Interaction of factors determining oxygen uptake at the onset of exercise

Journal of Applied Physiology

Volumn 86, Issue 4, 1999, Pages 1101-1113

  Tschakovsky, M E ^a   Hughson, R L ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

Author keywords

Exercise; Mitochondrial respiration; Muscle energetics; Oxygen delivery

Indexed keywords

ENZYME ACTIVATION; EXERCISE; HUMAN; MITOCHONDRIAL RESPIRATION; MUSCLE METABOLISM; OXIDATION REDUCTION POTENTIAL; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; OXYGEN TRANSPORT; PRIORITY JOURNAL; REVIEW;

EID: 0032938841     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1999.86.4.1101     Document Type: Review

References (105)

1. Arthur, P. G., M. C. Hogan, D. E. Bebout, P. D. Wagner, and P. W. Hochachka. Modeling the effects of hypoxia on ATP turnover in exercising muscle. J. Appl. Physiol. 73: 737-742, 1992.
2. Balaban, R. S. Regulation of oxidative phosphorylation in the mammalian cell. Am. J. Physiol. 258 (Cell Physiol. 27): C377-C389, 1990.
3. Barstow, T. J., S. Buchthal, S. Zanconato, and D. M. Cooper. Muscle energetics and pulmonary oxygen uptake kinetics during moderate exercise. J. Appl. Physiol. 77: 1742-1749, 1994.
4. Barstow, T. J., S. D. Buchthal, S. Zanconato, and D. M. Cooper. Changes in potential controllers of human skeletal muscle respiration during incremental calf exercise. J. Appl. Physiol. 77: 2169-2176, 1994.
5. 2 deficit as related to exercise intensity and blood lactate. J. Appl. Physiol. 75: 755-762, 1993.
6. 2 uptake by circulatory dynamics during exercise. J. Appl. Physiol. 68: 979-989, 1990.
7. 2 uptake during exercise transients in humans. J. Appl. Physiol. 63: 2253-2261, 1987.
8. Barstow, T. J., and P.A. Molé. Linear and nonlinear characteristics of oxygen uptake kinetics during heavy exercise. J. Appl. Physiol. 71: 2099-2106, 1991.
9. Berg, B. R., K. D. Cohen, and I. H. Sarelius. Direct coupling between blood flow and metabolism at the capillary level in striated muscle. Am. J. Physiol. 272 (Heart Circ. Physiol. 41): H2693-H1222, 1997.
10. Berg, W. Individual differences in respiratory gas exchange during recovery from moderate exercise. Am. J. Physiol. 149: 597-610, 1947.
11. Binzoni, T., and P. Cerretelli. Bioenergetic approach to transfer function of human skeletal muscle. J. Appl. Physiol. 77: 1784-1789, 1994.
12. 31P-NMR at the onset of constant-load exercise in humans. J. Appl. Physiol. 73: 1644-1649, 1992.
13. Brown, G. C. Control of respiration and ATP synthesis in mammalian mitochondria and cells. Biochem. J. 284: 1-13, 1992.
14. Carafoli, E. Regulation of aerobic metabolism in muscle. In: Exercise Bioenergetics and Gas Exchange: Proceedings of the International Symposium on Exercise Bioenergetics and Gas Exchange, edited by P. Cerretelli and B. J. Whipp. Amsterdam: Elsevier/North-Holland Biomedical, 1980, p. 3-23.
15. 2 on-response and early blood lactate. J. Appl. Physiol. 47: 761-769, 1979.
16. Cerretelli, P., R. Sikand, and L. E. Farhi. Readjustments in cardiac output and gas exchange during onset of exercise and recovery. J. Appl. Physiol. 21: 1345-1350, 1966.
17. Chance, B., and C. M. Williams. The respiratory chain and oxidative phosphorylation. Adv. Enzymol. 17: 65-134, 1956.
18. 2 transport and utilization mechanisms at the onset of exercise. J. Appl. Physiol. 73: 2382-2388, 1992.
19. Connett, R. J. Factors governing the recruitment of glycolysis and oxygen consumption during the rest-work transition in red skeletal muscle. In: Biochemical Aspects of Physical Exercise, edited by G. Benzi, L. Packer, and N. Siliprandi. Amsterdam: Elsevier Science Biomedical, 1986, p. 113-127.
