensteiner, E. E. Wolfel, M. R. Carry, and E. P. Brass. Effect of exercise training on skeletal muscle histology and metabolism in peripheral arterial disease. J. Appl. Physiol. 81: 780-788, 1996.
20. Hiatt, W. R., E. E. Wolfel, R. H. Meier, and J. G. Regensteiner. Superiority of treadmill walking exercise vs. strength training for patients with peripheral arterial disease. Implications for the mechanism of the training response. Circulation 90: 1866-1874, 1994.
21. Hiatt, W. R., E. E. Wolfel, J. G. Regensteiner, and E. P. Brass. Skeletal muscle carnitine metabolism in patients with unilateral peripheral arterial disease. J. Appl. Physiol. 73: 346-353, 1992.
22. Jansson, E., J. Johansson, C. Sylven, and L. Kaijser. Calf muscle adaptation in intermittent claudication. Side-differences in muscle metabolic characteristics in patients with unilateral arterial disease. Clin. Physiol. 8: 17-29, 1988.
23. 31P magnetic resonance spectroscopy. Clin. Sci. (Colch.) 89: 581-590, 1995.
24. 31P magnetic resonance spectroscopy of abnormal mitochondrial oxidation in skeletal muscle during recovery from exercise. NMR Biomed. 6: 302-310, 1993.
25. Koike, A., M. Hiroe, H. Adachi, T. Yajima, Y. Yamauchi, A. Nogami, H. Ito, Y. Miyahara, M. Korenaga, and F. Marumo. Oxygen uptake kinetics are determined by cardiac function at onset of exercise rather than peak exercise in patients with prior myocardial infarction. Circulation 90: 2324-2332, 1994.
26. Koike, A., K. Wasserman, D. K. McKenzie, S. Zanconato, and D. Weiler-Ravell. Evidence that diffusion limitation determines oxygen uptake kinetics during exercise in humans. J. Clin. Invest. 86: 1698-1706, 1990.
27. Koike, A., T. Yajima, H. Adachi, N. Shimizu, H. Kano, K. Sugimoto, A. Niwa, F. Marumo, and M. Hiroe. Evaluation of exercise capacity using submaximal exercise at a constant work rate in patients with cardiovascular disease. Circulation 91: 1719-1724, 1995.
28. Lundgren, F., K. Bennegard, A. Elander, K. Lundholm, T. Schersten, and A. C. Bylund-Fellenius. Substrate exchange in human limb muscle during exercise at reduced blood flow. Am. J. Physiol. 255 (Heart Circ. Physiol 24): H1156-H1164, 1988.
29. Pernow, B., and S. Zetterquist. Metabolic evaluation of the leg blood flow in claudicating patients with arterial obstructions at different levels. Scand. J. Clin. Lab. Invest. 21: 277-287, 1968.
30. Petersen, E. S., B. J. Whipp, J. A. Davis, D. J. Huntsman, H. V. Brown, and K. Wasserman. Effects of beta-adrenergic blockade on ventilation and gas exchange during exercise in humans. J. Appl. Physiol. 54: 1306-1313, 1983.
31. 2 kinetics at the onset of submaximal exercise. J. Appl. Physiol. 79: 1914-1920, 1995.
32. Regensteiner, J. G., E. E. Wolfel, E. P. Brass, M. R. Carry, S. P. Ringel, M. E. Hargarten, E. R. Stamm, and W. R. Hiatt. Chronic changes in skeletal muscle histology and function in peripheral arterial disease. Circulation 87: 413-421, 1993.
33. Rotstein, A., M. Sagiv, A. Yaniv-Tamir, N. Fisher, and R. Dotan. Smoking effect on exercise response kinetics of oxygen uptake and related variables. Int. J. Sports Med. 12: 281-284, 1991.
34. Sietsema, K. E., I. Ben-Dov, Y. Y. Zhang, C. Sullivan, and K. Wasserman. Dynamics of oxygen uptake for submaximal exercise and recovery in patients with chronic heart failure. Chest 105: 1693-1700, 1994.
35. Sietsema, K. E., D. M. Cooper, J. K. Perloff, M. H. Rosove, J. S. Child, M. M. Canobbio, B. J. Whipp, and K. Wasserman. Dynamics of oxygen uptake during exercise in adults with cyanotic congenital heart disease. Circulation 73: 1137-1144, 1986.
36. Whipp, B. J., S. A. Ward, N. Lamarra, J. A. Davis, and K. Wasserman. Parameters of ventilatory and gas exchange dynamics during exercise. J. Appl. Physiol. 52: 1506-1513, 1982.
37. 31P nuclear magnetic resonance spectroscopy: noninvasive biochemical analysis of the ischemic extremity. J. Vasc. Surg. 3: 411-420, 1986.
38. 2 uptake kinetics in response to exercise. A measure of tissue anaerobiosis in heart failure. Chest 103: 735-741, 1993.