20. 2. J. Appl. Physiol. 68: 833-842, 1990.
21. Davies, C. T. M., P. E. Di Prampero, and P. Cerretelli. Kinetics of cardiac output and respiratory gas exchange during exercise and recovery. J. Appl. Physiol. 32: 618-625, 1972.
22. De Cort, S. C., J. A. Innes, T. J. Barstow, and A. Guz. Cardiac output, oxygen consumption and arteriovenous oxygen difference following a sudden rise in exercise level in humans. J. Physiol. (Lond.) 441: 501-512, 1991.
23. Delp, M. D., and M. H. Laughlin. Regulation of skeletal muscle perfusion during exercise. Acta Physiol. Scand. 162: 411-419, 1998.
24. 2 deficit at the onset of stepping and cycling. J. Appl. Physiol. 66: 2023-2031, 1989.
25. 2 debt in exercise. Pflügers Arch. 304: 11-19, 1968.
26. Douguet, D., J. Raynaud, A. Capderou, C. Pannier, G. Reiss, and J. Durand. Muscular venous blood metabolites during rhythmic forearm exercise while breathing air or normoxic helium and argon gas mixtures. Clin. Physiol. 8: 367-378, 1988.
27. Eriksen, M., B. A. Waaler, L. Walloe, and J. Wesche. Dynamics and dimensions of cardiac output changes in humans at the onset and at the end of moderate rhythmic exercise. J. Physiol. (Lond.) 426: 423-437, 1990.
28. Essfeld, D., U. Hoffman, and J. Stegemann. A model for studying the distortion of muscle oxygen uptake patterns by circulation parameters. Eur. J. Appl. Physiol. 62: 83-90, 1991.
29. Folkow, B., U. Haglund, M. Jodal, and O. Lundgren. Blood flow in the calf muscle of man during heavy rhythmic exercise. Acta Physiol. Scand. 81: 157-163, 1971.
30. From, A. H., S. K. Zimmer, S. P. Michurski, P. Mohanakrishnan, V. K. Ulstad, W. J. Thoma, and K. Ugurbil. Regulation of the oxidative phosphorylation rate in the intact cell. Biochemistry 29: 3731-3743, 1990.
31. Funk, C. I., A. J. Clark, and R. J. Connett. A simple model of aerobic metabolism: applications to work transitions in muscle. Am. J. Physiol. 258 (Cell Physiol. 27): C995-C1005, 1990.
32. Gayeski, T. E., R. J. Connett, and C. R. Honig. Oxygen transport in rest-work transition illustrates new functions for myoglobin. Am. J. Physiol. 248 (Heart Circ. Physiol. 17): H914-H921, 1985.
33. 2 for maximum cytochrome turnover in red muscle in situ. Am. J. Physiol. 252 (Heart Circ. Physiol. 21): H906-H915, 1987.
34. Gerbino, A., S. A. Ward, and B. J. Whipp. Effects of prior exercise on pulmonary gas-exchange kinetics during high-intensity exercise in humans. J. Appl. Physiol. 80: 99-107, 1996.
35. 2 on-kinetics in isolated in situ canine muscle. J. Appl. Physiol. 85: 1394-1403, 1998.
36. 2 on-kinetics in isolated in situ canine muscle. J. Appl. Physiol. 85: 1404-1412, 1998.
37. Grassi, B., C. Marconi, M. Meyer, M. Rieu, and P. Cerretelli. Gas exchange and cardiovascular kinetics with different exercise protocols in heart transplant recipients. J. Appl. Physiol. 82: 1952-1962, 1997.
38. 2 uptake kinetics in humans: implications for metabolic control. J. Appl. Physiol. 80: 988-998, 1996.
39. Hansford, R. G. Role of calcium in respiratory control. Med. Sci. Sports Exerc. 26: 44-51, 1994.
40. O2. J. Appl. Physiol. 85: 1457-1463, 1998.
41. Henry, F. M. Aerobic oxygen consumption and alactic debt in muscular work. J. Appl. Physiol. 3: 427-438, 1951.
42. Henry, F. M., and J. C. De Moor. Lactic and alactic oxygen consumption in moderate exercise of graded intensity. J. Appl. Physiol. 8: 608-614, 1956.
43. Hochachka, P. W. Integrating ATP supply and demand. In: Muscles as Molecular and Metabolic Machines, edited by P. W. Hochachka. Boca Raton, FL: CRC Press, 1994, p. 95-118.
44. Hochachka, P. W., and G. O. Matheson. Regulating ATP turnover rates over broad dynamic work ranges in skeletal muscles. J. Appl. Physiol. 73: 1697-1703, 1992.
45. Hochachka, P. W., and G. B. McClelland. Cellular metabolic homeostasis during large-scale change in ATP turnover rates in muscles. J. Exp. Biol. 200: 381-386, 1997.
46. 2 in regulating tissue respiration in dog muscle working in situ. J. Appl. Physiol. 73: 728-736, 1992.
47. 2 delivery in dog muscle in situ. J. Appl. Physiol. 70: 2656-2662, 1991.
48. Hogan, M. C., L. B. Gladden, B. Grassi, C. M. Stary, and M. Samaja. Bioenergetics of contracting skeletal muscle after partial reduction of blood flow. J. Appl. Physiol. 84: 1882-1888, 1998.
49. 2 delivery conditions. J. Appl. Physiol. 73: 1662-1670, 1992.
50. 2 tensions on muscle metabolism in dog skeletal muscle during fatiguing work. Am. J. Physiol. 251 (Cell Physiol. 20): C216-C222, 1986.
51. Honig, C. R., C. L. Odoroff, and J. L. Frierson. Capillary recruitment in exercise: rate, extent, uniformity, and relation to blood flow. Am. J. Physiol. 238 (Heart Circ. Physiol. 7): H31-H42, 1980.
52. Hughson, R. L. Alterations in the oxygen deficit-oxygen debt relationships with β-adrenergic receptor blockade in man. J. Physiol. (Lond.) 349: 375-387, 1984.
53. Hughson, R. L. Exploring cardiorespiratory control mechanisms through gas exchange dynamics. Med. Sci. Sports Exerc. 22: 72-79, 1990.
54. Hughson, R. L., J. G. Cochrane, and G. C. Butler. Faster oxygen uptake kinetics at onset of supine exercise with lower body negative pressure. J. Appl. Physiol. 75: 1962-1967, 1993.
55. Hughson, R. L., and M. D. Inman. Faster kinetics of oxygen uptake during arm exercise with circulatory occlusion of the legs (Abstract). Int. J. Sports Med. 7: 22-25, 1986.
56. Hughson, R. L., and J. M. Kowalchuk. Beta-blockade and oxygen delivery to muscle during exercise. Can. J. Physiol. Pharmacol. 69: 285-289, 1991.
57. Hughson, R. L., and J. M. Kowalchuk. Kinetics of oxygen uptake for submaximal exercise in hyperoxia, normoxia, and hypoxia. Can. J. Appl. Physiol. 20: 199-211, 1995.
58. Hughson, R. L., and M. A. Morrissey. Delayed kinetics of respiratory gas exchange in the transition from prior exercise. J. Appl. Physiol. 52: 921-929, 1982.
59. 2 kinetics: a review. Int. J. Sports Med. 4: 31-39, 1983.
60. 2 on blood flow dynamics at onset of forearm exercise. J. Appl. Physiol. 81: 1619-1626, 1997.
61. Idstrom, J.-P., V. Harihara Subramanian, B. Chance, T. Schersten, and A.-C. Bylund-Fellenius. Oxygen dependence of energy metabolism in contracting and recovering rat skeletal muscle. Am. J. Physiol. 248 (Heart Circ. Physiol. 17): H40-H48, 1985.
62. Johnson, P. C., P. D. Wagner, and D. F. Wilson. Regulation of oxidative metabolism and blood flow in skeletal muscle: summary report of the first ACSM Basic Science Specialty Conference. Med. Sci. Sports Exerc. 28: 305-314, 1996.
63. Kagaya, A., and F. Ogita. Blood flow during muscle contraction and relaxation in rhythmic exercise at different intensities. Ann. Physiol. Anthrop. 11: 251-256, 1992.
64. Katz, L. A., J. A. Swain, M. A. Portman, and R. S. Balaban. Relation between phosphate metabolites and oxygen consumption of heart in vivo. Am. J. Physiol. 256 (Heart Circ. Physiol. 25): H265-H274, 1989.
65. Krogh, A., and J. Lindhard. The regulation of respiration and circulation during the initial stages of muscular work. J. Physiol. (Lond.) 47: 112-136, 1913.
66. Laughlin, M. H. Skeletal muscle blood flow capacity: the role of the muscle pump in exercise hyperemia. Am. J. Physiol. 253 (Heart Circ. Physiol. 22): H296-H306, 1987.
67. Laughlin, M. H., R. J. Korthuis, D. J. Duncker, and R. J. Bache. Control of blood flow to cardiac and skeletal muscle during exercise. In: Handbook of Physiology. Exercise: Regulation and Integration of Multiple Systems. Bethesda, MD: Am. Physiol. Soc., 1996, sect. 12, chapt. 16, p. 705-769.
68. Linnarsson, D., J. Karlson, L. Fagraeus, and B. Saltin. Muscle metabolites and oxygen deficit with exercise in hypoxia and hyperoxia. J. Appl. Physiol. 36: 399-402, 1974.
69. 2 kinetics in heavy submaximal exercise by hyperoxia and prior high-intensity exercise. J. Appl. Physiol. 83: 1318-1325, 1997.
70. MacDonald, M. J., M. E. Tschakovsky, and R. L. Hughson. Alveolar oxygen uptake and femoral artery blood flow dynamics in upright and supine exercise in humans. J. Appl. Physiol. 85: 1622-1628, 1998.
71. Mahler, M. Kinetics and control of oxygen consumption in skeletal muscle. In: Exercise Bioenergetics and Gas Exchange: Proceedings of the International Symposium on Exercise Bioenergetics and Gas Exchange, edited by P. Cerretelli and B. J. Whipp. Amsterdam: Elsevier/North-Holland Biomedical, 1980, p. 53-66.
72. 2 and phosphorylcreatine level. J. Gen. Physiol. 86: 136-165, 1985.
73. Marsh, G. D., D. H. Paterson, J. J. Potwarka, and R. T. Thompson. Transient changes in muscle high-energy phosphates during moderate exercise. J. Appl. Physiol. 75: 648-656, 1993.
74. Meyer, R. A. A linear model of muscle respiration explains monoexponential phosphocreatine changes. Am. J. Physiol. 254 (Cell Physiol. 23): C548-C553, 1988.
75. Meyer, R. A., and J. M. Foley. Testing models of respiratory control in skeletal muscle. Med. Sci. Sports Exerc. 26: 52-57, 1994.
76. Moreno-Sanchez, R., B. A. Hogue, and R. G. Hansford. Influence of NAD-linked dehydrogenase activity on flux through oxidative phosphorylation. Biochem. J. 268: 421-428, 1990.
77. Murphy, P. C., L. A. Cuervo, and R. L. Hughson. A study of cardiorespiratory dynamics with step and ramp exercise tests in normoxia and hypoxia. Cardiovasc. Res. 23: 825-832, 1989.
78. Newsholme, E. A., and A. R. Leech. Biochemistry for the Medical Sciences. Toronto: Wiley, 1983.
79. Pendergast, D. R., D. Shindell, P. Cerretelli, and D. W. Rennie. Role of central and peripheral circulatory adjustments in oxygen transport at the onset of exercise. Int. J. Sports Med. 1: 160-170, 1980.
80. Piiper, J. Unequal distribution of blood flow in exercising muscle of the dog. Res. Physiol. 80: 129-136, 1990.
81. 2 transport. J. Clin. Invest. 96: 1916-1926, 1995.
82. 2 consumption (Abstract). Med. Sci. Sports Exerc. 29: S272, 1997.
83. Robergs, R. A., M. V. Icenogle, T. L. Hudson, and E. R. Greene. Temporal inhomogeneity in brachial artery blood flow during forearm exercise. Med. Sci. Sports Exerc. 29: 1021-1027, 1997.
84. Rowell, L. B. Human Cardiovascular Control. New York: Oxford Univ. Press, 1993.
85. Saltin, B. Hemodynamic adaptations to exercise. Am. J. Cardiol. 55: 42D-47D, 1985.
86. Saltin, B., G. Radegran, M. D. Koskolou, and R. C. Roach. Skeletal muscle blood flow in humans and its regulation during exercise. Acta Physiol. Scand. 162: 421-436, 1998.
87. Sarelius, I. H. Cell and oxygen flow in arterioles controlling capillary perfusion. Am. J. Physiol. 265 (Heart Circ. Physiol. 34): H1682-H1687, 1993.
88. Sheriff, D. D., L. B. Rowell, and A. M. Scher. Is rapid rise in vascular conductance at onset of dynamic exercise due to muscle pump? Am. J. Physiol. 265 (Heart Circ. Physiol. 34): H1227-H1234, 1993.
89. Shoemaker, J. K., J. R. Halliwill, R. L. Hughson, and M. J. Joyner. Contributions of acetylcholine and nitric oxide to forearm blood flow at exercise onset and recovery. Am. J. Physiol. 273 (Heart Circ. Physiol. 42): H2388-H2395, 1997.
90. Shoemaker, J. K., S. M. Phillips, H. J. Green, and R. L. Hughson. Faster femoral artery blood velocity kinetics at the onset of exercise following short-term training. Cardiovasc. Res. 31: 278-286, 1996.
91. Timmons, J. A., T. Gustafsson, C. J. Sundberg, E. Jansson, and P. L. Greenhaff. Muscle acetyl group availability is a major determinant of oxygen deficit in humans during submaximal exercise. Am. J. Physiol. 274 (Endocrinol. Metab. 37): E377-E380, 1998.
92. Timmons, J. A., T. Gustafsson, C. J. Sundberg, E. Jansson, E. Hultman, L. Kaijser, J. Chwalbinska-Moneta, D. Constantin-Teodosiu, I. A. Macdonald, and P. L. Greenhaff. Substrate availability limits human skeletal muscle oxidative ATP regeneration at the onset of ischemic exercise. J. Clin. Invest. 97: 879-883, 1996.
93. Tschakovsky, M. E., J. K. Shoemaker, and R. L. Hughson. Vasodilation and muscle pump contribution to immediate exercise hyperemia. Am. J. Physiol. 271 (Heart Circ. Physiol. 40): H1697-H1701, 1996.
94. Van Beek, J. H. G. M., and N. Westerhof. Response time of cardiac mitochondrial oxygen consumption to heart rate steps. Am. J. Physiol. 260 (Heart Circ. Physiol. 29): H613-H625, 1991.
95. Van Bolhuis, B. M., W. P. Medendorp, and C. C. A. M. Gielen. Motor unit firing behavior in human arm flexor muscles during sinusoidal isometric contractions and movements. Exp. Brain Res. 117: 120-130, 1997.
96. Wagner, P. D. Central and peripheral aspects of oxygen transport and adaptations with exercise. Sports Med. 11: 133-142, 1991.
97. Whipp, B. J., and M. Mahler. Dynamics of pulmonary gas exchange during exercise. In: Pulmonary Gas Exchange, edited by J. B. West. New York: Academic, 1980, vol. II, p. 33-96.
98. Whipp, B. J., and S. A. Ward. Physiological determinants of pulmonary gas exchange kinetics during exercise. Med. Sci. Sports Exerc. 22: 62-71, 1990.
99. Williamson, J. W., P. B. Raven, and B. J. Whipp. Unaltered oxygen uptake kinetics at exercise onset with lower-body positive pressure in humans. Exp. Physiol. 81: 695-705, 1996.
100. Wilson, D. F., M. Erecinska, E. M. Nuutinen, and I. A. Silver. Dependence of cellular metabolism and local oxygen delivery on oxygen tension. Adv. Exp. Med. Biol. 180: 629-634, 1984.
101. Wilson, D. F., M. Erecinska, and I. A. Silver. Metabolic effects of lowering oxygen tension in vivo. Adv. Exp. Med. Biol. 159: 293-301, 1983.
102. Wilson, D. F., and W. L. Rumsey. Factors modulating the oxygen dependence of mitochondrial oxidative phosphorylation. Adv. Exp. Med. Biol. 222: 121-131, 1988.
103. Wilson, D. F., W. L. Rumsey, T. J. Green, and J. M. Vanderkooi. The oxygen dependence of mitochondrial oxidative phosphorylation measured by a new optical method for measuring oxygen concentration. J. Biol. Chem. 263: 2712-2718, 1983.
104. Yoshida, T., J. Kamiya, and K. Hishimoto. Are oxygen uptake kinetics at the onset of exercise speeded up by local metabolic status in active muscles? Eur. J. Appl. Physiol. 70: 482-486, 1995.
105. Yoshida, T., and B. J. Whipp. Dynamic asymmetries of cardiac output transients in response to muscular exercise in man. J. Physiol. (Lond.) 480: 355-359, 1994.